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Literature summary for 1.1.1.1 extracted from

  • Wagner, F.W.; Burger, A.R.; Vallee, B.L.
    Kinetic properties of human liver alcohol dehydrogenase: oxidation of alcohols by class I isoenzymes (1983), Biochemistry, 22, 1857-1863.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km values for the class I isoenzymes with the substrates ethanol, methanol, ethylene glycol, benzyl alcohol, octanol, cyclohexanol and 16-hydroxyhexadecanoic acid Homo sapiens
0.008
-
Cyclohexanol isoenzyme alpha,gamma1 Homo sapiens
0.08
-
Octanol isoenzyme alpha,gamma1 Homo sapiens
1.7
-
ethanol isoenzyme alpha,gamma1 Homo sapiens
23
-
Cyclohexanol isoenzyme beta1,beta1 Homo sapiens
50
-
ethylene glycol isoenzyme alpha,gamma1 Homo sapiens
150
-
methanol isoenzyme alpha,gamma1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
class I isoenzymes: alpha,gamma2, gamma2gamma2, alpha,gamma1, alpha,beta1, beta1,gamma2, gamma1,gamma1, beta1,gamma1, beta1,beta1
-

Purification (Commentary)

Purification (Comment) Organism
class I isoenzymes Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
16-hydroxyhexadecanoate + NAD+
-
Homo sapiens 16-oxohexadecanoic acid + NADH
-
?
3-phenyl-1-propanol + NAD+
-
Homo sapiens 3-phenyl-1-propanone + NADH
-
?
benzyl alcohol + NAD+
-
Homo sapiens benzaldehyde + NADH
-
?
cyclohexanol + NAD+
-
Homo sapiens cyclohexanone + NADH
-
?
ethanol + NAD+
-
Homo sapiens acetaldehyde + NADH
-
?
ethylene glycol + NAD+
-
Homo sapiens ? + NADH
-
?
methanol + NAD+ class I isoenzymes Homo sapiens formaldehyde + NADH + H+
-
?
octan-1-ol + NAD+
-
Homo sapiens n-octanal + NADH
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information turnover-numbers for the class I isoenzymes with the substrates ethanol, methanol, ethylene glycol, benzyl alcohol, octanol, cyclohexanol and 16-hydroxyhexadecanoic acid Homo sapiens
3.83
-
ethanol isoenzyme gamma1,gamma1 Homo sapiens
4
-
ethanol isoenzyme alpha,gamma1 Homo sapiens
4.33
-
Octanol isoenzyme alpha,gamma1 Homo sapiens
4.67
-
benzyl alcohol isoenzyme alpha,gamma1 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens