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1-ethyladenine + O2 + 2-oxoglutarate
adenine + CO2 + acetaldehyde + succinate + H+
-
-
-
-
?
1-methyl-adenine in 5'-dAAAA-1MeA-YYAAA + 2-oxoglutarate + O2
5'-dAAAAAYYAAA + formaldehyde + succinate + CO2
-
-
-
-
?
1-methyl-dAMP + 2-oxoglutarate + O2
dAMP + formaldehyde + succinate + CO2
1-methyl-dATP + 2-oxoglutarate + O2
dATP + formaldehyde + succinate + CO2
1-methyladenine + O2 + 2-oxoglutarate
adenine + CO2 + formaldehyde + succinate + H+
-
-
-
-
?
2'-deoxy-1-methyl-adenosine 3'-phosphate + 2-oxoglutarate + O2
2'-deoxyadenosine 3'-phosphate + formaldehyde + succinate + CO2
3-methylcytosine + O2 + 2-oxoglutarate
cytosine + CO2 + formaldehyde + succinate + H+
-
-
-
-
?
d(Tpm1A) + 2-oxoglutarate + O2
d(TpA) + formaldehyde + succinate + CO2
d(Tpm1ApT) + 2-oxoglutarate + O2
d(TpApT) + formaldehyde + succinate + CO2
DNA-1,6-ethenoadenine + O2
DNA-adenine + glyoxal
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-(2-hydroxypropyl)-adenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-ethanoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-ethyladenine + 2-oxoglutarate + O2
DNA-adenine + acetaldehyde + succinate + CO2
DNA-1-hydroxyethyladenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
DNA-1-methyldeoxyadenine + 2-oxoglutarate + O2
DNA-deoxyadenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
DNA-2-furfurylguanosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-2-methylguanosine + 2-oxoglutarate + O2
DNA-guanosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
DNA-4-methylcytosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
DNA-N1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
highest activity
-
-
?
DNA-tetrahydro-2-furfurylguanosine + 2-oxoglutarate + O2
?
-
-
-
?
double-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
double-stranded DNA-adenine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
double-stranded DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
methylated DNA bacteriophage M13mp18 + 2-oxoglutarate + O2
DNA bacteriophage M13mp18 + formaldehyde + succinate + CO2
methylated double-stranded bacteriophage lambda + 2-oxoglutarate + O2
double-stranded bacteriophage lambda + formaldehyde + succinate + CO2
-
-
-
?
methylated luciferase-mRNA + 2-oxoglutarate + O2
luciferase-mRNA + formaldehyde + succinate + CO2
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
methylated poly(deoxythymine) + 2-oxoglutarate + O2
poly(deoxythymine) + formaldehyde + succinate + CO2
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
methylated single-stranded poly(deoxyadenosine) + 2-oxoglutarate + O2
single-stranded poly(deoxyadenosine) + formaldehyde + succinate + CO2
methylated tRNA-Phe + 2-oxoglutarate + O2
tRNA-Phe + formaldehyde + succinate + CO2
-
-
-
-
?
methylated tRNA-Phe + 2-oxoglutarate + O2
tRNAPhe + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyl-ATP + 2-oxoglutarate + O2
ATP + formaldehyde + succinate + CO2
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
N1-methyladenine in DNA + 2-oxoglutarate + O2
adenine in DNA + formaldehyde + succinate + CO2
-
strong substrate in ss-DNA
-
-
?
N1-methylguanine in DNA + 2-oxoglutarate + O2
guanine in DNA + formaldehyde + succinate + CO2
-
weak substrate in ds-DNA
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
N3-methylcytosine in DNA + 2-oxoglutarate + O2
cytosine in DNA + formaldehyde + succinate + CO2
-
strong substrate in ss-DNA
-
-
?
N3-methylthymine in DNA + 2-oxoglutarate + O2
thymine in DNA + formaldehyde + succinate + CO2
-
weak substrate in ds-DNA
-
-
?
N6-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
-
via 6-hydroxymethyl adenine derivative
-
-
?
poly(dm1A) + 2-oxoglutarate + O2
poly(dA) + formaldehyde + succinate + CO2
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
single-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
single-stranded DNA-adenine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
single-stranded DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
tRNA-1-methylguanine + 2-oxoglutarate + O2
tRNA-guanine + formaldehyde + succinate + CO2
additional information
?
-
1-methyl-dAMP + 2-oxoglutarate + O2
dAMP + formaldehyde + succinate + CO2
-
-
-
-
?
1-methyl-dAMP + 2-oxoglutarate + O2
dAMP + formaldehyde + succinate + CO2
-
low activity
-
-
?
1-methyl-dATP + 2-oxoglutarate + O2
dATP + formaldehyde + succinate + CO2
-
-
-
-
?
1-methyl-dATP + 2-oxoglutarate + O2
dATP + formaldehyde + succinate + CO2
-
low activity
-
-
?
2'-deoxy-1-methyl-adenosine 3'-phosphate + 2-oxoglutarate + O2
2'-deoxyadenosine 3'-phosphate + formaldehyde + succinate + CO2
-
-
-
-
?
2'-deoxy-1-methyl-adenosine 3'-phosphate + 2-oxoglutarate + O2
2'-deoxyadenosine 3'-phosphate + formaldehyde + succinate + CO2
-
low activity
-
-
?
d(Tpm1A) + 2-oxoglutarate + O2
d(TpA) + formaldehyde + succinate + CO2
-
-
-
-
?
d(Tpm1A) + 2-oxoglutarate + O2
d(TpA) + formaldehyde + succinate + CO2
-
low activity
-
-
?
d(Tpm1ApT) + 2-oxoglutarate + O2
d(TpApT) + formaldehyde + succinate + CO2
-
-
-
-
?
d(Tpm1ApT) + 2-oxoglutarate + O2
d(TpApT) + formaldehyde + succinate + CO2
-
low activity
-
-
?
DNA-1,6-ethenoadenine + O2
DNA-adenine + glyoxal
-
-
-
-
?
DNA-1,6-ethenoadenine + O2
DNA-adenine + glyoxal
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1-ethyladenine + 2-oxoglutarate + O2
DNA-adenine + acetaldehyde + succinate + CO2
-
-
-
ir
DNA-1-ethyladenine + 2-oxoglutarate + O2
DNA-adenine + acetaldehyde + succinate + CO2
-
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
715241, 715464, 715470, 716220, 716324, 716325, 716362, 716363, 716364, 716368, 742862 -
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
best substrate for AlkB
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
purified AlkB repairs the cytotoxic lesion 1-methyladenine in single- and double-stranded DNA
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
this reaction occurs on both single- and double-stranded DNA
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
DNA-1-methyladenine is demethylated by isoforms ABH2 and ABH3
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylcytosine-CH3 + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
-
DNA-1-methylguanine is also repaired by AlkB, but less efficiently as DNA-1-methyladenine or DNA-3-methylcytosine
-
-
?
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
-
DNA-1-methylguanine is also repaired by AlkB, but less efficiently as DNA-1-methyladenine or DNA-3-methylcytosine
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
high activity
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
715241, 715464, 715470, 716220, 716324, 716325, 716362, 716363, 716364, 716368, 742862 -
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
best substrate for AlkB
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
preferred substrate of AlkB
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
purified AlkB repairs the cytotoxic lesion 3-methylcytosine in single- and double-stranded DNA
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
this reaction occurs on both single- and double-stranded DNA
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
good substrate
-
-
ir
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
DNA-1-methylcytosine is demethylated by isoforms ABH2 and ABH3. Isoform ABH1 exclusively repairs DNA-3-methylcytosine in single-stranded DNA with low activity
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
3-methylthymine residues in DNA is repaired inefficiently in vivo. The AlkB protein repairs 3-methylthymine in both single-stranded and double-stranded polydeoxynucleotidese
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
DNA-3-methylthymine is also repaired by AlkB, but less efficiently as DNA-1-methyladenine or DNA-3-methylcytosine
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
weak substrate
-
-
ir
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
3-methylthymine residues in DNA is repaired inefficiently in vivo. The ABH3 protein repairs 3-methylthymine in both single-stranded and double-stranded polydeoxynucleotides, whereas the ABH2 protein prefers a duplex substrate
-
-
?
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
DNA-3-methylthymine is also repaired by AlkB, but less efficiently as DNA-1-methyladenine or DNA-3-methylcytosine. Isoform FTO repairs DNA-3-methylthymine
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
methylated DNA bacteriophage M13mp18 + 2-oxoglutarate + O2
DNA bacteriophage M13mp18 + formaldehyde + succinate + CO2
-
-
-
-
?
methylated DNA bacteriophage M13mp18 + 2-oxoglutarate + O2
DNA bacteriophage M13mp18 + formaldehyde + succinate + CO2
-
-
-
-
?
methylated DNA bacteriophage M13mp18 + 2-oxoglutarate + O2
DNA bacteriophage M13mp18 + formaldehyde + succinate + CO2
-
-
-
-
?
methylated luciferase-mRNA + 2-oxoglutarate + O2
luciferase-mRNA + formaldehyde + succinate + CO2
-
AlkB is used at a maximal concentration of 0.00083 mM for this reaction since the luciferase-mRNA is degraded when higher AlkB concentrations are used
-
-
?
methylated luciferase-mRNA + 2-oxoglutarate + O2
luciferase-mRNA + formaldehyde + succinate + CO2
-
-
-
-
?
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
-
0.1 pmol AlkB protein removes 1.7 pmol 1-methyladenine from methylated poly(deoxyadenine) in 15 min
-
-
?
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
-
the activity of AlkB on methylated poly(deoxyadenine) annealed to unmethylated poly(deoxythymine) is 3fold higher than with methylated poly(deoxyadenine) alone
-
-
?
methylated poly(deoxyadenine) + 2-oxoglutarate + O2
poly(deoxyadenine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
-
-
-
-
?
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxycytosine) + 2-oxoglutarate + O2
poly(deoxycytosine) + formaldehyde + succinate + CO2
-
-
-
ir
methylated poly(deoxythymine) + 2-oxoglutarate + O2
poly(deoxythymine) + formaldehyde + succinate + CO2
-
-
-
-
?
methylated poly(deoxythymine) + 2-oxoglutarate + O2
poly(deoxythymine) + formaldehyde + succinate + CO2
-
-
-
-
?
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
-
-
-
-
?
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
-
-
-
-
?
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
-
-
-
-
?
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
isoform ABH3 reactivates methylated single-stranded RNA bacteriophage MS2
-
-
?
methylated single-stranded poly(deoxyadenosine) + 2-oxoglutarate + O2
single-stranded poly(deoxyadenosine) + formaldehyde + succinate + CO2
-
-
-
-
?
methylated single-stranded poly(deoxyadenosine) + 2-oxoglutarate + O2
single-stranded poly(deoxyadenosine) + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyl-ATP + 2-oxoglutarate + O2
ATP + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyl-ATP + 2-oxoglutarate + O2
ATP + formaldehyde + succinate + CO2
-
low activity
-
-
?
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
-
-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
poly(dm1A) + 2-oxoglutarate + O2
poly(dA) + formaldehyde + succinate + CO2
-
-
-
-
?
poly(dm1A) + 2-oxoglutarate + O2
poly(dA) + formaldehyde + succinate + CO2
-
low activity
-
-
?
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-1-methyladenine + 2-oxoglutarate + O2
RNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-3-methylcytosine + 2-oxoglutarate + O2
RNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
tRNA-1-methylguanine + 2-oxoglutarate + O2
tRNA-guanine + formaldehyde + succinate + CO2
-
-
-
-
?
tRNA-1-methylguanine + 2-oxoglutarate + O2
tRNA-guanine + formaldehyde + succinate + CO2
-
-
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
-
the viral AlkB protein prefers single-stranded RNA over single-stranded DNA substrates (10fold)
-
-
?
additional information
?
-
-
the viral AlkB protein prefers single-stranded RNA over single-stranded DNA substrates (10fold)
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
-
adenosine, deoxythymine, 3-methyldeoxythymidine, guanosine, 1-methylguanosine, 1-methylguanine and 3-methylthymine do not stimulate AlkB-mediated decarboxylation of 2-oxoglutarate
-
-
?
additional information
?
-
-
AlkB also repairs RNA. AlkB prefers single-stranded nucleic acids.
-
-
?
additional information
?
-
AlkB binds to single-stranded DNA, but less efficiently to double-stranded DNA
-
-
?
additional information
?
-
-
AlkB can repair damage in both single- and double-stranded DNA
-
-
?
additional information
?
-
-
AlkB has no detectable nuclease, DNA glycosylase or methyltransferase activity
-
-
?
additional information
?
-
-
AlkB preferentially binds and reactivates methylated single-stranded DNA
-
-
?
additional information
?
-
-
AlkB prefers single-stranded DNA and RNA
-
-
?
additional information
?
-
-
although the lesions targeted by AlkB are introduced primarily into single-stranded DNA, AlkB is also capable of removing lesions from double-stranded DNA
-
-
?
additional information
?
-
-
Escherichia coli AlkB is approximately 10fold more active on single-stranded DNA compared to single-stranded RNA, Eschichia coli AlkB displays a somewhat lower activity on double-stranded RNA substrates than on single-stranded RNA substrates
-
-
?
additional information
?
-
-
the enzyme does not demethylate 3-methyladenine, 7-methyladenine, 7-methylguanine, thymine (5-methyluracil), and 5-methylcytosine
-
-
?
additional information
?
-
-
exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB
-
-
?
additional information
?
-
-
AlkB prefers to repair N1-methylguanine and N3-methylthymine lesions in ds-DNA over ss-DNA. The enzyme is able to repair the lesion when the adduct is present in a mismatched base pair
-
-
?
additional information
?
-
-
although the lesions targeted by AlkB are introduced primarily into single-stranded DNA, AlkB is also capable of removing lesions from double-stranded DNA
-
-
?
additional information
?
-
-
the viral AlkB protein prefers single-stranded RNA over single-stranded DNA substrates (10fold)
-
-
?
additional information
?
-
-
isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
-
ABH3 prefers single-stranded DNA and RNA substrates, whereas ABH2 can repair damage in both single- and double-stranded DNA. Isoform ABH1 does not show any DNA repair activity
-
-
?
additional information
?
-
-
ABH2 does not repair RNA. ABH2 acts more efficiently on double-stranded DNA
-
-
?
additional information
?
-
ABH2 does not repair RNA. ABH2 acts more efficiently on double-stranded DNA
-
-
?
additional information
?
-
-
ABH3 also repairs RNA. ABH3 prefers single-stranded nucleic acids
-
-
?
additional information
?
-
ABH3 also repairs RNA. ABH3 prefers single-stranded nucleic acids
-
-
?
additional information
?
-
-
isoform ABH2 prefers double-stranded DNA while isoforms ABH3 and ABH1 work better on single-stranded substrates
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dA) over methylated poly(dC) and also prefers a double-stranded substrate. not ABH2 cannot demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dA) over methylated poly(dC) and also prefers a double-stranded substrate. not ABH2 cannot demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dC) over methylated poly(dA) and also prefers a single-stranded substrate. Isoform ABH3 can also demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
isoform ABH2 shows some preference for methylated poly(dC) over methylated poly(dA) and also prefers a single-stranded substrate. Isoform ABH3 can also demethylate 1-methyladenine in RNA
-
-
?
additional information
?
-
-
isoform ABH3 prefers single-stranded DNA (also under magnesium-free conditions) and RNA, while isoform ABH2 prefers double-stranded DNA (only in the presence of magnesium) and RNA
-
-
?
additional information
?
-
-
repair of alkylated poly(A) by ABH3 is almost as efficient as repair of poly(dA), and repair of poly(C) is substantially more efficient than repair of poly(dA), although not as good as repair of poly(dC) and single-stranded bacteriophage M13 DNA
-
-
?
additional information
?
-
repair of alkylated poly(A) by ABH3 is almost as efficient as repair of poly(dA), and repair of poly(C) is substantially more efficient than repair of poly(dA), although not as good as repair of poly(dC) and single-stranded bacteriophage M13 DNA
-
-
?
additional information
?
-
-
the enzyme does not demethylate 3-methyladenine, 7-methyladenine, 7-methylguanine, thymine (5-methyluracil), and 5-methylcytosine
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
no activity with DNA-1-methyladenine-CH3
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-(2-hydroxypropyl)-adenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-ethanoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-hydroxyethyladenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
DNA-1-methylguanine + 2-oxoglutarate + O2
DNA-guanine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-2-furfurylguanosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-2-methylguanosine + 2-oxoglutarate + O2
DNA-guanosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
DNA-3-methylthymine + 2-oxoglutarate + O2
DNA-thymine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-4-methylcytosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
DNA-tetrahydro-2-furfurylguanosine + 2-oxoglutarate + O2
?
-
-
-
?
double-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
double-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
methylated double-stranded bacteriophage lambda + 2-oxoglutarate + O2
double-stranded bacteriophage lambda + formaldehyde + succinate + CO2
-
-
-
?
methylated RNA bacteriophage MS2 + 2-oxoglutarate + O2
RNA bacteriophage MS2 + formaldehyde + succinate + CO2
isoform ABH3 reactivates methylated single-stranded RNA bacteriophage MS2
-
-
?
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
N6-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
-
via 6-hydroxymethyl adenine derivative
-
-
?
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
single-stranded DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
single-stranded DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
major substrate, AlkB demethylates DNA-1-methyladenine and DNA-3-methylcytosine with comparable efficiencies and has only a modest preference for a single-stranded DNA substrate over its double-stranded DNA counterpart
-
-
?
additional information
?
-
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-1,N6-ethenoadenine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-1-methyladenine + 2-oxoglutarate + O2
DNA-adenine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
-
-
-
?
DNA-3,N4-ethenocytosine + 2-oxoglutarate + O2
?
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
DNA-cytosine + formaldehyde + succinate + CO2
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
DNA-base-CH3 + 2-oxoglutarate + O2
DNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
-
-
-
-
?
N1-methyladenine + 2-oxoglutarate + O2
adenine + formaldehyde + succinate + CO2
-
-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
N3-methylcytosine + 2-oxoglutarate + O2
cytosine + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
RNA-base-CH3 + 2-oxoglutarate + O2
RNA-base + formaldehyde + succinate + CO2
-
-
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB
-
-
?
additional information
?
-
-
isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
isoform ABH2 does not reactivate methylated RNA bacteriophage MS2 or methylated double-stranded bacteriophage lambda
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
additional information
?
-
-
the enzyme displays both DNA repair activity and wobble uridine modification of tRNA
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Breast Neoplasms
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.
Carcinogenesis
Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
Carcinogenesis
DNA repair is indispensable for survival after acute inflammation.
Carcinogenesis
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Carcinogenesis
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Carcinoma
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Carcinoma
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Carcinoma
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Carcinoma in Situ
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Carcinoma in Situ
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Carcinoma, Non-Small-Cell Lung
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.
Colitis
DNA repair is indispensable for survival after acute inflammation.
Colonic Neoplasms
DNA repair is indispensable for survival after acute inflammation.
Colorectal Neoplasms
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
dna oxidative demethylase deficiency
Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming?.
Glioblastoma
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
Hodgkin Disease
Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome.
Intellectual Disability
Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification.
Leukemia
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
Lung Neoplasms
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Lung Neoplasms
Down-regulation of ALKBH2 increases cisplatin sensitivity in H1299 lung cancer cells.
Lung Neoplasms
TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers.
Neoplasm Metastasis
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
Neoplasms
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Neoplasms
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.
Neoplasms
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
Neoplasms
ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-?B pathway.
Neoplasms
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Neoplasms
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Neoplasms
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.
Neoplasms
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Neoplasms
Association of AlkB homolog 3 expression with tumor recurrence and unfavorable prognosis in hepatocellular carcinoma.
Neoplasms
CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.
Neoplasms
DNA repair is indispensable for survival after acute inflammation.
Neoplasms
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Neoplasms
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
Neoplasms
Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.
Neoplasms
Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells.
Neoplasms
Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
Neoplasms
The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.
Neoplasms
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Neoplasms
TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.
Neoplasms
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Neoplasms
Unraveling a connection between DNA demethylation repair and cancer.
Prostatic Hyperplasia
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Prostatic Neoplasms
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Prostatic Neoplasms
Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells.
Prostatic Neoplasms
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
Prostatic Neoplasms
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Squamous Cell Carcinoma of Head and Neck
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
Urinary Bladder Neoplasms
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
Urinary Bladder Neoplasms
ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.
Urinary Bladder Neoplasms
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals.
Urinary Bladder Neoplasms
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.
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Yi, C.; Yang, C.G.; He, C.
A non-heme iron-mediated chemical demethylation in DNA and RNA
Acc. Chem. Res.
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519-529
2009
Escherichia coli, Homo sapiens
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Mishina, Y.; Chen, L.X.; He, C.
Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli
J. Am. Chem. Soc.
126
16930-16936
2004
Escherichia coli
brenda
Koivisto, P.; Duncan, T.; Lindahl, T.; Sedgwick, B.
Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase
J. Biol. Chem.
278
44348-44354
2003
Escherichia coli, Homo sapiens
brenda
Koivisto, P.; Robins, P.; Lindahl, T.; Sedgwick, B.
Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases
J. Biol. Chem.
279
40470-40474
2004
Escherichia coli, Homo sapiens
brenda
Sedgwick, B.; Robins, P.; Lindahl, T.
Direct removal of alkylation damage from DNA by AlkB and related DNA dioxygenases
Methods Enzymol.
408
108-120
2006
Escherichia coli (P05050), Homo sapiens (Q6NS38), Homo sapiens (Q96Q83)
brenda
Ougland, R.; Zhang, C.M.; Liiv, A.; Johansen, R.F.; Seeberg, E.; Hou, Y.M.; Remme, J.; Falnes, P.O.
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
Mol. Cell
16
107-116
2004
Escherichia coli, Homo sapiens
brenda
Trewick, S.C.; Henshaw, T.F.; Hausinger, R.P.; Lindahl, T.; Sedgwick, B.
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
Nature
419
174-178
2002
Escherichia coli
brenda
Falnes, P.O.; Johansen, R.F.; Seeberg, E.
AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
Nature
419
178-182
2002
Escherichia coli, Escherichia coli W3110 / ATCC 27325
brenda
Aas, P.A.; Otterlei, M.; Falnes, P.O.; Vagbo, C.B.; Skorpen, F.; Akbari, M.; Sundheim, O.; Bjoras, M.; Slupphaug, G.; Seeberg, E.; Krokan, H.E.
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Nature
421
859-863
2003
Escherichia coli, Homo sapiens, Homo sapiens (Q96Q83)
brenda
Yi, C.; Jia, G.; Hou, G.; Dai, Q.; Zhang, W.; Zheng, G.; Jian, X.; Yang, C.G.; Cui, Q.; He, C.
Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase
Nature
468
330-333
2010
Escherichia coli (P05050)
brenda
Mishina, Y.; Lee, C.H.; He, C.
Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies
Nucleic Acids Res.
32
1548-1554
2004
Escherichia coli, Homo sapiens
brenda
Falnes, P.O.; Bjoras, M.; Aas, P.A.; Sundheim, O.; Seeberg, E.
Substrate specificities of bacterial and human AlkB proteins
Nucleic Acids Res.
32
3456-3461
2004
Escherichia coli, Homo sapiens
brenda
Falnes, P.O.
Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins
Nucleic Acids Res.
32
6260-6267
2004
Escherichia coli, Homo sapiens
brenda
Roy, T.W.; Bhagwat, A.S.
Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation
Nucleic Acids Res.
35
e147
2007
Escherichia coli
brenda
van den Born, E.; Omelchenko, M.V.; Bekkelund, A.; Leihne, V.; Koonin, E.V.; Dolja, V.V.; Falnes, P.?.
Viral AlkB proteins repair RNA damage by oxidative demethylation
Nucleic Acids Res.
36
5451-5461
2008
Escherichia coli, blueberry scorch virus, Blackberry virus Y, grapevine virus A
brenda
Begley, T.J.; Samson, L.D.
AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism
Trends Biochem. Sci.
28
2-5
2003
Escherichia coli
brenda
Duncan, T.; Trewick, S.C.; Koivisto, P.; Bates, P.A.; Lindahl, T.; Sedgwick, B.
Reversal of DNA alkylation damage by two human dioxygenases
Proc. Natl. Acad. Sci. USA
99
16660-5
2002
Homo sapiens
brenda
Li, P.; Gao, S.; Wang, L.; Yu, F.; Li, J.; Wang, C.; Li, J.; Wong, J.
ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair
Cell Rep.
4
817-829
2013
Homo sapiens
brenda
Vagbo, C.B.; Svaasand, E.K.; Aas, P.A.; Krokan, H.E.
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response
DNA Repair
12
188-195
2013
Escherichia coli, Escherichia coli AB1157
brenda
Li, D.; Delaney, J.C.; Page, C.M.; Yang, X.; Chen, A.S.; Wong, C.; Drennan, C.L.; Essigmann, J.M.
Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB
J. Am. Chem. Soc.
134
8896-8901
2012
Escherichia coli
brenda
Chen, F.; Tang, Q.; Bian, K.; Humulock, Z.; Yang, X.; Jost, M.; Drennan, C.; Essigmann, J.; Li, D.
Adaptive response enzyme AlkB preferentially repairs 1-methylguanine and 3-methylthymine adducts in double-stranded DNA
Chem. Res. Toxicol.
29
687-693
2016
Escherichia coli
brenda
Beharry, A.A.; Lacoste, S.; OConnor, T.R.; Kool, E.T.
Fluorescence monitoring of the oxidative repair of DNA alkylation damage by ALKBH3, a prostate cancer marker
J. Am. Chem. Soc.
138
3647-3650
2016
Homo sapiens
brenda
Zhu, C.; Yi, C.
Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues
Angew. Chem. Int. Ed. Engl.
53
3659-3662
2014
Escherichia coli (P05050)
brenda
Wang, P.; Wu, J.; Ma, S.; Zhang, L.; Yao, J.; Hoadley, K.A.; Wilkerson, M.D.; Perou, C.M.; Guan, K.L.; Ye, D.; Xiong, Y.
Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH mutant cells to alkylating agents
Cell Rep.
13
2353-2361
2015
Homo sapiens
brenda
Wang, B.; Usharani, D.; Li, C.; Shaik, S.
Theory uncovers an unusual mechanism of DNA repair of a lesioned adenine by AlkB enzymes
J. Am. Chem. Soc.
136
13895-13901
2014
Escherichia coli (P05050)
brenda
Ergel, B.; Gill, M.L.; Brown, L.; Yu, B.; Palmer, A.G.; Hunt, J.F.
Protein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkB
J. Biol. Chem.
289
29584-29601
2014
Escherichia coli
brenda
Silvestrov, P.; Mueller, T.A.; Clark, K.N.; Hausinger, R.P.; Cisneros, G.A.
Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1)
J. Mol. Graph. Model.
54
123-130
2014
Homo sapiens
brenda
Zdzalik, D.; Vagbo, C.B.; Kirpekar, F.; Davydova, E.; Puscian, A.; Maciejewska, A.M.; Krokan, H.E.; Klungland, A.; Tudek, B.; van den Born, E.; Falnes, P.O.
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
PLoS ONE
9
e98729
2014
Agrobacterium tumefaciens, Cryptosporidium parvum, Tetrahymena thermophila, Acanthamoeba polyphaga Mimivirus, Rickettsia felis, Roseobacter denitrificans (Q16D46), Roseobacter denitrificans OCh (Q16D46), Agrobacterium tumefaciens C58 / ATCC 33970, Tetrahymena thermophila SB210
brenda
Tishinov, K.; Gillingham, D.
Synthesis of new alkylated mononucleotide analogues and their repair proficiency by the prokaryotic DNA repair protein AlkB
Synlett
26
2720-2723
2015
Escherichia coli (P05050)
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brenda
Soll, J.M.; Sobol, R.W.; Mosammaparast, N.
Regulation of DNA alkylation damage repair lessons and therapeutic opportunities
Trends Biochem. Sci.
42
206-218
2017
Homo sapiens (Q6NS38)
brenda