1.1.2.4: D-lactate dehydrogenase (cytochrome)
This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (cytochrome), go to the full flat file.
Word Map on EC 1.1.2.4
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1.1.2.4
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l-ildh
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kluyveromyces
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hansenula
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polymorpha
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lactis
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1.1.2.3
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euglena
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gracilis
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amperometric
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dl-lactate
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protist
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ruminantium
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d-lactic
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c-oxidoreductase
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rumen
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mixed-type
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methylotrophic
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non-fermentable
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thermotolerant
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selenomonas
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synthesis
- 1.1.2.4
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l-ildh
-
kluyveromyces
-
hansenula
- polymorpha
- lactis
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1.1.2.3
- euglena
- gracilis
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amperometric
- dl-lactate
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protist
- ruminantium
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d-lactic
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c-oxidoreductase
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rumen
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mixed-type
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methylotrophic
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non-fermentable
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thermotolerant
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selenomonas
- synthesis
Reaction
+ = + 2 ferrocytochrome c + 2 H+
Synonyms
AtD-LDH, cytochrome-dependent D-(-)-lactate dehydrogenase, cytochromec-dependent D-LDH, D(-)-lactic cytochrome c reductase, D-iLDH, D-lactate cytochrome c oxidoreductase, D-lactate dehydrogenase (cytochrome), D-lactate dehydrogenase [cytochrome], mitochondrial, D-lactate ferricytochrome c oxidoreductase, D-lactate-cytochrome c reductase, D-lactate: cytochrome c oxidoreductase, D-LCR, D-LDH, DLD, DLD1, DLDH, glycolate deshydrogenase, iLDH, L-lactate-cytochrome c oxidoreductase, lactic acid dehydrogenase, NAD+-independent LDH, Os07g06890
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General Information
General Information on EC 1.1.2.4 - D-lactate dehydrogenase (cytochrome)
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malfunction
metabolism
physiological function
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under methylglyoxal treatment, silencing of OsD-LDH in rice results in the accumulation of methylglyoxal and D-lactate, the decrease of reduced glutathione in leaves, and ultimately severe growth inhibition. The silencing of OsD-LDH does not affect the growth under photorespiration conditions
malfunction
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under methylglyoxal treatment, silencing of OsD-LDH in rice results in the accumulation of methylglyoxal and D-lactate, the decrease of reduced glutathione in leaves, and ultimately severe growth inhibition. The silencing of OsD-LDH does not affect the growth under photorespiration conditions
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prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria being twofold higher in cancer compared to healthy cells, overview
metabolism
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the enzyme participates in methylglyoxal metabolism by affecting the activity of the glyoxalase system and aldoketo reductases
metabolism
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the enzyme participates in methylglyoxal metabolism by affecting the activity of the glyoxalase system and aldoketo reductases
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physiological function
the mitochondrial D-lactate dehydrogenase, a membrane flavoprotein, from both cancer (PC-3) and normal (PNT1A) prostate cells can metabolize D-lactate in an energy competent manner
physiological function
transgenic plants overexpressing both D-LDH and cytochrome c have enhanced capacity to detoxify D-lactate and methylglyoxal, indicating that both proteins can be limiting factors in the detoxification process