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Literature summary for 1.1.1.1 extracted from

  • Wagner, F.W.; Pares, X.; Holmquist, B.; Vallee, B.L.
    Physical and enzymatic properties of a class III isozyme of human liver alcohol dehydrogenase: chi-ADH (1984), Biochemistry, 23, 2193-2199.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Methylpyrazole class III enzyme is completely insensitive to inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
NADH
-
Homo sapiens
0.0064
-
NADH isoenzyme beta1,beta1 Homo sapiens
0.007
-
NADH isoenzyme gamma1,gamma1 Homo sapiens
0.0074
-
NAD+ isoenzyme beta2,beta2 Homo sapiens
0.0079
-
NAD+ isoenzyme gamma1,gamma1 Homo sapiens
0.0087
-
NAD+ isoenzyme gamma2,gamma2 Homo sapiens
0.011
-
NADH isoenzyme alpha,alpha Homo sapiens
0.013
-
NAD+ isoenzyme alpha,alpha Homo sapiens
0.025
-
NAD+
-
Homo sapiens
0.1
-
12-hydroxydodecanoate
-
Homo sapiens
0.105
-
NADH isoenzyme beta2,beta2 Homo sapiens
0.18
-
NAD+ isoenzyme beta1,beta1 Homo sapiens
1.2
-
Octanol
-
Homo sapiens
2.4
-
octanal
-
Homo sapiens
11
-
Vanillyl alcohol
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc contains 3.8 mol of Zn per mol of protein Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
2 * 40000, SDS-PAGE Homo sapiens
41000
-
2 * 41000, class III isoenzyme chi ADH, SDS-PAGE Homo sapiens
82700
-
equilibrium sedimentation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoenzyme chi-ADH
-
Homo sapiens
-
class III isoenzyme
-

Purification (Commentary)

Purification (Comment) Organism
class III isoenzyme chi-ADH Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.6
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
4°C, 10 mM HEPES buffer, 1 mM dithioerythritol, pH 7.5, stable for 2 weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxydodecanoate + NAD+
-
Homo sapiens 12-oxododecanoic acid + NADH
-
?
17beta-hydroxyetiocholan-3-one + NAD+
-
Homo sapiens ethiocholan-3,17-dione + NADH
-
?
benzyl alcohol + NAD+
-
Homo sapiens benzaldehyde + NADH
-
?
butanol + NAD+
-
Homo sapiens butyraldehyde + NADH
-
?
digitose + NAD+
-
Homo sapiens ? + NADH
-
?
ethanol + NAD+ class III isoenzyme chi-ADH oxidizes ethanol very poorly Homo sapiens acetaldehyde + NADH
-
?
ethylene glycol + NAD+ class III isoenzyme chi-ADH shows no activity Homo sapiens ? + NADH
-
?
furfuryl alcohol + NAD+
-
Homo sapiens furfural + NADH
-
?
methanol + NAD+ class III isoenzyme chi-ADH shows no activity Homo sapiens formaldehyde + NADH + H+
-
?
octan-2-ol + NAD+
-
Homo sapiens octan-2-one + NADH
-
?
octanal + NADH + H+
-
Homo sapiens octanol + NAD+
-
?
pentanal + NAD+
-
Homo sapiens pentanone + NADH
-
?
phenylalaninol + NAD+
-
Homo sapiens ? + NADH
-
?
vanillyl alcohol + NAD+
-
Homo sapiens vanillin + NADH
-
?

Subunits

Subunits Comment Organism
dimer 2 * 40000, SDS-PAGE Homo sapiens
dimer 2 * 41000, class III isoenzyme chi ADH, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.245
-
Pentanol
-
Homo sapiens
0.467
-
Vanillyl alcohol
-
Homo sapiens
3.03
-
12-hydroxydodecanoate
-
Homo sapiens
3.33
-
octanal
-
Homo sapiens
7.33
-
Octanol
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens