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2-oxoglutaramate + glycine
L-glutamine + glyoxylate
-
poor substrate
-
?
2-oxoglutaramate + L-alanine
L-glutamine + pyruvate
-
poor substrate
-
?
2-oxoglutaramate + L-asparagine
L-glutamine + 2-oxosuccinamate
-
poor substrate
-
?
2-oxoglutaramate + L-cysteine
L-glutamine + 3-mercapto-2-oxopropanoate
-
poor substrate
-
?
2-oxoglutaramate + L-ethionine
L-glutamine + 4-ethylsulfanyl-2-oxobutanoate
-
-
-
?
2-oxoglutaramate + L-glutamic acid 4-benzylester
L-glutamine + 2-oxopentane-1,5-dioic acid benzyl ester
-
poor substrate
-
?
2-oxoglutaramate + L-homoserine
L-glutamine + 4-hydroxy-2-oxobutanoate
-
-
-
?
2-oxoglutaramate + L-methionine
L-glutamine + 4-methylsulfanyl-2-oxobutanoate
2-oxoglutaramate + L-methionine (SR)-sulfoxide
L-glutamine + 4-methylsulfinyl-2-oxobutanoate
-
-
-
?
2-oxoglutaramate + L-methionine sulfone
L-glutamine + 4-methylsulfonyl-2-oxobutanoate
-
-
-
?
2-oxoglutaramate + L-phenylalanine
L-glutamine + phenylpyruvate
-
poor substrate
-
?
2-oxoglutaramate + L-serine
L-glutamine + 3-hydroxy-2-oxopropanoate
-
poor substrate
-
?
gamma-glutamylhydrazone of glyoxylate + glyoxylate
glycine + ?
-
-
-
-
?
gamma-glutamylhydrazones of 2-oxo acid
L-amino acid + 2-hydroxy-tetrahydro-6-pyridazinone-3-carboxylic acid
glyoxylate + 4-glutamylmethylamide
glycine + ?
glyoxylate + DL-homocysteine
glycine + 2-oxo-4-thiobutanoate
-
poor substrate
-
?
glyoxylate + glutamic acid 4-methyl ester
glycine + 2-oxoglutarate 4-methyl ester
glyoxylate + L-2-amino-4-oxo-5-chloropentanoic acid
glycine + 5-chloro-2,4-dioxopentanoate
-
poor substrate
-
?
glyoxylate + L-alanine
glycine + pyruvate
-
poor substrate
-
?
glyoxylate + L-asparagine
glycine + 2-oxosuccinamate
-
poor substrate
-
?
glyoxylate + L-cysteine
glycine + 3-mercapto-2-oxopropanoate
glyoxylate + L-ethionine
glycine + 4-ethylsulfanyl-2-oxobutanoate
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
glyoxylate + L-homoserine
glycine + 4-hydroxy-2-oxobutanoate
glyoxylate + L-methionine
glycine + 4-methylsulfanyl-2-oxobutanoate
glyoxylate + L-methionine (SR)-sulfoxide
glycine + ?
glyoxylate + L-methionine sulfone
glycine + 4-methylsulfonyl-2-oxobutanoate
glyoxylate + L-phenylalanine
glycine + phenylpyruvate
glyoxylate + L-serine
glycine + 3-hydroxy-2-oxopropanoate
-
poor substrate
-
?
glyoxylate + S-methyl-L-cysteine
glycine + 3-methylsulfanyl-2-oxopropanoate
L-albizziin + glyoxylate
glycine + 2-imidazolidone-5-hydroxy-5-carboxylic acid
L-glutamine + 2-oxoglutaramate
2-oxoglutaramate + L-glutamine
L-glutamine + 3-hydroxypyruvate
2-oxoglutaramate + L-serine
-
-
-
?
L-glutamine + 3-mercaptopyruvate
2-oxoglutaramate + L-cysteine
L-glutamine + 4-methylsulfanyl-2-oxobutanoate
2-oxoglutaramate + L-methionine
-
-
-
?
L-glutamine + alpha-keto acid
alpha-ketoglutarate + amino acid
L-glutamine + indol-3-pyruvate
2-oxoglutaramate + ?
-
-
-
?
L-glutamine + oxaloacetate
2-oxoglutaramate + L-aspartate
-
-
-
?
L-glutamine + phenylpyruvate
2-oxoglutaramate + L-phenylalanine
-
-
-
?
L-glutamine + pyruvate
2-oxoglutaramate + L-alanine
-
-
-
?
L-phenylalanine + 4-methylthio-2-oxobutanoate
phenylpyruvate + 2-amino-4-methylthiobutanoate
-
-
-
-
?
pyruvate + L-4-glutamylmethylamide
L-alanine + ?
-
-
-
?
pyruvate + L-glutamine
L-alanine + 2-oxoglutaramate
pyruvate + L-methionine
L-alanine + 4-methylsulfanyl-2-oxobutanoate
-
poor substrate
-
?
pyruvate + L-methionine (SR)-sulfoxide
L-alanine + 4-methylsulfinyl-2-oxobutanoate
-
poor substrate
-
?
pyruvate + L-methionine sulfone
L-alanine + 4-methylsulfonyl-2-oxobutanoate
-
poor substrate
-
?
pyruvate + L-phenylalanine
L-alanine + phenylpyruvate
S-(3-aminopropyl)cysteine + pyruvate
S-(3-aminopropyl)thiopyruvic acid + amino acid
-
-
-
?
selenium-(3-aminopropyl)selenocysteine + pyruvate
selenium-(3-aminopropyl)selenopyruvic acid + amino acid
-
-
-
?
selenomethionine + phenylpyruvate
2-oxo-gamma-methylselenobutyrate + L-phenylalanine
-
-
-
?
additional information
?
-
2-oxoglutaramate + L-methionine
L-glutamine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
?
2-oxoglutaramate + L-methionine
L-glutamine + 4-methylsulfanyl-2-oxobutanoate
-
best amino group donor
-
?
gamma-glutamylhydrazones of 2-oxo acid
L-amino acid + 2-hydroxy-tetrahydro-6-pyridazinone-3-carboxylic acid
-
-
-
?
gamma-glutamylhydrazones of 2-oxo acid
L-amino acid + 2-hydroxy-tetrahydro-6-pyridazinone-3-carboxylic acid
-
gamma-glutamylhydrazones of 4-ethylsulfanyl-2-oxobutanoate, glyoxylate, 2-oxoisovalerate, transfers the 2-amino group of the glutamyl moiety to the oxo acid moiety, the reaction rates are higher than those of the corresponding glutamine alpha-keto acid transaminations
-
?
glyoxylate + 4-glutamylmethylamide
glycine + ?
-
-
-
?
glyoxylate + 4-glutamylmethylamide
glycine + ?
-
-
-
?
glyoxylate + glutamic acid 4-methyl ester
glycine + 2-oxoglutarate 4-methyl ester
-
-
-
?
glyoxylate + glutamic acid 4-methyl ester
glycine + 2-oxoglutarate 4-methyl ester
-
-
-
?
glyoxylate + L-cysteine
glycine + 3-mercapto-2-oxopropanoate
-
-
-
?
glyoxylate + L-cysteine
glycine + 3-mercapto-2-oxopropanoate
-
poor substrate
-
?
glyoxylate + L-ethionine
glycine + 4-ethylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-ethionine
glycine + 4-ethylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-ethionine
glycine + 4-ethylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
-
-
-
?
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
-
-
-
?
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
-
-
-
?
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
-
-
2-oxoglutaramate cyclizes spontaneously to form 2-pyrrolidone-5-hydroxy-5-carboxylate
?
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
-
best substrate
-
?
glyoxylate + L-glutamine
glycine + 2-oxoglutaramate
-
-
-
?
glyoxylate + L-homoserine
glycine + 4-hydroxy-2-oxobutanoate
-
-
-
?
glyoxylate + L-homoserine
glycine + 4-hydroxy-2-oxobutanoate
-
poor substrate
-
?
glyoxylate + L-methionine
glycine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-methionine
glycine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-methionine
glycine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-methionine
glycine + 4-methylsulfanyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-methionine (SR)-sulfoxide
glycine + ?
-
-
-
?
glyoxylate + L-methionine (SR)-sulfoxide
glycine + ?
-
-
-
?
glyoxylate + L-methionine (SR)-sulfoxide
glycine + ?
-
-
-
?
glyoxylate + L-methionine sulfone
glycine + 4-methylsulfonyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-methionine sulfone
glycine + 4-methylsulfonyl-2-oxobutanoate
-
-
-
?
glyoxylate + L-phenylalanine
glycine + phenylpyruvate
-
-
-
?
glyoxylate + L-phenylalanine
glycine + phenylpyruvate
-
poor substrate
-
?
glyoxylate + S-methyl-L-cysteine
glycine + 3-methylsulfanyl-2-oxopropanoate
-
-
-
?
glyoxylate + S-methyl-L-cysteine
glycine + 3-methylsulfanyl-2-oxopropanoate
-
poor substrate
-
?
L-albizziin + glyoxylate
glycine + 2-imidazolidone-5-hydroxy-5-carboxylic acid
-
-
undergoes non-enzymatic dehydration to 2-imidazolinone-5-carboxylate
?
L-albizziin + glyoxylate
glycine + 2-imidazolidone-5-hydroxy-5-carboxylic acid
-
S-carbamoyl-L-cysteine or O-carbamoyl-L-serine can replace albizziin
-
?
L-glutamine + 2-oxoglutaramate
2-oxoglutaramate + L-glutamine
-
-
-
?
L-glutamine + 2-oxoglutaramate
2-oxoglutaramate + L-glutamine
-
-
-
?
L-glutamine + 3-mercaptopyruvate
2-oxoglutaramate + L-cysteine
-
-
-
?
L-glutamine + 3-mercaptopyruvate
2-oxoglutaramate + L-cysteine
-
-
-
?
L-glutamine + alpha-keto acid
alpha-ketoglutarate + amino acid
-
-
-
?
L-glutamine + alpha-keto acid
alpha-ketoglutarate + amino acid
-
-
-
?
L-glutamine + alpha-keto acid
alpha-ketoglutarate + amino acid
-
-
-
?
L-glutamine + alpha-keto acid
alpha-ketoglutarate + amino acid
-
-
-
?
L-glutamine + alpha-keto acid
alpha-ketoglutarate + amino acid
-
-
-
?
pyruvate + L-glutamine
L-alanine + 2-oxoglutaramate
-
-
-
?
pyruvate + L-glutamine
L-alanine + 2-oxoglutaramate
-
pyruvate cannot be replaced by its hydrazone, oxime or semicarbazone derivatives
-
?
pyruvate + L-glutamine
L-alanine + 2-oxoglutaramate
-
L-glutamine cannot be replaced by glycine
-
?
pyruvate + L-phenylalanine
L-alanine + phenylpyruvate
-
-
-
?
pyruvate + L-phenylalanine
L-alanine + phenylpyruvate
-
-
-
?
pyruvate + L-phenylalanine
L-alanine + phenylpyruvate
-
-
-
?
additional information
?
-
recombinant mouse KAT3/GTL selectively metabolizes selenomethionine to 2-oxo-gamma-methylselenobutyrate, KAT3/GTLis more efficient in transamination of both than is KAT1/GTK
-
-
-
additional information
?
-
-
recombinant mouse KAT3/GTL selectively metabolizes selenomethionine to 2-oxo-gamma-methylselenobutyrate, KAT3/GTLis more efficient in transamination of both than is KAT1/GTK
-
-
-
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Acidosis
Effect of chronic alkalosis and acidosis on glutaminase II path in the dog kidney in vivo.
Alkalosis
Effect of chronic alkalosis and acidosis on glutaminase II path in the dog kidney in vivo.
Astrocytoma
GLUTAMINE TRANSAMINASE IN BRAIN TISSUE PREPARATIONS AND IN CELLS OF A HUMAN STRAIN OF DEDIFFERENTIATED ASTROCYTOMA.
Astrocytoma
[Glutamine transaminase in brain preparations and in cells of a strain of differentiated human astrocytoma.]
Carcinogenesis
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Carcinoma
[Specificity of glutamine metabolism in pre-tumorous diseases and cancer of the human stomach]
Gastritis, Atrophic
[Specificity of glutamine metabolism in pre-tumorous diseases and cancer of the human stomach]
Hepatic Encephalopathy
[Analysis of prognostic factors and construction of a logistic regression model for patients with drug-induced liver failure].
Hepatorenal Syndrome
[Analysis of prognostic factors and construction of a logistic regression model for patients with drug-induced liver failure].
Liver Diseases
[Analysis of prognostic factors and construction of a logistic regression model for patients with drug-induced liver failure].
Neoplasms
High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'.
Neoplasms
The Metabolic Importance of the Glutaminase II Pathway in Normal and Cancerous Cells.
Neoplasms
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Nephrosis
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states.
Pancreatic Neoplasms
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Prostatic Neoplasms
High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in 'Glutamine Addiction'.
Protein-Energy Malnutrition
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states.
Renal Insufficiency, Chronic
[Activity of glutamine deaminating enzymes in the kidneys, liver and serum of dogs with renal failure and under normal conditions]
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Cooper, A.J.L.; Meister, A.
Action of liver glutamine transaminase and L-amino acid oxidase on several glutamine analogs. Preparation and properties of the 4-S, O, and NH analogs of alpha-ketoglutaramic acid
J. Biol. Chem.
248
8499-8505
1973
Rattus norvegicus
brenda
Mosca, M.; Croci, C.; Mostardini, M.; Breton, J.; Malyszko, J.; Avanzi, N.; Toma, S.; Benatti, L.; Gatti, S.
Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs
Biochim. Biophys. Acta
1628
1-10
2003
Rattus norvegicus
brenda
Cooper, A.J.L.; Meister, A.
Glutamine transaminase L from rat liver
Methods Enzymol.
113
338-343
1985
Rattus norvegicus
brenda
Cooper, A.J.L.; Meister, A.
Isolation and properties of highly purified glutamine transaminase
Biochemistry
11
661-671
1972
Rattus norvegicus
brenda
Cooper, A.J.L.; Meister, A.
Activity of liver glutamine transaminase toward L-gamma-glutamyl hydrazones of alpha-keto acids
J. Biol. Chem.
248
8489-8498
1973
Rattus norvegicus
brenda
Cooper, A.J.L.; Meister, A.
Isolation and properties of a new glutamine transaminase form rat kidney
J. Biol. Chem.
249
2554-2561
1974
Rattus norvegicus
brenda
Coccia, R.; Foppoli, C.; Blarzino, C.; De Marco, C.; Pensa, B.
Transamination of some sulphur- or selenium-containing amino acids by bovine liver glutamine transaminase
Physiol. Chem. Phys. Med. NMR
24
313-321
1992
Bos taurus
brenda
Duran, S.; Calderon, J.
Role of the glutamine transaminase-omega-amidase pathway and glutaminase in glutamine degradation in Rhizobium etli
Microbiology
141
589-595
1995
Rhizobium etli
-
brenda
Yang, C.; Zhang, L.; Han, Q.; Liao, C.; Lan, J.; Ding, H.; Zhou, H.; Diao, X.; Li, J.
Kynurenine aminotransferase 3/glutamine transaminase L/cysteine conjugate beta-lyase 2 is a major glutamine transaminase in the mouse kidney
Biochem. Biophys. Rep.
8
234-241
2016
Mus musculus (Q71RI9), Mus musculus
brenda