Reference on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Billheimer, J.T.; Alcorn, M.; Gaylor, J.L.
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis
Arch. Biochem. Biophys.
211
430-438
1981
Rattus norvegicus
Appelkvist, E.L.; Reinhart, M.; Fischer, R.; Billheimer, J.; Dallner, G.
Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes
Arch. Biochem. Biophys.
282
318-325
1990
Rattus norvegicus
Pascal, S.; Taton, M.; Rahier, A.
Plant sterol biosynthesis: identification of a NADPH dependent sterone reductase involved in sterol-4 demethylation
Arch. Biochem. Biophys.
312
260-271
1994
Zea mays
Wieland, S.J.; Fox, T.O.
A DNA-binding of mouse kidney 3-ketosteroid reductase: comparison with androgen receptors
Steroids
37
527-538
1981
Mus musculus
Vanden Bossche, H.; Marichal, P.; Le Jeune, L.; Coene, M.C.; Gorrens, J.; Cools, W.
Effects of itraconazole on cytochrome P-450-dependent sterol 14alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans
Antimicrob. Agents Chemother.
37
2101-2105
1993
Cryptococcus neoformans
Huang, X.F.; Luu-The, V.
Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha->beta)-hydroxysteroid epimerase
Biochim. Biophys. Acta
1520
124-130
2001
Homo sapiens
De Launoit, Y.; Zhao, H.F.; Belanger, A.; Labrie, F.; Simard, J.
Expression of liver-specific member of the 3beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity
J. Biol. Chem.
267
4513-4517
1992
Rattus norvegicus
Rizner, T.L.; Lin, H.K.; Peehl, D.M.; Steckelbroeck, S.; Bauman, D.R.; Penning, T.M.
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
Endocrinology
144
2922-2932
2003
Homo sapiens
Steckelbroeck, S.; Jin, Y.; Gopishetty, S.; Oyesanmi, B.; Penning, T.M.
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action
J. Biol. Chem.
279
10784-10795
2004
Homo sapiens (Q04828), Homo sapiens
Marijanovic, Z.; Laubner, D.; Moeller, G.; Gege, C.; Husen, B.; Adamski, J.; Breitling, R.
Closing the gap: Identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
Mol. Endocrinol.
17
1715-1725
2003
Homo sapiens, Mus musculus
Tam, H.; Schlinger, B.A.
Activities of 3beta-HSD and aromatase in slices of developing and adult zebra finch brain
Gen. Comp. Endocrinol.
150
26-33
2006
Taeniopygia guttata
Steckelbroeck, S.; Oyesanmi, B.; Jin, Y.; Lee, S.H.; Kloosterboer, H.J.; Penning, T.M.
Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily
J. Pharmacol. Exp. Ther.
316
1300-1309
2006
Homo sapiens
Jin, Y.; Penning, T.M.
Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences
Steroids
71
380-391
2006
Homo sapiens (Q04828), Homo sapiens
Taramino, S.; Valachovic, M.; Oliaro-Bosso, S.; Viola, F.; Teske, B.; Bard, M.; Balliano, G.
Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast
Biochim. Biophys. Acta
1801
156-162
2010
Saccharomyces cerevisiae
Taramino, S.; Teske, B.; Oliaro-Bosso, S.; Bard, M.; Balliano, G.
Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts
Biochim. Biophys. Acta
1801
1232-1237
2010
Homo sapiens (P56937), Homo sapiens, Mus musculus (O88736), Mus musculus
Mo, C.; Valachovic, M.; Randall, S.K.; Nickels, J.T.; Bard. M.
Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis
Proc. Natl. Acad. Sci. USA
99
39-44
2002
Saccharomyces cerevisiae
Endo, S.; Matsunaga, T.; Kumada, S.; Fujimoto, A.; Ohno, S.; El-Kabbani, O.; Hu, D.; Toyooka, N.; Mano, J.; Tajima, K.; Hara, A.
Characterization of rabbit aldose reductase-like protein with 3beta-hydroxysteroid dehydrogenase activity
Arch. Biochem. Biophys.
527
23-30
2012
Oryctolagus cuniculus
Thomas, J.L.; Mack, V.L.; Sun, J.; Terrell, J.R.; Bucholtz, K.M.
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis
J. Steroid Biochem. Mol. Biol.
120
192-199
2010
Homo sapiens
Debieu, D.; Bach, J.; Montesinos, E.; Fillinger, S.; Leroux, P.
Role of sterol 3-ketoreductase sensitivity in susceptibility to the fungicide fenhexamid in Botrytis cinerea and other phytopathogenic fungi
Pest Manag. Sci.
69
642-651
2013
Botrytis cinerea
Layer, J.; Barnes, B.; Yamasaki, Y.; Barbuch, R.; Li, L.; Taramino, S.; Balliano, G.; Bard, M.
Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway
Biochim. Biophys. Acta
1831
361-369
2013
Mus musculus (O88736), Mus musculus
Ferrante, T.; Barge, A.; Taramino, S.; Oliaro-Bosso, S.; Balliano, G.
4-Methylzymosterone and other intermediates of sterol biosynthesis from yeast mutants engineered in the ERG27 gene encoding 3-ketosteroid reductase
Lipids
51
1103-1113
2016
Saccharomyces cerevisiae (Q12452), Saccharomyces cerevisiae
Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process
PLoS ONE
10
e113194
2015
Sus scrofa
Mythen, S.; Devendran, S.; Mndez-Garca, C.; Cann, I.; Ridlon, J.
Targeted synthesis and characterization of a gene cluster encoding NAD(P)H-dependent 3alpha-, 3beta-, and 12alpha-hydroxysteroid dehydrogenases from Eggerthella CAG 298, a gut metagenomic sequence
Appl. Environ. Microbiol.
84
e02475-17
2018
Eggerthella sp. CAG:298 (R7AF73)
Ferrante, T.; Adinolfi, S.; DArrigo, G.; Poirier, D.; Daga, M.; Lolli, M.L.; Balliano, G.; Spyrakis, F.; Oliaro-Bosso, S.
Multiple catalytic activities of human 17beta-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors
Biochimie
170
106-117
2020
Homo sapiens (P56937), Homo sapiens
Rozycka, M.; Kurowska, P.; Grzesiak, M.; Kotula-Balak, M.; Tworzydlo, W.; Rame, C.; Gregoraszczuk, E.; Dupont, J.; Rak, A.
Apelin and apelin receptor at different stages of corpus luteum development and effect of apelin on progesterone secretion and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) in pigs
Anim. Reprod. Sci.
192
251-260
2018
Sus scrofa
Wang, X.Q.; Aka, J.A.; Li, T.; Xu, D.; Doillon, C.J.; Lin, S.X.
Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78
J. Steroid Biochem. Mol. Biol.
172
188-197
2017
Homo sapiens (P56937)
Pham, J.H.; Will, C.M.; Mack, V.L.; Halbert, M.; Conner, E.A.; Bucholtz, K.M.; Thomas, J.L.
Structure-function relationships for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 by a novel androgen analog
J. Steroid Biochem. Mol. Biol.
174
257-264
2017
Homo sapiens (P14060)
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