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(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
4-hydroxybutanoic acid + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
D-2-hydroxybutyrate + 2-oxoglutarate
?
-
-
-
-
r
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
additional information
?
-
-
D-2-hydroxyglutaric aciduria is not associated to the enzyme activity
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
radiolabeled substrate 3-hydroxybutyrate, stereospecific reaction
radiolabeled product D-2-hydroxyglutarate
-
r
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
-
-
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
-
hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + 2-hydroxyglutarate
-
hydrogen attached to hydroxyl-bearing C of 4-hydroxybutyrate is transferred to ketone-bearing C of 2-oxoglutarate, oxoacid not NAD+ or NADP+ acts as hydrogen acceptor
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
recombinant enzyme in HEK-293 cells
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
stereospecific reaction, no activity with L-2-hydroxyglutarate
-
-
r
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
-
-
-
?
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
-
-
-
?
D-2-hydroxyglutarate + succinic semialdehyde
2-oxoglutarate + 4-hydroxybutyrate
-
-
-
?
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
-
-
-
?
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
-
oxidized at 33% the rate of 4-hydroxybutyrate
-
?
L-3-hydroxybutyrate + 2-oxoglutarate
acetoacetate + 2-oxoglutarate
-
oxidized at 33% the rate of 4-hydroxybutyrate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
-
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
62.5% of activity with D-2-hydroxyglutarate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate
-
?
L-3-hydroxybutyrate + succinic semialdehyde
acetoacetate + 4-hydroxybutyrate
-
62.5% of activity with D-2-hydroxyglutarate
-
?
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(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
3-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
additional information
?
-
-
D-2-hydroxyglutaric aciduria is not associated to the enzyme activity
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
(S)-3-hydroxybutanoate + 2-oxoglutarate
acetoacetate + (R)-2-hydroxyglutarate
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
D-2-hydroxyglutarate + succinate semialdehyde
-
-
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
recombinant enzyme in HEK-293 cells
-
-
?
4-hydroxybutyrate + 2-oxoglutarate
succinic semialdehyde + D-2-hydroxyglutarate
-
-
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Adenoma
Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation.
Adenoma
Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.
Adenoma
Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas.
alcohol dehydrogenase deficiency
D-2-hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon?
Breast Neoplasms
ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.
Breast Neoplasms
ADHFE1 is a MYC-linked oncogene that induces metabolic reprogramming and cellular de-differentiation in breast cancer.
Breast Neoplasms
Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast Carcinoma.
Carcinogenesis
Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer.
Carcinoma
Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas.
Colonic Neoplasms
Identification of regulatory role of DNA methylation in colon cancer gene expression via systematic bioinformatics analysis.
Colorectal Neoplasms
Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation.
Colorectal Neoplasms
Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells.
Colorectal Neoplasms
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
Insulin Resistance
A genome scan for positive selection in thoroughbred horses.
Mouth Neoplasms
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer.
Neoplasms
ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.
Neoplasms
ADHFE1 is a correlative factor of patient survival in cancer.
Neoplasms
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.
Neoplasms
Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.
Stomach Neoplasms
ADHFE1 is a correlative factor of patient survival in cancer.
Stomach Neoplasms
Screening and Survival Analysis of Hub Genes in Gastric Cancer Based on Bioinformatics.
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Kaufman, E.E.; Nelson, T.
An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway
Neurochem. Res.
16
965-974
1991
Rattus norvegicus
brenda
Kaufman, E.E.; Nelson, T.; Fales, H.M.; Levin, D.M.
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria
J. Biol. Chem.
263
16872-16879
1988
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Kardon, T.; Noel, G.; Vertommen, D.; Van Schaftingen, E.
Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate
FEBS Lett.
580
2347-2350
2006
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Struys, E.A.; Verhoeven, N.M.; Ten Brink, H.J.; Wickenhagen, W.V.; Gibson, K.M.; Jakobs, C.
Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
J. Inherit. Metab. Dis.
28
921-930
2005
Homo sapiens
brenda
Lyon, R.C.; Johnston, S.M.; Panopoulos, A.; Alzeer, S.; McGarvie, G.; Ellis, E.M.
Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1
Chem. Biol. Interact.
178
283-287
2009
Homo sapiens (Q8IWW8), Homo sapiens
brenda
Gaona-Lopez, C.; Julian-Sanchez, A.; Riveros-Rosas, H.
Diversity and evolutionary analysis of iron-containing (type-III) alcohol dehydrogenases in eukaryotes
PLoS ONE
11
e0166851
2016
Dictyostelium discoideum, Heterostelium pallidum, Capsaspora owczarzaki, Acytostelium subglobosum, Aphanomyces invadans (A0A024TMA3), Saprolegnia parasitica (A0A067BRK4), Thecamonas trahens (A0A0L0DHP5), Phaeodactylum tricornutum (B7FWP2), Dictyostelium purpureum (F1A5G4), Tieghemostelium lacteum (F4PTP3), Thalassiosira oceanica (K0T042), Acanthamoeba castellanii (L8HAM2), Saprolegnia diclina (T0Q1Z2), Aphanomyces astaci (W4G0G7), Reticulomyxa filosa (X6NPJ7), Acytostelium subglobosum LB1, Phaeodactylum tricornutum CCAP 1055/1 (B7FWP2), Aphanomyces astaci APO3 (W4G0G7), Saprolegnia parasitica CBS223.65 (A0A067BRK4), Aphanomyces invadans NJM9701 (A0A024TMA3), Capsaspora owczarzaki ATCC 30864, Saprolegnia diclina VS20 (T0Q1Z2), Thecamonas trahens ATCC 50062 (A0A0L0DHP5), Acanthamoeba castellanii NEFF (L8HAM2)
brenda
Yang, X.; Xie, W.; Li, R.M.; Zhou, X.M.; Wang, S.L.; Wu, Q.J.; Yang, N.N.; Xia, J.X.; Yang, Z.Z.; Guo, L.T.; Liu, Y.T.; Zhang, Y.J.
RNA interference-mediated knockdown of the hydroxyacid-oxoacid transhydrogenase gene decreases thiamethoxam resistance in adults of the whitefly Bemisia tabaci
Sci. Rep.
7
41201
2017
Bemisia tabaci (S5YSM1), Bemisia tabaci
brenda
Chen, Q.; Wu, Q.; Peng, Y.
ADHFE1 is a correlative factor of patient survival in cancer
Open Life Sci.
16
571-582
2021
Homo sapiens (Q8IWW8), Homo sapiens
brenda