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5,10-methylenetetrahydrofolate + H2O + dCMP
tetrahydrofolate + 5-hydroxymethyl-dCMP
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
additional information
?
-
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
bacteriophage T6r+
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
bacteriophage T6r+
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
the hydroxymethylation is catalyzed by dCMP hydroxymethylase, which transfers a methylene group from methylenetetrahydrofolate to C5 of dCMP and then uses a water molecule to hydrate the methylene group to form hydroxymethyl-dCMP, one precursor for phage DNA replication
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
the enzyme uses the solvent water as the hydroxyl group donor
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
enzyme forms part of phage DNA protection system
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
5-hydroxymethyl-dCMP is a virus-specific DNA precursor
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
involved in biosynthesis of DNA precursor
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
involved in biosynthesis of DNA precursor
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
stoichiometry of dCMP binding to the dimeric enzyme is 1:1 and depends upon a reduced thiol group, one thiol-containing active site per mol of dimeric enzyme, sequential order of substrate binding
-
r
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
Cys-148 is catalytically essential
-
r
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
Cys-148 is catalytically essential
-
r
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
role of active site Glu-60 is to accelerate bond cleavage between N5 of tetrahydrofolate and the methylene being transferred
-
r
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
enzyme structure, dCMP binding site, folate cofactor binding site, way of substrate binding in the active site, key catalytic residue Cys-148 acts as nucleophile to attack the C6-atom of the cytosine base
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
dCTP depresses the synthesis of 5-hydroxymethyldeoxycytidylate
-
?
additional information
?
-
bacteriophage T6r+
-
biosynthesis of enzyme de novo after infection
-
-
?
additional information
?
-
-
direct interaction between NDP kinase and dCMP hydroxymethylase
-
-
?
additional information
?
-
-
5-hydroxymethylcytosine in phage is formed by hydroxymethylation of the cytosine base in deoxycytidylate (dCMP) by deoxycytidylate hydroxymethylase, which uses the solvent water as the hydroxyl group donor
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme also catalyzes 18O exchange from solvent water into 5-hydroxymethyl-dCMP in the absence of exogenous tetrahydrofolate and in the presence of tetrahydrofolate analogues that lack N-5, mechanism
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme is part of the dNTP synthetase complex
-
-
?
additional information
?
-
Tequatrovirus T4
enzyme functions in vivo as a component of a multienzyme complex called dNTP synthetase
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus
-
-
?
additional information
?
-
Tequatrovirus T4
enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme is part of a complex catalyzing DNA precursor biosynthesis
-
-
?
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5,10-methylenetetrahydrofolate + H2O + dCMP
tetrahydrofolate + 5-hydroxymethyl-dCMP
Tequatrovirus T4
-
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
additional information
?
-
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
-
the hydroxymethylation is catalyzed by dCMP hydroxymethylase, which transfers a methylene group from methylenetetrahydrofolate to C5 of dCMP and then uses a water molecule to hydrate the methylene group to form hydroxymethyl-dCMP, one precursor for phage DNA replication
-
-
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
enzyme forms part of phage DNA protection system
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
5-hydroxymethyl-dCMP is a virus-specific DNA precursor
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
-
involved in biosynthesis of DNA precursor
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
involved in biosynthesis of DNA precursor
?
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate
tetrahydrofolate + 5-hydroxymethyldeoxycytidylate
Tequatrovirus T4
-
dCTP depresses the synthesis of 5-hydroxymethyldeoxycytidylate
-
?
additional information
?
-
bacteriophage T6r+
-
biosynthesis of enzyme de novo after infection
-
-
?
additional information
?
-
-
direct interaction between NDP kinase and dCMP hydroxymethylase
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme is part of the dNTP synthetase complex
-
-
?
additional information
?
-
Tequatrovirus T4
enzyme functions in vivo as a component of a multienzyme complex called dNTP synthetase
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus
-
-
?
additional information
?
-
Tequatrovirus T4
enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus
-
-
?
additional information
?
-
Tequatrovirus T4
-
enzyme is part of a complex catalyzing DNA precursor biosynthesis
-
-
?
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10-methyl-5,8-dideazatetrahydrofolate
Tequatrovirus T4
-
competitive inhibitor with respect to tetrahydrofolate
5,5'-dithiobis(2-nitrobenzoic acid)
Tequatrovirus T4
-
complete loss of activity, second-order kinetics, inactivation is reversed by dithiothreitol, inactivation involves the modification of one thiol group per mol of dimeric enzyme
5-Fluoro-2'-deoxycytidine 5'-monophosphate
Tequatrovirus T4
-
competitive inhibitor with respect to dCMP, not mechanism-based inhibitor
5-hydroxymethyl-dCMP
Tequatrovirus T4
-
competitor of dCMP, inhibits formation of 5-hydroxymethyl-dCMP
aminopterin
Tequatrovirus T4
-
competitive inhibitor with respect to tetrahydrofolate
dihydrofolate
Tequatrovirus T4
-
competitive inhibitor with respect to tetrahydrofolate
methotrexate
Tequatrovirus T4
-
competitive inhibitor with respect to tetrahydrofolate
N-ethylmaleimide
Tequatrovirus T4
-
complete loss of activity, second-order kinetics, pH-dependent inactivation, dCMP protects against inactivation, dCMP plus either methotrexate or aminopterin greatly enhances protection, inactivation involves the modification of one thiol group per mol of dimeric enzyme
5-deazatetrahydrofolate
Tequatrovirus T4
-
competitive inhibitor with respect to tetrahydrofolate
5-deazatetrahydrofolate
Tequatrovirus T4
-
1 mM, 54% inhibition
5-fluorodeoxyuridylate
Tequatrovirus T4
-
inactivates by formation of a covalent complex containing enzyme, inhibitor and methylenetetrahydrofolate in a time-dependent manner, 1 mol 5-fluoro-dUMP per enzyme monomer, no substantial inhibition of wild-type enzyme in vivo, inhibition mechanism
5-fluorodeoxyuridylate
Tequatrovirus T4
-
-
5-fluorodeoxyuridylate
Tequatrovirus T4
-
mechanism-based inhibitor
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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DCHM_BPT2
246
0
28583
Swiss-Prot
other Location (Reliability: 2)
DCHM_BPT4
246
0
28489
Swiss-Prot
other Location (Reliability: 2)
DCHM_BPT6
246
0
28621
Swiss-Prot
other Location (Reliability: 2)
A0A7T7K982_9CAUD
246
0
28556
TrEMBL
other Location (Reliability: 2)
A0A384TC73_9CAUD
238
0
27202
TrEMBL
other Location (Reliability: 3)
A0A193H1W5_9CAUD
246
0
28556
TrEMBL
other Location (Reliability: 2)
A0A193H0S0_9CAUD
246
0
28572
TrEMBL
other Location (Reliability: 2)
A0A2K9VF54_9CAUD
246
0
28556
TrEMBL
other Location (Reliability: 2)
A0A5P8PJY0_9CAUD
237
0
27323
TrEMBL
other Location (Reliability: 3)
A0A384SHE7_9CAUD
246
0
28542
TrEMBL
other Location (Reliability: 2)
A0A7S9XFG0_9VIRU
212
0
25213
TrEMBL
other Location (Reliability: 2)
A0A384SIG1_9CAUD
246
0
28542
TrEMBL
other Location (Reliability: 2)
A0A7D5DSZ0_9CAUD
236
0
27138
TrEMBL
other Location (Reliability: 1)
A0A8K1S5C4_9CAUD
245
0
28203
TrEMBL
other Location (Reliability: 1)
A0A449C3J4_9CAUD
246
0
28565
TrEMBL
other Location (Reliability: 1)
A0A7G7WW17_9CAUD
260
0
30151
TrEMBL
other Location (Reliability: 1)
A0A3G2KBP1_9CAUD
238
0
27276
TrEMBL
other Location (Reliability: 2)
A0A193H0K3_9CAUD
246
0
28528
TrEMBL
other Location (Reliability: 2)
A0A193H267_9CAUD
238
0
27246
TrEMBL
other Location (Reliability: 3)
A0A6M5CEJ9_9CAUD
236
0
27165
TrEMBL
other Location (Reliability: 1)
A0A7I8V0Y7_9CAUD
246
0
28556
TrEMBL
other Location (Reliability: 2)
A0A249XYV0_9CAUD
246
0
28556
TrEMBL
other Location (Reliability: 2)
A0A2K9VB22_9CAUD
246
0
28617
TrEMBL
other Location (Reliability: 1)
A0A384SZ85_9CAUD
238
0
27202
TrEMBL
other Location (Reliability: 3)
A0A2K9VFW4_9CAUD
246
0
28556
TrEMBL
other Location (Reliability: 2)
A0A219YCW6_9CAUD
231
0
26955
TrEMBL
other Location (Reliability: 3)
A0A449C5M2_9CAUD
246
0
28621
TrEMBL
other Location (Reliability: 2)
A0A1J0MGX1_9CAUD
118
0
14043
TrEMBL
other Location (Reliability: 2)
A0A482JV18_9CAUD
232
0
26549
TrEMBL
other Location (Reliability: 1)
A0A240F314_9CAUD
231
0
26975
TrEMBL
other Location (Reliability: 3)
A0A384SM57_9CAUD
246
0
28542
TrEMBL
other Location (Reliability: 2)
A0A3G2KC45_9CAUD
238
0
27276
TrEMBL
other Location (Reliability: 2)
A0A345AUR4_9CAUD
235
0
27183
TrEMBL
other Location (Reliability: 1)
A0A653G055_9CAUD
246
0
28617
TrEMBL
other Location (Reliability: 1)
J7I4U5_9CAUD
227
0
26466
TrEMBL
other Location (Reliability: 1)
A0A240F3N7_9CAUD
231
0
27030
TrEMBL
other Location (Reliability: 3)
A0A219YAA9_9CAUD
231
0
26994
TrEMBL
other Location (Reliability: 3)
A0A449C4F1_9CAUD
246
0
28573
TrEMBL
other Location (Reliability: 2)
A0A219Y961_9CAUD
231
0
26856
TrEMBL
other Location (Reliability: 3)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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C148G
Tequatrovirus T4
-
mutant is unable to catalyze a detectable 18O exchange in either the absence or presence of the folate cofactor
C148S/D179N
Tequatrovirus T4
active site mutant
D145N
Tequatrovirus T4
the mutant shows no activity
D179A
Tequatrovirus T4
-
mutant not inactivated by 5-fluoro-dUMP
D179S
Tequatrovirus T4
-
mutant not inactivated by 5-fluoro-dUMP
E60D
Tequatrovirus T4
-
mutant with decreased enzyme activity, impaired enzyme function in vitro and in vivo, uncoupling of early steps from later steps in catalysis
E60Q
Tequatrovirus T4
-
mutant with decreased enzyme activity, impaired enzyme function in vitro and in vivo, uncoupling of early steps from later steps in catalysis
S94A
Tequatrovirus T4
the mutant 25% residual activity compared to the wild type enzyme
S94N
Tequatrovirus T4
the mutant shows no activity
Y96F
Tequatrovirus T4
the mutant shows no activity
D179N
Tequatrovirus T4
-
mutant with altered substrate preference, favoring dUMP rather than dCMP
D179N
Tequatrovirus T4
mutant with altered substrate preference, favoring dUMP rather than dCMP
D179N
Tequatrovirus T4
-
mutation of active site, 10fold increased rate of inhibition by 5-fluoro-dUMP
D179N
Tequatrovirus T4
the mutation significantly decreases the binding affinity to dCMP
additional information
Tequatrovirus T4
-
transition mutations in gene 42
additional information
Tequatrovirus T4
-
gene 42 amber mutants synthesize truncated forms of enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Allen, J.R.; Lasser, G.W.; Goldman, D.A.; Booth, J.W.; Mathews, C.K.
T4 phage deoxyribonucleotide-synthesizing enzyme complex. Further studies on enzyme composition and regulation
J. Biol. Chem.
258
5746-5753
1983
Tequatrovirus T4
brenda
Mathews, C.K.; Brown, F.; Cohen, S.S.
Virus-induced acquisition of metabolic function. VII. Biosynthesis de novo of deoxycytidylate hydroxymethylase
J. Biol. Chem.
239
2957-2963
1964
bacteriophage T6r+
brenda
Pizer, L.I.; Cohen, S.S.
Virus-induced acquisition of metabolic function. V. Purification and properties of deoxycytidylate hydroxymethylase and studies on its origin
J. Biol. Chem.
237
1251-1259
1962
bacteriophage T6r+
brenda
Lamm, N.; Tomaschewski, J.; Ruger, W.
Nucleotide sequence of the deoxycytidylate hydroxymethylase gene of bacteriophage T4 (g42) and the homology of its gene product with thymidylate synthase of E. coli
Nucleic Acids Res.
15
3920
1987
Tequatrovirus T4
brenda
Lamm, N.; Wang, Y.; Mathews, C.K.; Ruger, W.
Deoxycytidylate hydroxymethylase gene of bacteriophage T4. Nucleotide sequence determination and over-expression of the gene
Eur. J. Biochem.
172
553-563
1988
Escherichia phage T2, Tequatrovirus T4, Enterobacteria phage T6
brenda
Lee, M.H.; Gautam-Basak, M.; Wooley, C.; Sander, E.G.
Deoxycytidylate hydroxymethylase: purification, properties, and the role of a thiol group in catalysis
Biochemistry
27
1367-1373
1988
Tequatrovirus T4
brenda
North, T.W.; Mathews, C.K.
T4 phage-coded deoxycytidylate hydroxymethylase: purification and studies on intermolecular interactions
Biochem. Biophys. Res. Commun.
77
898-904
1977
Tequatrovirus T4
brenda
Subramaniam, R.; Wang, Y.; Mathews, C.K.; Santi, D.V.
On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2-deoxycytidine 5-monophosphate
Arch. Biochem. Biophys.
275
11-15
1989
Tequatrovirus T4
brenda
Mathews, C.K.; Wheeler, L.J.; Ungermann, C.; Young, J.P.; Ray, N.B.
Enzyme interactions involving T4 phage-coded thymidylate synthase and deoxycytidylate hydroxymethylase
Adv. Exp. Med. Biol.
338
563-570
1993
Tequatrovirus T4
brenda
Graves, K.L.; Hardy, L.W.
Kinetic and equilibrium alpha-secondary tritium isotope effects on reactions catalyzed by dCMP hydroxymethylase from bacteriophage T4
Biochemistry
33
13049-13056
1994
Tequatrovirus T4
brenda
Butler, M.M.; Graves, K.L.; Hardy, L.W.
Evidence from 18O exchange studies for an exocyclic methylene intermediate in the reaction catalyzed by T4 deoxycytidylate hydroxymethylase
Biochemistry
33
10521-10526
1994
Tequatrovirus T4
brenda
Hardy, L.W.; Graves, K.L.; Nalivaika, E.
Electrostatic guidance of catalysis by a conserved glutamic acid in Escherichia coli dTMP synthase and bacteriophage T4 dCMP hydroxymethylase
Biochemistry
34
8422-8432
1995
Tequatrovirus T4
brenda
Song, H.K.; Sohn, S.H.; Suh, S.W.
Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex
EMBO J.
18
1104-1113
1999
Tequatrovirus T4 (P08773)
brenda
Shen, R.; Olcott, M.C.; Kim, J.; Rajagopal, I.; Mathews, C.K.
Escherichia coli nucleoside diphosphate kinase interactions with T4 phage proteins of deoxyribonucleotide synthesis and possible regulatory functions
J. Biol. Chem.
279
32225-32232
2004
Escherichia coli
brenda
Chen, C.; Gao, T.; Zhao, G.; Deng, Z.; Hu, S.; Xu, H.; He, X.
Evidence from 18O feeding studies for hydroxyl group donor in the reaction catalyzed by cytidylate hydroxymethylase MilA
Chin. Sci. Bull.
58
864-868
2013
Tequatrovirus
-
brenda
Park, S.H.; Suh, S.W.; Song, H.K.
A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate
IUCrJ
6
206-217
2019
Tequatrovirus T4 (P08773)
brenda