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(2E)-oct-2-enethioyl-CoA + (3S,5Z,8Z)-3-hydroxytetradeca-5,8-dienoyl-CoA
(3S,5S,7Z,10Z)-2-hexyl-3,5-dihydroxyhexadeca-7,10-dienoic acid + ?
-
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
2-methylbutyryl-CoA is the preferred primer substrate of isozyme FabH1
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
2-methylcrotonyl-CoA + malonyl-[acyl-carrier protein]
(4E)-4-methylhex-4-enoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
3-oxoacyl-ACP + acetyl-CoA
acetyl-ACP + 3-ketoacyl-CoA
-
-
-
-
?
acetoacetyl-ACP + acetyl-CoA
acetyl-ACP + acetoacetyl-CoA
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + ACP
acetyl-ACP + CoA
acetyl-CoA:ACP transacylase activity
-
-
?
acetyl-CoA + malonyl-ACP
acetoacetyl-ACP + CoA + CO2
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + [acyl-carrier protein]
acetyl-[acyl-carrier protein] + CoA
the enzyme also shows acetyltransferase activity
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
arachidoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-docosanoyl-[acyl-carrier protein] + CoA + CO2
-
low activity
-
-
?
butanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) (2E)-2,4-dimethylpent-2-enethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl (3E)-3,5-dimethylhex-3-enoate + N-(2-sulfanylethyl)acetamide
-
44% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 2-hydroxy-6-methylbenzene-1-carbothioate
7-deoxy-7-demethylpactamycin + N-(2-sulfanylethyl)acetamide
-
100% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 2-methylbutanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 2-methylbutanoate + N-(2-sulfanylethyl)acetamide
-
20% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 2-methylpropanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 2-methylpropanoate + N-(2-sulfanylethyl)acetamide
-
83% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 3-aminobenzene-1-carbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 3-aminobenzoate + N-(2-sulfanylethyl)acetamide
-
17% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 3-methylbutanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 3-methylbutanoate + N-(2-sulfanylethyl)acetamide
-
61% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) 4-chlorobutanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl 4-chlorobutanoate + N-(2-sulfanylethyl)acetamide
-
100% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) benzenecarbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl benzoate + N-(2-sulfanylethyl)acetamide
-
43% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) butanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl butanoate + N-(2-sulfanylethyl)acetamide
-
91% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) cycloheptanecarbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl cycloheptanecarboxylate + N-(2-sulfanylethyl)acetamide
-
87% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) cyclohexanecarbothioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl cyclohexanecarboxylate + N-(2-sulfanylethyl)acetamide
-
57% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) ethanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl acetate + N-(2-sulfanylethyl)acetamide
-
71% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) phenylethanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl phenylacetate + N-(2-sulfanylethyl)acetamide
-
95% conversion
-
-
?
de-(6-methylsalicylyl)-7-deoxy-7-demethylpactamycin + S-(2-acetamidoethyl) propanethioate
[(1S,2R,3S,4S,5S)-5-(3-acetylanilino)-4-amino-3-[(dimethylcarbamoyl)amino]-1,2-dihydroxy-2,3-dimethylcyclopentyl]methyl propanoate + N-(2-sulfanylethyl)acetamide
-
87% conversion
-
-
?
de-6-methylsalicylyl-7-deoxypactamycin + 6-methylsalicylyl N-acetylcysteamine thioester
?
-
-
-
-
?
de-6-methylsalicylyl-pactamycate + 6-methylsalicylyl N-acetylcysteamine thioester
?
-
-
-
-
?
decanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-lauroyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
malonyl-ACP + acyl-CoA
3-oxoacyl-ACP + CoA + CO2
specificity for branched acyl-CoA substrate
-
-
?
malonyl-ACP + acyl-CoA
CO2 + CoA + ?
-
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
octanoyl-CoA + (3S,5Z,8Z)-3-hydroxytetradeca-5,8-dienoyl-CoA
(5S,7Z,10Z)-2-hexyl-5-hydroxy-3-oxohexadeca-7,10-dienoic acid + ?
-
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
palmitoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2
propanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxopentanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
stearoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-arachidoyl-[acyl-carrier protein] + CoA + CO2
-
low activity
-
-
?
valeryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-heptanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
valeryl-CoA + malonyl-[acyl-carrier protein]
3-oxoheptanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
[PtmQ]-S-methyl 2-methylbenzene-1-carbothioate + de-6-methylsalicylyl-pactamycin
pactamycin + ?
-
-
-
-
?
additional information
?
-
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
2-methylbutyryl-CoA is the preferred substrate
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
2-methylbutyryl-CoA is the preferred substrate
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme shows a high selectivity for acetyl-CoA over acyl-ACP as its substrate. Escherichia coli FabH is inactive for longer-chain (greater than C4) primers and all branched-chain CoA primers
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-ACP
acetoacetyl-ACP + CoA + CO2
ACP acceptor substrates with eight carbons and potentially also with ten carbons are used, substrate specificity is not limited to using C2-CoA
-
-
?
acetyl-CoA + malonyl-ACP
acetoacetyl-ACP + CoA + CO2
ACP acceptor substrates with eight carbons and potentially also with ten carbons are used, substrate specificity is not limited to using C2-CoA
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
first condensing step in fatty acid synthase reaction, the enzyme is feedback regulated in biosynthesis of medium chain fatty acids
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
regulation of the enzyme activity is involved in regulation of fatty acid synthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
regulation of the enzyme activity is involved in regulation of the fatty acid synthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
initial condensation reaction to start fatty acid biosynthesis by the type II fatty acid synthase, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein]
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
regulation by feedback inhibition
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
acetyl-CoA and propionyl-CoA are the preferred primers
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
low activity
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is involved in initiation of fatty acid elogantion by the fatty acid synthase II catalyzing the decarboxylative condensation between malonyl-ACP and acetyl-CoA, the enzyme is essential for viability, overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
preferred CoA primer is acetyl-CoA
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
FabH initiates the elongation of straight-chain fatty acids by the fatty acid synthase II complex, fatty acid synthesis pathway overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis, overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
substrate malonyl-ACP is produced by FabC or Escherichia coli AcpP, but not by TcmM
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
the condensation reaction is the first step in elongation in fatty acid synthesis by fatty acid synthase complex
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
the enzyme prefers long-chain fatty acids
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
the enzyme prefers long-chain fatty acids
-
-
?
butanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
butanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier-protein] + CoA + CO2
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
heptanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
hexanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2
-
high activity
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
isobutyryl-CoA is the preferred CoA primer substrate
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
isobutyryl-CoA is the preferred primer substrate
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
isovaleryl-CoA is the preferred primer substrate of isozyme FabH2
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
-
lauroyl-CoA is the preferred primer
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel
-
-
?
lauroyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
-
-
-
-
?
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
-
-
-
?
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
-
-
-
?
malonyl-ACP + acetyl-CoA
CO2 + CoA + acetoacetyl-ACP
-
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme prefers long-chain acyl-CoA substrates for the Claisen condensation reaction
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
-
low activity with octanoyl-CoA as primer substrate of isozyme FabH1, no activity with FabH2
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
octanoyl-CoA + malonyl-[acyl-carrier protein]
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
palmitoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
palmitoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-stearoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
acetyl-CoA and propionyl-CoA are the preferred primers
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
the enzyme specifies the propionate-starter unit for type II polyketide biosynthesis
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
intermediate binding of propionyl to the enzyme at Ser118
-
-
?
additional information
?
-
-
substrate specificities of FabH1 and FabH2 with different primer substrates, both isozymes prefer branched-chain fatty acids
-
-
?
additional information
?
-
-
fatty acid composition and acyl-ACP content in the seeds
-
-
?
additional information
?
-
-
structural and dynamical aspect of catalytic mechanism of FabH, overview
-
-
?
additional information
?
-
-
the enzyme is a key catalyst of fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
-
the wild-type enzyme is able to induce synthesis of polyhydroxyalkanoates PHA copolymers from glucose in a strain which is transformed with gene phaC from Aeromonas caviae or gene phaC1 from Pseudomonas sp. strain 61-3, thus fatty acid biosynthesis may supply monomers for PHA production, overview
-
-
?
additional information
?
-
-
no activity with hexanoyl-CoA or octanoyl-CoA
-
-
?
additional information
?
-
-
the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
-
the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
substrate binding channel at the active site, structure, overview
-
-
?
additional information
?
-
-
substrate binding channel at the active site, structure, overview
-
-
?
additional information
?
-
FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence
-
-
?
additional information
?
-
-
FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence
-
-
?
additional information
?
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme prefers short-chain CoA primer substrates
-
-
?
additional information
?
-
-
the enzyme prefers short-chain CoA primer substrates
-
-
?
additional information
?
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
-
-
?
additional information
?
-
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
-
-
?
additional information
?
-
substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview
-
-
?
additional information
?
-
-
substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview
-
-
?
additional information
?
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
-
-
?
additional information
?
-
substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview
-
-
?
additional information
?
-
specificity of the enzyme for longer acyl-CoA chains, overview, the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
-
specificity of the enzyme for longer acyl-CoA chains, overview, the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
-
substrate specificity, no activity with isovaleryl-CoA, butyryl-CoA, and acetyl-CoA, the enzyme prefers long chain acyl-CoAs as primers rather than acyl-ACPs
-
-
?
additional information
?
-
FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
-
-
?
additional information
?
-
-
FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
-
-
?
additional information
?
-
specificity of the enzyme for longer acyl-CoA chains, overview, the enzyme shows also acyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
-
-
?
additional information
?
-
-
fatty acid composition and acyl-ACP content in the leaves
-
-
?
additional information
?
-
the enzyme shows also acetyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
-
the enzyme shows also acetyl-CoA-[acyl-carrier-protein] transacylase activity
-
-
?
additional information
?
-
-
substrate binding channel at the active site, structure, overview
-
-
?
additional information
?
-
-
substrate binding channel at the active site, structure, overview
-
-
?
additional information
?
-
fatty acid composition and acyl-ACP content in the leaves
-
-
?
additional information
?
-
-
fatty acid composition and acyl-ACP content in the leaves
-
-
?
additional information
?
-
-
substrate specificity, the enzyme also shows acetyltransferase activity, which is lower than the 3-ketoacyl carrier protein synthase activity
-
-
?
additional information
?
-
-
the enzyme possesses a large primer binding pocket determining the substrate specificity
-
-
?
additional information
?
-
substrate specificity, the recombinant enzyme prefers straight short-chain CoA primer substrates, preferred CoA primer is acetyl-CoA, no activity with lauroyl-CoA and palmitoyl-CoA
-
-
?
additional information
?
-
-
substrate specificity, the recombinant enzyme prefers straight short-chain CoA primer substrates, preferred CoA primer is acetyl-CoA, no activity with lauroyl-CoA and palmitoyl-CoA
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview
-
-
?
additional information
?
-
the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
-
-
?
additional information
?
-
-
the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
-
-
?
additional information
?
-
the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
-
-
?
additional information
?
-
-
the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
-
-
?
additional information
?
-
-
the enzyme is involved in biosynthesis of straight-chain and branched-chain fatty acids with the specificity for acyl-CoA substrate determining the produced fatty acid spectrum
-
-
?
additional information
?
-
-
the enzyme is not directly involved in tetracenomycin C biosynthesis
-
-
?
additional information
?
-
-
the enzyme shows also acyl-CoA:[acyl-carrier-protein] transacylase activity, i.e. ACAT activity, in a ratio of 1:0.12 with beta-oxoacyl-[acyl-carrier-protein] synthase III activity
-
-
?
additional information
?
-
-
no activity with acetyl-CoA, malonyl-CoA, and 2-methylmalonyl-CoA as primer for elongation of fatty acids, the enzyme shows also acyl-CoA:ACP transacylase activity for transfer of propionate to ACP
-
-
?
additional information
?
-
Product profile analysis of FabH from Synechococcus sp. strain PCC 7002, overview. t´The major products are lauric acid, myristic acid, palmitic acid, and stearic acid
-
-
?
additional information
?
-
-
Product profile analysis of FabH from Synechococcus sp. strain PCC 7002, overview. t´The major products are lauric acid, myristic acid, palmitic acid, and stearic acid
-
-
?
additional information
?
-
-
structure-function relationship, overview
-
-
?
additional information
?
-
-
the enzyme has a preferance for using branched chain acyl-CoAs as primers and also displays a strong activity towards short or medium chain acyl-CoAs (about C4-C10)
-
-
-
additional information
?
-
-
structure-function relationship, overview
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?
additional information
?
-
enzyme substrate specificity, overview
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-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
butyryl-CoA + malonyl-[acyl-carrier protein]
3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
isobutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
isovaleryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
myristoyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-palmitoyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme plays a key role in initiation of the long-chain fatty acid route of meromycolic acid biosynthesis, a different enzyme with specificity for short-chain acyl-CoAs might also be responsible for meromycolic acid biosynthesis, biosynthetic pathway regulation mechanism
-
-
?
propionyl-CoA + malonyl-[acyl-carrier protein]
3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2
-
the enzyme specifies the propionate-starter unit for type II polyketide biosynthesis
-
-
?
additional information
?
-
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + a malonyl-[acyl-carrier protein]
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
first condensing step in fatty acid synthase reaction, the enzyme is feedback regulated in biosynthesis of medium chain fatty acids
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
regulation of the enzyme activity is involved in regulation of fatty acid synthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
regulation of the enzyme activity is involved in regulation of the fatty acid synthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
initial condensation reaction to start fatty acid biosynthesis by the type II fatty acid synthase, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein]
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
regulation by feedback inhibition
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is essential for fatty acid biosynthesis, especially of short-chain fatty acids, by fatty acid synthase II initiating the elongation of fatty acids
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
condensation of fatty acid synthase I-derived acyl-CoAs with malonyl-ACPs to initiates fatty acid synthase II-catalyzed fatty acid elongation, the enzyme links the two fatty acid synthase complexes
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
r
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme catalyzes the initial step in fatty acid biosynthesis via type II fatty acid synthase
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme is involved in initiation of fatty acid elogantion by the fatty acid synthase II catalyzing the decarboxylative condensation between malonyl-ACP and acetyl-CoA, the enzyme is essential for viability, overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
-
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
FabH initiates the elongation of straight-chain fatty acids by the fatty acid synthase II complex, fatty acid synthesis pathway overview
-
-
?
acetyl-CoA + malonyl-[acyl-carrier protein]
acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
the enzyme initiates the fatty acid biosynthesis, overview
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
the condensation reaction is the first step in elongation in fatty acid synthesis by fatty acid synthase complex
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
acyl-CoA + malonyl-[acyl-carrier protein]
acetoacyl-[acyl-carrier protein] + CoA + CO2
-
-
-
?
additional information
?
-
-
fatty acid composition and acyl-ACP content in the seeds
-
-
?
additional information
?
-
-
the enzyme is a key catalyst of fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is important in fatty acid biosynthesis
-
-
?
additional information
?
-
-
the wild-type enzyme is able to induce synthesis of polyhydroxyalkanoates PHA copolymers from glucose in a strain which is transformed with gene phaC from Aeromonas caviae or gene phaC1 from Pseudomonas sp. strain 61-3, thus fatty acid biosynthesis may supply monomers for PHA production, overview
-
-
?
additional information
?
-
FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence
-
-
?
additional information
?
-
-
FabH catalyzes the initial step of fatty acid biosynthesis via a type II fatty acid synthase, FabH has an important role as essential enzyme combined with unique structural features and ubiquitous occurrence
-
-
?
additional information
?
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
the enzyme is essential for fatty acid biosynthesis
-
-
?
additional information
?
-
-
the enzyme prefers short-chain CoA primer substrates
-
-
?
additional information
?
-
-
the enzyme prefers short-chain CoA primer substrates
-
-
?
additional information
?
-
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
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additional information
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beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
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additional information
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beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria
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additional information
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FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
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additional information
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FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
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additional information
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FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview
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additional information
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fatty acid composition and acyl-ACP content in the leaves
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fatty acid composition and acyl-ACP content in the leaves
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fatty acid composition and acyl-ACP content in the leaves
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fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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additional information
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the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability
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additional information
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the enzyme is involved in biosynthesis of straight-chain and branched-chain fatty acids with the specificity for acyl-CoA substrate determining the produced fatty acid spectrum
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additional information
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the enzyme is not directly involved in tetracenomycin C biosynthesis
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(2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dien-1-yl]thiophen-3(2H)-one
-
-
(5R)-4-hydroxy-3,5-dimethyl-5-tetradecylthiophen-2(5H)-one
-
-
(5R)-4-hydroxy-3,5-dimethyl-5-tridecylthiophen-2(5H)-one
-
-
(5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one
-
-
(5R)-5-dodecyl-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
-
-
(5R)-5-[3-(4-acetyl-3-hydroxyphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
-
-
(5R)-5-[3-(4-acetylphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
-
-
(9E)-N-[(4-aminophenyl)sulfonyl]undec-9-enamide
-
-
(E) -N'-((E)-3-(2-methoxyphenyl)al lyl idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E) -N'-((E)-3-(2-Ni trophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E) -N'-((E)-3-(4-bromophenyl)al lyl idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate
-
-
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate
-
-
(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)methanamine
-
(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine
-
(E)-2-(2,6-dimethylphenyl)ethenyl phenyl sulfone
-
-
(E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine
-
(E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine
-
(E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile
-
(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate
-
-
(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-isopropylphenylamino)acrylate
-
-
(E)-N'-((E)-3-(2-fluorophenyl)allyl-idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
-
(E)-N'-((E)-3-(2-methoxyphenyl)allyl-idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
-
(E)-N'-((E)-3-(2-methoxyphenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E)-N'-((E)-3-(2-ni trophenyl)allyl-idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(2-nitrophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E)-N'-((E)-3-(4-bromophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine
-
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine
-
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine
-
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine
-
(E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate
-
(Z)-1-methyl-2-phenylethenyl phenyl sulfone
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2,4-dibromophenylamino)acrylate
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2-chlorophenylamino)acrylate
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate
-
-
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-fluorophenylamino)acrylate
-
-
(Z)-ethyl 3-(p-toluidino)-2-(4-(benzyloxy)phenyl)acrylate
-
-
1,1'-disulfanediyldinaphthalen-2-ol
-
-
1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
-
1-(2,6-dichlorobenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
-
1-(2,6-dichlorobenzyl)-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 98% at 0.0375 mM
1-(2-bromobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
-
1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
-
-
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (2E)-3-(biphenyl-4-yl)prop-2-enoate
-
1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
-
-
1-(4-carboxybenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 80% at 0.040 mM
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
-
-
1-(4-[(E)-[3-(benzyloxy)benzylidene]amino]phenyl)-3-phenylthiourea
molecular docking indicates that the compound has one hydrogen bonding interaction with Thr 81 of Escherichia coli FabH
1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
-
-
1-(5-carboxypentyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
-
1-(5-carboxypentyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
-
1-cyclohexyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)-5-oxopyrrolidine-3-carboxamide
-
1-phenylethyl (2Z)-3-[(4,5-dimethyl-2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]but-2-enoate
-
-
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
-
1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
10,10-dimethyl-7-(2-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(3-chlorophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(3-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-chlorophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-hydroxy-3-methoxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-hydroxyphenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(4-nitrophenyl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(naphthalen-2-yl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
10,10-dimethyl-7-(thiophen-2-yl)-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione
-
-
14-bromo-3-diethylsulfamoyl-5-methylbenzoic acid
-
-
2,2'-(benzene-1,3-diyldisulfonyl)dibenzene-1,4-diol
-
-
2,2'-disulfanediylbis(4-chlorophenol)
-
-
2,2'-disulfanediyldiphenol
-
-
2,2'-sulfanediylbis(4-chlorophenol)
-
-
2,2'-trisulfane-1,3-diylbis(4-chlorophenol)
-
-
2,4-dibromo-6-[(E)-(2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene)methyl]phenol
-
2,4-dibromo-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
2,4-dibromo-6-[(E)-[2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol
the binding model demonstrated that the phenolic hydroxy group of 40 interacts with the amino hydrogen of Asn247 of Escherichia coli FabH by hydrogen bonds
2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,4-dichloro-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
2,5-dichloro-4-nitro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
-
-
2,5-dichloro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
-
-
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole
-
-
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol
-
-
2-((4-bromo-3-[(diethylamino)sulfonyl]benzoyl)amino)benzoic acid
benzoylamino-benzoic acid derivative inhibitor-enzyme interaction analysis, overview
2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole
-
2-(2-methyl-5-nitro-1H-imidazol-1-yl)-N'-[(E)-(3,4,5-trimethylphenyl)methylidene]acetohydrazide
-
2-(3,4-diethoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-bromobenzoylamino)benzoic acid methyl ester
-
-
2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
-
2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-diethylsulfamoyl-4-fluorobenzoylamino)benzoic acid
-
IC50 is 0.0084 mM
2-(3-diethylsulfamoyl-4-methoxybenzoylamino)benzoic acid
-
IC50 is 0.0114 mM
2-(3-diethylsulfamoyl-4-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0061 mM
2-(3-diethylsulfamoyl-4-piperidin-1-ylbenzoylamino)benzoic acid
-
IC50 is 0.0022 mM
2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(3-methoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(3-phenoxy-4-piperazin-1-ylbenzoylamino)benzoic acid
-
IC50 is 0.185 mM
2-(3-phenoxy-4-piperidin-1-ylbenzoylamino)benzoic acid
-
IC50 is 0.00029 mM
2-(3-phenoxy-4-pyridin-3-ylbenzoylamino)benzoic acid
-
IC50 is 0.00011 mM
2-(3-phenoxy-4-thiomorpholin-4-ylbenzoylamino)benzoic acid
-
IC50 is 0.0012 mM
2-(3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0027 mM
2-(3-phenoxybenzoylamino)nicotinic acid
-
IC50 is above 1.0 mM
2-(3-phenoxybenzoylamino)thiophene-3-carboxylic acid
-
IC50 is 0.043 mM
2-(4-bromo-3-diethylsulfamoyl-5-methylbenzoylamino)-benzoic acid
-
IC50 is 0.16 mM
2-(4-bromo-3-diethylsulfamoylbenzoylamino)-benzoic acid
-
IC50 is 0.0016 mM
2-(4-bromo-3-phenoxybenzoylamino)-6-hydroxybenzoic acid
-
IC50 is 0.000062 mM
2-(4-bromo-3-phenoxybenzoylamino)-6-methoxybenzoic acid
-
-
2-(4-bromo-3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0011 mM
2-(4-bromo-3-phenoxybenzoylamino)benzoic acid methyl ester
-
-
2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(4-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
-
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(4-cyclopentylmethoxy-3-diethylsulfamoylbenzoylamino)benzoic acid
-
IC50 is 0.0021 mM
2-(4-fluoro-3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0038 mM
2-(4-fluoro-3-phenoxybenzoylamino)benzoic acid methyl ester
-
-
2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
-
2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione
2-(4-morpholin-4-yl-3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.0032 mM
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
2-(benzenesulfonyl)naphthalene-1,4-diol
2-(butylsulfonyl)ethyl 4-nitrobenzoate
-
-
2-(decane-1-sulfonyl)acetamide
FAS20013
2-(methanesulfonyl)naphthalene-1,4-diol
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
2-(tert-butylsulfonyl)-1-(2,4-dichlorophenyl)ethanone
-
-
2-([3-[(diethylamino)sulfonyl]-4-fluorobenzoyl]amino)benzoic acid
-
-
2-([3-[(diethylamino)sulfonyl]-4-methoxybenzoyl]amino)benzoic acid
-
-
2-([4-bromo-3-[(diethylamino)sulfonyl]-5-methylbenzoyl]amino)benzoic acid
-
-
2-([4-bromo-3-[(diethylamino)sulfonyl]benzoyl]amino)benzoic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)benzoic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)benzoic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-(3,5-dimethylpiperazin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-(4-methylpiperazin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
2-amino-5-(3-chlorophenyl)thiazole-4-carboxylic acid
MIC value is 0.125 mM
2-amino-5-methylthiazole-4-carboxylic acid
MIC value is 0.00035 mM
2-amino-6-(naphthalen-2-ylsulfonyl)quinazolin-4-ol
-
-
2-chloro-4-sulfanylphenol
-
-
2-fluoro-6-(3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.006 mM
2-fluoro-6-[(3-phenoxybenzoyl)amino]benzoic acid
-
-
2-hydroxy-4-[(phenylsulfonyl)amino]benzoic acid
-
-
2-hydroxy-6-(3-phenoxybenzoylamino)benzoic acid
-
IC50 is 0.00041 mM
2-hydroxy-6-[(2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000004 mM
2-hydroxy-6-[(3-phenoxybenzoyl)amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
2-phenyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
-
2-[(2',4'-difluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00016 mM
2-[(2-diethylsulfamoyl-biphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.0016 mM
2-[(2-phenoxy-3'-trifluoromethoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00047 mM
2-[(2-phenoxy-4'-trifluoromethylbiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000096 mM
2-[(2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000056 mM
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
-
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(4-chlorophenyl)-1,3-thiazole
-
-
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole
-
-
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole
-
-
2-[(3',4'-difluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00033 mM
2-[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00057 mM
2-[(3'-isopropyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00079 mM
2-[(3-phenoxy-4-pyridin-3-ylbenzoyl)amino]benzoic acid
-
-
2-[(3-phenoxybenzoyl)amino]benzoic acid
-
-
2-[(3-phenoxybenzoyl)amino]thiophene-3-carboxylic acid
-
-
2-[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00025 mM
2-[(4'-ethoxy-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00022 mM
2-[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00024 mM
2-[(4'-hydroxy-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00041 mM
2-[(4'-methanesulfonyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.000028 mM
2-[(4'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
-
IC50 is 0.00016 mM
2-[(4-aminocyclohexyl)sulfonyl]naphthalene-1,4-diol
-
-
2-[(4-aminophenyl)sulfonyl]benzene-1,4-diol
-
-
2-[(4-bromo-3-phenoxybenzoyl)amino]-6-hydroxybenzoic acid
-
-
2-[(4-bromo-3-phenoxybenzoyl)amino]benzoic acid
-
-
2-[(4-fluoro-3-phenoxybenzoyl)amino]benzoic acid
-
-
2-[(4-methylphenyl)sulfonyl]benzene-1,4-diol
-
-
2-[(4-methylphenyl)sulfonyl]naphthalene-1,4-diol
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
2-[3-(3,4-dichlorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
2-[3-(3-carboxyphenoxy)benzoylamino]benzoic acid
-
IC50 is 0.0037 mM
2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-carboxyphenoxy)benzoylamino]benzoic acid
-
IC50 is 0.0044 mM
2-[3-(4-fluorophenoxy)benzoylamino]benzoic acid
-
IC50 is 0.005 mM
2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[3-(pyridin-4-yloxy)benzoylamino]benzoic acid
-
IC50 is 0.010 mM
2-[3-phenoxy-4-(1H-pyrazol-4-yl)benzoylamino]benzoic acid
-
IC50 is 0.022 mM
2-[4-(2,4-dinitrophenyl)-1H-pyrazol-1-yl]-4-(trifluoromethyl)pyrimidine
-
2-[4-(3,5-dimethylpiperazin-1-yl)-3-phenoxybenzoylamino]benzoic acid
-
IC50 is 0.038 mM
2-[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxybenzoylamino]benzoic acid
-
IC50 is 0.00027 mM
2-[4-(4-methylpiperazin-1-yl)-3-phenoxybenzoylamino]benzoic acid
-
IC50 is 0.025 mM
2-[4-[3-bromo-4-(hydroxymethyl)phenyl]piperazin-1-yl]-1-(5-nitrofuran-2-yl)ethanone
-
-
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
-
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole
-
-
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
-
-
2-[5-(furan-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]benzoic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
2-[[3-(3-carboxyphenoxy)benzoyl]amino]benzoic acid
-
-
2-[[3-(4-carboxyphenoxy)benzoyl]amino]benzoic acid
-
-
2-[[3-(4-fluorophenoxy)benzoyl]amino]benzoic acid
-
-
2-[[3-(pyridin-4-yloxy)benzoyl]amino]benzoic acid
-
-
2-[[3-phenoxy-4-(1H-pyrazol-4-yl)benzoyl]amino]benzoic acid
-
-
3,6-dihydroxyflavone
-
i.e. YKAF01
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
3-(2-phenylethyl)-1lambda6,3-thiazolidine-1,1,2-trione
-
3-(3-phenoxybenzoylamino)pyridine-2-carboxylic acid
-
IC50 is 0.290 mM
3-(3-phenoxybenzoylamino)thiophene-2-carboxylic acid
-
IC50 is 0.0101 mM
3-(4-hydroxyphenyl)-1-(2,4,6-tri-hydroxyphenyl)propan-1-one
-
i.e. YKAF04, or 4,2',4',6'-tetrahydroxychalcone, or phloretin
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
3-(4-phenoxybenzyl)-1,3-thiazolidine-2-thione
-
-
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
3-benzyl-1,3-thiazolidin-2-one
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
3-benzyl-1,3-thiazolidine-2-thione
3-benzyl-1lambda6,3-thiazolidine-1,1,2-trione
-
3-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
fitting 3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide into the active site of Escherichia coli FabH,PDB ID 3IL9
3-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-diethylsulfamoyl-4-fluorobenzoic acid
-
-
3-diethylsulfamoyl-4-methoxybenzoic acid
-
-
3-ethoxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-methoxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
3-methyl-1,3-thiazolidine-2-thione
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
3-propyl-1,3-thiazolidine-2-thione
3-[(1E)-N-(4-methyl-1,3-thiazol-2-yl)ethanehydrazonoyl]phenol
-
i.e. YKA3003
3-[(3-phenoxybenzoyl)amino]thiophene-2-carboxylic acid
-
-
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
3-[(4-aminophenyl)sulfonyl]-5-methylbenzene-1,2-diol
-
-
3-[(4-phenoxyphenyl)methyl]-1,3-thiazolidin-2-one
-
3-[(4-phenoxyphenyl)methyl]-1lambda6,3-thiazolidine-1,1,2-trione
-
3-[2-(3,4-dihydroxyphenyl)-1-methyl-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
-
i.e. YKA3001
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidin-2-one
-
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidine-2-thione
-
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1lambda6,3-thiazolidine-1,1,2-trione
-
4'-(2-carboxyphenylcarbamoyl)-2'-phenoxybiphenyl-4-carboxylic acid
-
IC50 is 0.0021 mM
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
4'-[(3-hydroxy-2,4-dimethyl-5-oxo-2,5-dihydrothiophen-2-yl)methyl]biphenyl-4-carboxylic acid
-
4,4'-disulfanediylbis(2,3,6-trichlorophenol)
-
-
4,4'-sulfanediyldibenzene-1,3-diol
-
-
4,4'-sulfonylbis(3-chloroaniline)
-
-
4,5-dichloro-1,2-dithiole-3-one
4,5-dichloro-3H-1,2-dithiol-3-one
4,5-dichloro-3H-1,2-dithiole-3-thione
-
-
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
4-(4-chlorophenyl)-2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole
-
-
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
-
-
4-bromo-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
4-bromo-2-[(E)-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol
-
4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-bromo-3-diethylsulfamoylbenzoic acid
-
-
4-bromo-3-phenoxybenzoic acid
-
-
4-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
4-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
-
4-chloro-2-[(4-hydroxyphenyl)sulfonyl]phenol
-
-
4-chloro-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol
-
-
4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
-
-
4-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
4-fluoro-2-[(E)-[[2-(4-hydroxyphenyl)ethyl]imino]methyl]phenol
-
4-fluoro-3-phenoxybenzoic acid
-
-
4-fluoro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
4-methylphenyl naphthalen-2-yl sulfone
-
-
4-methylphenyl phenyl sulfone
-
-
4-phenyl-5-phenylimino-[1,2,4]dithiazolidin-3-one
-
CAS-No. 5338-82-9, IC50 is 0.00078 mM
4-[(1Z)-N,2-bis(4-chlorophenyl)ethanimidoyl]benzene-1,3-diol
-
4-[(E)-(cyclohexylimino)methyl]benzene-1,3-diol
4-[(E)-[2-[5-(trifluoromethyl)pyridin-2-yl]hydrazinylidene]methyl]benzene-1,3-diol
-
4-[(Z)-(cyclohexylimino)methyl]benzene-1,3-diol
YKAs3003
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
5-benzyl-2-(2-bromoacetamido)thiazole-4-carboxylic acid
-
5-chloro-1,2-dithiole-3-ones
5-chloro-1,2-dithiole-3-thiones
5-chloro-4-phenyl-3H-1,2-dithiol-3-one
-
-
5-chloro-4-phenyl-[1,2]-dithiol-3-one
-
CAS-No. 2425-05-0, IC50 is 0.0019 mM
5-ethyl-4-fluoro-2-[(2-fluoropyridin-3-yl)oxy]phenol
-
5-hydroxy-2-phenyl-7-(2-(piperazin-1-yl)ethoxy)-4H-chromen-4-one
a chrysine derivative, strong inhibition with MIC of 0.001560.00625 mg/ml, molecular docking simulation and determination of inhibitor binding structure at the active site, overview
5-hydroxy-2-phenyl-7-(2-(piperidin-1-yl)ethoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(2-(pyrrolidin-1-yl)ethoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(3-(2-hydroxyethylamino)propoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(3-(piperazin-1-yl)propoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-(3-(propylamino)propoxy)-4H-chromen-4-one
-
5-hydroxy-2-phenyl-7-[3-(pyrrolidin-1-yl)propoxy]-2,3-dihydro-4H-chromen-4-one
a strong inhibitor, interacts with Escherichia coli FabH via a hydrogen bond between its 5-hydroxy group and the amino hydrogen of Asn247 and a hydrophobic interaction between the pyrrolidine moiety at the C7 position and Asn274, Ile 156, Phe157, and Met2
5-hydroxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one
-
5-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-2-phenyl-4H-chromen-4-one
-
5-[(2,6-dichlorobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid
-
5-[(2,6-dichlorobenzyl)oxy]-1-[(6-methyl-1,3-benzodioxol-5-yl)methyl]-1H-indole-2-carboxylic acid
-
5-[(2,6-dichlorobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 98% at 0.0375 mM
5-[(2-bromobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid
-
5-[(2-bromobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
an indole derivative, inhibits FabH by 80% at 0.040 mM
5-[(4-methoxybenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
-
5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
-
5-[[4-(hydroxyamino)phenyl]sulfonyl]-1,3-thiazol-2-amine
-
-
6-amino-2-hydroxy-2,5-dimethylhexanamide
-
-
6-[(2,6-dichlorophenyl)methoxy]-3-(phenylsulfanyl)-1H-indole-2-carboxylic acid
SB418011
7-(2-(dibutylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(2-(diethylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(2-(dipropylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(2-(propylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(3-(dibutylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(3-(diethylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-(3-(dipropylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one
-
7-[(1E)-nonadec-1-en-1-yl]-3,4-dihydro-2H-1,5-benzodioxepine
-
acyl-[acyl-carrier protein]
-
mixed inhibition type, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein], inhibitory potency increases with increasing chain length between C12 and C20
ampicillin
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
arsenite
-
45% inhibition at 5 mM, 98% inhibition at 20 mM
benzyl (E)-2-[(4-methylphenyl)sulfanyl]ethenyl sulfone
-
-
bis(4-chlorophenyl)trisulfane
-
-
bis(4-methylphenyl)trisulfane
-
-
bis[4-(1-methylethyl)phenyl] sulfone
-
-
butyryl-[acyl-carrier protein]
-
feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism
chrysine
i.e 1,5,7-dihydroxyflavone
CoA methyldisulfide
CoA methyldisulfide shows rapid inhibition of one monomer of FabH through formation of a methyl disulfide conjugate. Reaction of the second subunit with either MeSSCoA or acetyl-CoA is much slower. In the presence of malonyl-ACP, the acylation rate of the second subunit is restored to that of the native FabH
decanoyl-CoA
-
IC50 is 0.004 mM
decanoyl-[acyl-carrier protein]
-
reversible, noncompetitive inhibition versus malonyl-[acyl-carrier-protein] and uncompetitive versus acetyl-CoA, IC50 is 0.00045 mM
Ethionamide
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
ethyl (2Z)-2-[4-(benzyloxy)phenyl]-3-[(4-methylphenyl)amino]prop-2-enoate
displays effective FabH inhibitory activity and excellent antibacterial activity against Gram-negative Escherichia coli. Binds to FabH through two interactions: a hydrogen bond between the N-H group and the side chain carbonyl group of Gly 209 and a hydro
ethyl 4-methylpyridine-3-carboxylate
-
-
hexanoyl-[acyl-carrier protein]
-
feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism
isoniazid
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
isoxyl
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
lauroyl-ACP
feedback inhibition; feedback inhibition
methyl 2-(2-bromoacetamido)-5-(3-chlorophenyl) thiazole-4-carboxylate
-
methyl 2-(2-bromoacetamido)-5-phenylthiazole-4-carboxylate
-
methyl 2-amino-5-benzylthiazole-4-carboxylate
MIC value is 240 nM
methyl 2-amino-5-methylthiazole-4-carboxylate
MIC value is 0.093 mM
methyl 4-bromo-3-hydroxybenzoate
-
-
methyl 5-benzyl-2-(2-bromoacetamido)thiazole-4-carboxylate
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine 2-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
N'-[(E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
-
N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-4-hydroxy-3-methoxybenzohydrazide
-
N-(3-(5-bromo-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide
-
N-(3-chlorophenyl)benzenesulfonamide
-
-
N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid
the malonyl carboxylate forms hydrogen bonds to the backbone nitrogen of Phe304, inhibitor binding mode, overview
N-(4-phenyl-1,3-thiazol-2-yl)-5,8-dihydronaphthalene-2-carboxamide
-
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
N-(4-phenyl-1,3-thiazol-2-yl)morpholine-4-carboxamide
-
N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-1-carboxamide
-
N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-2-carboxamide
-
N-(4-[[4-(acetylamino)phenyl]sulfonyl]phenyl)-2-hydroxybenzamide
-
-
N-ethylmaleimide
-
complete inhibition at 5 mM
N-[3,5-bis(trifluoromethyl)phenyl]-4-[[3,5-bis(trifluoromethyl)phenyl]amino]-3-nitrocyclopenta-1,3-diene-1-sulfonamide
-
-
N-[3-[(E)-(5-bromo-2-hydroxybenzylidene)amino]propyl]-2-hydroxybenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3,4-diethoxyphenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-phenylacetamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-chlorobenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-ethoxybenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-methoxybenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-chlorobenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-fluorobenzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-5,8-dihydronaphthalene-2-carboxamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]morpholine-4-carboxamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-1-carboxamide
-
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
naringenin
-
naringenin docks more strongly with efKAS III than apigenin, resulting in the intensive hydrogen bond network between naringenin and efKAS III. Only naringenin shows antibacterial activity against Enterococcus faecalis at 0.256 mg/ml
octanoyl-[acyl-carrier protein]
-
feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism
pyridin-4-yloxybenzoic acid
-
-
rifampicin
-
inhibition of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
S-[2-(4-methoxyphenyl)-2-oxoethyl] benzenesulfonothioate
-
-
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
(E) -N'-((E)-3-(2-Ni trophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E) -N'-((E)-3-(2-Ni trophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
-
(E)-N'-((E)-3-(2-methoxyphenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(2-methoxyphenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(2-nitrophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(2-nitrophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(4-bromophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(4-bromophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-(4-bromophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide
-
-
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
-
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
-
-
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
-
-
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
-
-
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
-
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
-
-
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
-
-
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
-
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
-
-
2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid
-
-
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
-
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
-
-
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
-
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
-
-
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
-
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
-
-
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione
-
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione
-
-
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
-
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
-
-
2-(benzenesulfonyl)naphthalene-1,4-diol
-
2-(benzenesulfonyl)naphthalene-1,4-diol
-
-
2-(methanesulfonyl)naphthalene-1,4-diol
-
2-(methanesulfonyl)naphthalene-1,4-diol
-
-
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
-
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
-
-
2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid
-
-
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
-
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
-
-
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
IC50: 0.0019 mM
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
-
IC50: 0.0216 mM
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
IC50: 0.1 mM, above
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
-
IC50: 0.0555 mM
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
-
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
-
-
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
-
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
-
-
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
IC50: 0.0109 mM
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
-
IC50: 0.0671 mM
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
IC50: 0.0009 mM
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
-
IC50: 0.0494 mM
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
IC50: 0.0177 mM; IC50: 0.1 mM, above
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
-
IC50: 0.0053 mM; IC50: 0.0556 mM
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
IC50: 0.0207 mM
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
-
IC50: 0.0784 mM
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
IC50: 0.1 mM, above
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
-
IC50: 0.0734 mM
3-benzyl-1,3-thiazolidin-2-one
IC50: 0.0137 mM
3-benzyl-1,3-thiazolidin-2-one
-
IC50: 0.0909 mM
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
IC50: 0.0011 mM
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
-
IC50: 0.0676 mM
3-benzyl-1,3-thiazolidine-2-thione
IC50: 0.1 mM, above
3-benzyl-1,3-thiazolidine-2-thione
-
IC50: 0.0616 mM
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
IC50: 0.1 mM, above
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
-
IC50: 0.1 mM, above
3-methyl-1,3-thiazolidine-2-thione
IC50: 0.1 mM, above
3-methyl-1,3-thiazolidine-2-thione
-
IC50: 0.1 mM, above
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
IC50: 0.1 mM, above
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
-
IC50: 0.1 mM, above
3-propyl-1,3-thiazolidine-2-thione
IC50: 0.1 mM, above
3-propyl-1,3-thiazolidine-2-thione
-
IC50: 0.1 mM, above
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
IC50: 0.0024 mM
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
-
IC50: 0.0108 mM
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
-
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
-
-
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
-
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
-
-
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
-
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
-
-
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
-
-
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
-
-
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
-
-
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
-
-
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
-
-
3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid
-
-
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
-
-
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
-
-
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
-
-
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
-
-
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
-
-
4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid
-
-
4,5-dichloro-1,2-dithiole-3-one
IC50 is 0.002 mM
4,5-dichloro-1,2-dithiole-3-one
-
IC50 is 0.00016 mM
4,5-dichloro-3H-1,2-dithiol-3-one
-
4,5-dichloro-3H-1,2-dithiol-3-one
HR45
4,5-dichloro-3H-1,2-dithiol-3-one
-
-
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
IC50: 0.0144 mM
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
-
IC50: 0.0111 mM
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
IC50: 0.0177 mM
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
-
IC50: 0.0053 mM
4-[(E)-(cyclohexylimino)methyl]benzene-1,3-diol
-
4-[(E)-(cyclohexylimino)methyl]benzene-1,3-diol
-
i.e. YKA3013
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid
-
-
5-chloro-1,2-dithiole-3-ones
binding mode, structural features for optimal complex formation, inhibition potencies of derivatives, the derivatives differ in case of reversibility of the inhibition dependent on the substituting groups, overview
5-chloro-1,2-dithiole-3-ones
-
binding mode, structural features for optimal complex formation, inhibition potencies of derivatives, the derivatives differ in case of reversibility of the inhibition dependent on the substituting groups, overview
5-chloro-1,2-dithiole-3-thiones
binding mode, structural features for optimal complex formation, inhibition potencies of derivatives, the derivatives differ in case of reversibility of the inhibition dependent on the substituting groups, overview
5-chloro-1,2-dithiole-3-thiones
-
binding mode, structural features for optimal complex formation, inhibition potencies of derivatives, the derivatives differ in case of reversibility of the inhibition dependent on the substituting groups, overview
cerulenin
-
cerulenin
the IC50 is 0.2 mM
kanamycin
-
methyl-CoA disulfide
-
-
methyl-CoA disulfide
inhibition mechanism involving enzyme residues His249 and Cys112, overview
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
-
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
-
-
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
-
-
penicillin G
-
penicillin G
fitting penicillin G into the active site of Escherichia coli FabH, PDB ID 3IL9
platencin
a dual inhibitor of FabH and FabF/FabB
platensimycin
-
-
SB418011
-
SB418011
potent inhibition, the IC50 is 16 nM
thiolactomycin
-
-
thiolactomycin
specific for FabH
thiolactomycin
-
inhibition of the purified enzyme in vitro, and of the recombinant enzyme in transformed Mycobacterium bovis strain BCG in vivo
thiolactomycin
uncompetitive, IC50 is 0.7 mM
thiolactomycin
-
weak inhibition, IC50 is above 0.1 mM
thiolactomycin
weak inhibition, the IC50 is 0.008 mM
thiolactomycin
-
inhibits both KAS III and ACAT activities
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
-
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
-
-
additional information
synthesis and evaluation of three series of 21 cinnamaldehyde acylhydrazone derivatives for FabH-inhibitory activity, active site docking simulation and binding model, based on the Escherichia ccoli FabH-CoA complex structure, PDB ID 1HNJ. Antibacterial activity of the synthesized 1,4-benzodioxan derivatives compounds, MIC values, overview
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition
-
additional information
-
inhibitor design by computational chemistry, antibacterial potency of inhibitors, overview
-
additional information
-
HQSAR study of beta-ketoacyl-acyl-carrier protein synthase III (FabH) inhibitors
-
additional information
-
benzoylaminobenzoic acid derivatives: inhibitor design and quantitative structure-activity relationship studies, the compounds show FabH inhibitory activity in cell free and whole cell system, overview. The inhibitory activity increases with increase in hydrophobicity, molar refractivity, aromaticity, and presence of OH group, on x position of the nucleus. The presence of hetero-atoms like N, O, or S at R1 position of the nucleus decreases the inhibitory activity
-
additional information
inhibition mechanism, molecular modeling
-
additional information
-
inhibition mechanism, molecular modeling
-
additional information
-
no inhibition by non-esterified [acyl-carrier-protein]
-
additional information
-
regulation by feedback inhibition
-
additional information
-
no significant inhibitory activity at 0.3 mM: butyl-CoA disulfide, sec-butyl-CoA disulfide, octyl-CoA disulfide, decyl-CoA disulfide
-
additional information
-
inhibitor design and synthesis, analysis of inhibitory potencies against FabH and antibacterial activities, overview
-
additional information
-
benzoylaminobenzoic acid derivatives: inhibitor design and quantitative structure-activity relationship studies, the compounds show FabH inhibitory activity in cell free and whole cell system, overview. The inhibitory activity increases with increase in hydrophobicity, molar refractivity, aromaticity, and presence of OH group, on x position of the nucleus. The presence of hetero-atoms like N, O, or S at R1 position of the nucleus decreases the inhibitory activity
-
additional information
design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors, inhibitor antibacterial activity against the respective Gram-negative and Gram-positive bacterial strains, overview
-
additional information
-
design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors, inhibitor antibacterial activity against the respective Gram-negative and Gram-positive bacterial strains, overview
-
additional information
synthesis and evaluation of three series of 21 cinnamaldehyde acylhydrazone derivatives for FabH-inhibitory activity, active site docking simulation and binding model, based on the Escherichia coli FabH-CoA complex structure, PDB ID 1HNJ. Antibacterial activity of the synthesized 1,4-benzodioxan derivatives compounds, MIC values, overview
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition. Aryl-alkyl disulfide derivatives can selectively inhibit FabH by reversibly capping the active-site cysteine through a thioldisulfide exchange
-
additional information
design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity, MIC values, docking simulation and structure-activity relationsship study, binding mode, overview
-
additional information
the dimer interface could be a potential target for anti-infection drug discovery, structure-based inhibitor design, overview. Cerulenin is no inhibitor of FabH
-
additional information
indole analogue inhibitor-enzyme interaction analysis, overview
-
additional information
2-tosylnaphthalene-1,4-diol analogues are reversible inhibitors (10-20 nM) of Escherichia coli FabH. The sulfonyl group and naphthalene-1,4 diol are required for activity against all enzymes but the toluene portion can be significantly altered. Inhibitors are also effective against the Mycobacterium tuberculosis (EC 2.3.1.301) and Plasmodium falciparum FabH enzymes; synthesis and evalutation of cyclic sulfones. The compounds are selectively active against Escherichia coli FabH, but not Mycobacterium tuberculosis FabH (EC 2.3.1.301) or Plasmodium falciparum KASIII
-
additional information
-
2-tosylnaphthalene-1,4-diol analogues are reversible inhibitors (10-20 nM) of Escherichia coli FabH. The sulfonyl group and naphthalene-1,4 diol are required for activity against all enzymes but the toluene portion can be significantly altered. Inhibitors are also effective against the Mycobacterium tuberculosis (EC 2.3.1.301) and Plasmodium falciparum FabH enzymes; synthesis and evalutation of cyclic sulfones. The compounds are selectively active against Escherichia coli FabH, but not Mycobacterium tuberculosis FabH (EC 2.3.1.301) or Plasmodium falciparum KASIII
-
additional information
-
inhibitor design, structures, and binding analysis, antibacterial activities, overview
-
additional information
-
inhibitor structure analysis by NMR, binding analysis, and antibacterial activities, overview
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. No inhibition of the enzyme FabH from Mycobacterium tuberculosis by methyl 2-amino-5-benzylthiazole-4-carboxylate
-
additional information
-
the mitochondrial enzyme is not affected by cerulenin
-
additional information
no enzyme inhibition by several derivatives of cyclic sulfones, overview
-
additional information
-
no enzyme inhibition by several derivatives of cyclic sulfones, overview
-
additional information
-
no significant inhibitory activity at 0.3 mM: methyl-CoA disulfide, butyl-CoA disulfide, sec-butyl-CoA disulfide
-
additional information
modeling studies of binding of 2-aminothiazole-4-carboxylate analogues to FabH, overview
-
additional information
-
modeling studies of binding of 2-aminothiazole-4-carboxylate analogues to FabH, overview
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. No inhibition of the enzyme FabH from Mycobacterium tuberculosis by methyl 2-amino-5-benzylthiazole-4-carboxylate
-
additional information
-
benzoylaminobenzoic acid derivatives: inhibitor design and quantitative structure-activity relationship studies, the compounds show FabH inhibitory activity in cell free and whole cell system, overview. The inhibitory activity increases with increase in hydrophobicity, molar refractivity, aromaticity, and presence of OH group, on x position of the nucleus. The presence of hetero-atoms like N, O, or S at R1 position of the nucleus decreases the inhibitory activity
-
additional information
-
2-tosylnaphthalene-1,4-diol analogues are reversible inhibitors of Plasmodium falciparum FabH. The sulfonyl group and naphthalene-1,4 diol are required for activity against all enzymes but the toluene portion can be significantly altered. Inhibitors are also effective against the Mycobacterium tuberculosis (EC 2.3.1.301) and Escherichia coli FabH enzymes
-
additional information
synthesis and evaluation of three series of 21 cinnamaldehyde acylhydrazone derivatives for FabH-inhibitory activity, active site docking simulation and binding model, based on the Escherichia ccoli FabH-CoA complex structure, PDB ID 1HNJ. Antibacterial activity of the synthesized 1,4-benzodioxan derivatives compounds, MIC values, overview
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition
-
additional information
-
antibacterial potency of inhibitors, overview
-
additional information
-
inhibition mechanism, molecular modeling
-
additional information
-
benzoylaminobenzoic acid derivatives: inhibitor design and quantitative structure-activity relationship studies, the compounds show FabH inhibitory activity in cell free and whole cell system, overview. The inhibitory activity increases with increase in hydrophobicity, molar refractivity, aromaticity, and presence of OH group, on x position of the nucleus. The presence of hetero-atoms like N, O, or S at R1 position of the nucleus decreases the inhibitory activity
-
additional information
-
synthesis and evaluation of three series of 21 cinnamaldehyde acylhydrazone derivatives for FabH-inhibitory activity, active site docking simulation and binding model, based on the Escherichia ccoli FabH-CoA complex structure, PDB ID 1HNJ. Antibacterial activity of the synthesized 1,4-benzodioxan derivatives compounds, MIC values, overview
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition
-
additional information
-
benzoylaminobenzoic acid derivatives: inhibitor design and quantitative structure-activity relationship studies, the compounds show FabH inhibitory activity in cell free and whole cell system, overview. The inhibitory activity increases with increase in hydrophobicity, molar refractivity, aromaticity, and presence of OH group, on x position of the nucleus. The presence of hetero-atoms like N, O, or S at R1 position of the nucleus decreases the inhibitory activity
-
additional information
inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. No inhibition of the enzyme FabH from Mycobacterium tuberculosis by methyl 2-amino-5-benzylthiazole-4-carboxylate
-
additional information
-
benzoylaminobenzoic acid derivatives: inhibitor design and quantitative structure-activity relationship studies, the compounds show FabH inhibitory activity in cell free and whole cell system, overview. The inhibitory activity increases with increase in hydrophobicity, molar refractivity, aromaticity, and presence of OH group, on x position of the nucleus. The presence of hetero-atoms like N, O, or S at R1 position of the nucleus decreases the inhibitory activity
-
additional information
inhibitor interaction with the active site, structure analysis, docking study, overview. Cerulenin is a poor inhibitor of FabH
-
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0.08
(5R)-4-hydroxy-3,5-dimethyl-5-tetradecylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
0.08
(5R)-4-hydroxy-3,5-dimethyl-5-tridecylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
0.017 - 0.019
(5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one
0.04
(5R)-5-dodecyl-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
0.00702
(5R)-5-[3-(4-acetyl-3-hydroxyphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
0.00404
(5R)-5-[3-(4-acetylphenyl)prop-2-yn-1-yl]-4-hydroxy-3,5-dimethylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
1
(9E)-N-[(4-aminophenyl)sulfonyl]undec-9-enamide
Plasmodium falciparum
-
above
0.0094
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0401
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0275
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0082
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0067
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0198
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0156
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0343
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0025
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0489
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0067
(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine
Escherichia coli
at pH 7.0 and 37°C
0.4477
(E)-2-(2,6-dimethylphenyl)ethenyl phenyl sulfone
Plasmodium falciparum
-
-
0.0123
(E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine
Escherichia coli
at pH 7.0 and 37°C
0.0128
(E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine
Escherichia coli
at pH 7.0 and 37°C
0.0099
(E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile
Escherichia coli
at pH 7.0 and 37°C
0.043
(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0085
(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-isopropylphenylamino)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0857
(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0074
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine
Escherichia coli
at pH 7.0 and 37°C
0.0151
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine
Escherichia coli
at pH 7.0 and 37°C
0.0038
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine
Escherichia coli
at pH 7.0 and 37°C
0.0145
(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine
Escherichia coli
at pH 7.0 and 37°C
0.0021
(E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate
Escherichia coli
at pH 7.0 and 37°C
0.1646
(Z)-1-methyl-2-phenylethenyl phenyl sulfone
Plasmodium falciparum
-
-
0.024
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2,4-dibromophenylamino)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.028
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2-chlorophenylamino)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0033
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0082
(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-fluorophenylamino)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0026
(Z)-ethyl 3-(p-toluidino)-2-(4-(benzyloxy)phenyl)acrylate
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.00013
1,1'-disulfanediyldinaphthalen-2-ol
Plasmodium falciparum
-
-
0.006 - 0.026
1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
0.015
1-(2,6-dichlorobenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.004
1-(2,6-dichlorobenzyl)-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.017
1-(2-bromobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.0515
1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0025
1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (2E)-3-(biphenyl-4-yl)prop-2-enoate
Escherichia coli
pH and temperature not specified in the publication
0.0717
1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.04
1-(4-carboxybenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.00014 - 0.007
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
0.0101
1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0043
1-(4-[(E)-[3-(benzyloxy)benzylidene]amino]phenyl)-3-phenylthiourea
Escherichia coli
pH and temperature not specified in the publication
0.0564
1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0218
1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0374
1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.041
1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0047
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
0.0066
1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.042
1-(5-carboxypentyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.0258
1-phenylethyl (2Z)-3-[(4,5-dimethyl-2-oxido-1,3,2-dioxaphospholan-2-yl)oxy]but-2-enoate
Plasmodium falciparum
-
-
0.00004 - 0.00088
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
0.0196
1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0173
1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0467
1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.007 - 0.036
1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
0.0314
1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0104
1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0076
1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0042
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0382
2,2'-(benzene-1,3-diyldisulfonyl)dibenzene-1,4-diol
Plasmodium falciparum
-
-
0.00014
2,2'-disulfanediylbis(4-chlorophenol)
Plasmodium falciparum
-
-
0.0019
2,2'-disulfanediyldiphenol
Plasmodium falciparum
-
-
0.0031
2,2'-sulfanediylbis(4-chlorophenol)
Plasmodium falciparum
-
-
0.00053
2,2'-trisulfane-1,3-diylbis(4-chlorophenol)
Plasmodium falciparum
-
-
0.0036
2,4-dibromo-6-[(E)-[2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol
Escherichia coli
pH and temperature not specified in the publication
0.0036
2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0784
2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0165
2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0576
2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.00028
2,5-dichloro-4-nitro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
Plasmodium falciparum
-
-
0.0022
2,5-dichloro-N-[4-(trifluoromethyl)phenyl]thiophene-3-sulfonamide
Plasmodium falciparum
-
-
0.0051
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0405
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0016
2-((4-bromo-3-[(diethylamino)sulfonyl]benzoyl)amino)benzoic acid
Enterococcus faecalis
pH and temperature not specified in the publication
0.0043
2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0043
2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole
Escherichia coli
pH and temperature not specified in the publication
0.0169
2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0269
2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0098
2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0123
2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0084
2-(3-diethylsulfamoyl-4-fluorobenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0084 mM
0.0114
2-(3-diethylsulfamoyl-4-methoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0114 mM
0.0061
2-(3-diethylsulfamoyl-4-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0061 mM
0.0022
2-(3-diethylsulfamoyl-4-piperidin-1-ylbenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0022 mM
0.0094
2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.185
2-(3-phenoxy-4-piperazin-1-ylbenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.185 mM
0.00029
2-(3-phenoxy-4-piperidin-1-ylbenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.00029 mM
0.00011
2-(3-phenoxy-4-pyridin-3-ylbenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.00011 mM
0.0012
2-(3-phenoxy-4-thiomorpholin-4-ylbenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0012 mM
0.0027
2-(3-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0027 mM
1
2-(3-phenoxybenzoylamino)nicotinic acid
Enterococcus faecalis
-
IC50 is above 1.0 mM
0.043
2-(3-phenoxybenzoylamino)thiophene-3-carboxylic acid
Enterococcus faecalis
-
IC50 is 0.043 mM
0.16
2-(4-bromo-3-diethylsulfamoyl-5-methylbenzoylamino)-benzoic acid
Enterococcus faecalis
-
IC50 is 0.16 mM
0.0016
2-(4-bromo-3-diethylsulfamoylbenzoylamino)-benzoic acid
Enterococcus faecalis
-
IC50 is 0.0016 mM
0.000062
2-(4-bromo-3-phenoxybenzoylamino)-6-hydroxybenzoic acid
Enterococcus faecalis
-
IC50 is 0.000062 mM
0.0011
2-(4-bromo-3-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0011 mM
0.0438
2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0481
2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0000088 - 0.0001287
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
0.0283
2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0418
2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0021
2-(4-cyclopentylmethoxy-3-diethylsulfamoylbenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0021 mM
0.0038
2-(4-fluoro-3-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0038 mM
0.0186
2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0384
2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0001124 - 0.0003411
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
0.0000136 - 0.0000736
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
0.0001872
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione
Escherichia coli
pH 7.4, 23°C
0.0032
2-(4-morpholin-4-yl-3-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.0032 mM
0.0000097 - 0.0000726
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
0.00000212 - 0.0002787
2-(benzenesulfonyl)naphthalene-1,4-diol
0.00032
2-(butylsulfonyl)ethyl 4-nitrobenzoate
Plasmodium falciparum
-
-
0.0000275 - 0.0000873
2-(methanesulfonyl)naphthalene-1,4-diol
0.0000154 - 0.000393
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
0.0629
2-(tert-butylsulfonyl)-1-(2,4-dichlorophenyl)ethanone
Plasmodium falciparum
-
-
0.0057
2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid
Escherichia coli
-
-
0.0183
2-amino-6-(naphthalen-2-ylsulfonyl)quinazolin-4-ol
Plasmodium falciparum
-
-
0.0028
2-chloro-4-sulfanylphenol
Plasmodium falciparum
-
-
0.006
2-fluoro-6-(3-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.006 mM
0.005
2-hydroxy-4-[(phenylsulfonyl)amino]benzoic acid
Plasmodium falciparum
-
-
0.00041
2-hydroxy-6-(3-phenoxybenzoylamino)benzoic acid
Enterococcus faecalis
-
IC50 is 0.00041 mM
0.000004
2-hydroxy-6-[(2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.000004 mM
0.000004 - 0.0038
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
0.00016
2-[(2',4'-difluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00016 mM
0.0016
2-[(2-diethylsulfamoyl-biphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.0016 mM
0.00047
2-[(2-phenoxy-3'-trifluoromethoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00047 mM
0.000096
2-[(2-phenoxy-4'-trifluoromethylbiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.000096 mM
0.000056
2-[(2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.000056 mM
0.00033
2-[(3',4'-difluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00033 mM
0.00057
2-[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00057 mM
0.00079
2-[(3'-isopropyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00079 mM
0.00025
2-[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00025 mM
0.00022
2-[(4'-ethoxy-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00022 mM
0.00024
2-[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00024 mM
0.00041
2-[(4'-hydroxy-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00041 mM
0.000028
2-[(4'-methanesulfonyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.000028 mM
0.00016
2-[(4'-methyl-2-phenoxybiphenyl-4-carbonyl)amino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00016 mM
0.00044
2-[(4-aminocyclohexyl)sulfonyl]naphthalene-1,4-diol
Plasmodium falciparum
-
-
0.0638
2-[(4-aminophenyl)sulfonyl]benzene-1,4-diol
Plasmodium falciparum
-
-
0.1926
2-[(4-methylphenyl)sulfonyl]benzene-1,4-diol
Plasmodium falciparum
-
-
0.00038
2-[(4-methylphenyl)sulfonyl]naphthalene-1,4-diol
Plasmodium falciparum
-
-
0.0046
2-[3-(3,4-dichlorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
pH and temperature not specified in the publication
0.0037
2-[3-(3-carboxyphenoxy)benzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.0037 mM
0.0197
2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0097
2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0271
2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0233
2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0044
2-[3-(4-carboxyphenoxy)benzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.0044 mM
0.005
2-[3-(4-fluorophenoxy)benzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.005 mM
0.0084
2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0223
2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0899
2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0306
2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0136
2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0109
2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.01
2-[3-(pyridin-4-yloxy)benzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.010 mM
0.022
2-[3-phenoxy-4-(1H-pyrazol-4-yl)benzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.022 mM
0.038
2-[4-(3,5-dimethylpiperazin-1-yl)-3-phenoxybenzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.038 mM
0.00027
2-[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxybenzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.00027 mM
0.025
2-[4-(4-methylpiperazin-1-yl)-3-phenoxybenzoylamino]benzoic acid
Enterococcus faecalis
-
IC50 is 0.025 mM
0.0032
2-[4-[3-bromo-4-(hydroxymethyl)phenyl]piperazin-1-yl]-1-(5-nitrofuran-2-yl)ethanone
Plasmodium falciparum
-
-
0.0184
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0157
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0046
2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.002
2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid
Escherichia coli
-
-
0.001
2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid
Escherichia coli
-
-
0.0000465 - 0.0000965
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
0.0019 - 0.0216
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
0.0555 - 0.1
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
0.0019
3-(2-phenylethyl)-1lambda6,3-thiazolidine-1,1,2-trione
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.29
3-(3-phenoxybenzoylamino)pyridine-2-carboxylic acid
Enterococcus faecalis
-
IC50 is 0.290 mM
0.0101
3-(3-phenoxybenzoylamino)thiophene-2-carboxylic acid
Enterococcus faecalis
-
IC50 is 0.0101 mM
0.0109 - 0.0671
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
0.0009 - 0.0494
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
0.0556
3-(4-phenoxybenzyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
-
0.0109 - 0.0671
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
0.0009 - 0.0494
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
0.0053 - 0.1
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
0.0207 - 0.0784
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
0.0734 - 0.1
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
0.0137 - 0.0909
3-benzyl-1,3-thiazolidin-2-one
0.0011 - 0.0676
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
0.0616 - 0.1
3-benzyl-1,3-thiazolidine-2-thione
0.0011
3-benzyl-1lambda6,3-thiazolidine-1,1,2-trione
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0269
3-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0058
3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0123
3-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.1
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
0.1
3-methyl-1,3-thiazolidine-2-thione
0.1
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
0.1
3-propyl-1,3-thiazolidine-2-thione
0.0024 - 0.0108
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
0.0272
3-[(4-aminophenyl)sulfonyl]-5-methylbenzene-1,2-diol
Plasmodium falciparum
-
-
0.0109
3-[(4-phenoxyphenyl)methyl]-1,3-thiazolidin-2-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0009
3-[(4-phenoxyphenyl)methyl]-1lambda6,3-thiazolidine-1,1,2-trione
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0111 - 0.0144
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
0.0024 - 0.0108
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
0.0053 - 0.0177
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
0.0144
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidin-2-one
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0177
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidine-2-thione
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0024
3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1lambda6,3-thiazolidine-1,1,2-trione
Escherichia coli
pH not specified in the publication, temperature not specified in the publication
0.0021
4'-(2-carboxyphenylcarbamoyl)-2'-phenoxybiphenyl-4-carboxylic acid
Enterococcus faecalis
-
IC50 is 0.0021 mM
0.003
4'-[(3-hydroxy-2,4-dimethyl-5-oxo-2,5-dihydrothiophen-2-yl)methyl]biphenyl-4-carboxylic acid
Mycobacterium tuberculosis
-
0.00024
4,4'-disulfanediylbis(2,3,6-trichlorophenol)
Plasmodium falciparum
-
-
0.0108
4,4'-sulfanediyldibenzene-1,3-diol
Plasmodium falciparum
-
-
0.00013
4,4'-sulfonylbis(3-chloroaniline)
Plasmodium falciparum
-
-
0.00016 - 0.002
4,5-dichloro-1,2-dithiole-3-one
0.00225
4,5-dichloro-3H-1,2-dithiol-3-one
Staphylococcus aureus
-
-
0.00319
4,5-dichloro-3H-1,2-dithiole-3-thione
Staphylococcus aureus
-
-
0.0111 - 0.0144
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
0.0053 - 0.0177
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
1
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
Plasmodium falciparum
-
above
0.0434
4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0068
4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0481
4-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.1146
4-chloro-2-[(4-hydroxyphenyl)sulfonyl]phenol
Plasmodium falciparum
-
-
0.0396
4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0117
4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol
Escherichia coli
-
-
0.0418
4-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0027
4-fluoro-2-[(E)-[[2-(4-hydroxyphenyl)ethyl]imino]methyl]phenol
Escherichia coli
pH and temperature not specified in the publication
0.0384
4-fluoro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0537
4-methylphenyl naphthalen-2-yl sulfone
Plasmodium falciparum
-
-
0.1575
4-methylphenyl phenyl sulfone
Plasmodium falciparum
-
-
0.00078
4-phenyl-5-phenylimino-[1,2,4]dithiazolidin-3-one
Staphylococcus aureus
-
CAS-No. 5338-82-9, IC50 is 0.00078 mM
0.0018
4-[(1Z)-N,2-bis(4-chlorophenyl)ethanimidoyl]benzene-1,3-diol
Escherichia coli
pH and temperature not specified in the publication
0.718
5-benzyl-2-(2-bromoacetamido)thiazole-4-carboxylic acid
Mycobacterium tuberculosis
-
0.00192
5-chloro-4-phenyl-3H-1,2-dithiol-3-one
Staphylococcus aureus
-
-
0.0019
5-chloro-4-phenyl-[1,2]-dithiol-3-one
Staphylococcus aureus
-
CAS-No. 2425-05-0, IC50 is 0.0019 mM
0.017
5-[(2,6-dichlorobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.006
5-[(2,6-dichlorobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.017
5-[(2-bromobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.002
5-[(2-bromobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.02
5-[(4-methoxybenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.015
5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.022
5-[[4-(hydroxyamino)phenyl]sulfonyl]-1,3-thiazol-2-amine
Plasmodium falciparum
-
-
0.00024
6-amino-2-hydroxy-2,5-dimethylhexanamide
Plasmodium falciparum
-
-
0.00052
benzyl (E)-2-[(4-methylphenyl)sulfanyl]ethenyl sulfone
Plasmodium falciparum
-
-
0.00063
bis(4-chlorophenyl)trisulfane
Plasmodium falciparum
-
-
0.0014
bis(4-methylphenyl)trisulfane
Plasmodium falciparum
-
-
0.0225
bis[4-(1-methylethyl)phenyl] sulfone
Plasmodium falciparum
-
-
0.2
cerulenin
Streptococcus pneumoniae
the IC50 is 0.2 mM
0.0434
Cinnamic acid
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.0571
CoA methyldisulfide
Escherichia coli
pH 7.4, 23°C
0.004
decanoyl-CoA
Cuphea lanceolata
-
IC50 is 0.004 mM
0.00045
decanoyl-[acyl-carrier protein]
Cuphea lanceolata
-
reversible, noncompetitive inhibition versus malonyl-[acyl-carrier-protein] and uncompetitive versus acetyl-CoA, IC50 is 0.00045 mM
0.0012
decyl-CoA disulfide
Mycobacterium tuberculosis
-
-
0.00065
diphenyl sulfide
Plasmodium falciparum
-
-
0.0026
ethyl (2Z)-2-[4-(benzyloxy)phenyl]-3-[(4-methylphenyl)amino]prop-2-enoate
Escherichia coli
pH and temperature not specified in the publication
0.0049
ethyl 4-methylpyridine-3-carboxylate
Plasmodium falciparum
-
-
0.00243
methyl 2-(2-bromoacetamido)-5-(3-chlorophenyl) thiazole-4-carboxylate
Mycobacterium tuberculosis
-
0.0032
methyl 2-(2-bromoacetamido)-5-phenylthiazole-4-carboxylate
Mycobacterium tuberculosis
-
0.1598
methyl 5-benzyl-2-(2-bromoacetamido)thiazole-4-carboxylate
Mycobacterium tuberculosis
-
0.0571
methyl-CoA disulfide
Escherichia coli
-
-
0.1
N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
Escherichia coli
above, pH 7.4, 37°C
0.0035
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0147
N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0113
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0148
N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0591
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0066
N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.009
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0094
N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide
Escherichia coli
pH 7.4, 37°C
0.0021
N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-4-hydroxy-3-methoxybenzohydrazide
Escherichia coli
pH and temperature not specified in the publication
0.00088
N-(3-(5-bromo-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide
Escherichia coli
pH and temperature not specified in the publication
0.1952
N-(3-chlorophenyl)benzenesulfonamide
Plasmodium falciparum
-
-
0.0053
N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid
Escherichia coli
pH and temperature not specified in the publication
0.1
N-(4-phenyl-1,3-thiazol-2-yl)benzamide
Escherichia coli
above, pH 7.0, 37°C, recombinant His-tagged enzyme
0.0481
N-(4-[[4-(acetylamino)phenyl]sulfonyl]phenyl)-2-hydroxybenzamide
Plasmodium falciparum
-
-
0.0052
N-[3,5-bis(trifluoromethyl)phenyl]-4-[[3,5-bis(trifluoromethyl)phenyl]amino]-3-nitrocyclopenta-1,3-diene-1-sulfonamide
Plasmodium falciparum
-
-
0.0656
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0347
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0293
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide
Escherichia coli
pH and temperature not specified in the publication
0.0093
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-chlorobenzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0066
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-methoxybenzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0347
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-chlorobenzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.0293
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-fluorobenzamide
Escherichia coli
pH 7.0, 37°C, recombinant His-tagged enzyme
0.1
N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide
Escherichia coli
above, pH 7.0, 37°C, recombinant His-tagged enzyme
0.0301
octyl-CoA disulfide
Mycobacterium tuberculosis
-
-
0.0049
penicillin G
Escherichia coli
pH 7.0, 37°C
0.0015
S-[2-(4-methoxyphenyl)-2-oxoethyl] benzenesulfonothioate
Plasmodium falciparum
-
-
0.000016
SB418011
Streptococcus pneumoniae
potent inhibition, the IC50 is 16 nM
0.0285
secnidazole
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.008 - 0.7
thiolactomycin
0.0000118 - 0.0000296
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
additional information
additional information
Staphylococcus aureus
-
IC50 for platencin is 0.00391 ng/ml
-
0.017
(5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
0.019
(5R)-4-hydroxy-5-[[4'-(hydroxymethyl)biphenyl-4-yl]methyl]-3,5-dimethylthiophen-2(5H)-one
Mycobacterium tuberculosis
-
-
0.006
1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.026
1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.00014
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
Escherichia coli
-
-
0.007
1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
Haemophilus influenzae
-
-
0.0047
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
Escherichia coli
pH and temperature not specified in the publication
0.0047
1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea
Escherichia coli
-
pH 7.0, temperature not specified in the publication
0.00004
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
Haemophilus influenzae
-
-
0.00088
1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid
Escherichia coli
-
-
0.007
1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.036
1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid
Francisella tularensis subsp. holarctica
pH 7.0, 37°C
0.0042
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
pH and temperature not specified in the publication
0.0042
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0000088
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.0001287
2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.0001124
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.0003411
2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.0000136
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.0000736
2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.0000097
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.0000726
2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.00000212
2-(benzenesulfonyl)naphthalene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.0002787
2-(benzenesulfonyl)naphthalene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.0000275
2-(methanesulfonyl)naphthalene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.0000873
2-(methanesulfonyl)naphthalene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.0000154
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
Escherichia coli
pH 7.4, 23°C
0.000393
2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol
Plasmodium falciparum
-
pH 7.4, 23°C
0.000004
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
Streptococcus pyogenes
-
-
0.000004
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
Enterococcus faecium
-
-
0.0014
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
Escherichia coli
-
-
0.0024
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
Haemophilus influenzae
-
-
0.0038
2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid
Staphylococcus aureus
-
-
0.0000465
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
Plasmodium falciparum
-
pH 7.4, 23°C
0.0000965
3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid
Escherichia coli
pH 7.4, 23°C
0.0019
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
-
0.0019
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
IC50: 0.0019 mM
0.0216
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
-
0.0216
3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
IC50: 0.0216 mM
0.0555
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
-
0.0555
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.0555 mM
0.1
3-(2-phenylethyl)-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.1 mM, above
0.0109
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
Escherichia coli
-
0.0671
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one
Plasmodium falciparum
-
-
0.0009
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
-
0.0494
3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
-
0.0109
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
Escherichia coli
IC50: 0.0109 mM
0.0671
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one
Plasmodium falciparum
-
IC50: 0.0671 mM
0.0009
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
IC50: 0.0009 mM
0.0494
3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
IC50: 0.0494 mM
0.0053
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.0053 mM
0.0177
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.0177 mM
0.0556
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.0556 mM
0.1
3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.1 mM, above
0.0207
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
Escherichia coli
-
0.0207
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
Escherichia coli
IC50: 0.0207 mM
0.0784
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
Plasmodium falciparum
-
-
0.0784
3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one
Plasmodium falciparum
-
IC50: 0.0784 mM
0.0734
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
-
0.0734
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.0734 mM
0.1
3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.1 mM, above
0.0137
3-benzyl-1,3-thiazolidin-2-one
Escherichia coli
-
0.0137
3-benzyl-1,3-thiazolidin-2-one
Escherichia coli
IC50: 0.0137 mM
0.0909
3-benzyl-1,3-thiazolidin-2-one
Plasmodium falciparum
-
-
0.0909
3-benzyl-1,3-thiazolidin-2-one
Plasmodium falciparum
-
IC50: 0.0909 mM
0.0011
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
-
0.0011
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
IC50: 0.0011 mM
0.0676
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
-
0.0676
3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
IC50: 0.0676 mM
0.0616
3-benzyl-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
-
0.0616
3-benzyl-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.0616 mM
0.1
3-benzyl-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.1 mM, above
0.1
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
IC50: 0.1 mM, above
0.1
3-methyl-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
IC50: 0.1 mM, above
0.1
3-methyl-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.1 mM, above
0.1
3-methyl-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.1 mM, above
0.1
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
IC50: 0.1 mM, above
0.1
3-propyl-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
IC50: 0.1 mM, above
0.1
3-propyl-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.1 mM, above
0.1
3-propyl-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.1 mM, above
0.0024
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
IC50: 0.0024 mM
0.0108
3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
IC50: 0.0108 mM
0.0111
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
Plasmodium falciparum
-
-
0.0144
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one
Escherichia coli
-
0.0024
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
Escherichia coli
-
0.0108
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide
Plasmodium falciparum
-
-
0.0053
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
-
0.0177
3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione
Escherichia coli
-
0.00016
4,5-dichloro-1,2-dithiole-3-one
Staphylococcus aureus
-
IC50 is 0.00016 mM
0.002
4,5-dichloro-1,2-dithiole-3-one
Escherichia coli
IC50 is 0.002 mM
0.0111
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
Plasmodium falciparum
-
IC50: 0.0111 mM
0.0144
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one
Escherichia coli
IC50: 0.0144 mM
0.0053
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
Plasmodium falciparum
-
IC50: 0.0053 mM
0.0177
4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione
Escherichia coli
IC50: 0.0177 mM
0.008
thiolactomycin
Streptococcus pneumoniae
weak inhibition, the IC50 is 0.008 mM
0.075
thiolactomycin
Plasmodium falciparum
-
-
0.075
thiolactomycin
Mycobacterium tuberculosis
-
0.1
thiolactomycin
Staphylococcus aureus
-
weak inhibition, IC50 is above 0.1 mM
0.11
thiolactomycin
Escherichia coli
-
-
0.7
thiolactomycin
Pisum sativum
uncompetitive, IC50 is 0.7 mM
0.0000118
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
Escherichia coli
pH 7.4, 23°C
0.0000296
[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid
Plasmodium falciparum
-
pH 7.4, 23°C
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Clough, R.; Matthis, A.L.; Barnum, S.R.; Jaworski, J.G.
Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis
J. Biol. Chem.
267
20992-20998
1992
Spinacia oleracea
brenda
Verwoert, I.I.G.S.; van der Linden, K.H.; Walsh, M.C.; Nijkamp, H.J.J.; Stuitje, A.R.
Modification of Brassica napus seed oil by expression of the Escherichia coli fabH gene, encoding 3-ketoacyl-acyl carrier protein synthase III
Plant Mol. Biol.
27
875-886
1995
Escherichia coli
brenda
Han, L.; Lobo, S.; Reynolds, K.A.
Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis
J. Bacteriol.
180
4481-4486
1998
Streptomyces glaucescens
brenda
Bao, W.; Sheldon, P.J.; Hutchinson, C.R.
Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis
Biochemistry
38
9752-9757
1999
Streptomyces peucetius
brenda
Choi, K.H.; Heath, R.J.; Rock, C.O.
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis
J. Bacteriol.
182
365-370
2000
Bacillus subtilis
brenda
Smirnova, N.; Reynolds, K.A.
Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III
J. Bacteriol.
183
2335-2342
2001
Streptomyces glaucescens
brenda
Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
J. Biol. Chem.
276
30024-30030
2001
Streptococcus pneumoniae (P0A3C5), Streptococcus pneumoniae
brenda
He, X.; Reynolds, K.A.
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Antimicrob. Agents Chemother.
46
1310-1318
2002
Staphylococcus aureus
brenda
Lai, C.Y.; Cronan, J.E.
beta-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis
J. Biol. Chem.
278
51494-51503
2003
Escherichia coli, Lactococcus lactis ssp. lactis, Lactococcus lactis ssp. lactis IL1403
brenda
Brown, A.K.; Sridharan, S.; Kremer, L.; Lindenberg, S.; Dover, L.G.; Sacchettini, J.C.; Besra, G.S.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III mtFabH: Factors influencing catalysis and substrate specificity
J. Biol. Chem.
280
32539-32547
2005
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
brenda
Musayev, F.; Sachdeva, S.; Scarsdale, J.N.; Reynolds, K.A.; Wright, H.T.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
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346
1313-1321
2005
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
brenda
Qiu, X.; Choudhry, A.E.; Janson, C.A.; Grooms, M.; Daines, R.A.; Lonsdale, J.T.; Khandekar, S.S.
Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Protein Sci.
14
2087-2094
2005
Staphylococcus aureus
brenda
Janson, C.A.; Konstantinidis, A.K.; Lonsdale, J.T.; Qiu, X.
Crystallization of Escherichia coli beta-ketoacyl-ACP synthase III and the use of a dry flash-cooling technique for data collection
Acta Crystallogr. Sect. D
56
747-748
2000
Escherichia coli
brenda
He, X.; Reeve, A.M.; Desai, U.R.; Kellogg, G.E.; Reynolds, K.A.
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)
Antimicrob. Agents Chemother.
48
3093-3102
2004
Staphylococcus aureus, Escherichia coli (P0A6R0), Escherichia coli
brenda
Kiatpapan, P.; Kobayashi, H.; Sakaguchi, M.; Ono, H.; Yamashita, M.; Kaneko, Y.; Murooka, Y.
Molecular characterization of Lactobacillus plantarum genes for beta-ketoacyl-acyl carrier protein synthase III (fabH) and acetyl coenzyme A carboxylase (accBCDA), which are essential for fatty acid biosynthesis
Appl. Environ. Microbiol.
67
426-433
2001
Lactiplantibacillus plantarum (Q88YZ4), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 (Q88YZ4)
brenda
Nomura, C.T.; Taguchi, K.; Taguchi, S.; Doi, Y.
Coexpression of genetically engineered 3-ketoacyl-ACP synthase III (fabH) and polyhydroxyalkanoate synthase (phaC) genes leads to short-chain-length-medium-chain-length polyhydroxyalkanoate copolymer production from glucose in Escherichia coli JM109
Appl. Environ. Microbiol.
70
999-1007
2004
Escherichia coli
brenda
Khandekar, S.S.; Konstantinidis, A.K.; Silverman, C.; Janson, C.A.; McNulty, D.E.; Nwagwu, S.; Van Aller, G.S.; Doyle, M.L.; Kane, J.F.; Qiu, X.; Lonsdale, J.
Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III
Biochem. Biophys. Res. Commun.
270
100-107
2000
Escherichia coli
brenda
Abbadi, A.; Brummel, M.; Schutt, B.S.; Slabaugh, M.B.; Schuch, R.; Spener, F.
Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme
Biochem. J.
345
153-160
2000
Cuphea wrightii
brenda
Florova, G.; Kazanina, G.; Reynolds, K.A.
Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity
Biochemistry
41
10462-10471
2002
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Escherichia coli
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Escherichia coli
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Discovery of vinylogous carbamates as a novel class of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
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Escherichia coli
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Escherichia coli
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Escherichia coli
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Escherichia coli
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Helianthus annuus (A5A0S1), Helianthus annuus CAS-6 (A5A0S1)
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Escherichia coli (P0A6R0), Escherichia coli
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Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitor
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Escherichia coli (P0A6R0)
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Homology modeling and docking studies of FabH (beta-ketoacyl-ACP synthase III) enzyme involved in type II fatty acid biosynthesis of Chlorella variabilis: a potential algal feedstock for biofuel production
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Streptococcus gordonii (A8AYW5), Streptococcus gordonii ATCC 35105 (A8AYW5)
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A highly promiscuous beta-ketoacyl-ACP synthase (KAS) III-like protein is involved in pactamycin biosynthesis
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Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance
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Shewanella oneidensis, Shewanella oneidensis ATCC 700550
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Zhou, Y.; Yang, Y.S.; Song, X.D.; Lu, L.; Zhu, H.L.
Study of Schiff-base-derived with dioxygenated rings and nitrogen heterocycle as potential beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
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Escherichia coli (P0A6R0)
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Patil, K.; Wakkar, L.; Undare, S.; Kolekar, G.; Deshmukh, M.; Choudhari, P.; Anbhule, P.
Selective synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione using copper oxide nanoparticles for potential inhibitors of beta-ketoacyl-[acyl-carrier-protein] synthase III of Mycobacterium tuberculosis
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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A KAS-III heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton
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Streptomyces toxytricini
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Escherichia coli (P0A6R0)
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3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis
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Alhamadsheh, M.; Waters, N.; Sachdeva, S.; Lee, P.; Reynolds, K.
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