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EC Tree
IUBMB Comments This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH-dependent), by its coenzyme requirement, reaction direction, and enantiomeric preference.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mgr, methylglyoxal reductase, mgr ii, mgr i,
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D-lactaldehyde dehydrogenase
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dehydrogenase, D-lactaldehyde
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methylglyoxal reductase
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(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+
(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+
similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+
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(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+
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(R)-lactaldehyde:NAD+ oxidoreductase
This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH-dependent), by its coenzyme requirement, reaction direction, and enantiomeric preference.
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acetaldehyde + NADH + H+
ethanol + NAD+
DL-glyceraldehyde + NAD+
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glutaraldehyde + NADH
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glyceraldehyde + NADH
glycerol + NAD+
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?
glyoxal + NADH
glycolaldehyde + NAD+
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?
methylglyoxal + NADH
(R)-lactaldehyde + NAD+
methylglyoxal + NADPH
lactaldehyde + NADP+
methylglyoxal + NADPH + H+
(R)-lactataldehyde + NADP+
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phenylglyoxal + NADH
hydroxyphenylacetaldehyde + NAD+
additional information
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acetaldehyde + NADH + H+
ethanol + NAD+
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acetaldehyde + NADH + H+
ethanol + NAD+
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DL-glyceraldehyde + NAD+
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DL-glyceraldehyde + NAD+
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methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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r
methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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?
methylglyoxal + NADPH
lactaldehyde + NADP+
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methylglyoxal + NADPH
lactaldehyde + NADP+
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phenylglyoxal + NADH
hydroxyphenylacetaldehyde + NAD+
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phenylglyoxal + NADH
hydroxyphenylacetaldehyde + NAD+
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additional information
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NADH better substrate than NADPH
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additional information
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enzyme utilizes both: NADH and NADPH
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additional information
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specific for lactaldehyde
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?
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methylglyoxal + NADH
(R)-lactaldehyde + NAD+
methylglyoxal + NADPH
lactaldehyde + NADP+
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?
methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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ir
methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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?
methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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r
methylglyoxal + NADH
(R)-lactaldehyde + NAD+
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?
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NADH
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NADH
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utilizes both NADPH and NADH
NADH
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NADH better substrate than NADPH
NADPH
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NADPH
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NADH better substrate than NADPH
NADPH
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utilizes both NADH and NADPH
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5,5'-dithiobis(2-nitrobenzoate)
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iodoacetate
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N-ethylmaleimide
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p-chloromercuribenzoate
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p-chloromercuribenzoate
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p-chloromercuribenzoate
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p-chloromercuribenzoate
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2-mercaptoethanol
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slight activation
dithiothreitol
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slight activation
glutathione
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slight activation
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Alzheimer Disease
Membrane-Associated Effects of Glucocorticoid on BACE1 Upregulation and A? Generation: Involvement of Lipid Raft-Mediated CREB Activation.
Arthritis, Rheumatoid
The moderate intestinal side effects of auranofin do not require prophylactic therapy with a bulkforming agent. Dutch Ridaura Study Group.
Brain Edema
Prolonged hyperglycemia in the early subacute period after cerebral infarction: effects on short term prognosis.
Diabetes Mellitus
Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice.
Diverticulitis
[Intestinal infarct caused by giant cell arteritis]
Duodenal Ulcer
Eradication of Campylobacter pylori and recurrence of duodenal ulcer. A six-month follow-up study.
Lymphoma
Immunoaffinity isolation of native membrane glucocorticoid receptor from S-49++ lymphoma cells: biochemical characterization and interaction with Hsp 70 and Hsp 90.
Lymphoma
Use of receptor antibodies to demonstrate membrane glucocorticoid receptor in cells from human leukemic patients.
Malnutrition
Effects of undernutrition on diaphragm fiber size, SDH activity, and fatigue resistance.
Marfan Syndrome
Aortic wall mechanics and composition in a transgenic mouse model of Marfan syndrome.
Marfan Syndrome
Induction of macrophage chemotaxis by aortic extracts from patients with Marfan syndrome is related to elastin binding protein.
Melanoma
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study.
Neoplasm Metastasis
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study.
Neoplasms
Characteristics of clinically node negative breast cancer patients needing preoperative MRI.
Neoplasms
Genetic characterization of adenovirus transformed cell revertants resistant to methylglyoxal bis(guanylhydrazone): evidence for the involvement of three genetic loci.
Neoplasms
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study.
Neoplasms
[Kaposi's angiosarcoma developing in a patient with a renal transplant]
Neoplasms
[The marrow granulocyte reserve in lung cancer patients]
Neutropenia
Visualizing the marrow granulocyte reserve.
Obesity, Morbid
Major microbiota dysbiosis in severe obesity: fate after bariatric surgery.
Osteoporosis
[Multicenter comparative study of synthetic salmon calcitonin administered nasally in the treatment of established postmenopausal osteoporosis]
Overweight
[Complete nutritional status in school children. Opinions and attitudes]
Papilloma
[Lysozyme in the treatment of juvenile laryngeal papillomatosis. A new concept in its etiopathogenesis]
Pulmonary Emphysema
Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome.
Scoliosis
Management of progressive late onset scoliosis with magnetic growth rod insertion leading to improvement of neural anomalies-a case report.
Spasm
[Selective arteriography in the study of arterial vasculogenic impotence]
Syringomyelia
Management of progressive late onset scoliosis with magnetic growth rod insertion leading to improvement of neural anomalies-a case report.
Typhoid Fever
Unsaturated vitamin B12 binding capacity and serum lysozyme activity during the marrow granulocytes reserve tests.
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0.013
DL-lactaldehyde
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additional information
additional information
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11
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in the oxidation of D-lactaldehyde, increase of reaction rate up to pH 11
7
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similar enzyme with NADPH-requirement for methylglyoxal reduction, that is inactive with NAD+, NADH and NADP+
6.5
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reduction of methylglyoxal
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4.5 - 9.5
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pH 4.5 and pH 9.5: about 50% of activity maximum
6 - 8
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pH 6.0 and pH 8.0: about 50% of activity maximum
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25 - 75
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25°C and 75°C: about 50% of activity maximum
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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highest activity
brenda
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brenda
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brenda
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brenda
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brenda
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A0A364N0B2_9PLEO
351
0
37476
TrEMBL
other Location (Reliability: 1 )
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35000
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2 * 35000, SDS-PAGE
46000
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2 * 46000, SDS-PAGE
43000
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gel filtration, SDS-PAGE
43000
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1 * 43000, SDS-PAGE
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dimer
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2 * 46000, SDS-PAGE
dimer
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2 * 35000, SDS-PAGE
monomer
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1 * 43000, SDS-PAGE
monomer
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1 * 43000, SDS-PAGE
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11
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1 min, 40°C, 50% loss of activity 4
207971
4.5
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1 min, 40°C, 50% loss of activity
207971
6
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1 min, 40°C, stable
207971
8
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1 min, 40°C, stable
207971
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39
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3 min, 50% loss of activity
44
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80 s, 50% loss of activity
50
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40 s, 50% loss of activity
60
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35 s, 50% loss of activity
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Tran-Din, K.; Gottschalk, G.
Formation of D(-)-1,2-propanediol and D(-)-lactate from glucose by Clostridium sphenoides under phosphate limitation
Arch. Microbiol.
142
87-92
1985
Lacrimispora sphenoides
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brenda
Ting, S.M.; Miller, O.N.; Sellinger, O.Z.
The metabolism of lactaldehyde: VII. The oxidation of D-lactaldehyde in rat liver
Biochim. Biophys. Acta
97
407-415
1965
Rattus norvegicus
brenda
Ray, M.; Ray, S.
Purification and partial characterization of a methylglyoxal reductase from goat liver
Biochim. Biophys. Acta
802
119-127
1984
Capra hircus
brenda
Kato, H.; Miyauchi, Y.; Nishimura, T.; Liang, Z.Q.
Purification and partial characterization of NADH-dependent methylglyoxal-reducing enzyme from porcine liver
Agric. Biol. Chem.
52
2641-2642
1988
Sus scrofa
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brenda
Saikusa, T.; Rhee, H.; Watanabe, K.; Murata, K.; Kimura, A.
Metabolism of 2-oxoaldehydes in bacteria: purification and characterization of methylglyoxal reductase from Escherichia coli
Agric. Biol. Chem.
51
1893-1899
1987
Escherichia coli
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brenda
Chen, C.N.; Porubleva, L.; Shearer, G.; Svrakic, M.; Holden, L.G.; Dover, J.L.; Johnston, M.; Chitnis, P.R.; Kohl, D.H.
Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae
Yeast
20
545-554
2003
Saccharomyces cerevisiae
brenda
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