Information on EC 1.1.1.408 - 4-phospho-D-threonate 3-dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.1.408
-
RECOMMENDED NAME
GeneOntology No.
4-phospho-D-threonate 3-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-dehydro-4-phospho-D-erythronate = glycerone phosphate + CO2
show the reaction diagram
(1b), spontaneous
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-
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4-phospho-D-threonate + NAD+ = 3-dehydro-4-phospho-D-erythronate + NADH + H+
show the reaction diagram
(1a)
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-
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4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH + H+
show the reaction diagram
overall reaction
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-
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SYSTEMATIC NAME
IUBMB Comments
4-phospho-D-threonate:NAD+ 3-oxidoreductase
The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-dehydro-4-phospho-D-erythronate
glycerone phosphate + CO2
show the reaction diagram
4-hydroxy-L-threonine 4-phosphate + NAD+
3-amino-2-oxopropyl phosphate + CO2 + NADH + H+
show the reaction diagram
4-phospho-D-erythronate + NAD+
glycerone phosphate + CO2 + NADH + H+
show the reaction diagram
4-phospho-D-threonate + NAD+
3-dehydro-4-phospho-D-erythronate + NADH + H+
show the reaction diagram
4-phospho-D-threonate + NAD+
glycerone phosphate + CO2 + NADH + H+
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19 - 0.2
4-hydroxy-L-threonine 4-phosphate
-
0.054 - 0.12
4-phospho-D-threonate
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.35 - 0.37
4-hydroxy-L-threonine 4-phosphate
-
3.4 - 8.9
4-phospho-D-threonate
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8 - 1.9
4-hydroxy-L-threonine 4-phosphate
-
29 - 160
4-phospho-D-threonate