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Information on EC 2.2.1.12 - 3-acetyloctanal synthase

for references in articles please use BRENDA:EC2.2.1.12
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EC Tree
IUBMB Comments
Requires thiamine diphosphate. The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin. The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction. In vitro the enzyme can act on a number of alpha,beta-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyse both 1-2 and 1-4 carboligations depending on the substrate.
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The enzyme appears in viruses and cellular organisms
Synonyms
pigD, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + (E)-oct-2-enal = (S)-3-acetyloctanal + CO2
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