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(R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
(S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate
5'-adenylyl-beta,gamma-imidodiphosphate + D-ribose 5-phosphate
?
9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate
9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + D-ribose 5-phosphate
ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
?
ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
?
ATP + 6-deoxyhomoribose 6-phosphonate
AMP + 6-deoxyhomoribose 6-phosphonate 1-diphosphate
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + D-ribose 5-phosphothionate
AMP + 5-phosphotionate-alpha-D-ribose 1-diphosphate
ATP + ribulose-5-phosphate
AMP + 5-phospho-ribulose-1-diphosphate
-
-
-
r
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
D-ribose 5-phosphate + ATP
5-phospho-alpha-D-ribose 1-diphosphate + AMP
biosynthesis of purines and pyrimidines
-
-
?
D-ribose 5-phosphate + ATP
phosphoribosyldiphosphate + AMP
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
ITP + D-ribose 5-phosphate
IMP + 5-phospho-alpha-D-ribose 1-diphosphate
Mg-ATP2- + D-ribose 5-phosphate
Mg-AMP2- + 5-phospho-alpha-D-ribose 1-diphosphate
Mn-ATP2- + D-ribose 5-phosphate
Mn-AMP + 5-phospho-alpha-D-ribose 1-diphosphate
ribose-5-phosphate + ATP
phosphoribosyldiphosphate + AMP
first step in purine metabolic pathway
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
additional information
?
-
(R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(R)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(S)9-(2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate
-
-
-
r
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate
-
-
-
r
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate + 5-phospho-alpha-D-ribose 1-diphosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-triphosphate + D-ribose 5-phosphate
-
-
-
r
5'-adenylyl-beta,gamma-imidodiphosphate + D-ribose 5-phosphate
?
-
-
-
-
?
5'-adenylyl-beta,gamma-imidodiphosphate + D-ribose 5-phosphate
?
-
-
-
-
?
9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
9-(2-phosphonylmethoxyethoxy)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethoxy)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
9-(2-phosphonylmethoxyethyl)adenine + 5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethyl)adenine-diphosphate + D-ribose 5-phosphate
-
-
-
r
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + D-ribose 5-phosphate
-
-
-
r
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + D-ribose 5-phosphate
-
-
-
r
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
ATP + D-ribose 5-phosphate
-
-
-
r
ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
?
-
very poor substrate
-
-
?
ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
?
-
very poor substrate
-
-
?
ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
?
-
very poor substrate, better than 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
-
-
?
ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
?
-
very poor substrate, better than 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
-
-
?
ATP + 6-deoxyhomoribose 6-phosphonate
AMP + 6-deoxyhomoribose 6-phosphonate 1-diphosphate
-
-
-
r
ATP + 6-deoxyhomoribose 6-phosphonate
AMP + 6-deoxyhomoribose 6-phosphonate 1-diphosphate
-
-
-
r
ATP + 6-deoxyhomoribose 6-phosphonate
AMP + 6-deoxyhomoribose 6-phosphonate 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as PRPP, ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for D-ribose 5-phosphate
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
ATP is bound to the enzyme in the form of MgATP2- complex
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
the enzymatic activity of PRS is regulated by both the activator phosphate and the inhibitor ADP competing for binding at a common allosteric regulatory site
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
allosteric regulatory mechanism, overview
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme accepts ATP and dATP equally well as diphosphoryl donor
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme accepts ATP and dATP equally well as diphosphoryl donor
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
ir
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
ir
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for D-ribose 5-phosphate
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for D-ribose 5-phosphate
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
ir
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
ir
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as PRPP
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as PRPP
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for D-ribose 5-phosphate
ribose product also known as PRPP, ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
maximal velocity of the reverse reaction is 9-10% of the forward reaction
ribose product also known as PRPP
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
maximal velocity of the reverse reaction is 9-10% of the forward reaction
ribose product also known as PRPP
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
maximal velocity of the reverse reaction is 9-10% of the forward reaction
ribose product also known as 5-phosphoryl-D-ribofuranose alpha-1-diphosphate
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
highly specific for ATP
ribose product also known as PRPP
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
maximal velocity of the reverse reaction is 9-10% of the forward reaction
ribose product also known as PRPP
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
ir
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
ATP + D-ribose 5-phosphothionate
AMP + 5-phosphotionate-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphothionate
AMP + 5-phosphotionate-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphothionate
AMP + 5-phosphotionate-alpha-D-ribose 1-diphosphate
-
-
-
r
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
CTP + D-ribose 5-phosphate
CMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less effective than ATP
-
r
D-ribose 5-phosphate + ATP
phosphoribosyldiphosphate + AMP
-
PRPP (phosphoribosylpyrophosphate) synthetases are a family of enzymes that catalyse the synthesis of PRPP from ATP and R5P (ribose 5-phosphate) by transferring the beta, gamma-diphosphoryl moiety of ATP to the C1-hydroxy group of R5P.
-
-
?
D-ribose 5-phosphate + ATP
phosphoribosyldiphosphate + AMP
PRPP (phosphoribosylpyrophosphate) synthetases are a family of enzymes that catalyse the synthesis of PRPP from ATP and R5P (ribose 5-phosphate) by transferring the beta, gamma-diphosphoryl moiety of ATP to the C1-hydroxy group of R5P.
-
-
?
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
in erythrocyte enzyme and tumor cell enzyme
-
r
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme accepts ATP and dATP equally well as diphosphoryl donor
-
-
?
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme accepts ATP and dATP equally well as diphosphoryl donor
-
-
?
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
in erythrocyte enzyme and tumor cell enzyme
-
r
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
slightly more effective than ATP
-
r
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
dATP + D-ribose 5-phosphate
dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
equally effective as ATP
-
r
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
GTP + D-ribose 5-phosphate
GMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less effective than ATP
-
r
ITP + D-ribose 5-phosphate
IMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
ITP + D-ribose 5-phosphate
IMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
Mg-ATP2- + D-ribose 5-phosphate
Mg-AMP2- + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
Mg-ATP2- + D-ribose 5-phosphate
Mg-AMP2- + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
Mn-ATP2- + D-ribose 5-phosphate
Mn-AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
Mn-ATP2- + D-ribose 5-phosphate
Mn-AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
does not serve as substrate
-
-
?
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less than 3% of the activity with ATP
-
r
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
UTP + D-ribose 5-phosphate
UMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
less effective than ATP
-
r
additional information
?
-
-
other nucleosides di and triphosphates than ATP do not serve as substrates
-
-
?
additional information
?
-
-
other nucleosides di and triphosphates than ATP do not serve as substrates
-
-
?
additional information
?
-
-
the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis
-
-
?
additional information
?
-
the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis
-
-
?
additional information
?
-
the enzyme is essentially unable to use GTP (0.4% of the activity obtained with ATP), UTP (0.5%) or CTP (3%) as phosphoryl donor
-
-
?
additional information
?
-
-
the enzyme is essentially unable to use GTP (0.4% of the activity obtained with ATP), UTP (0.5%) or CTP (3%) as phosphoryl donor
-
-
?
additional information
?
-
the enzyme is essentially unable to use GTP (0.4% of the activity obtained with ATP), UTP (0.5%) or CTP (3%) as phosphoryl donor
-
-
?
additional information
?
-
-
other nucleosides di and triphosphates than ATP do not serve as substrates
-
-
?
additional information
?
-
diphosphate donors GTP, CTP and UTP are not processed
-
-
-
additional information
?
-
-
diphosphate donors GTP, CTP and UTP are not processed
-
-
-
additional information
?
-
diphosphate donors GTP, CTP and UTP are not processed
-
-
-
additional information
?
-
-
-
-
-
?
additional information
?
-
-
ribose, ribose-1-phosphate, deoxyribose-5-phosphate, glucose-6-phosphate are not effective as substrates
-
-
?
additional information
?
-
-
2-deoxyribose-5-phosphate is not substrate
-
-
?
additional information
?
-
-
D-ribitol-5-phosphate, alpha-methyl-D-ribofuranoside-5-phosphate, beta-methyl-D-ribofuranoside-5-phosphate are no substrates
-
-
?
additional information
?
-
-
other nucleosides di and triphosphates than ATP do not serve as substrates
-
-
?
additional information
?
-
-
2-deoxyribose-5-phosphate is not substrate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
D-ribose 5-phosphate + ATP
5-phospho-alpha-D-ribose 1-diphosphate + AMP
biosynthesis of purines and pyrimidines
-
-
?
D-ribose 5-phosphate + ATP
phosphoribosyldiphosphate + AMP
ribose-5-phosphate + ATP
phosphoribosyldiphosphate + AMP
first step in purine metabolic pathway
-
-
?
additional information
?
-
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
the enzymatic activity of PRS is regulated by both the activator phosphate and the inhibitor ADP competing for binding at a common allosteric regulatory site
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
ATP + D-ribose 5-phosphate
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
D-ribose 5-phosphate + ATP
phosphoribosyldiphosphate + AMP
-
PRPP (phosphoribosylpyrophosphate) synthetases are a family of enzymes that catalyse the synthesis of PRPP from ATP and R5P (ribose 5-phosphate) by transferring the beta, gamma-diphosphoryl moiety of ATP to the C1-hydroxy group of R5P.
-
-
?
D-ribose 5-phosphate + ATP
phosphoribosyldiphosphate + AMP
PRPP (phosphoribosylpyrophosphate) synthetases are a family of enzymes that catalyse the synthesis of PRPP from ATP and R5P (ribose 5-phosphate) by transferring the beta, gamma-diphosphoryl moiety of ATP to the C1-hydroxy group of R5P.
-
-
?
additional information
?
-
-
the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis
-
-
?
additional information
?
-
the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis
-
-
?
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1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
2-deoxy-D-ribose 5-phosphate
-
92% inhibition at 1 mM
5-phospho-alpha-D-ribose 1-diphosphate
9-(2-phosphonylmethoxyethoxy)adenine
9-(2-phosphonylmethoxyethyl)adenine
adenosine 5'-(beta,gamma-imido)-triphosphate
-
inhibition at 1 mM
allopurinol ribonucleotides
-
23% inhibition at 1 mM
alpha,beta-methylene ATP
-
D-fructose 1,6-diphosphate
D-ribose 1-phosphate
-
13% inhibition at 1 mM
dATP
-
inhibition at 1 mM
diadenosine pentaphosphate
Inhibits the dephosphorylation of ATP and ADP by nonspecific phosphatases.
DL-1,4-Anhydroribitol 5-phosphate
-
competitive inhibition to D-ribose-5-phosphate
FAD
-
51% inhibition at 1 mM
glyceraldehyde 3-phosphate
GSH
-
marked inhibition of enzyme in crude extract at 1 mM
IMP
-
21% inhibition at 1 mM
Mn2+
-
complete inhibition above 0.4 mM
NAD+
-
100% inhibition at 1 mM
NADH
-
72% inhibition at 1 mM
NADPH
-
100% inhibition at 1 mM
PRPP synthetase-associated proteins
-
SO42-
-
1 M, strong inhibition
TTP
-
47% inhibition at 1 mM
XDP
-
36% inhibition at 1 mM
XTP
-
22% inhibition at 1 mM
1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
-
mixed-type inhibition with respect to D-ribose 5-phosphate and no inhibition against ATP
1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
-
at pH 7.5, competitive inhibition with respect to D-ribose 5-phosphate and noncompetitive inhibition with respect to ATP
1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate
-
at pH 7.5, competitive inhibition with respect to D-ribose 5-phosphate and noncompetitive inhibition with respect to ATP
1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
-
partial noncompetitive inhibition with respect to D-ribose 5-phosphate and no inhibition with respect to ATP
1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate
-
partial mixed-type inhibition with respect to D-ribose 5-phosphate and ATP
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
-
-
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
-
-
2,3-diphosphoglycerate
-
competitive to D-ribose 5-phosphate; inhibition of the erythrocyte enzyme
2,3-diphosphoglycerate
-
30% inhibition at 1 mM; competitive to D-ribose 5-phosphate
2,3-diphosphoglycerate
-
at 1 mM, inhibition of isoenzyme PRSI and PRSII, at 1-10 mM, stimulation of isoenzyme PRSI
2,3-diphosphoglycerate
-
-
2,3-diphosphoglycerate
-
inhibition, even in the presence of stabilizing agents such as albumin, EDTA and dithiothreitol
5-phospho-alpha-D-ribose 1-diphosphate
-
competitive with respect to ATP and noncompetitive with respect to D-ribose 5-phosphate
5-phospho-alpha-D-ribose 1-diphosphate
-
-
5-phospho-alpha-D-ribose 1-diphosphate
-
competitive to ribose 5-phosphate
5-phospho-alpha-D-ribose 1-diphosphate
-
-
5-phospho-alpha-D-ribose 1-diphosphate
-
competitive with respect to ATP and noncompetitive with respect to D-ribose 5-phosphate
9-(2-phosphonylmethoxyethoxy)adenine
-
IC50 of 0.86 mM
9-(2-phosphonylmethoxyethoxy)adenine
-
IC50 of more than 2.5 mM
9-(2-phosphonylmethoxyethyl)adenine
-
IC50 of 1.9 mM
9-(2-phosphonylmethoxyethyl)adenine
-
IC50 of 2.1 mM
adenosine
-
no inhibition
adenosine
-
27% inhibition at 1 mM
ADP
-
ADP
-
allosterical inhibition
ADP
-
nonlinear competitive inhibition
ADP
-
competitive inhibition to ATP
ADP
-
99% inhibition at 1 mM; competitive inhibition to ATP; end product inhibition; the most effective
ADP
-
even in the presence of stabilizing agents such as albumin, EDTA and dithiothreitol; the most effective
ADP
allosterical inhibition
ADP
a single ADP binding site, the active site, is present per subunit
ADP
-
competitive inhibition to ATP
ADP
-
one of the most effective
ADP
-
the enzyme in MAU V cells is less sensitive than the enzyme in extracts of wild-type cells
ADP
-
one of the most effective
ADP
-
when PAP39 complexes with PRSI or PRSII, the sensitivity to ADP inhibition is lowered
ADP
-
one of the most effective
ADP
-
non competitive with respect to ATP at 0.2 mM D-ribose-5-phosphate; the most effective
ADP
-
competitive inhibition to ATP
ADP
-
inhibits isoenzymes PRS1 and PRS2 efficiently, but not isoenzymes PRS3 and PRS4
ADP
-
at low concentrations ADP inhibition is linearly competitive with respect to ATP. Less than 1% residual activity in presence of 5 mM ADP
alpha,beta-methyleneATP
-
competitive inhibition to ATP
alpha,beta-methyleneATP
-
competitive inhibition to ATP
AMP
-
68% inhibition at 5 mM
AMP
-
noncompetitive with respect to D-ribose 5-phosphate and competitive with respect to ATP
AMP
-
69% inhibition at 1 mM
AMP
-
noncompetitive to both substrates
AMP
-
one of the most effective
AMP
-
the enzyme in MAU V cells is less sensitive than the enzyme in extracts of wild-type cells, competitive with respect to ATP
AMP
-
one of the most effective
AMP
-
non competitive with respect to D-ribose 5-phosphate and ATP
AMP
-
noncompetitive to both substrates
ATP
-
moderate inhibition above 3 mM
ATP
-
free form, slight inhibition at 1 mM
ATP
-
free form, slight inhibition at 1 mM
Ca2+
-
inhibition even in presence of excess Mg2+
Ca2+
-
inhibition even in presence of excess Mg2+
Ca2+
-
IC50 of 0.05 mM; inhibition even in presence of excess Mg2+
Ca2+
-
low concentrations of CaCl2 in the presence of an excess of MgCl2 result in a reduction in catalytic activity. At CaCl2 1 mM, the enzyme is less sensitive to ADP inhibition
CDP
-
44% inhibition at 1 mM
CTP
-
40% inhibition at 1 mM
CTP
-
weak inhibition at 1 mM
CTP
-
the most effective pyrimidine nucleotide inhibitor
Cu2+
-
-
D-fructose 1,6-diphosphate
-
no inhibition
D-fructose 1,6-diphosphate
-
20% inhibition at 1 mM
D-fructose 1,6-diphosphate
-
no inhibition
D-Fructose 1-phosphate
-
19% inhibition at 1 mM
D-Fructose 1-phosphate
-
no inhibition
D-ribose 5-phosphate
-
-
D-ribose 5-phosphate
-
at unsaturating phosphate concentrations
D-ribose 5-phosphate
-
substrate inhibition above 1.5 mM
D-ribose 5-phosphate
-
inhibition in presence of Ca2+, without ADP; substrate inhibition in presence of ADP, not in its absence
D-ribose 5-phosphate
-
substrate inhibition in presence of ADP, not in its absence
D-ribose 5-phosphate
-
inhibition in presence of Ca2+, without ADP; substrate inhibition in presence of ADP, not in its absence
dADP
-
competitive to ATP
dADP
-
induces substrate inhibition by D-ribose-5-phosphate
GDP
-
GDP
-
64% inhibition at 5 mM
GDP
-
even in the presence of stabilizing agents such as albumin, EDTA and dithiothreitol
GDP
-
the enzyme is weakly sensitive to GDP
GDP
50% residual activity at 5 mM
GDP
-
one of the most effective
GDP
-
when PAP39 complexes with PRSI or PRSII, the sensitivity to ADP inhibition is lowered
GDP
-
one of the most effective
GDP
-
below 3-4 mM, linear competitive inhibition with respect to ATP
GDP
-
5 mM, less than 1% residual activity
glyceraldehyde 3-phosphate
-
no inhibition
glyceraldehyde 3-phosphate
-
14% inhibition at 1 mM
GMP
-
88% inhibition at 5 mM
GMP
-
27% inhibition at 1 mM
GTP
-
no inhibition
GTP
-
51% inhibition at 1 mM
GTP
-
weak inhibition at 1 mM
GTP
-
below 3-4 mM, linear competitive inhibition with respect to ATP
GTP
-
substrate inhibition
guanosine
-
no inhibition
guanosine
-
20% inhibition at 1 mM
IDP
-
47% inhibition at 1 mM
IDP
-
below 3-4 mM, linear competitive inhibition with respect to ATP
ITP
-
36% inhibition at 1 mM
ITP
-
below 3-4 mM, linear competitive inhibition with respect to ATP
L-histidine
-
no inhibition
L-histidine
-
no inhibition
L-histidine
-
weak inhibition or no inhibition
L-histidine
-
no inhibition
L-histidine
-
no inhibition
L-tryptophan
-
no inhibition
L-tryptophan
-
no inhibition
L-tryptophan
-
weak inhibition or no inhibition
L-tryptophan
-
no inhibition
L-tryptophan
-
no inhibition
nucleotides
-
-
-
nucleotides
-
enzyme from HTC cells has an altered sensitivity to feedback inhibition by purine and pyrimidine nucleotides
-
nucleotides
-
nucleoside tri- and diphosphates are more effective than nucleoside monophosphates, ribonucleotides more effective than deoxynucleotides; purines more effective than pyrimidines
-
nucleotides
-
purines more effective than pyrimidines
-
phosphate
-
inhibition at low concentrations of D-ribose 5-phosphate
phosphate
-
inhibition at high concentrations, more pronounced in the reverse reaction
phosphate
-
IC50 of 28 mM
PRPP synthetase-associated proteins
-
inhibit catalytic and perhaps regulatory functions of the enzyme
-
PRPP synthetase-associated proteins
-
inhibit catalytic and perhaps regulatory functions of the enzyme
-
TDP
-
100% inhibition at 1 mM
TDP
-
the enzyme in MAU V cells is less sensitive than the enzyme in extracts of wild-type cells, competitive with respect to ATP
UDP
-
no inhibition
UDP
-
10%-16% inhibition at 1 mM
UDP
-
10%-16% inhibition at 1 mM
UDP
-
10%-16% inhibition at 1 mM
UMP
-
no inhibition
UMP
-
10%-18% inhibition at 1 mM
UMP
-
10%-18% inhibition at 1 mM
UTP
-
no inhibition
UTP
-
weak inhibition at 1 mM
UTP
-
substrate inhibition
UTP
-
5.0 mM, significant inhibition
additional information
-
D-glucose-6-phosphate have no effects on the enzyme activity; dihydroxyacetone phosphate, D-glucose-1-phosphate, fructose-6-phosphate, ribose, sucrose, glutamine, glutamic acid, aspartic acid, alanine, alpha-ketoglutarate, pyruvate, citrate, malate, fumarate, succinate, cytidine, uridine, adenine, orotate, guanine, cytosine and xanthine have no effects on the enzyme activity
-
additional information
-
-
-
additional information
-
inhibition by pair of inhibitors tested is not greater than the sum of the inhibition produced by each alone
-
additional information
-
pyrimidine, pyridine and purine nucleotides and reaction products
-
additional information
-
no inhibitory effects are shown by the presence of pyrimidine nucleoside mono- or diphosphates or of histidine, up to 2 mM
-
additional information
the enzyme activity is not affected by the presence of 8 M urea or 4 M guanidinium chloride
-
additional information
-
the enzyme activity is not affected by the presence of 8 M urea or 4 M guanidinium chloride
-
additional information
-
-
-
additional information
-
native enzyme is less sensitive to nucleotide inhibition than the major component of the enzyme, rPRSI
-
additional information
-
GSH, 2-mercaptoethanol, 2,3-dimercaptopropanol, dithiothreitol, at 1 mM, have no effect or slightly inhibit the highly purified enzyme
-
additional information
-
purines are more effective than pyrimidines, nucleoside tri and diphosphates are more effective than monophosphates, ribonucleotides are more effective than deoxynucleotides
-
additional information
-
Ba2+, Fe2+, Mn2+ and Zn2+ do not inhibit at concentrations below 1 mM; purines are more effective than pyrimidines, nucleoside tri and diphosphates are more effective than monophosphates, ribonucleotides are more effective than deoxynucleotides
-
additional information
-
6-phosphogluconate, 3-phosphoglycerate, phosphoenolpyruvate and ribulose-5-phosphate have no effect on the activity; D-glucose-6-phosphate have no effects on the enzyme activity; purines are more effective than pyrimidines, nucleoside tri and diphosphates are more effective than monophosphates, ribonucleotides are more effective than deoxynucleotides
-
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1.29 - 3.571
(R)9-(2-phosphonylmethoxypropyl)adenine
1.14 - 1.923
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
1.54 - 2.174
(S)9-(2-phosphonylmethoxypropyl)adenine
0.575 - 3.636
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
0.317 - 0.377
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
0.0289 - 0.0418
5-phospho-alpha-D-ribose 1-diphosphate
0.29
5-phospho-D-ribose diphosphate
0.308 - 0.789
9-(2-phosphonylmethoxyethoxy)adenine
0.656 - 1.47
9-(2-phosphonylmethoxyethyl)adenine
0.116
CTP
-
pH 7.6, 37ºC, isoenzyme 3
0.0082 - 2.8
D-ribose 5-phosphate
0.233
dATP
-
pH 7.6, 37ºC, isoenzyme 3
0.65
GTP
-
pH 7.6, 37ºC, isoenzyme 3
0.137
UTP
-
pH 7.6, 37ºC, isoenzyme 3
additional information
additional information
-
increasing phosphate concentrations, increases Km values for ATP and D-ribose-5-phosphate
-
1.29
(R)9-(2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC
3.571
(R)9-(2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC
1.14
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC
1.923
(R)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC, isoenzyme I
1.54
(S)9-(2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC
2.174
(S)9-(2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC
0.575
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC
3.636
(S)9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
-
pH 8.0, 37ºC, isoenzyme I
0.317
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
-
pH 8.0, 37ºC, isoenzyme II
0.323
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
-
pH 8.0, 37ºC, isoenzyme I
0.377
2',3'-dideoxy-2',3'-didehydro-adenosine-5'-monophosphate
-
pH 8.0, 37ºC
0.0289
5-phospho-alpha-D-ribose 1-diphosphate
-
pH 7.4, 37ºC, native enzyme from liver
0.0402
5-phospho-alpha-D-ribose 1-diphosphate
-
pH 7.4, 37ºC, isoenzyme rPRSII
0.0418
5-phospho-alpha-D-ribose 1-diphosphate
-
pH 7.4, 37ºC, isoenzyme rPRSI
0.29
5-phospho-D-ribose diphosphate
-
pH and temperature conditions not mentioned
0.29
5-phospho-D-ribose diphosphate
-
pH and temperature conditions not mentioned
0.29
5-phospho-D-ribose diphosphate
-
pH 7.6, 37ºC
0.308
9-(2-phosphonylmethoxyethoxy)adenine
-
pH 8.0, 37ºC, isoenzyme I
0.422
9-(2-phosphonylmethoxyethoxy)adenine
-
pH 8.0, 37ºC
0.588
9-(2-phosphonylmethoxyethoxy)adenine
-
pH 8.0, 37ºC
0.789
9-(2-phosphonylmethoxyethoxy)adenine
-
pH 8.0, 37ºC, isoenzyme II
0.656
9-(2-phosphonylmethoxyethyl)adenine
-
pH 8.0, 37ºC, isoenzyme I
0.661
9-(2-phosphonylmethoxyethyl)adenine
-
pH 8.0, 37ºC
1.013
9-(2-phosphonylmethoxyethyl)adenine
-
pH 8.0, 37ºC, isoenzyme II
1.47
9-(2-phosphonylmethoxyethyl)adenine
-
pH 8.0, 37ºC
0.117
AMP
-
pH 7.4, 37ºC, native enzyme from liver
0.123
AMP
-
pH 7.4, 37ºC, isoenzyme rPRSII
0.125
AMP
-
pH 7.4, 37ºC, isoenzyme rPRSI
0.15 - 0.4
AMP
-
pH 7.5, 37ºC
0.167
AMP
-
pH 8.0, 37ºC, isoenzyme II
0.263
AMP
-
pH 8.0, 37ºC, isoenzyme I
0.32
AMP
-
pH and temperature conditions not mentioned
0.007
ATP
-
pH 8.0, 37ºC
0.008
ATP
-
pH 8.0, 37ºC, isoenzyme I
0.014
ATP
-
pH and temperature conditions not mentioned
0.014
ATP
-
ATP in form of MgATP2-
0.021
ATP
-
pH 7.5, 37ºC, isoenzyme PRSI
0.021
ATP
-
pH and temperature conditions not mentioned, rPRSI isoenzyme
0.021
ATP
-
ATP in form of MgATP2-
0.025
ATP
-
in 50 mM Tris-HCl pH 8.0, at 25°C
0.03
ATP
-
pH conditions not mentioned, 37ºC, wild type and mutant enzyme
0.03
ATP
-
ATP in form of MgATP2-
0.044
ATP
-
pH 7.4, 37ºC, isoenzyme PRSI
0.044
ATP
-
pH 7.4, 37ºC, isoenzyme rPRSI
0.046
ATP
-
pH and temperature conditions not mentioned
0.046
ATP
-
ATP in form of MgATP2-
0.049
ATP
-
pH 7.4, 37ºC, native enzyme from liver
0.05
ATP
wild type enzyme, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.051
ATP
-
pH 8.0, 37ºC, isoenzyme II
0.053
ATP
-
pH and temperature conditions not mentioned
0.057
ATP
-
mutant enzyme K199A
0.058
ATP
S0.5 value, Hill coefficient 1.7, pH 7.5, 25°C
0.06
ATP
-
pH 7.5, 37ºC, excess of Mn2+
0.06
ATP
-
pH 7.4, 37ºC, isoenzyme PRSII
0.06
ATP
-
pH 7.4, 37ºC, isoenzyme rPRSII
0.06
ATP
mutant enzyme N120S, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.06
ATP
-
ATP in form of MnATP2-
0.077
ATP
-
pH conditions not mentioned, 37ºC
0.078
ATP
-
pH 7.6, 37ºC, 100 mM phosphate
0.078
ATP
-
ATP in form of MgATP2-
0.08
ATP
pH 10.5, 55°C, recombinant enzyme
0.083
ATP
mutant enzyme D58H, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.094
ATP
mutant enzyme L135I, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.1
ATP
-
pH 7.5, 37ºC, excess of Mg2+, bimodal kinetic behavior
0.1
ATP
-
ATP in form of MgATP2-
0.12
ATP
-
mutant enzyme K197A
0.13
ATP
-
mutant enzyme P200A
0.16
ATP
-
mutant enzyme V207A
0.17
ATP
-
pH 7.6, 37ºC, isoenzyme 3
0.19
ATP
-
mutant enzyme R198A
0.19
ATP
-
mutant enzyme V204A
0.191
ATP
-
wild-type enzyme
0.22
ATP
-
pH and temperature conditions not mentioned
0.22
ATP
-
pH 7.6, 37ºC, excess of Mg2+
0.22
ATP
-
ATP in form of MgATP2-
0.23
ATP
-
mutant enzyme M208A
0.29
ATP
-
mutant enzyme P202A
0.35
ATP
-
pH 7.5, 37ºC, no excess of Mn2+
0.35
ATP
-
ATP in form of MnATP2-
0.48
ATP
-
mutant enzyme E206A
0.56
ATP
-
mutant enzyme R201A
0.58
ATP
-
pH 7.5, 37ºC, excess of Mg2+, bimodal kinetic behavior
0.58
ATP
-
ATP in form of MgATP2-
0.87
ATP
-
mutant enzyme N203A
2.6
ATP
pH and temperature not specified in the publication
2.9
ATP
-
pH 7.5, 37ºC, no excess of Mg2+
2.9
ATP
-
ATP in form of MgATP2-
0.0082
D-ribose 5-phosphate
-
at pH 7.5 and 37°C
0.011
D-ribose 5-phosphate
pH 8.0, 75°C
0.014
D-ribose 5-phosphate
-
cosubstrate ATP, in 50 mM Tris-HCl pH 8.0, at 25°C
0.034
D-ribose 5-phosphate
pH 8.0, 75°C
0.038
D-ribose 5-phosphate
-
pH and temperature conditions not mentioned
0.04
D-ribose 5-phosphate
-
pH 7.5, 37ºC
0.04
D-ribose 5-phosphate
-
pH 7.4, 37ºC, isoenzyme PRSI
0.04
D-ribose 5-phosphate
-
pH 7.4, 37ºC, isoenzyme rPRSI
0.048
D-ribose 5-phosphate
-
pH conditions not mentioned, 37ºC
0.05 - 0.13
D-ribose 5-phosphate
-
pH 7.5, 37ºC
0.052
D-ribose 5-phosphate
-
pH 7.5, 37ºC, isoenzyme PRSI
0.052
D-ribose 5-phosphate
-
pH and temperature conditions not mentioned, rPRSI isoenzyme
0.059
D-ribose 5-phosphate
pH 7.5, 25°C
0.06
D-ribose 5-phosphate
-
in the presence of 5 mM Mn2+, in 50 mM potassium phosphate pH 8.0, at 37°C
0.06
D-ribose 5-phosphate
pH 10.5, 55°C, recombinant enzyme
0.064
D-ribose 5-phosphate
-
pH 7.4, 37ºC, native enzyme from liver
0.07
D-ribose 5-phosphate
-
in the presence of 5 mM Mg2+, in 50 mM potassium phosphate pH 8.0, at 37°C
0.071
D-ribose 5-phosphate
-
in the absence of Mg2+ or Mn2+, in 50 mM potassium phosphate pH 8.0, at 37°C
0.073
D-ribose 5-phosphate
-
pH 7.4, 37ºC, isoenzyme PRSII
0.073
D-ribose 5-phosphate
-
pH 7.4, 37ºC, isoenzyme rPRSII
0.083
D-ribose 5-phosphate
-
pH 7.5, 37ºC, isoenzyme PRSII
0.083
D-ribose 5-phosphate
-
pH and temperature conditions not mentioned, rPRSII isoenzyme
0.105
D-ribose 5-phosphate
wild type enzyme, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.107
D-ribose 5-phosphate
-
mutant enzyme K199A
0.11
D-ribose 5-phosphate
-
pH 7.6, 37ºC, isoenzyme 3
0.135
D-ribose 5-phosphate
-
pH 8.0, 37ºC
0.157
D-ribose 5-phosphate
mutant enzyme D58H, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.16
D-ribose 5-phosphate
-
pH and temperature conditions not mentioned
0.18
D-ribose 5-phosphate
mutant enzyme N120S, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.189
D-ribose 5-phosphate
mutant enzyme L135I, in 50 mM potassium phosphate at pH 7.5, 5 mM MgCl2, at 37°C
0.19
D-ribose 5-phosphate
-
pH 8.0, 37ºC, phosphate 50 mM
0.2
D-ribose 5-phosphate
-
pH 7.4, 37ºC
0.217
D-ribose 5-phosphate
-
mutant enzyme K197A
0.23
D-ribose 5-phosphate
-
wild-type enzyme
0.298
D-ribose 5-phosphate
-
pH 8.0, 37ºC
0.41
D-ribose 5-phosphate
-
pH conditions not mentioned, 37ºC, mutant enzyme
0.48
D-ribose 5-phosphate
-
pH 8.2, 37ºC
0.53
D-ribose 5-phosphate
-
-
0.57
D-ribose 5-phosphate
-
pH conditions not mentioned, 37ºC, wild type enzyme
0.791
D-ribose 5-phosphate
-
pH 8.0, 37ºC
2.8
D-ribose 5-phosphate
pH and temperature not specified in the publication
0.0002
Mg2+
-
pH 7.4, 37ºC
0.041
Mg2+
-
pH 8.0, 37ºC, phosphate 50 mM
0.059
Mg2+
-
pH 8.0, 37ºC, phosphate 5 mM
0.07
Mg2+
-
pH 7.5, 37ºC, isoenzyme PRSI
0.11
Mg2+
-
pH 7.5, 37ºC, isoenzyme PRSII
0.2
Mg2+
-
pH and temperature conditions not mentioned
0.6
Mg2+
-
pH and temperature conditions not mentioned
0.008
phosphate
-
pH 7.4, 37ºC
0.7
phosphate
-
pH 7.5, 37ºC, isoenzyme PRSI
2.1
phosphate
-
pH 7.5, 37ºC, isoenzyme PRSII
2.3
phosphate
-
pH 7.5, 37ºC, high affinity site
40
phosphate
-
pH 7.5, 37ºC, low affinity site
0.033
ribose 5-phosphate
-
pH 7.4, 37ºC
0.033
ribose 5-phosphate
-
pH and temperature conditions not mentioned
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PLoS Genet.
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Drosophila melanogaster (Q9VT33)
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Donini, S.; Garavaglia, S.; Ferraris, D.M.; Miggiano, R.; Mori, S.; Shibayama, K.; Rizzi, M.
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PLoS ONE
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Mycolicibacterium smegmatis (A0R3C8), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0R3C8)
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Walter, B.M.; Szulc, A.; Glinkowska, M.K.
Reliable method for high quality His-tagged and untagged E. coli phosphoribosyl phosphate synthase (Prs) purification
Protein Expr. Purif.
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Escherichia coli
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Esipov, R.; Abramchik, Y.; Fateev, I.; Muravyova, T.; Artemova, K.; Konstantinova, I.; Kuranova, I.; Miroshnikov, A.
Recombinant phosphoribosyl pyrophosphate synthetases from Thermus thermophilus HB27 Isolation and properties
Russ. J. Bioorg. Chem.
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512-521
2016
Thermus thermophilus (Q72I58), Thermus thermophilus (Q72IE8)
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Pei, W.; Xu, L.; Varshney, G.K.; Carrington, B.; Bishop, K.; Jones, M.; Huang, S.C.; Idol, J.; Pretorius, P.R.; Beirl, A.; Schimmenti, L.A.; Kindt, K.S.; Sood, R.; Burgess, S.M.
Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases
Sci. Rep.
6
29946
2016
Danio rerio (Q08CA5), Danio rerio (Q4KME9), Danio rerio
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