Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
beta-D-Gal-(1->4)-beta-D-Glc-(1->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate
CMP + ganglioside GM3 (d18:1(4E)) + H+
-
-
-
?
CMP-N-acetylneuraminate + 1-deoxy-1-cholesteryl (N-acetyl)-ethanolaminolactitol
CMP + ?
-
115% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + 1-deoxy-1-cholesterylethanolaminolactitol
CMP + ?
-
28% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + 1-deoxy-1-cholesterylphospho (N-acetyl)-ethanolaminolactitol
CMP + ?
-
151% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + 1-deoxy-1-cholesterylphosphoethanolaminolactitol
CMP + ?
-
60% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + 2,3-dicholesteryl-1-beta-lactosylglycerol
?
-
113% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + 2-cholesteryl-1-beta-lactosylglycerol
?
-
138% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + 3-cholesteryl-1-beta-lactosylglycerol
?
-
163% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + asialoGM1
?
-
27.7% relative activity to lactosylceramide
-
-
?
CMP-N-acetylneuraminate + asialoGM1
CMP + GM1
-
-
-
?
CMP-N-acetylneuraminate + asialoGM2
CMP + GM2
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetylgalactosamin-1,4-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + ?
-
i.e. asialo-ganglioside GM1, sialylated at about 84% the rate of lactosylceramide
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetylgalactosamin-lactosylceramide
CMP + ?
-
14% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-N-acetylneuraminate + beta-lactosylcholesterol
?
-
138% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + boron dipyrromethene difluoride-lactosylceramide
CMP + boron dipyrromethene difluoride-ganglioside GM3
CMP-N-acetylneuraminate + cholesteryl-beta-lactosylpropane-1,3-diol
?
-
143% of activity with lactosylceramide
-
-
?
CMP-N-acetylneuraminate + galactosylceramide
?
-
30% relative activity to lactosylceramide
-
-
?
CMP-N-acetylneuraminate + galactosylceramide
CMP + ?
-
sialylated at about 40% the rate of lactosylceramide
-
-
?
CMP-N-acetylneuraminate + galactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-ceramide
-
-
-
?
CMP-N-acetylneuraminate + galactosylceramide
CMP + ganglioside GM3
-
-
-
?
CMP-N-acetylneuraminate + glucosylceramide
CMP + ?
-
sialylated at about 65% the rate of lactosylceramide
-
-
?
CMP-N-acetylneuraminate + GM3
?
-
4.5% relative activity to lactosylceramide
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
CMP-N-acetylneuraminate + lactosylceramide
CMP + ganglioside GM4
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP-Neu5Ac + lactosylceramide
?
-
caveolin-1 is a GM3-interacting protein in GM3 synthase overexpressing cells
-
-
?
CMP-sialic acid + galactosylceramide
CMP + ganglioside GM4
additional information
?
-
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
-
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
i.e. lactosylceramide, high specificity
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
preferred acceptors have the general structure beta1-O-ceramide, disaccharides are preferred to monosaccharide
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
no acceptors are fetuin, mucin, alpha1-acid glycoprotein, glycophorin or their respective asialo-derivatives, gangliosides GD1b, GM3, GM2, GM1 or GD1a
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
brain sialyltransferase shows high activity with d18:1-16:0, d18:1-22:1, and d18:0-18:0 lactosylceramide molecular species, specificity changes when the lipid composition of the neuronal microsomal membrane resembles that of liver Golgi membrane lipids
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
i.e. ganglioside GM3
?
CMP-N-acetylneuraminate + boron dipyrromethene difluoride-lactosylceramide
CMP + boron dipyrromethene difluoride-ganglioside GM3
-
-
-
-
?
CMP-N-acetylneuraminate + boron dipyrromethene difluoride-lactosylceramide
CMP + boron dipyrromethene difluoride-ganglioside GM3
-
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
?
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
?
-
100% relative activity
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
metabolic flux and expression levels of enzymes involved in the sialic acid biosynthetic pathway, overview
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
ganglioside GM3 is involved in neuronal cell death
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
synthesizes the first ganglioside of the gangliotetraose series, GM3
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
-
-
?
CMP-N-acetylneuraminate + lactosylceramide
CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
involved in sequential addition of monosaccharides from sugar nucleotides to non-reducing end of oligosaccharide chains of glycosphingolipids
-
-
?
CMP-sialic acid + galactosylceramide
CMP + ganglioside GM4
-
-
-
?
CMP-sialic acid + galactosylceramide
CMP + ganglioside GM4
-
-
-
?
CMP-sialic acid + galactosylceramide
CMP + ganglioside GM4
-
-
-
?
CMP-sialic acid + galactosylceramide
CMP + ganglioside GM4
-
-
-
?
additional information
?
-
no activity with asialofetuin, Galbeta(1,3)GalNAc and Galbeta(1,3)GlcNAc
-
-
?
additional information
?
-
-
the cAMP responsive element binding protein binding site of the hST3Gal V promoter plays a critical role in transcriptional regulation of the hST3Gal V gene during HL-60 cell differentiation
-
-
?
additional information
?
-
-
upregulation of GM3 synthase through protein kinase C/extracellular regulated kinases-dependent cAMP-responsive element binding protein activation results in the differentiation of HL-60 cells by inducing expression of CD11b
-
-
?
additional information
?
-
-
overexpression of recombinant UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, GNE, in HEK AD293 cells up-regulates GM3 synthase, while GNE down-regulation by RNA interference or exogenous GM3 and GD3 down-regulates the GM3 synthase
-
-
?
additional information
?
-
-
substrate specificity of isozymes, no activity with GD3 and GM1a as acceptors, overview
-
-
?
additional information
?
-
substrate specificity of isozymes, no activity with GD3 and GM1a as acceptors, overview
-
-
?
additional information
?
-
-
no acitvity with GM1 or asialofetuin as acceptor
-
-
?
additional information
?
-
-
the -177 to -83 region, which contains a cAMP-responsive element at -143, functions as the valproic acid-inducible promoter by actively binding cAMP-responsive element binding protein. The cAMP-responsive element at -143 is crucial for the valproic acid-induced expression of hST3Gal V in SK-NBE(2)-C cells
-
-
?
additional information
?
-
-
mice with a disrupted gene encoding GM3 synthase have an enhanced phosphorylation of the skeletal muscle insulin receptor after ligand binding. They show heightened responses in glucose and insulin tolerance tests. The mutant mice are protected from high-fat diet induced insulin resistance
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Bieberich, E.; MacKinnon, S.; Silva, J.; Li, D.D.; Tencomnao, T.; Irwin, L.; Kapitonov, D.; Yu, R.K.
Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases
Biochemistry
41
11479-11487
2002
Mus musculus
brenda
Basu, S.K.; Whisler, R.L.; Yates, A.J.
Effects of lectin activation on sialyltransferase activities in human lymphocytes
Biochemistry
25
2577-2581
1986
Homo sapiens, Rattus norvegicus
brenda
Higashi, H.; Basu, M.; Basu, S.
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain
J. Biol. Chem.
260
824-828
1985
Gallus gallus
brenda
Freischutz, B.; Saito, M.; Rahmann, H.; Yu, R.K.
Activities of five different sialyltransferases in fish and rat brains
J. Neurochem.
62
1965-1973
1994
Oreochromis mossambicus, Rattus norvegicus
brenda
Busam, K.; Decker, K.
Ganglioside biosynthesis in rat liver. Characterization of three sialyltransferases
Eur. J. Biochem.
160
23-30
1986
Rattus norvegicus
brenda
Iber, H.; van Echten, G.; Sandhoff, K.
Substrate specificity of alpha 2->3-sialyltransferases in ganglioside biosynthesis of rat liver Golgi
Eur. J. Biochem.
195
115-120
1991
Rattus norvegicus
brenda
Fishman, P.H.; Bradley, R.M.; Henneberry, R.C.
Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase
Arch. Biochem. Biophys.
172
618-626
1976
Homo sapiens
brenda
Trinchera, M.; Pirovano, B.; Ghidoni, R.
Sub-Golgi distribution in rat liver of CMP-NeuAc GM3- and CMP-NeuAc:GT1b alpha 2->8sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis
J. Biol. Chem.
265
18242-18247
1990
Rattus norvegicus
brenda
Cambron, L.D.; Leskawa, K.C.
Inhibition of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase by nucleotides, nucleotide sugars and nucleotide dialdehydes
Biochem. Biophys. Res. Commun.
193
585-590
1993
Gallus gallus
brenda
Trinchera, M.; Fabbri, M.; Ghidoni, R.
Topography of glycosyltransferases involved in the initial glycosylations of gangliosides
J. Biol. Chem.
266
20907-20912
1991
Rattus norvegicus
brenda
Melkerson-Watson, L.J.; Sweeley, C.C.
Purification to apparent homogeneity by immunoaffinity chromatography and partial characterization of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1), from rat liver Golgi [published erratum appears in J Biol Chem 1991 Oct 15;266(29):19865]
J. Biol. Chem.
266
4448-4457
1991
Rattus norvegicus
brenda
Melkerson-Watson, L.J.; Sweeley, C.C.
Special considerations in the purification of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): effects of protease inhibitors on rat hepatic SAT-1 activity
Biochem. Biophys. Res. Commun.
175
325-332
1991
Rattus norvegicus
brenda
Melkerson-Watson, L.J.; Sweeley, C.C.
Special considerations in the purification of the GM3 ganglioside forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): solubilization of SAT-1 with lauryldimethylamine oxide
Biochem. Biophys. Res. Commun.
172
165-171
1990
Rattus norvegicus
brenda
Preuss, U.; Gu, X.; Gu, T.; Yu, R.K.
Purification and characterization of CMP-N-acetylneuraminic acid:lactosylceramide (alpha 2-3) sialyltransferase (GM3-synthase) from rat brain
J. Biol. Chem.
268
26273-26278
1993
Rattus norvegicus
brenda
Gu, X.B.; Gu, T.J.; Yu, R.K.
Purification to homogeneity of GD3 synthase and partial purification of GM3 synthase from rat brain
Biochem. Biophys. Res. Commun.
166
387-393
1990
Rattus norvegicus
brenda
Burczak, J.D.; Fairley, J.L.; Sweeley, C.C.
Characterization of a CMP-sialic acid:lactosylceramide sialyltransferase activity in cultured hamster cells
Biochim. Biophys. Acta
804
442-449
1984
Mesocricetus auratus
brenda
Eppler, C.M.; Morr, D.J.; Keenan, T.W.
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides
Biochim. Biophys. Acta
619
332-343
1980
Rattus norvegicus
brenda
Kadowaki, H.; Grant, M.A.
Relationship of membrane phospholipid composition, lactosylceramide molecular species, and the specificity of CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase to the molecular species composition of GM3 ganglioside
J. Lipid Res.
36
1274-1282
1995
Rattus norvegicus
brenda
Pohlentz, G.; Mokros, A.; Egge, H.
Cholesterol-containing lactose derived neoglycolipids serve as acceptors for sialyltransferases from rat liver Golgi vesicles
Glycoconjugate J.
13
147-152
1996
Rattus norvegicus
brenda
Osanai, T.; Watanabe, Y.; Sanai, Y.
Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19
Biochem. Biophys. Res. Commun.
241
327-333
1997
Mus musculus
brenda
Bobryshev, Y.V.; Golovanova, N.K.; Tran, D.; Samovilova, N.N.; Gracheva, E.V.; Efremov, E.E.; Sobolev, A.Y.; et al.
Expression of GM3 synthase in human atherosclerotic lesions
Atherosclerosis
184
63-71
2006
Homo sapiens
brenda
Golovanova, N.K.; Samovilova, N.N.; Gracheva, E.V.; Peklo, M.M.; Vlasik, T.N.; Sobolev, A.Y.; Jurchenko, Y.V.; Prokazova, N.V.
Development of antibody to human GM3 synthase and immunodetection of the enzyme in human tissues
Biochemistry
69
275-280
2004
Homo sapiens (Q9UNP4)
brenda
Choi, H.J.; Chung, T.W.; Kang, N.Y.; Kim, K.S.; Lee, Y.C.; Kim, C.H.
Transcriptional regulation of the human GM3 synthase (hST3Gal V) gene during monocytic differentiation of HL-60 cells
FEBS Lett.
555
204-208
2003
Homo sapiens
brenda
Chung, T.W.; Choi, H.J.; Lee, Y.C.; Kim, C.H.
Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells
Glycobiology
15
233-244
2005
Homo sapiens
brenda
Iwamori, M.; Iwamori, Y.
Changes in the glycolipid composition and characteristic activation of GM3 synthase in the thymus of mouse after administration of dexamethasone
Glycoconj. J.
22
119-126
2005
Mus musculus (O88829)
brenda
Yamashita, T.; Hashiramoto, A.; Haluzik, M.; Mizukami, H.; Beck, S.; Norton, A.; Kono, M.; Tsuji, S.; Daniotti, J.L.; Werth, N.; Sandhoff, R.; Sandhoff, K.; Proia, R.L.
Enhanced insulin sensitivity in mice lacking ganglioside GM3
Proc. Natl. Acad. Sci. USA
100
3445-3449
2003
Mus musculus
brenda
Berselli, P.; Zava, S.; Sottocornola, E.; Milani, S.; Berra, B.; Colombo, I.
Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein
Biochim. Biophys. Acta
1759
348-358
2006
Homo sapiens, Homo sapiens (Q9UNP4)
brenda
Sohn, H.; Kim, Y.; Kim, H.; Kim, C.; Cho, E.; Kang, H.; Kim, N.; Kim, C.; Ryu, S.E.; Lee, J.; Ko, J.H.
Ganglioside GM3 is involved in neuronal cell death
FASEB J.
20
1248-1250
2006
Mus musculus (O88829)
brenda
Wang, Z.; Sun, Z.; Li, A.V.; Yarema, K.J.
Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation, and apoptosis, and ERK1/2 phosphorylation
J. Biol. Chem.
281
27016-27028
2006
Homo sapiens
brenda
Choi, H.J.; Park, Y.G.; Kim, C.H.
Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells
Mol. Cell
23
138-144
2007
Homo sapiens
brenda
Choi, H.J.; Park, Y.G.; Kim, C.H.
Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells
Mol. Cells
23
138-144
2007
Homo sapiens
brenda
Kwon, H.Y.; Kang, N.Y.; Dae, H.M.; Kim, K.S.; Kim, C.H.; Do, S.I.; Lee, Y.
Valproic acid-mediated transcriptional regulation of human GM3 synthase (hST3Gal V) in SK-N-BE(2)-C human neuroblastoma cells
Acta Pharmacol. Sin.
29
999-1005
2008
Homo sapiens
brenda
Gu, Y.; Zhang, J.; Mi, W.; Yang, J.; Han, F.; Lu, X.; Yu, W.
Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells
Breast Cancer Res.
10
R1
2008
Mus musculus
brenda
Prinetti, A.; Aureli, M.; Illuzzi, G.; Prioni, S.; Nocco, V.; Scandroglio, F.; Gagliano, N.; Tredici, G.; Rodriguez-Menendez, V.; Chigorno, V.; Sonnino, S.
GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells
Glycobiology
20
62-77
2010
Homo sapiens
brenda
Uemura, S.; Yoshida, S.; Shishido, F.; Inokuchi, J.
The cytoplasmic tail of GM3 synthase defines its subcellular localization, stability, and in vivo activity
Mol. Biol. Cell
20
3088-3100
2009
Homo sapiens, Mus musculus
brenda
Gracheva, E.V.; Samovilova, N.N.; Golovanova, N.K.; Kashirina, S.V.; Shevelev, A.; Rybalkin, I.; Gurskaya, T.; Vlasik, T.N.; Andreeva, E.R.; Prokazova, N.V.
Enhancing of GM3 synthase expression during differentiation of human blood monocytes into macrophages as in vitro model of GM3 accumulation in atherosclerotic lesion
Mol. Cell. Biochem.
330
121-129
2009
Homo sapiens
brenda
Yoshikawa, M.; Go, S.; Takasaki, K.; Kakazu, Y.; Ohashi, M.; Nagafuku, M.; Kabayama, K.; Sekimoto, J.; Suzuki, S.; Takaiwa, K.; Kimitsuki, T.; Matsumoto, N.; Komune, S.; Kamei, D.; Saito, M.; Fujiwara, M.; Iwasaki, K.; Inokuchi, J.
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti
Proc. Natl. Acad. Sci. USA
106
9483-9488
2009
Mus musculus
brenda
Kim, S.J.; Chung, T.W.; Choi, H.J.; Kwak, C.H.; Song, K.H.; Suh, S.J.; Kwon, K.M.; Chang, Y.C.; Park, Y.G.; Chang, H.W.; Kim, K.S.; Kim, C.H.; Lee, Y.C.
Ganglioside GM3 participates in the TGF-beta1-induced epithelial-mesenchymal transition of human lens epithelial cells
Biochem. J.
449
241-251
2013
Homo sapiens (Q9UNP4)
brenda
Gracheva, E.; Samovilova, N.; Golovanova, N.; Piksina, G.; Shishkina, V.; Prokazova, N.
Activation of ganglioside GM3 biosynthesis in human blood mononuclear cells in atherosclerosis
Biomed. Khim.
59
459-468
2013
Homo sapiens
brenda
Song, N.; Kim, S.J.; Kwon, H.Y.; Son, S.W.; Kim, K.S.; Ahn, H.B.; Lee, Y.C.
Transcriptional activation of human GM3 synthase (hST3Gal V) gene by valproic acid in ARPE-19 human retinal pigment epithelial cells
BMB Rep.
44
405-409
2011
Homo sapiens (Q9UNP4), Homo sapiens
brenda
Paccalet, T.; Coulombe, Z.; Tremblay, J.P.
Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease
PLoS ONE
5
e10055
2010
Mus musculus (O88829)
brenda
Uh, J.; Chung, T.W.; Song, K.H.; Kwak, C.H.; Choi, H.J.; Ha, K.T.; Chang, Y.C.; Lee, Y.C.; Kim, C.H.
Ganglioside GM3 is required for caffeic acid phenethyl ester-induced megakaryocytic differentiation of human chronic myelogenous leukemia K562 cells
Biochem. Cell Biol.
92
243-249
2014
Homo sapiens (Q9UNP4)
brenda
Kreutz, F.; dos Santos Petry, F.; Camassola, M.; Schein, V.; Guma, F.C.; Nardi, N.B.; Trindade, V.M.
Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I)
Gene
527
109-114
2013
Mus musculus (O88829), Mus musculus C57BL/6 (O88829)
brenda
Uemura, S.; Go, S.; Shishido, F.; Inokuchi, J.
Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells
Glycoconj. J.
31
101-108
2014
Mus musculus, Mus musculus (O88829), Cricetulus griseus (Q80WL0), Mesocricetus auratus (Q9QXF5), Homo sapiens (Q9UNP4)
brenda
Yoon, H.K.; Lee, J.W.; Kim, K.S.; Mun, S.W.; Kim, D.H.; Kim, H.J.; Kim, C.H.; Lee, Y.C.
Serum deprivation-induced human GM3 synthase (hST3Gal V) gene expression is mediated by Runx2 in human osteoblastic MG-63 cells
Int. J. Mol. Sci.
17
35
2016
Homo sapiens (Q9UNP4), Homo sapiens
brenda
Kidani, S.; Kaneoka, H.; Okuzaki, Y.; Asai, S.; Kojima, Y.; Nishijima, K.I.; Iijima, S.
Analyses of chicken sialyltransferases related to O-glycosylation
J. Biosci. Bioeng.
122
379-384
2016
Gallus gallus (Q6R3Q5)
brenda
Sun, C.Q.; Hubl, U.; Hoefakker, P.; Vasudevamurthy, M.K.; Johnson, K.D.
A new assay for determining ganglioside sialyltransferase activities lactosylceramide-2,3-sialyltransferase (SAT I) and monosialylganglioside-2,3-sialyltransferase (SAT IV)
PLoS ONE
9
e94206
2014
Bos taurus, Ovis aries
brenda
Yamanaka, K.; Takahashi, Y.; Azuma, Y.; Hantani, Y.
Assay development and screening for the identification of ganglioside GM3 synthase inhibitors
Biochemistry
59
1242-1251
2020
Homo sapiens (Q9UNP4), Homo sapiens
brenda
Lee, M.; Choi, H.; Kim, K.; Kim, D.; Kim, C.; Lee, Y.
Curcumin downregulates human GM3 synthase (hST3Gal V) gene expression with autophagy induction in human colon carcinoma HCT116 cells
Evid. Based. Complement Alternat. Med.
2018
6746412
2018
Homo sapiens (Q9UNP4), Homo sapiens
brenda
Indellicato, R.; Parini, R.; Domenighini, R.; Malagolini, N.; Iascone, M.; Gasperini, S.; Masera, N.; dallOlio, F.; Trinchera, M.
Total loss of GM3 synthase activity by a normally processed enzyme in a novel variant and in all ST3GAL5 variants reported to cause a distinct congenital disorder of glycosylation
Glycobiology
29
229-241
2019
Homo sapiens (Q9UNP4)
brenda
Shimizu, T.; Nagane, M.; Suzuki, M.; Yamauchi, A.; Kato, K.; Kawashima, N.; Nemoto, Y.; Maruo, T.; Kawakami, Y.; Yamashita, T.
Tumor hypoxia regulates ganglioside GM3 synthase, which contributes to oxidative stress resistance in malignant melanoma
Biochim. Biophys. Acta Gen. Subj.
1864
129723
2020
Homo sapiens, Mus musculus
brenda