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12-aminododecanoic acid + 2-oxoglutarate
?
1H-indole-2-carbaldehyde + cadaverine
1-(1H-indol-2-yl)methanamine + piperideine + H2O
1H-indole-2-carbaldehyde + isopropylamine
1-(1H-indol-2-yl)methanamine + acetone + H2O
-
-
-
?
2,3-dimethoxybenzaldehyde + cadaverine
3,5-dimethoxybenzylamine + piperideine + H2O
-
-
-
?
2,3-dimethoxybenzaldehyde + isopropylamine
2,3-dimethoxybenzylamine + acetone + H2O
-
-
-
?
2,4-dimethoxybenzaldehyde + cadaverine
2,4-dimethoxybenzylamine + piperideine + H2O
-
-
-
?
2,4-dimethoxybenzaldehyde + isopropylamine
2,4-dimethoxybenzylamine + acetone + H2O
-
-
-
?
2-(trifluoromethyl)benzaldehyde + cadaverine
2-(trifluoromethyl)benzylamine + piperideine + H2O
-
-
-
?
2-(trifluoromethyl)benzaldehyde + isopropylamine
2-(trifluoromethyl)benzylamine + acetone + H2O
-
-
-
?
2-formylbenzoic acid + cadaverine
2-(aminomethyl)benzoic acid + piperideine + H2O
-
-
-
?
2-formylbenzoic acid + isopropylamine
2-(aminomethyl)benzoic acid + acetone + H2O
-
-
-
?
2-formylbenzonitrile + cadaverine
2-(aminomethyl)benzonitrile + piperideine + H2O
-
-
-
?
2-formylbenzonitrile + isopropylamine
2-(aminomethyl)benzonitrile + acetone + H2O
-
-
-
?
2-methoxybenzaldehyde + cadaverine
2-methoxybenzylamine + piperideine + H2O
-
-
-
?
2-methoxybenzaldehyde + isopropylamine
2-methoxybenzylamine + acetone + H2O
-
-
-
?
2-methoxypyridine-3-carbaldehyde + cadaverine
1-(2-methoxypyridin-3-yl)methanamine + piperideine + H2O
-
-
-
?
2-methoxypyridine-3-carbaldehyde + isopropylamine
1-(2-methoxypyridin-3-yl)methanamine + acetone + H2O
-
-
-
?
2H-1,3-benzodioxole-4-carbaldehyde + cadaverine
1-(2H-1,3-benzodioxol-4-yl)methanamine + piperideine + H2O
-
-
-
?
2H-1,3-benzodioxole-4-carbaldehyde + isopropylamine
1-(2H-1,3-benzodioxol-4-yl)methanamine + acetone + H2O
-
-
-
?
3,4-difluorobenzaldehyde + cadaverine
3,4-difluorobenzylamine + piperideine + H2O
-
-
-
?
3,4-difluorobenzaldehyde + isopropylamine
3,4-difluorobenzylamine + acetone + H2O
-
-
-
?
3,5-dibromobenzaldehyde + cadaverine
3,5-dibromobenzylamine + piperideine + H2O
-
-
-
?
3,5-dibromobenzaldehyde + isopropylamine
3,5-dibromobenzylamine + acetone + H2O
-
-
-
?
3,5-dimethoxybenzaldehyde + cadaverine
3,5-dimethoxybenzylamine + piperideine + H2O
3,5-dimethoxybenzaldehyde + isopropylamine
3,5-dimethoxybenzylamine + acetone + H2O
-
-
-
?
3-acetylbenzoic acid + cadaverine
3-(1-aminoethyl)benzoic acid + piperideine + H2O
-
-
-
?
3-acetylbenzoic acid + isopropylamine
3-(1-aminoethyl)benzoic acid + acetone + H2O
-
-
-
?
3-chlorobenzaldehyde + cadaverine
3-chlorobenzylamine + piperideine + H2O
-
-
-
?
3-chlorobenzaldehyde + isopropylamine
3-chlorobenzylamine + acetone + H2O
-
-
-
?
3-fluorobenzaldehyde + cadaverine
3-fluorobenzylamine + piperideine + H2O
-
-
-
?
3-fluorobenzaldehyde + isopropylamine
3-fluorobenzylamine + acetone + H2O
-
-
-
?
3-formylbenzonitrile + cadaverine
3-(aminomethyl)benzonitrile + piperideine + H2O
-
-
-
?
3-formylbenzonitrile + isopropylamine
3-(aminomethyl)benzonitrile + acetone + H2O
-
-
-
?
3-methoxybenzaldehyde + cadaverine
3-methoxybenzylamine + piperideine + H2O
-
-
-
?
3-methoxybenzaldehyde + isopropylamine
3-methoxybenzylamine + acetone + H2O
-
-
-
?
3-nitrobenzaldehyde + cadaverine
3-nitrobenzylamine + piperideine + H2O
-
-
-
?
3-nitrobenzaldehyde + isopropylamine
3-nitrobenzylamine + acetone + H2O
-
-
-
?
4-acetylbenzoic acid + cadaverine
4-(1-aminoethyl)benzoic acid + piperideine + H2O
-
-
-
?
4-acetylbenzoic acid + isopropylamine
4-(1-aminoethyl)benzoic acid + acetone + H2O
-
-
-
?
4-chlorobenzaldehyde + cadaverine
4-chlorobenzylamine + piperideine + H2O
-
-
-
?
4-chlorobenzaldehyde + isopropylamine
4-chlorobenzylamine + acetone + H2O
-
-
-
?
4-fluorobenzaldehyde + cadaverine
4-fluorobenzylamine + piperideine + H2O
-
-
-
?
4-fluorobenzaldehyde + isopropylamine
4-fluorobenzylamine + acetone + H2O
-
-
-
?
4-formylbenzoic acid + cadaverine
4-(aminomethyl)benzoic acid + piperideine + H2O
-
-
-
?
4-formylbenzoic acid + isopropylamine
4-(aminomethyl)benzoic acid + acetone + H2O
-
-
-
?
4-formylbenzonitrile + cadaverine
4-(aminomethyl)benzonitrile + piperideine + H2O
-
-
-
?
4-formylbenzonitrile + isopropylamine
4-(aminomethyl)benzonitrile + acetone + H2O
-
-
-
?
4-nitrobenzaldehyde + cadaverine
4-nitrobenzylamine + piperideine + H2O
-
-
-
?
4-nitrobenzaldehyde + isopropylamine
4-nitrobenzylamine + acetone + H2O
-
-
-
?
5-chlorothiophene-2-carbaldehyde + cadaverine
1-(5-chlorothiophen-2-yl)methanamine + piperideine + H2O
-
-
-
?
5-chlorothiophene-2-carbaldehyde + isopropylamine
1-(5-chlorothiophen-2-yl)methanamine + acetone + H2O
-
-
-
?
5-formylthiophene-2-carboxylic acid + cadaverine
5-(aminomethyl)thiophene-2-carboxylic acid + piperideine + H2O
-
-
-
?
5-formylthiophene-2-carboxylic acid + isopropylamine
5-(aminomethyl)thiophene-2-carboxylic acid + acetone + H2O
-
-
-
?
5-methylfuran-2-carbaldehyde + cadaverine
1-(5-methylfuran-2-yl)methanamine + piperideine + H2O
-
-
-
?
5-methylfuran-2-carbaldehyde + isopropylamine
1-(5-methylfuran-2-yl)methanamine + acetone + H2O
-
-
-
?
6-acetylpyridine-2-carboxylic acid + cadaverine
6-(1-aminoethyl)pyridine-2-carboxylic acid + piperideine + H2O
-
-
-
?
6-acetylpyridine-2-carboxylic acid + isopropylamine
6-(1-aminoethyl)pyridine-2-carboxylic acid + acetone + H2O
-
-
-
?
6-methoxypyridine-3-carbaldehyde + cadaverine
1-(6-methoxypyridin-3-yl)methanamine + piperideine + H2O
-
-
-
?
6-methoxypyridine-3-carbaldehyde + isopropylamine
1-(6-methoxypyridin-3-yl)methanamine + acetone + H2O
-
-
-
?
agmatine + 2-oxoglutarate
?
2% activity
-
-
?
alpha-ketobutyric acid + putrescine
L-aspartate + 4-aminobutanal
38% activity
-
-
?
cadaverine + 2-oxoglutarate
L-glutamate + 5-aminopentanal
97% activity
-
-
?
cadaverine + 2-oxoglutarate
piperideine + L-glutamate + H2O
-
-
-
?
isopropylamine + 2-oxoglutarate
acetone + L-glutamate + H2O
-
-
-
?
L-ornithine + 2-oxoglutarate
?
2% activity
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
putrescine + 2-oxoglutarate
L-glutamate + 4-aminobutanal
pyruvate + putrescine
L-alanine + 4-aminobutanal
12% activity
-
-
?
quinoline-3-carbaldehyde + cadaverine
1-(quinolin-3-yl)methanamine + piperideine + H2O
-
-
-
?
quinoline-3-carbaldehyde + isopropylamine
1-(quinolin-3-yl)methanamine + acetone + H2O
-
-
-
?
spermidine + 2-oxoglutarate
?
32% activity
-
-
?
additional information
?
-
12-aminododecanoic acid + 2-oxoglutarate
?
-
-
-
-
?
12-aminododecanoic acid + 2-oxoglutarate
?
-
-
-
-
?
1H-indole-2-carbaldehyde + cadaverine
1-(1H-indol-2-yl)methanamine + piperideine + H2O
-
-
-
?
1H-indole-2-carbaldehyde + cadaverine
1-(1H-indol-2-yl)methanamine + piperideine + H2O
-
-
-
?
3,5-dimethoxybenzaldehyde + cadaverine
3,5-dimethoxybenzylamine + piperideine + H2O
-
-
-
?
3,5-dimethoxybenzaldehyde + cadaverine
3,5-dimethoxybenzylamine + piperideine + H2O
-
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
-
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
overall reaction
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
-
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
overall reaction
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
-
-
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
-
overall reaction
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
-
-
-
-
?
putrescine + 2-oxoglutarate
1-pyrroline + L-glutamate + H2O
-
overall reaction
-
-
?
putrescine + 2-oxoglutarate
L-glutamate + 4-aminobutanal
-
-
-
-
?
putrescine + 2-oxoglutarate
L-glutamate + 4-aminobutanal
-
coupling action of Escherichia coli YgjG putrescine transaminase and YdcW dehydrogenase
-
-
?
putrescine + 2-oxoglutarate
L-glutamate + 4-aminobutanal
putrescine best amino group donor for the enzyme, 100% activity
-
-
?
additional information
?
-
enzyme prefers diaminoalkanes as substrates and thereby generates cyclic imines from the omega-amino aldehyde intermediates
-
-
?
additional information
?
-
-
only modified PATase is a ClpS-dependent ClpAP substrate
-
-
?
additional information
?
-
enzyme prefers diaminoalkanes as substrates and thereby generates cyclic imines from the omega-amino aldehyde intermediates
-
-
?
additional information
?
-
-
enzyme prefers diaminoalkanes as substrates and thereby generates cyclic imines from the omega-amino aldehyde intermediates
-
-
?
additional information
?
-
-
enzyme prefers diaminoalkanes as substrates and thereby generates cyclic imines from the omega-amino aldehyde intermediates
-
-
?
additional information
?
-
the enzyme shows dual substrate recognition for biogenic diamines (i.e. cadaverine) and readily available monoamines (i.e. isopropylamine) for the synthesis of benzylamine derivatives with excellent product conversions and extremely broad substrate tolerance. Biocatalytic synthesis of a range of substituted benzylamines mediated by Pp-SpuC in a coupled assay approach with cadaverine or isopropylamine as co-substrate at 50 mM Tris-HCl, pH 9.0, 30°C, 1 mM PLP, and 1% v/v DMSO, overview
-
-
-
additional information
?
-
-
the enzyme shows dual substrate recognition for biogenic diamines (i.e. cadaverine) and readily available monoamines (i.e. isopropylamine) for the synthesis of benzylamine derivatives with excellent product conversions and extremely broad substrate tolerance. Biocatalytic synthesis of a range of substituted benzylamines mediated by Pp-SpuC in a coupled assay approach with cadaverine or isopropylamine as co-substrate at 50 mM Tris-HCl, pH 9.0, 30°C, 1 mM PLP, and 1% v/v DMSO, overview
-
-
-
additional information
?
-
the enzyme shows dual substrate recognition for biogenic diamines (i.e. cadaverine) and readily available monoamines (i.e. isopropylamine) for the synthesis of benzylamine derivatives with excellent product conversions and extremely broad substrate tolerance. Biocatalytic synthesis of a range of substituted benzylamines mediated by Pp-SpuC in a coupled assay approach with cadaverine or isopropylamine as co-substrate at 50 mM Tris-HCl, pH 9.0, 30°C, 1 mM PLP, and 1% v/v DMSO, overview
-
-
-
additional information
?
-
-
the activity of KES24511 is determined using an alanine dehydrogenase enzyme-coupled assay, the purified protein exhibited activity with two substrates, putrescine and 12-aminododecanoic acid, with pyruvate as the co-substrate for transamination. The transaminase reaction co-product (L-alanine) is converted in situ by the dehydrogenase in an NAD+-dependent oxidation, and nicotinamide conversion is spectrophotometrically monitored by the change in UV absorbance at 340 nm
-
-
-
additional information
?
-
-
the activity of KES24511 is determined using an alanine dehydrogenase enzyme-coupled assay, the purified protein exhibited activity with two substrates, putrescine and 12-aminododecanoic acid, with pyruvate as the co-substrate for transamination. The transaminase reaction co-product (L-alanine) is converted in situ by the dehydrogenase in an NAD+-dependent oxidation, and nicotinamide conversion is spectrophotometrically monitored by the change in UV absorbance at 340 nm
-
-
-
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Prieto-Santos, M.I.; Martin-Checa, J.; Balane-Fouce, R.; Garrido-Pertierra, A.
A pathway for putrescine catabolism in Escherichia coli
Biochim. Biophys. Acta
880
242-244
1986
Escherichia coli
brenda
Samsonova, N.N.; Smirnov, S.V.; Altman, I.B.; Ptitsyn, L.R.
Molecular cloning and characterization of Escherichia coli K12 ygjG gene
BMC Microbiol.
3
2
2003
Escherichia coli (P42588)
brenda
Samsonova, N.N.; Smirnov, S.V.; Novikova, A.E.; Ptitsyn, L.R.
Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase
FEBS Lett.
579
4107-4112
2005
Escherichia coli
brenda
Ninnis, R.L.; Spall, S.K.; Talbo, G.H.; Truscott, K.N.; Dougan, D.A.
Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli
EMBO J.
28
1732-1744
2009
Escherichia coli
brenda
Yeo, S.J.; Jeong, J.H.; Yu, S.N.; Kim, Y.G.
Crystallization and preliminary X-ray crystallographic analysis of YgjG from Escherichia coli
Acta Crystallogr. Sect. F
68
1070-1072
2012
Escherichia coli (P42588), Escherichia coli
brenda
Jorge, J.M.; Leggewie, C.; Wendisch, V.F.
A new metabolic route for the production of gamma-aminobutyric acid by Corynebacterium glutamicum from glucose
Amino Acids
48
2519-253
2016
Escherichia coli (P42588), Escherichia coli
brenda
Kim, Y.S.; Shin, H.C.; Lee, J.H.
Two mechanisms for putrescine-dependent transcriptional expression of the putrescine aminotransferase gene, ygjG, in Escherichia coli
Arch. Microbiol.
196
611-618
2014
Escherichia coli
brenda
Slabu, I.; Galman, J.; Weise, N.; Lloyd, R.; Turner, N.
Putrescine transaminases for the synthesis of saturated nitrogen heterocycles from polyamines
ChemCatChem
8
1038-1042
2016
Priestia megaterium, Bacillus mycoides (A0A0B5S7N0), Escherichia coli (P42588), Priestia megaterium WSH-002
-
brenda
Cha, H.; Jeong, J.; Rojviriya, C.; Kim, Y.
Structure of putrescine aminotransferase from Escherichia coli provides insights into the substrate specificity among class III aminotransferases
PLoS ONE
9
e113212
2014
Escherichia coli (P42588), Escherichia coli
brenda
Wilding, M.; Scott, C.; Newman, J.; Peat, T.S.
Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC
Acta Crystallogr. Sect. F
73
29-35
2017
Pseudomonas sp., Pseudomonas sp. AAC
brenda
Galman, J.L.; Gahloth, D.; Parmeggiani, F.; Slabu, I.; Leys, D.; Turner, N.J.
Characterization of a putrescine transaminase from Pseudomonas putida and its application to the synthesis of benzylamine derivatives
Front. Bioeng. Biotechnol.
6
205
2018
Pseudomonas putida (A0A4P8GNL5), Pseudomonas putida, Pseudomonas putida NBRC 14161 (A0A4P8GNL5)
brenda