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Literature summary for 1.1.1.1 extracted from

  • Herrera, E.; Zorzano, A.; Fresneda, V.
    Comparative kinetics of human and rat liver alcohol dehydrogenase (1983), Biochem. Soc. Trans., 11, 729-730.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
pyrazole 0.05 mM, 50% inhibition Homo sapiens
pyrazole 0.05 mM, complete inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.8
-
ethanol
-
Rattus norvegicus
1.8
-
ethanol
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ethanol + NAD+ Homo sapiens enzyme is responsible for the major ethanol oxidation capacity in the body. The products acetaldehyde and NADH are responsible for the most of the toxic effects and metabolic disturbances produced by ethanol ingestion acetaldehyde + NADH
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethanol + NAD+
-
Homo sapiens acetaldehyde + NADH
-
?
ethanol + NAD+
-
Rattus norvegicus acetaldehyde + NADH
-
?
ethanol + NAD+ enzyme is responsible for the major ethanol oxidation capacity in the body. The products acetaldehyde and NADH are responsible for the most of the toxic effects and metabolic disturbances produced by ethanol ingestion Homo sapiens acetaldehyde + NADH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.5
-
-
Homo sapiens
10.5
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus
NADH
-
Homo sapiens
NADH
-
Rattus norvegicus