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denatured collagen type I + UDP-alpha-D-galactose
UDP + galactosylated collagen type I
-
-
-
?
UDP-alpha-D-galactose + calf skin collagen
?
-
-
-
-
?
UDP-alpha-D-galactose + hydroxylysyl acceptor sites
?
-
-
-
-
?
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
UDP-alpha-D-galactose + [procollagen]-(5R)-5-hydroxy-L-lysine
UDP + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
UDP-galactose + bovine collagen type I (deglycosylated)
UDP + ?
-
-
-
?
UDPgalactose + alpha1-glycoprotein with sialic acid and galactose removed
?
-
less active than with guinea pig skin collagen with sugar residues removed
-
-
?
UDPgalactose + fetuin with sialic acid and galactose removed
?
-
33% of activity with bovine achilles tendon collagen with glucose and galactose residues removed
-
-
?
UDPgalactose + ichthyocol
?
-
fish collagen ichthyocol as best substrate, peptides derived from collagenase- and pronase-digestion of ichthyocol are less effective
-
-
?
UDPgalactose + ovalbumin
?
-
17.9% of activity with bovine achilles tendon collagen with glucose and galactose residues removed
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
UDPgalactose + submaxillary glycoprotein with sialic acid removed
?
additional information
?
-
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
-
-
-
?
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
-
-
?
UDP-alpha-D-galactose + [procollagen]-(5R)-5-hydroxy-L-lysine
UDP + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
-
-
-
?
UDP-alpha-D-galactose + [procollagen]-(5R)-5-hydroxy-L-lysine
UDP + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
human lysyl hydroxylase 3 (LH3/PLOD3) is a multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3. Two distinct catalytic sites at the N- and C-terminal boundaries of each monomer are separated by an accessory domain. Collagen glucosyltransferase (EC 2.4.1.66) and procollagen galactosyltransferase (EC 2.4.1.50) activities localize at the N-terminus of the enzyme, whereas the lysyl hydroxylase activity (EC 1.14.11.4) is segregated at the LH3 C-terminus
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
guinea pig skin collagen with sugar residues removed
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
high specificity for galactosyl acceptor
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
triple helix conformation of native collagen at 30°C prevents glycosylation
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
triple helix conformation of native collagen at 30°C prevents glycosylation
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
guinea pig skin collagen with sugar residues removed
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
peptides derived from citrate soluble collagen by collagenase digestion, longer peptides are better substrates
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
bovine renal glomerular basement membrane
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
bovine anterior lens capsule collagen with carbohydrate units removed
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
heat-denatured citrate-soluble rat skin collagen is a more effective substrate than gelatinized insoluble calf skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
dialyzable peptides prepared by collagenase digestion of bovine Achilles tendon collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
gelatinized insoluble calf skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
gelatinized insoluble calf skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
gelatinized insoluble calf skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
gelatinized insoluble calf skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
acceptor specificity: requires free epsilon-amino group in hydroxylysyl-residues
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
high specificity for galactosyl acceptor
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
denatured citrat-soluble rat skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
denatured citrat-soluble rat skin collagen
beta-glycosidic bond
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
acid-soluble calf skin collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
fish collagen ichthyocol as best substrate, peptides derived from collagenase- and pronase-digestion of ichthyocol are less effective, native collagens from swim bladder or calf skin are more efficient substrates than collagen glycopeptides
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
bovine achilles tendon collagen with glucose and galactose residues removed
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
bovine glomerular basement membranes with carbohydrate units removed, native less effective
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
high specificity for specific hydroxylysine residues in collagen
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
high specificity for specific hydroxylysine residues in collagen
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
incorporation of monosaccharide precursors into the heterosaccharide chains of collagen
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
-
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + submaxillary glycoprotein with sialic acid removed
?
-
not porcine
-
-
?
UDPgalactose + submaxillary glycoprotein with sialic acid removed
?
-
bovine submaxillary glycoprotein with sialic acid removed, 9.5% of activity with achilles tendon collagen with glucose and galactose residues removed
-
-
?
additional information
?
-
-
no sugar donor: UDPglucose
-
-
?
additional information
?
-
-
no acceptors: galactose, glucose, glucosamine, N-acetylgalactosamine, lysine, hydroxyproline, threonine, serine, fetuin, native guinea pig collagen, glucose-free guinea pig skin collagen, native alpha1-glycoprotein
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
no sugar donors: UDPxylose, GDPmannose, GDPfucose
-
-
?
additional information
?
-
-
no acceptor: native collagen
-
-
?
additional information
?
-
-
free thiol groups in the active centre
-
-
?
additional information
?
-
-
no acceptor: galactosylhydroxylysine
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
intracellular post-translational modification in collagen biosynthesis
-
-
?
additional information
?
-
-
collagen biosynthesis
-
-
?
additional information
?
-
-
no sugar donors: ADP-glucose, UDP-N-acetylglucosamine, UDP-N-acetylgalactosamine
-
-
?
additional information
?
-
-
no sugar donor: UDPglucose
-
-
?
additional information
?
-
-
no acceptor: thyroglobulin unit B
-
-
?
additional information
?
-
-
no acceptors: transferrin, native fetuin
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
additional information
?
-
-
intracellular post-translational modification in collagen biosynthesis
-
-
?
additional information
?
-
-
LH3 is the only enzyme capable of glucosylating the galactosylhydroxylysine residues in proteins with a collagenous domain
-
-
?
additional information
?
-
-
no acceptor: free hydroxylysine
-
-
?
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UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
UDP-alpha-D-galactose + [procollagen]-(5R)-5-hydroxy-L-lysine
UDP + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
-
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
additional information
?
-
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
-
-
-
?
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
incorporation of monosaccharide precursors into the heterosaccharide chains of collagen
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
UDPgalactose + procollagen 5-hydroxy-L-lysine
UDP + procollagen 5-(D-galactosyloxy)-L-lysine
-
involved in collagen biosynthesis, post-translational modification, probably involved in synthesis of carbohydrate units in complement
-
-
?
additional information
?
-
-
intracellular post-translational modification in collagen biosynthesis
-
-
?
additional information
?
-
-
collagen biosynthesis
-
-
?
additional information
?
-
-
intracellular post-translational modification in collagen biosynthesis
-
-
?
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Carcinoma
Galactosyltransferase II: role in the diagnosis of pancreatic carcinoma.
Carcinoma, Hepatocellular
The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein.
Cataract
Corneal clouding, cataract, and colobomas with a novel missense mutation in B4GALT7-a review of eye anomalies in the linkeropathy syndromes.
Cerebral Small Vessel Diseases
Biallelic COLGALT1 variants are associated with cerebral small vessel disease.
Congenital Abnormalities
Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders.
Connective Tissue Diseases
Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders.
Contracture
Defective Initiation of Glycosaminoglycan Synthesis due to B3GALT6 Mutations Causes a Pleiotropic Ehlers-Danlos Syndrome-like Connective Tissue Disorder.
Ehlers-Danlos Syndrome
A B3GALT6 variant in patient originally described as Al-Gazali syndrome and implicating the endoplasmic reticulum quality control in the mechanism of some ?3GalT6-pathy mutations.
Ehlers-Danlos Syndrome
Biallelic B3GALT6 mutations cause spondylodysplastic Ehlers-Danlos syndrome.
Ehlers-Danlos Syndrome
Broadening the phenotypic spectrum of Beta3GalT6-associated phenotypes.
Ehlers-Danlos Syndrome
Further Defining the Phenotypic Spectrum of B3GAT3 Mutations and Literature Review on Linkeropathy Syndromes.
Ehlers-Danlos Syndrome
Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders.
Ehlers-Danlos Syndrome
Spondyloepimetaphyseal dysplasia with joint laxity (Beighton type); mutation analysis in eight affected South African families.
Fatty Liver
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Fetal Death
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Glaucoma
Corneal clouding, cataract, and colobomas with a novel missense mutation in B4GALT7-a review of eye anomalies in the linkeropathy syndromes.
Hepatitis
Glt25d2 Knockout Directly Increases CD25+CD69- but Decreases CD25-CD69+ Subset Proliferation and is Involved in Concanavalin-Induced Hepatitis.
Infections
Serum and liver enzymes of collagen synthesis in hepatic murine schistosomiasis mansoni.
Intellectual Disability
Defective Initiation of Glycosaminoglycan Synthesis due to B3GALT6 Mutations Causes a Pleiotropic Ehlers-Danlos Syndrome-like Connective Tissue Disorder.
Intellectual Disability
Spondyloepimetaphyseal dysplasia with joint laxity (Beighton type); mutation analysis in eight affected South African families.
Joint Dislocations
Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders.
Joint Instability
A B3GALT6 variant in patient originally described as Al-Gazali syndrome and implicating the endoplasmic reticulum quality control in the mechanism of some ?3GalT6-pathy mutations.
Joint Instability
Broadening the phenotypic spectrum of Beta3GalT6-associated phenotypes.
Joint Instability
Insights in the etiopathology of galactosyltransferase II (GalT-II) deficiency from transcriptome-wide expression profiling of skin fibroblasts of two sisters with compound heterozygosity for two novel B3GALT6 mutations.
Joint Instability
Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders.
Joint Instability
Severe Peripheral Joint Laxity is a Distinctive Clinical Feature of Spondylodysplastic-Ehlers-Danlos Syndrome (EDS)-B4GALT7 and Spondylodysplastic-EDS-B3GALT6.
Kashin-Beck Disease
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Leukemia
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia, T-Cell
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Lipodystrophy
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Muscle Hypotonia
Defective Initiation of Glycosaminoglycan Synthesis due to B3GALT6 Mutations Causes a Pleiotropic Ehlers-Danlos Syndrome-like Connective Tissue Disorder.
Muscle Hypotonia
Mutations in B3GALT6, which Encodes a Glycosaminoglycan Linker Region Enzyme, Cause a Spectrum of Skeletal and Connective Tissue Disorders.
Muscle Hypotonia
Severe Peripheral Joint Laxity is a Distinctive Clinical Feature of Spondylodysplastic-Ehlers-Danlos Syndrome (EDS)-B4GALT7 and Spondylodysplastic-EDS-B3GALT6.
Muscular Diseases
Loss of function of Colgalt1 disrupts collagen post-translational modification and causes musculoskeletal defects.
Muscular Dystrophies
Loss of function of Colgalt1 disrupts collagen post-translational modification and causes musculoskeletal defects.
Neoplasm Metastasis
Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression.
Neoplasms
Asbestos-associated genome-wide DNA methylation changes in lung cancer.
Neoplasms
Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression.
Neoplasms
Nine glycolysis-related gene signature predicting the survival of patients with endometrial adenocarcinoma.
Neoplasms
Tissue polypeptide antigen, galactosyltransferase isoenzyme II and pancreatic oncofetal antigen serum determination: role in pancreatic cancer diagnosis.
Non-alcoholic Fatty Liver Disease
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Obesity
Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation.
Osteoarthritis
Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.
Osteoarthritis
Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis.
Osteosarcoma
Collagen Accumulation in Osteosarcoma Cells lacking GLT25D1 Collagen Galactosyltransferase.
Osteosarcoma
Exosomes Secreted by Adipose-Derived Mesenchymal Stem Cells Foster Metastasis and Osteosarcoma Proliferation by Increasing COLGALT2 Expression.
Ovarian Neoplasms
COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD3.
Pancreatic Neoplasms
Galactosyltransferase II in detection of pancreatic cancer.
Pancreatic Neoplasms
Tissue polypeptide antigen, galactosyltransferase isoenzyme II and pancreatic oncofetal antigen serum determination: role in pancreatic cancer diagnosis.
Pancreatitis, Chronic
Tissue polypeptide antigen, galactosyltransferase isoenzyme II and pancreatic oncofetal antigen serum determination: role in pancreatic cancer diagnosis.
Porencephaly
Biallelic Variants in the COLGALT1 Gene Causes Severe Congenital Porencephaly: A Case Report.
Porencephaly
Collagen glycosylation.
procollagen galactosyltransferase deficiency
Collagen ?(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice.
Pulmonary Fibrosis
Enzymes of collagen synthesis in lung tissues of bleomycin-induced pulmonary fibrosis.
Refractive Errors
Corneal clouding, cataract, and colobomas with a novel missense mutation in B4GALT7-a review of eye anomalies in the linkeropathy syndromes.
Retinal Detachment
Corneal clouding, cataract, and colobomas with a novel missense mutation in B4GALT7-a review of eye anomalies in the linkeropathy syndromes.
Retinoblastoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Sarcoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Strabismus
Corneal clouding, cataract, and colobomas with a novel missense mutation in B4GALT7-a review of eye anomalies in the linkeropathy syndromes.
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Kivirikko, K.I.; Myllyl, R.
Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes
Methods Enzymol.
82
245-304
1982
Cavia porcellus, Gallus gallus, Homo sapiens, Rattus norvegicus
brenda
Bosmann, H.B.; Eylar, E.H.
Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen
Biochem. Biophys. Res. Commun.
33
340-346
1968
Cavia porcellus
brenda
Barber, A.J.; Jamieson, G.A.
Characterization of membrane-bound collagen galactosyltransferase of human blood platelets
Biochim. Biophys. Acta
252
546-552
1971
Homo sapiens
brenda
Risteli, L.; Myllyl, R.; Kivirikko, K.I.
Partial purification and characterization of collagen galactosyltransferase from chick embryos
Biochem. J.
155
145-153
1976
Gallus gallus
brenda
Carnicero, H.H.; Adamany, A.M.; Englard, S.
Collagen glucosyl- and galactosyltransferases of cultured human fetal lung fibroblasts
Arch. Biochem. Biophys.
210
678-690
1981
Homo sapiens
brenda
Risteli, L.; Myllyl, R.; Kivirikko, K.I.
Affinity chromatography of collagen glycosyltransferases on collagen linked to agarose
Eur. J. Biochem.
67
197-202
1976
Gallus gallus
brenda
Risteli, L.
Further characterization of collagen galactosyltransferase from chick embryos
Biochem. J.
169
189-196
1978
Gallus gallus
brenda
Myllyl, R.; Risteli, L.; Kivirikko, K.I.
Assay of collagen-galactosyltransferase and collagen-glucosyltransferase activities and preliminary characterization of enzymic reactions with transferases from chick-embryo cartilage
Eur. J. Biochem.
52
401-410
1975
Gallus gallus
brenda
Salo, A.M.; Cox, H.; Farndon, P.; Moss, C.; Grindulis, H.; Risteli, M.; Robins, S.P.; Myllylae, R.
A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene
Am. J. Hum. Genet.
83
495-503
2008
Homo sapiens
brenda
Risteli, M.; Ruotsalainen, H.; Salo, A.M.; Sormunen, R.; Sipilae, L.; Baker, N.L.; Lamande, S.R.; Vimpari-Kauppinen, L.; Myllylae, R.
Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix
J. Biol. Chem.
284
28204-28211
2009
Mus musculus, Homo sapiens (O60568)
brenda
Wang, C.; Kovanen, V.; Raudasoja, P.; Eskelinen, S.; Pospiech, H.; Myllylae, R.
The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
J. Cell. Mol. Med.
13
508-521
2009
Homo sapiens
brenda
Schegg, B.; Huelsmeier, A.J.; Rutschmann, C.; Maag, C.; Hennet, T.
Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
Mol. Cell. Biol.
29
943-952
2009
Gallus gallus, Homo sapiens (Q8IYK4), Homo sapiens (Q8NBJ5), Homo sapiens
brenda
Liefhebber, J.; Punt, S.; Spaan, W.; van Leeuwen, H.
The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein
BMC Cell Biol.
11
33
2010
Homo sapiens (Q8NBJ5), Homo sapiens
brenda
Perrin-Tricaud, C.; Rutschmann, C.; Hennet, T.
Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1
PLoS ONE
6
e29390
2011
Homo sapiens (Q8NBJ5), Homo sapiens
brenda
Gilkes, D.M.; Bajpai, S.; Wong, C.C.; Chaturvedi, P.; Hubbi, M.E.; Wirtz, D.; Semenza, G.L.
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Mol. Cancer Res.
11
456-466
2013
Homo sapiens (O00469)
brenda
Malfait,F.; Kariminejad, A.; Van Damme,T.; Gauche, C.; Syx, D.; Merhi-Soussi, F.; Gulberti, S.; Symoens, S.; Vanhauwaert, S.; Willaert, A.; Bozorgmehr, B.; Kariminejad, M.H.; Ebrahimiadib, N.; Hausser, I.; Huysseune, A.; Fournel-Gigleux, S.; De Paepe, A.
Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-Syndrome-like connective tissue disorder
Am. J. Hum. Genet.
92
935-945
2013
Homo sapiens
brenda
Ishikawa, Y.; Baechinger, H.P.
An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1-cartilage-associated protein-cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro
J. Biol. Chem.
288
31437-31446
2013
Gallus gallus
brenda
Risteli, M.; Ruotsalainen, H.; Bergmann, U.; Venkatraman Girija, U.; Wallis, R.; Myllylae, R.
Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin
PLoS ONE
9
e113498
2014
Homo sapiens
brenda
Webster, J.A.; Yang, Z.; Kim, Y.H.; Loo, D.; Mosa, R.M.; Li, H.; Chen, C.
Collagen beta (1-O) galactosyltransferase 1 (GLT25D1) is required for the secretion of high molecular weight adiponectin and affects lipid accumulation
Biosci. Rep.
37
BSR20170105
2017
Homo sapiens (Q8NBJ5), Homo sapiens, Mus musculus (Q8K297)
brenda
Baumann, S.; Hennet, T.
Collagen accumulation in osteosarcoma cells lacking GLT25D1 collagen galactosyltransferase
J. Biol. Chem.
291
18514-18524
2016
Homo sapiens (Q8IYK4), Homo sapiens (Q8NBJ5)
brenda
Scietti, L.; Chiapparino, A.; De Giorgi, F.; Fumagalli, M.; Khoriauli, L.; Nergadze, S.; Basu, S.; Olieric, V.; Cucca, L.; Banushi, B.; Profumo, A.; Giulotto, E.; Gissen, P.; Forneris, F.
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Nat. Commun.
9
3163
2018
Homo sapiens (O60568)
brenda