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acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
CoA + UDP-N,N'-diacetylbacillosamine
-
-
-
?
acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine
CoA + UDP-N,N'-diacetylbacillosamine
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
-
-
?
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
-
-
?
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
-
-
-
?
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
-
-
-
?
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
-
-
?
acetyl-CoA + UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose
CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
-
-
?
acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine
CoA + UDP-N,N'-diacetylbacillosamine
-
-
i.e. UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
?
acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine
CoA + UDP-N,N'-diacetylbacillosamine
-
-
i.e. UDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose
-
?
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2-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-methyl-4-(methylamino)-thieno[2,3-d]pyrimidine-6-carboxylic acid
-
2-(2-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
2-(3-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
2-(3-chlorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
-
2-(3-fluorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
-
2-(3-methoxyphenethyl)-4-(methylamino)thieno[3,2-d]-pyrimidine-6-carboxylic acid
-
2-(3-methoxyphenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
2-(4-acetamidophenethyl)-4-((2-aminoethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
2-(4-acetamidophenethyl)-5-methyl-4-((2-(pyridin-2-yl)ethyl)-amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
2-(4-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-( (2,3-dihydro-1H-inden-2-yl )amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-((2-aminoethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]-pyrimidine-6-carboxylic acid
-
4-((2-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-((2-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
-
4-((3,5-dimethoxyphenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-((3-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-((3-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
-
4-((4-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-((4-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
-
4-(benzylamino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
4-(methylamino)-2-phenethylthieno[3,2-d]pyrimidine-6-carboxylic acid
-
5-methyl-2-phenethyl-4-((2-(pyridin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-2-phenethyl-4-((2-(pyridin-3-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-2-phenethyl-4-((2-(pyridin-4-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-2-phenethyl-4-(phenethylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
-
5-methyl-4-((2-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-4-((3-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-4-((4-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-4-(methylamino)-2-(2-(pyridin-2-yl)ethyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
-
5-methyl-4-(methylamino)-2-(3-(trifluoromethyl)phenethyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid
-
5-methyl-4-(methylamino)-2-(3-phenylpropyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
-
5-methyl-4-(methylamino)-2-(4-phenylbutyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
-
5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
-
ethyl (S)-2-(4-acetamidophenethyl)-4-((2-methoxy-2-phenylethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
-
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
-
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
-
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
-
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
-
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0.0018
2-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-methyl-4-(methylamino)-thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.009
2-(2-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0035
2-(3-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0021
2-(3-chlorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0023
2-(3-fluorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0014
2-(3-methoxyphenethyl)-4-(methylamino)thieno[3,2-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0011
2-(3-methoxyphenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0014
2-(4-acetamidophenethyl)-4-((2-aminoethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00028
2-(4-acetamidophenethyl)-5-methyl-4-((2-(pyridin-2-yl)ethyl)-amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0024
2-(4-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.001
4-( (2,3-dihydro-1H-inden-2-yl )amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00059
4-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0016
4-((2-aminoethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00048
4-((2-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00048
4-((2-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00037
4-((3,5-dimethoxyphenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00039
4-((3-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00045
4-((3-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00042
4-((4-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00054
4-((4-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0045
4-(benzylamino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0039
4-(methylamino)-2-phenethylthieno[3,2-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00042
5-methyl-2-phenethyl-4-((2-(pyridin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00034
5-methyl-2-phenethyl-4-((2-(pyridin-3-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00039
5-methyl-2-phenethyl-4-((2-(pyridin-4-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0014
5-methyl-2-phenethyl-4-(phenethylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00025
5-methyl-4-((2-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00042
5-methyl-4-((3-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00072
5-methyl-4-((4-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00046
5-methyl-4-(methylamino)-2-(2-(pyridin-2-yl)ethyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0046
5-methyl-4-(methylamino)-2-(3-(trifluoromethyl)phenethyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0044
5-methyl-4-(methylamino)-2-(3-phenylpropyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0041
5-methyl-4-(methylamino)-2-(4-phenylbutyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0022
5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00027
ethyl (S)-2-(4-acetamidophenethyl)-4-((2-methoxy-2-phenylethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00087
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.002
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.00042
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
0.0011
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate
Campylobacter jejuni subsp. jejuni
pH 7.8, temperature not specified in the publication
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Olivier, N.B.; Chen, M.M.; Behr, J.R.; Imperiali, B.
In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system
Biochemistry
45
13659-13669
2006
Campylobacter jejuni, Campylobacter jejuni NCTC 11168
brenda
Rangarajan, E.S.; Ruane, K.M.; Sulea, T.; Watson, D.C.; Proteau, A.; Leclerc, S.; Cygler, M.; Matte, A.; Young, N.M.
Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni
Biochemistry
47
1827-1836
2008
Campylobacter jejuni (Q0P9D1)
brenda
Hartley, M.D.; Morrison, M.J.; Aas, F.E.; B?rud, B.; Koomey, M.; Imperiali, B.
Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N-diacetylbacillosamine
Biochemistry
50
4936-4948
2011
Neisseria gonorrhoeae, Neisseria gonorrhoeae MS11
brenda
Ding, W.; Nothaft, H.; Szymanski, C.M.; Kelly, J.
Identification and quantification of glycoproteins using ion-pairing normal-phase liquid chromatography and mass spectrometry
Mol. Cell. Proteomics
8
2170-2185
2009
Campylobacter jejuni, Campylobacter jejuni NCTC 11168
brenda
Morrison, M.J.; Imperiali, B.
Biochemical analysis and structure determination of bacterial acetyltransferases responsible for the biosynthesis of UDP-N,N-diacetylbacillosamine
J. Biol. Chem.
288
32248-32260
2013
Acinetobacter baumannii (B0V6J7), Neisseria gonorrhoeae (Q5FAE1), Acinetobacter baumannii AYE (B0V6J7), Neisseria gonorrhoeae FA 1090 (Q5FAE1)
brenda
De Schutter, J.; Morrison, J.; Morrison, M.; Ciulli, A.; Imperiali, B.
Targeting bacillosamine biosynthesis in bacterial pathogens Development of inhibitors to a bacterial amino-sugar acetyltransferase from Campylobacter jejuni
J. Med. Chem.
60
2099-2118
2017
Campylobacter jejuni subsp. jejuni (Q0P9D1), Campylobacter jejuni subsp. jejuni NCTC 11168 (Q0P9D1)
brenda