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Reference on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mahmoud, S.S.; Croteau, R.B.
Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase
Proc. Natl. Acad. Sci. USA
98
8915-8920
2001
Mentha x piperita
Manually annotated by BRENDA team
Radykewicz, T.; Rohdich, F.; Wungsintaweekul, J.; Herz, S.; Kis, K.; Eisenreich, W.; Bacher, A.; Zenk, M.H.; Arigoni, D.
Biosynthesis of terpenoids: 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase
FEBS Lett.
465
157-160
2000
Escherichia coli
Manually annotated by BRENDA team
Yajima, S.; Nonaka, T.; Kuzuyama, T.; Seto, H.; Ohsawa, K.
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: Implications of a flexible loop movement upon substrate binding
J. Biochem.
131
313-317
2002
Escherichia coli
Manually annotated by BRENDA team
Reuter, K.; Sanderbrand, S.; Jomaa, H.; Wiesner, J.; Steinbrecher, I.; Beck, E.; Hintz, M.; Klebe, G.; Stubbs, M.T.
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis
J. Biol. Chem.
277
5378-5384
2002
Escherichia coli
Manually annotated by BRENDA team
Grolle, S.; Bringer-Meyer, S.; Sahm, H.
Isolation of the dxr gene of Zymomonas mobilis and characterization of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase
FEMS Microbiol. Lett.
191
131-137
2000
Zymomonas mobilis
Manually annotated by BRENDA team
Altincicek, B.; Hintz, M.; Sanderbrand, S.; Wiesner, J.; Beck, E.; Jomaa, H.
Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa
FEMS Microbiol. Lett.
190
329-333
2000
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Lange, B.M.; Croteau, R.
Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: Cloning and heterologous expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from peppermint
Arch. Biochem. Biophys.
365
170-174
1999
Mentha x piperita
Manually annotated by BRENDA team
Takahashi, S.; Kuzuyama, T.; Watanabe, H.; Seto, H.
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis
Proc. Natl. Acad. Sci. USA
95
9879-9884
1998
Escherichia coli
Manually annotated by BRENDA team
Kuzuyama, T.; Takahashi, S.; Takagi, M.; Seto, H.
Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues
J. Biol. Chem.
275
19928-19932
2000
Escherichia coli (P45568), Escherichia coli
Manually annotated by BRENDA team
Wiesner, J.; Hintz, M.; Altincicek, B.; Sanderbrand, S.; Weidemeyer, C.; Beck, E.; Jomaa, H.
Plasmodium falciparum: Detection of the deoxyxylulose 5-phosphate reductoisomerase activity
Exp. Parasitol.
96
182-186
2000
Plasmodium falciparum
Manually annotated by BRENDA team
Argyrou, A.; Blanchard, J.S.
Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase
Biochemistry
43
4375-4384
2004
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Yin, X.; Proteau, P.J.
Characterization of native and histidine-tagged deoxyxylulose 5-phosphate reductoisomerase from the cyanobacterium Synechocystis sp. PCC6803
Biochim. Biophys. Acta
1652
75-81
2003
Synechocystis sp.
Manually annotated by BRENDA team
Ricagno, S.; Grolle, S.; Bringer-Meyer, S.; Sahm, H.; Lindqvist, Y.; Schneider, G.
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution
Biochim. Biophys. Acta
1698
37-44
2004
Zymomonas mobilis
Manually annotated by BRENDA team
Phaosiri, C.; Proteau, P.J.
Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation
Bioorg. Med. Chem. Lett.
14
5309-5312
2004
Synechocystis sp.
Manually annotated by BRENDA team
Hoeffler, J.F.; Tritsch, D.; Grosdemange-Billiard, C.; Rohmer, M.
Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Eur. J. Biochem.
269
4446-4457
2002
Escherichia coli
Manually annotated by BRENDA team
Yajima, S.; Hara, K.; Sanders, J.M.; Yin, F.; Ohsawa, K.; Wiesner, J.; Jomaa, H.; Oldfield, E.
Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes
J. Am. Chem. Soc.
126
10824-10825
2004
Escherichia coli (P45568)
Manually annotated by BRENDA team
Mac Sweeney, A.; Lange, R.; Fernandes, R.P.; Schulz, H.; Dale, G.E.; Douangamath, A.; Proteau, P.J.; Oefner, C.
The crystal structure of E. coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation
J. Mol. Biol.
345
115-127
2005
Escherichia coli (P45568), Escherichia coli
Manually annotated by BRENDA team
Wong, A.; Munos, J.W.; Devasthali, V.; Johnson, K.A.; Liu, H.W.
Study of 1-deoxy-D-xylulose-5-phosphate reductoisomerase: synthesis and evaluation of fluorinated substrate analogues
Org. Lett.
6
3625-3628
2004
Escherichia coli
Manually annotated by BRENDA team
Carretero-Paulet, L.; Ahumada, I.; Cunillera, N.; Rodriguez-Concepcion, M.; Ferrer, A.; Boronat, A.; Campos, N.
Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway
Plant Physiol.
129
1581-1591
2002
Arabidopsis thaliana (Q9XFS9)
Manually annotated by BRENDA team
Hans, J.; Hause, B.; Strack, D.; Walter, M.H.
Cloning, characterization, and immunolocalization of a mycorrhiza-inducible 1-deoxy-d-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize
Plant Physiol.
134
614-624
2004
Zea mays
Manually annotated by BRENDA team
Henriksson, L.M.; Bjoerkelid, C.; Mowbray, S.L.; Unge, T.
The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target
Acta Crystallogr. Sect. D
D62
807-813
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Fernandes, R.P.; Phaosiri, C.; Proteau, P.J.
Mutation in the flexible loop of 1-deoxy-D-xylulose 5-phosphate reductoisomerase broadens substrate utilization
Arch. Biochem. Biophys.
444
159-164
2005
Synechocystis sp.
Manually annotated by BRENDA team
Fox, D.T.; Poulter, C.D.
Mechanistic studies with 2-C-methyl-D-erythritol 4-phosphate synthase from Escherichia coli
Biochemistry
44
8360-8368
2005
Escherichia coli
Manually annotated by BRENDA team
Fernandes, R.P.; Proteau, P.J.
Kinetic characterization of Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase mutants
Biochim. Biophys. Acta
1764
223-229
2006
Synechocystis sp.
Manually annotated by BRENDA team
Woo, Y.H.; Fernandes, R.P.; Proteau, P.J.
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Bioorg. Med. Chem.
14
2375-2385
2006
Synechocystis sp.
Manually annotated by BRENDA team
Merckle, L.; de Andres-Gomez, A.; Dick, B.; Cox, R.J.; Godfrey, C.R.
A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Chembiochem
6
1866-1874
2005
Escherichia coli (P45568)
Manually annotated by BRENDA team
Rohdich, F.; Lauw, S.; Kaiser, J.; Feicht, R.; Koehler, P.; Bacher, A.; Eisenreich, W.
Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana
FEBS J.
273
4446-4458
2006
Arabidopsis thaliana (Q9XFS9), Arabidopsis thaliana
Manually annotated by BRENDA team
Dhiman, R.K.; Schaeffer, M.L.; Bailey, A.M.; Testa, C.A.; Scherman, H.; Crick, D.C.
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin
J. Bacteriol.
187
8395-8402
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Singh, N.; Cheve, G.; Avery, M.A.; McCurdy, C.R.
Comparative protein modeling of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme from Plasmodium falciparum: a potential target for antimalarial drug discovery
J. Chem. Inf. Model.
46
1360-1370
2006
Plasmodium falciparum (O96693), Plasmodium falciparum
Manually annotated by BRENDA team
Fox, D.T.; Poulter, C.D.
Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphoric acid analogues as alternate substrates for methylerythritol phosphate synthase
J. Org. Chem.
70
1978-1985
2005
Escherichia coli
Manually annotated by BRENDA team
Walker, J.R.; Poulter, C.D.
Synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate analogues as chelation-based inhibitors of methylerythritol phosphate synthase
J. Org. Chem.
70
9955-9959
2005
Escherichia coli
Manually annotated by BRENDA team
Hsieh, M.H.; Goodman, H.M.
The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis
Plant Physiol.
138
641-653
2005
Arabidopsis thaliana (Q9XFS9)
Manually annotated by BRENDA team
Engprasert, S.; Taura, F.; Shoyama, Y.
Molecular cloning, expression and characterization of recombinant 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Coleus forskohlii Briq.
Plant Sci.
169
287-294
2005
Plectranthus barbatus (Q6R3F4)
Manually annotated by BRENDA team
Kim, S.; Kuzuyama, T.; Chang, Y.; Song, K.; Kim, S.
Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis
Planta Med.
72
234-240
2006
Ginkgo biloba (Q5J7B3), Ginkgo biloba
Manually annotated by BRENDA team
Yajima, S.; Hara, K.; Iino, D.; Sasaki, Y.; Kuzuyama, T.; Ohsawa, K.; Seto, H.
Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin
Acta Crystallogr. Sect. F
F63
466-470
2007
Escherichia coli (P45568), Escherichia coli
Manually annotated by BRENDA team
Tahar, R.; Basco, L.K.
Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Am. J. Trop. Med. Hyg.
77
214-220
2007
Plasmodium falciparum (O96693), Plasmodium falciparum
Manually annotated by BRENDA team
Wong, U.; Cox, R.J.
The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli
Angew. Chem. Int. Ed. Engl.
46
4926-4929
2007
Escherichia coli
Manually annotated by BRENDA team
Ortmann, R.; Wiesner, J.; Silber, K.; Klebe, G.; Jomaa, H.; Schlitzer, M.
Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues
Arch. Pharm.
340
483-490
2007
Escherichia coli (P45568)
Manually annotated by BRENDA team
Wungsintaweekul, J.; Sirisuntipong, T.; Kongduang, D.; Losuphanporn, T.; Ounaroon, A.; Tansakul, P.; De-Eknamkul, W.
Transcription profiles analysis of genes encoding 1-deoxy-D-xylulose 5-phosphate synthase and 2C-methyl-D-erythritol 4-phosphate synthase in plaunotol biosynthesis from Croton stellatopilosus
Biol. Pharm. Bull.
31
852-856
2008
Croton stellatopilosus (A4L795), Croton stellatopilosus
Manually annotated by BRENDA team
Wu, S.J.; Shi, M.; Wu, J.Y.
Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza hairy roots
Biotechnol. Appl. Biochem.
52(Pt1)
89-95
2008
Salvia miltiorrhiza (A0A1F2), Salvia miltiorrhiza
Manually annotated by BRENDA team
Henriksson, L.M.; Unge, T.; Carlsson, J.; Aqvist, J.; Mowbray, S.L.; Jones, T.A.
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis
J. Biol. Chem.
282
19905-19916
2007
Mycobacterium tuberculosis (P9WNS1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNS1)
Manually annotated by BRENDA team
Hasunuma, T.; Takeno, S.; Hayashi, S.; Sendai, M.; Bamba, T.; Yoshimura, S.; Tomizawa, K.; Fukusaki, E.; Miyake, C.
Overexpression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid production
J. Biosci. Bioeng.
105
518-526
2008
Synechocystis sp.
Manually annotated by BRENDA team
Yao, H.; Gong, Y.; Zuo, K.; Ling, H.; Qiu, C.; Zhang, F.; Wang, Y.; Pi, Y.; Liu, X.; Sun, X.; Tang, K.
Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata
J. Plant Physiol.
165
203-213
2008
Camptotheca acuminata (A1XG19), Camptotheca acuminata
Manually annotated by BRENDA team
Seetang-Nun, Y.; Sharkey, T.D.; Suvachittanont, W.
Molecular cloning and characterization of two cDNAs encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase from Hevea brasiliensis
J. Plant Physiol.
165
991-1002
2008
Hevea brasiliensis (A1KXW2), Hevea brasiliensis (Q0GYS3), Hevea brasiliensis
Manually annotated by BRENDA team
Zhang, M.; Li, K.; Zhang, C.; Gai, J.; Yu, D.
Identification and characterization of class 1 DXS gene encoding 1-deoxy-D: -xylulose-5-phosphate synthase, the first committed enzyme of the MEP pathway from soybean
Mol. Biol. Rep.
36
879-887
2008
Glycine max
Manually annotated by BRENDA team
Kaiser, J.; Yassin, M.; Prakash, S.; Safi, N.; Agami, M.; Lauw, S.; Ostrozhenkova, E.; Bacher, A.; Rohdich, F.; Eisenreich, W.; Safi, J.; Golan-Goldhirsh, A.
Anti-malarial drug targets: screening for inhibitors of 2C-methyl-D-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants
Phytomedicine
14
242-249
2007
Escherichia coli
Manually annotated by BRENDA team
Phillips, M.A.; Walter, M.H.; Ralph, S.G.; Dabrowska, P.; Luck, K.; Uros, E.M.; Boland, W.; Strack, D.; Rodriguez-Concepcion, M.; Bohlmann, J.; Gershenzon, J.
Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies)
Plant Mol. Biol.
65
243-257
2007
Picea abies (A7LA00), Picea abies (A7LA01), Picea abies (A7LA02)
Manually annotated by BRENDA team
Liao, Z.; Chen, R.; Chen, M.; Yang, C.; Wang, Q.; Gong, Y.
A new 1-Deoxy-D-xylulose 5-phosphate reductoisomerase gene encoding the committed-step enzyme in the MEP pathway from Rauvolfia verticillata
Z. Naturforsch. C
62
296-304
2007
Rauvolfia verticillata (Q1L7P3), Rauvolfia verticillata
Manually annotated by BRENDA team
Sando, T.; Takeno, S.; Watanabe, N.; Okumoto, H.; Kuzuyama, T.; Yamashita, A.; Hattori, M.; Ogasawara, N.; Fukusaki, E.; Kobayashi, A.
Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis
Biosci. Biotechnol. Biochem.
72
2903-2917
2008
Hevea brasiliensis (A9ZN08), Hevea brasiliensis, Escherichia coli (P45568), Escherichia coli, Arabidopsis thaliana (Q9XFS9), Arabidopsis thaliana
Manually annotated by BRENDA team
Yan, X.; Zhang, L.; Wang, J.; Liao, P.; Zhang, Y.; Zhang, R.; Kai, G.
Molecular characterization and expression of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) gene from Salvia miltiorrhiza
Acta Physiol. Plant.
31
1015-1022
2009
Salvia miltiorrhiza (B7UCR9)
-
Manually annotated by BRENDA team
Munos, J.; Pu, X.; Liu, H.
Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Bioorg. Med. Chem. Lett.
18
3090-3094
2008
synthetic construct
Manually annotated by BRENDA team
Giessmann, D.; Heidler, P.; Haemers, T.; Van Calenbergh, S.; Reichenberg, A.; Jomaa, H.; Weidemeyer, C.; Sanderbrand, S.; Wiesner, J.; Link, A.
Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors
Chem. Biodivers.
5
643-656
2008
Escherichia coli, Plasmodium falciparum
Manually annotated by BRENDA team
Perruchon, J.; Ortmann, R.; Altenkaemper, M.; Silber, K.; Wiesner, J.; Jomaa, H.; Klebe, G.; Schlitzer, M.
Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase
ChemMedChem
3
1232-1241
2008
Escherichia coli (P45568)
Manually annotated by BRENDA team
Lauw, S.; Illarionova, V.; Bacher, A.; Rohdich, F.; Eisenreich, W.
Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase
FEBS J.
275
4060-4073
2008
Arabidopsis thaliana, Bacillus subtilis, Mycobacterium tuberculosis, Escherichia coli (P45568), Escherichia coli
Manually annotated by BRENDA team
Munos, J.W.; Pu, X.; Mansoorabadi, S.O.; Kim, H.J.; Liu, H.W.
A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement
J. Am. Chem. Soc.
131
2048-2049
2009
synthetic construct
Manually annotated by BRENDA team
Cordoba, E.; Salmi, M.; Leon, P.
Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants
J. Exp. Bot.
60
2933-2943
2009
Hevea brasiliensis
Manually annotated by BRENDA team
Yoonram, K.; Takahashi, S.; Rattanapittayaporn, A.; Koyama, T.; Wititsuwannakul, D.; Wititsuwannakul, R.
cDNA, from Hevea brasiliensis latex, encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Plant Sci.
175
694-700
2008
Hevea brasiliensis
Manually annotated by BRENDA team
Kim, Y.B.; Kim, S.M.; Kang, M.K.; Kuzuyama, T.; Lee, J.K.; Park, S.C.; Shin, S.C.; Kim, S.U.
Regulation of resin acid synthesis in Pinus densiflora by differential transcription of genes encoding multiple 1-deoxy-D-xylulose 5-phosphate synthase and 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase genes
Tree Physiol.
29
737-749
2009
Pinus densiflora, Pinus densiflora (B9U4U7)
Manually annotated by BRENDA team
Sitthithaworn, W.; Wungsintaweekul, J.; Sirisuntipong, T.; Charoonratana, T.; Ebizuka, Y.; De-Eknamkul, W.
Cloning and expression of 1-deoxy-d-xylulose 5-phosphate synthase cDNA from Croton stellatopilosus and expression of 2C-methyl-d-erythritol 4-phosphate synthase and geranylgeranyl diphosphate synthase, key enzymes of plaunotol biosynthesis
J. Plant Physiol.
167
292-300
2010
Croton stellatopilosus
Manually annotated by BRENDA team
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Manually annotated by BRENDA team
Umeda, T.; Tanaka, N.; Kusakabe, Y.; Nakanishi, M.; Kitade, Y.; Nakamura, K.T.
Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum
Acta Crystallogr. Sect. F
66
330-332
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Xing, S.; Miao, J.; Li, S.; Qin, G.; Tang, S.; Li, H.; Gu, H.; Qu, L.J.
Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis
Cell Res.
20
688-700
2010
Arabidopsis thaliana
Manually annotated by BRENDA team
Deng, L.; Sundriyal, S.; Rubio, V.; Shi, Z.Z.; Song, Y.
Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase
J. Med. Chem.
52
6539-6542
2009
Bacillus anthracis, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Takenoya, M.; Ohtaki, A.; Noguchi, K.; Endo, K.; Sasaki, Y.; Ohsawa, K.; Yajima, S.; Yohda, M.
Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding
J. Struct. Biol.
170
532-539
2010
Thermotoga maritima (Q9WZZ1), Thermotoga maritima
Manually annotated by BRENDA team
Jawaid, S.; Seidle, H.; Zhou, W.; Abdirahman, H.; Abadeer, M.; Hix, J.H.; van Hoek, M.L.; Couch, R.D.
Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)
PLoS ONE
4
e8288
2009
Francisella tularensis
Manually annotated by BRENDA team
Goble, J.L.; Adendorff, M.R.; de Beer, T.A.; Stephens, L.L.; Blatch, G.L.
The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening
Protein Pept. Lett.
17
109-120
2010
Plasmodium falciparum (Q8IKG4), Plasmodium falciparum
Manually annotated by BRENDA team
Yang, J.; Adhikari, M.; Liu, H.; Xu, H.; He, G.; Zhan, R.; Wei, J.; Chen, W.
Characterization and functional analysis of the genes encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase and 1-deoxy-D-xylulose-5-phosphate synthase, the two enzymes in the MEP pathway, from Amomum villosum Lour
Mol. Biol. Rep.
39
8287-8296
2012
Wurfbainia villosa (C6G1Y8), Wurfbainia villosa
Manually annotated by BRENDA team
Xue, J.; Diao, J.; Cai, G.; Deng, L.; Zheng, B.; Yao, Y.; Song, Y.
Antimalarial and structural studies of pyridine-containing inhibitors of 1-deoxyxylulose-5-phosphate reductoisomerase
ACS Med. Chem. Lett.
4
278-282
2013
Escherichia coli, Plasmodium falciparum (O96693), Plasmodium falciparum
Manually annotated by BRENDA team
Liu, J.; Murkin, A.S.
Pre-steady-state kinetic analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Mycobacterium tuberculosis reveals partially rate-limiting product release by parallel pathways
Biochemistry
51
5307-5319
2012
Mycobacterium tuberculosis, no activity in Homo sapiens
Manually annotated by BRENDA team
Kholodar, S.A.; Murkin, A.S.
DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group
Biochemistry
52
2302-2308
2013
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Cai, G.; Deng, L.; Xue, J.; Moreno, S.N.; Striepen, B.; Song, Y.
Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Bioorg. Med. Chem. Lett.
23
2158-2161
2013
Toxoplasma gondii
Manually annotated by BRENDA team
Bodill, T.; Conibear, A.C.; Mutorwa, M.K.; Goble, J.L.; Blatch, G.L.; Lobb, K.A.; Klein, R.; Kaye, P.T.
Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors
Bioorg. Med. Chem.
21
4332-4341
2013
Escherichia coli, Plasmodium falciparum
Manually annotated by BRENDA team
Humnabadkar, V.; Jha, R.K.; Ghatnekar, N.; De Sousa, S.M.
A high-throughput screening assay for simultaneous selection of inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate synthase (Dxs) or 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr)
J. Biomol. Screen.
16
303-312
2011
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Andaloussi, M.; Henriksson, L.M.; Wieckowska, A.; Lindh, M.; Bjoerkelid, C.; Larsson, A.M.; Suresh, S.; Iyer, H.; Srinivasa, B.R.; Bergfors, T.; Unge, T.; Mowbray, S.L.; Larhed, M.; Jones, T.A.; Karlen, A.
Design, synthesis, and X-ray crystallographic studies of alpha-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase
J. Med. Chem.
54
4964-4976
2011
Mycobacterium tuberculosis (P9WNS1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNS1)
Manually annotated by BRENDA team
Mendoza-Poudereux, I.; Munoz-Bertomeu, J.; Arrillaga, I.; Segura, J.
Deoxyxylulose 5-phosphate reductoisomerase is not a rate-determining enzyme for essential oil production in spike lavender
J. Plant Physiol.
171
1564-1570
2014
Arabidopsis thaliana
Manually annotated by BRENDA team
Kholodar, S.A.; Tombline, G.; Liu, J.; Tan, Z.; Allen, C.L.; Gulick, A.M.; Murkin, A.S.
Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin
Biochemistry
53
3423-3431
2014
Mycobacterium tuberculosis (P9WNS1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNS1)
Manually annotated by BRENDA team
Zingle, C.; Tritsch, D.; Grosdemange-Billiard, C.; Rohmer, M.
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR)
Bioorg. Med. Chem.
22
3713-3719
2014
Escherichia coli (Q1RG16), Escherichia coli, Escherichia coli UPEC (Q1RG16)
Manually annotated by BRENDA team
Li, H.; Tian, J.; Sun, W.; Qin, W.; Gao, W.Y.
Mechanistic insights into 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a key enzyme of the MEP terpenoid biosynthetic pathway
FEBS J.
280
5896-5905
2013
Escherichia coli (Q8X8Y1), Escherichia coli, Escherichia coli O157 (Q8X8Y1)
Manually annotated by BRENDA team
Hui, X.; Liu, H.; Tian, F.L.; Li, F.F.; Li, H.; Gao, W.Y.
Inhibition of green tea and the catechins against 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway
Fitoterapia
113
80-84
2016
Escherichia coli
Manually annotated by BRENDA team
Liu, J.; Xu, Y.; Liang, L.; Wei, J.
Molecular cloning, characterization and expression analysis of the gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Aquilaria sinensis (Lour.) Gilg
J. Genet.
94
239-249
2015
Aquilaria sinensis (A0A059VDA9), Aquilaria sinensis
Manually annotated by BRENDA team
San Jose, G.; Jackson, E.R.; Uh, E.; Johny, C.; Haymond, A.; Lundberg, L.; Pinkham, C.; Kehn-Hall, K.; Boshoff, H.I.; Couch, R.D.; Dowd, C.S.
Design of potential bisubstrate inhibitors against Mycobacterium tuberculosis (Mtb) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) - evidence of a novel binding mode
MedChemComm
4
1099-1104
2013
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Fan, H.; Wu, Q.; Wang, X.; Wu, L.; Cai, Y.; Lin, Y.
Molecular cloning and expression of 1-deoxy-d-xylulose-5-phosphate synthase and 1-deoxy-d-xylulose-5-phosphate reductoisomerase in Dendrobium officinale
Plant Cell Tissue Organ Cult.
125
381-385
2016
Dendrobium catenatum (W0FI66)
-
Manually annotated by BRENDA team
Haymond, A.; Johny, C.; Dowdy, T.; Schweibenz, B.; Villarroel, K.; Young, R.; Mantooth, C.J.; Patel, T.; Bases, J.; San Jose, G.; Jackson, E.R.; Dowd, C.S.; Couch, R.D.
Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)
PLoS ONE
9
e106243
2014
Yersinia pestis (Q8ZH62), Yersinia pestis
Manually annotated by BRENDA team
Hui, X.; Yue, Q.; Zhang, D.D.; Li, H.; Yang, S.Q.; Gao, W.Y.
Antimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway
Sci. Rep.
6
38945
2016
Escherichia coli
Manually annotated by BRENDA team
Mirzaei, F.; Fatehi, F.; Ismaili, A.; Yaghotipoor, A.; Qaderi, A.
Expression of genes 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), sabinene synthase (Tctps1) and alpha-terpineol synthase (Tctps5) and its relation to thymol and carvacrol biosynthesis in Thymus vulgaris under water deficit stress
J. Med. Plants
16
58-70
2017
Thymus vulgaris (A0A1U9X9N3)
-
Manually annotated by BRENDA team
Haymond, A.; Dowdy, T.; Johny, C.; Johnson, C.; Ball, H.; Dailey, A.; Schweibenz, B.; Villarroel, K.; Young, R.; Mantooth, C.J.; Patel, T.; Bases, J.; Dowd, C.S.; Couch, R.D.
A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD)
Anal. Biochem.
542
63-75
2018
Francisella tularensis subsp. novicida (A0Q7Y5), Mycobacterium tuberculosis (P9WNS1), Yersinia pestis (Q8ZH62), Francisella tularensis subsp. novicida U112 (A0Q7Y5), Yersinia pestis A1122 (Q8ZH62), Mycobacterium tuberculosis H37Rv (P9WNS1), Mycobacterium tuberculosis ATCC 25618 (P9WNS1)
Manually annotated by BRENDA team
Sharma, R.; Devi, K.; Modi, M.K.; Sen, P.
In silico characterization and differential expression analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) of Centella asiatica
3 Biotech
11
184
2021
Centella asiatica (A0A0A6Z621), Centella asiatica
Manually annotated by BRENDA team
Hui, X.; Hua, S.H.; Wu, Q.Q.; Li, H.; Gao, W.Y.
Antimicrobial mechanism of epigallocatechin gallate and gallocatechin gallate they target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway
Arch. Biochem. Biophys.
622
1-8
2017
Escherichia coli (P45568)
Manually annotated by BRENDA team
Ussin, N.K.; Bagnell, A.M.; Offermann, L.R.; Abdulsalam, R.; Perdue, M.L.; Magee, P.; Chruszcz, M.
Structural characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Vibrio vulnificus
Biochim. Biophys. Acta
1866
1209-1215
2018
Vibrio vulnificus (Q8DBF5), Vibrio vulnificus, Vibrio vulnificus CMCP6 (Q8DBF5)
Manually annotated by BRENDA team
Cheng, Z.; Wang, R.; Shen, J.; Yang, Z.; Chen, Y.
Cloning, characterization, and expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene from Dioscorea zingiberensis
Biol. Plant.
63
262-267
2019
Dioscorea zingiberensis (A0A1P8JPV2)
-
Manually annotated by BRENDA team
Munier, M.; Tritsch, D.; Krebs, F.; Esque, J.; Hemmerlin, A.; Rohmer, M.; Stote, R.; Grosdemange-Billiard, C.
Synthesis and biological evaluation of phosphate isosters of fosmidomycin and analogs as inhibitors of Escherichia coli and Mycobacterium smegmatis 1-deoxyxylulose 5-phosphate reductoisomerases
Bioorg. Med. Chem.
25
684-689
2017
Mycolicibacterium smegmatis (A0QVH7), Escherichia coli (P45568), Mycolicibacterium smegmatis ATCC 700084 (A0QVH7)
Manually annotated by BRENDA team
You, M.K.; Lee, Y.J.; Kim, J.K.; Baek, S.A.; Jeon, Y.A.; Lim, S.H.; Ha, S.H.
The organ-specific differential roles of rice DXS and DXR, the first two enzymes of the MEP pathway, in carotenoid metabolism in Oryza sativa leaves and seeds
BMC Plant Biol.
20
167
2020
Oryza sativa Japonica Group (Q8W250)
Manually annotated by BRENDA team
Kesharwani, S.; Sundriyal, S.
Non-hydroxamate inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) a critical review and future perspective
Eur. J. Med. Chem.
213
113055
2021
Escherichia coli (P45568), Mycobacterium tuberculosis (P9WNS1), Plasmodium falciparum (Q8IKG4), Mycobacterium tuberculosis H37Rv (P9WNS1), Mycobacterium tuberculosis ATCC 25618 (P9WNS1)
Manually annotated by BRENDA team
Zhang, Y.; Yan, H.; Li, Y.; Xiong, Y.; Niu, M.; Zhang, X.; Teixeira da Silva, J.A.; Ma, G.
Molecular cloning and functional analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Santalum album
Genes (Basel)
12
626
2021
Santalum album (MH018577), Santalum album
Manually annotated by BRENDA team
Rad, M.; Abdossi, V.; Moradi, P.; Rakhshandehroo, F.; Mehrafarin, A.
Expression analysis of gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) and cardenolide and digitoxin production in digitalis purpurea L. using polyamines and methyl jasmonate as elicitors
J. Agric. Sci. Technol.
22
1551-1561
2020
Digitalis purpurea
-
Manually annotated by BRENDA team
Sharma, D.; Dada, R.; Tejavath, K.; Rai, P.; Soni, R.; Yaragorla, S.; Bhatt, T.
A paradigm towards the antimalarial quest in silico identification and biological evaluation of novel inhibitors targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
J. Biomol. Struct. Dyn.
38
295-301
2020
Plasmodium falciparum (Q8IKG4)
Manually annotated by BRENDA team
Yan, G.; Zhu, B.R.; Tian, F.L.; Hui, X.; Li, H.; Li, Y.M.; Gao, W.Y.
Inhibitory activity of plant essential oils against E. coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Molecules
24
2518
2019
Escherichia coli (P45568), Escherichia coli
Manually annotated by BRENDA team
Wadood, A.; Ghufran, M.; Hassan, S.; Khan, H.; Azam, S.; Rashid, U.
In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase for treatment of falciparum malaria
Pharm. Biol.
55
19-32
2017
Plasmodium falciparum (Q8IKG4), Plasmodium falciparum
Manually annotated by BRENDA team
Wang, C.; Lei, X.; Xia, J.; Wang, J.
Effect of down-regulating 1-deoxy-D-xylulose-5-phosphate reductoisomerase by RNAi on growth and artemisinin biosynthesis in Artemisia annua L.
Plant Growth Regul.
84
549-559
2018
Artemisia annua (Q9SP64)
-
Manually annotated by BRENDA team
Xu, C.; Wei, H.; Movahedi, A.; Sun, W.; Ma, X.; Li, D.; Yin, T.; Zhuge, Q.
Evaluation, characterization, expression profiling, and functional analysis of DXS and DXR genes of Populus trichocarpa
Plant Physiol. Biochem.
142
94-105
2019
Populus trichocarpa (A0A2K1XJL6), Populus trichocarpa
Manually annotated by BRENDA team
Guirimand, G.; Guihur, A.; Perello, C.; Phillips, M.; Mahroug, S.; Oudin, A.; Duge de Bernonville, T.; Besseau, S.; Lanoue, A.; Giglioli-Guivarch, N.; Papon, N.; St-Pierre, B.; Rodriguez-Concepcion, M.; Burlat, V.; Courdavault, V.
Cellular and subcellular compartmentation of the 2C-methyl-D-erythritol 4-phosphate pathway in the Madagascar periwinkle
Plants (Basel)
9
462
2020
Catharanthus roseus
Manually annotated by BRENDA team