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1-deoxy-6-methyl-D-glucitol + NADP+
1-deoxy-6-methyl-D-glucose + NADPH
-
poorer substrate than D-glucitol
-
?
1-deoxy-6-methyl-D-mannitol + NADP+
1-deoxy-6-methyl-D-fructose + NADPH
-
poorer substrate than D-mannitol
-
?
1-deoxy-D-glucitol + NADP+
1-deoxy-D-glucose + NADPH
-
poorer substrate than glucitol
-
?
1-deoxy-D-mannitol + NADP+
1-deoxy-D-fructose + NADPH
-
poorer substrate than D-mannitol
-
?
arabinose + NADPH + H+
arabinitol + NADP+
-
-
-
-
r
D-arabinitol + NADP+
D-xylulose + NADPH + H+
D-arabitol + NADP+
?
-
-
-
-
?
D-fructose + NADPH
D-mannitol + NADP+
D-fructose + NADPH + H+
D-mannitol + NADP+
D-glucitol + NADP+
D-glucose + NADPH + H+
-
-
-
-
r
D-mannitol + 3-acetylpyridine adenine dinucleotide phosphate
D-fructose + 3-acetylpyridine adenine dinucleotide phosphate(H)
-
7.5% of the activity compared to NADP+
-
?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
D-mannitol + NAD+
D-fructose + NADH + H+
D-mannitol + NADP+
D-fructose + NADPH + H+
D-mannitol + thio-NADP+
D-fructose + thio-NADPH
-
30% of the activity compared to NADP+
-
?
D-mannose + NADPH + H+
D-mannitol + NADP+
-
-
-
-
r
D-sorbitol + NADP+
?
-
-
-
-
?
D-sorbitol + NADP+
D-sorbose + NADPH + H+
glycerol + NADP+
?
-
-
-
-
?
L-arabinitol + NADP+
L-xylulose + NADPH + H+
L-sorbitol + NADP+
L-sorbose + NADPH
L-sorbitol + NADP+
L-sorbose + NADPH + H+
-
21% of the activity with D-mannitol
-
-
r
perseitol + NADP+
? + NADPH
-
6% of the activity compared to D-mannitol
-
?
ribose + NADPH + H+
ribitol + NADP+
-
-
-
-
r
xylose + NADPH + H+
xylitol + NADP+
-
-
-
-
r
additional information
?
-
D-arabinitol + NADP+
D-xylulose + NADPH + H+
-
3% of the activity compared to D-mannitol
-
?
D-arabinitol + NADP+
D-xylulose + NADPH + H+
-
substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
-
?
D-arabinitol + NADP+
D-xylulose + NADPH + H+
Diplodia viticola Desm.
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
Diplodia viticola Desm.
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
?
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
?
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
?
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH
D-mannitol + NADP+
-
-
-
-
r
D-fructose + NADPH + H+
D-mannitol + NADP+
-
-
-
r
D-fructose + NADPH + H+
D-mannitol + NADP+
-
-
-
r
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
-
-
-
-
?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
-
-
-
-
?
D-mannitol + NAD(P)+
D-fructose + NAD(P)H + H+
-
-
-
-
r
D-mannitol + NAD+
D-fructose + NADH + H+
-
less than 0.05% of the activity compared to NADP+
-
?
D-mannitol + NAD+
D-fructose + NADH + H+
-
less than 25% of the activity with NADP+
-
-
r
D-mannitol + NAD+
D-fructose + NADH + H+
-
-
-
-
?
D-mannitol + NAD+
D-fructose + NADH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
mannitol serves as storage carbon, plays a critical role in growth, fruit body development, osmoregulation and salt tolerance
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
Cenococcum graniforme
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
Ceratocystis multiannulata
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
Diplodia viticola Desm.
-
more specific for D-mannitol than for sorbitol or D-arabinitol
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
Diplodia viticola Desm.
-
involved in the mannitol cycle, important for NADPH regeneration
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
only the mutant enzymes D69A amd E68K, the wild-type enzyme utilizes NAD(H) as cofactor, EC 1.1.1.67
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
less than 3% the rate of fructose reduction
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
involved in the mannitol cycle, important for NADPH regeneration
-
?
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
enzyme regulation mode, overview
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
the enzyme has a dual role in mannitol metabolism, D-mannitol is the main storage sugar in spores
-
-
r
D-mannitol + NADP+
D-fructose + NADPH + H+
-
the reverse reaction occurs only when D-fructose is provided as substrate, and is preferred
-
-
r
D-sorbitol + NADP+
D-sorbose + NADPH + H+
-
21% of the activity compared to D-mannitol
-
?
D-sorbitol + NADP+
D-sorbose + NADPH + H+
-
-
-
-
?
L-arabinitol + NADP+
L-xylulose + NADPH + H+
-
2% of the activity compared to D-mannitol
-
?
L-arabinitol + NADP+
L-xylulose + NADPH + H+
-
5% of the activity compared to D-mannitol
-
?
L-sorbitol + NADP+
L-sorbose + NADPH
-
7.7% of the activity compared to D-mannitol
-
?
L-sorbitol + NADP+
L-sorbose + NADPH
-
substrate must have a primary hydroxyl group at C1, an R hydroxyl at C2, an R hydroxyl at C3, an R hydroxyl at C4 and either an R or S or primary hydroxyl at C5
-
r
L-sorbitol + NADP+
L-sorbose + NADPH
Diplodia viticola Desm.
-
-
-
r
L-sorbitol + NADP+
L-sorbose + NADPH
-
4% of the activity compared to D-mannitol
-
r
L-sorbitol + NADP+
L-sorbose + NADPH
-
4% of the activity compared to D-mannitol
-
r
L-sorbitol + NADP+
L-sorbose + NADPH
-
4% of the activity compared to D-mannitol
-
r
additional information
?
-
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
-
-
?
additional information
?
-
-
the enzyme is the major allergen in the organism causing allergic reaction e.g. in humans
-
-
?
additional information
?
-
-
the enzyme is able to reduce D-fructose, L-sorbose, and 5-keto D-gluconate in the presence of NADPH as an electron donor
-
-
?
additional information
?
-
-
no substrate: glucose, xylose, arabinose
-
-
?
additional information
?
-
-
specific for transferring the 4-pro-S hydrogen from NAD(P)H
-
-
?
additional information
?
-
-
specific for transfer of 4-pro-S hydrogen of NADPH
-
-
?
additional information
?
-
the enzyme has a high preference only for D-fructose and D-mannitol, while D-mannose, D-arabinose, D-ribose, D-glucose, D-galactose, D-xylose, D-sorbose and D-sorbitol show only poor activity
-
-
?
additional information
?
-
-
the enzyme has a high preference only for D-fructose and D-mannitol, while D-mannose, D-arabinose, D-ribose, D-glucose, D-galactose, D-xylose, D-sorbose and D-sorbitol show only poor activity
-
-
?
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1,10-phenanthroline
inhibits 96% at 4 mM, reduction reaction
Ca2+
inhibits 21% at 1 mM, reduction reaction
dithiothreitol
-
0.5 mM, complete inhibition
DTT
inhibits 89% at 0.5 mM, reduction reaction
Fe2+
-
86% inhibition at 1 mM
glutathione
-
0.5 mM, complete inhibition
KCl
-
half Vmax/Km at less than 0.1 M due to general ionic strength effect
KNO3
-
half Vmax/Km at less than 0.1 M due to general ionic strength effect
L-cysteine
-
0.5 mM, complete inhibition
Mg2+
inhibits 19% at 1 mM, reduction reaction
NaCl
-
half Vmax/Km at less than 0.1 M due to general ionic strength effect
p-chloromercuribenzoate
-
0.2 mM, complete inhibition
Sn2+
-
29% inhibition at 1 mM
2-mercaptoethanol
-
0.5 mM, complete inhibition
2-mercaptoethanol
inhibits 38% at 25 mM, reduction reaction
Cd2+
-
more potent inhibitor than Zn2+, reversible
Cd2+
-
65% inhibition at 0.002 mM
Cu2+
-
inactivation
Cu2+
-
complete inhibition at 1 mM
Cu2+
inhibits 81% at 0.005 mM, reduction reaction
D-fructose
substrate inhibition occurred at concentrations above 750 mM
D-fructose
-
inhibitory above 600 mM
D-fructose
inhibition patterns, overview
D-mannitol
-
-
D-mannitol
inhibition patterns, overview
EDTA
-
10 mM, 60% inhibition
EDTA
-
93% inhibition at 10 mM within 20 min, reversible by Zn2+ which restores 66% of control activity at 20 mM
Hg2+
Diplodia viticola Desm.
-
90% inhibition of D-mannitol oxidation at 1 mM
Hg2+
-
complete inhibition at 1 mM
Mn2+
-
11% inhibition at 1 mM
Mn2+
inhibits 43% at 1 mM, reduction reaction
NADP+
-
D-fructose reduction, NADP+/NADPH ratio of 38 necessary for 50% inhibition
NADP+
-
inhibition of fructose reduction, NADP+/NADPH ratio of 4:1 necessary for half maximal activity
NADP+
inhibition patterns, overview
NADPH
-
D-mannitol oxidation, NADPH/NADP+ ratio of 0.1 necessary for 50% inhibition
NADPH
-
inhibition of D-mannitol oxidation, NADP+/NADPH ratio of 0.25 necessary for half maximal activity
NADPH
-
inhibitory above 0.3 mM
NADPH
inhibition patterns, overview
Zn2+
-
reversible inhibition
Zn2+
-
30% inhibition at 0.02 mM
Zn2+
inhibits 76% at 0.01 mM, reduction reaction
additional information
-
not inhibitory: CaCl2, MgCl2, Cocl2, dithiothreitol
-
additional information
no inhibition by GSH, Fe2+, and EDTA
-
additional information
-
no inhibition by GSH, Fe2+, and EDTA
-
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385
arabinose
-
pH 7.5, 37°C
352
D-mannose
-
pH 7.5, 37°C
9
NAD+
-
pH 6.2, 37°C, recombinant enzyme
212
ribose
-
pH 7.5, 37°C
402
xylose
-
pH 7.5, 37°C
additional information
additional information
-
0.804
D-fructose
-
pH 5.2, recombinant enzyme
20
D-fructose
-
pH 5.5, 30°C
28
D-fructose
-
pH 7.5, 37°C
34
D-fructose
-
pH 5.4, 37°C, recombinant enzyme
47
D-fructose
reduction reaction, pH 7.5, 37°C
117
D-fructose
plusminus 20 mM, pH 7.5, room temperature
290
D-fructose
-
cosubstrate NADPH, pH 7.0, 30°C
474
D-fructose
+/- 80 mM, pH 7.0, room temperature
474
D-fructose
plusminus 80 mM, pH 7.0, room temperature
1170
D-fructose
pH 7.5, 22°C
1200
D-fructose
-
at pH 7.0
0.46
D-mannitol
-
-
16.2
D-mannitol
-
pH 10.25 and pH 7.0
33
D-mannitol
plusminus 5 mM, pH 7.5, room temperature
40
D-mannitol
-
cosubstrate NADP+, pH 9.0, 30°C
54
D-mannitol
-
pH 6.2, 37°C, recombinant enzyme
57
D-mannitol
-
cosubstrate NADP+, pH 7.0, 30°C
78
D-mannitol
-
pH 10.0, recombinant enzyme
128
D-mannitol
Diplodia viticola Desm.
-
-
230
D-mannitol
pH 7.5, 22°C
600
D-mannitol
oxidation reaction, pH 9.0, 37°C
680
D-mannitol
-
pH 7.5, 37°C
0.24
NADH
-
pH 5.4, 37°C, recombinant enzyme
0.612
NADH
-
pH 7.5, 37°C
0.014
NADP+
-
-
0.0256
NADP+
-
at pH 10.0, temperature not specified in the publication
0.034
NADP+
-
pH 10.0, recombinant enzyme
0.066
NADP+
oxidation reaction, pH 9.0, 37°C
0.067
NADP+
plusminus 0.007 mM, pH 7.5, room temperature
0.078
NADP+
-
cosubstrate mannitol, pH 9.0, 30°C
0.082
NADP+
Diplodia viticola Desm.
-
-
0.14
NADP+
-
cosubstrate mannitol, pH 7.0, 30°C
0.35
NADP+
-
pH 6.2, 37°C, recombinant enzyme
0.00525
NADPH
-
-
0.0187
NADPH
+/- 0.0035 mM, pH 7.0, room temperature
0.0187
NADPH
plusminus 0.0035 mM, pH 7.0, room temperature
0.038
NADPH
-
pH 5.2, recombinant enzyme
0.04
NADPH
-
pH 5.4, 37°C, recombinant enzyme
0.053
NADPH
plusminus 0.01 mM, pH 7.5, room temperature
0.0578
NADPH
-
pH 7.5, 37°C
0.07
NADPH
-
cosubstrate fructose, pH 7.0, 30°C
0.1
NADPH
reduction reaction, pH 7.5, 37°C
additional information
additional information
-
kinetic and thermodynamic analysis, recombinant enzyme
-
additional information
additional information
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
Michaelis-Menten kinetics, overview
-
additional information
additional information
-
steady-state kinetic analysis, recombinant mutant enzymes, overview
-
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Grant, C.R.; Rees, T.A.
Sorbitol metabolism by apple seedlings
Phytochemistry
20
1505-1511
1981
Laminaria digitata
-
brenda
Singh, M.; Scrutton, N.S.; Scrutton, M.C.
NADPH generation in Aspergillus nidulans: is the mannitol cycle involved?
J. Gen. Microbiol.
134
643-654
1988
Aspergillus nidulans
brenda
Hult, K.; Veide, A.; Gatenbeck, S.
The distribution of the NADPH regenerating mannitol cycle among fungal species
Arch. Microbiol.
128
253-255
1980
Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Thermomyces lanuginosus, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus
brenda
Stoop, J.M.H.; Mooibroek, H.
Cloning and characterization of NADP-dependent dehydrogenase cDNA from the button mushroom, Agaricus bisporus, and its expression in response to NaCl stress
Appl. Environ. Microbiol.
64
4689-4696
1998
Agaricus bisporus
brenda
Adachi, O.; Toyama, H.; Matsushita, K.
Crystalline NADP-dependent D-mannitol dehydrogenase from Gluconobacter suboxydans
Biosci. Biotechnol. Biochem.
63
402-407
1999
Gluconobacter oxydans, Gluconobacter oxydans IFO 12528
brenda
Kulkarni, R.K.
Mannitol metabolism in Lentinus edodes, the shiitake mushroom
Appl. Environ. Microbiol.
56
250-253
1990
Lentinula edodes
brenda
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