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1.1.3.15: (S)-2-hydroxy-acid oxidase

This is an abbreviated version!
For detailed information about (S)-2-hydroxy-acid oxidase, go to the full flat file.

Word Map on EC 1.1.3.15

Reaction

an (S)-2-hydroxy carboxylate
+
O2
=
a 2-oxo carboxylate
 +
H2O2

Synonyms

(L)-2-HAOX, (S)-2-hydroxy-acid oxidase, peroxisomal, 2-hydroxy acid oxidase, CSUB_C1080, EC 1.1.3.1, GLO, Glo1, GLO3, Glo4, glycolate oxidase, GO, GO1, GOX, GOX1, GOX2, HAO1, Hao2, HAOX, HAOX1, HAOX2, HAOX3, hydroxy-acid oxidase A, hydroxy-acid oxidase B, hydroxyacid oxidase 1, hydroxyacid oxidase A, L-2-hydroxy acid oxidase, L-2-hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, L-amino acid oxidase, L-LAC-OX, L-lactate monooxygenase, L-lactate oxidase, L-LOx, lactate oxidase, LCHAO, LctO, lHAOX1, lHAOX2, long chain hydroxy acid oxidase, long chain l-2-hydroxy acid oxidase, long chain L-2-hydroxy acid oxidase 2, long-chain 2-hydroxy acid oxidase, long-chain L-alpha-hydroxy acid oxidase, LOX, More, NbS00005125g0015, NbS00060838g0004, Nbv5tr6245008, Os03g0786100, Os04g0623500, Os07g0616500, oxidase, L-2-hydroxy acid, RCOM_0631490, RCOM_0684800

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.15 (S)-2-hydroxy-acid oxidase

Expression

Expression on EC 1.1.3.15 - (S)-2-hydroxy-acid oxidase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Arabidopsis thaliana plants overexpressing glycolate oxidase in chloroplasts accumulates both hydrogen peroxide and glyoxylate, enzyme-overexpressing plants show retarded development, yellowish rosettes, and impaired photosynthetic performance. The plants develop oxidative stress lesions under photorespiratory conditions but grow like wild-type plants under nonphotorespiratory conditions
expression increases about 65-75% in the booting and heading stages but not in other developmental periods. GLO1 transcripts increase by 60% under PEG treatment
expression is induced by 35% by NaCl treatment
expression is induced by NaCl, abscisic acid, H2O2 and AlCl3 treatments
expression is suppressed by 25-40% under abscisic acid, H2O2 and AlCl3 treatments
expression levels of isoform GLO3 are very low in rice leaves throughout all developmental periods
GLO1 transcripts decrease about 35-40% under NaCl and abscisic acid treatments
the metabolic gene HAO2 is downregulated in hepatocellular carcinoma. Hao2 downregulation is species- and etiology-independent in humans and rodents
the suppression effect of estradiol is dependent on the concentration of estradiol. A reduction of about 60% is observed when 0.001 mM estradiol is applied for 10 d, and the maximal reduction of over 90% occurs at 0.005 mM