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1.1.1.B47: succinate semialdehyde reductase (NADPH)

This is an abbreviated version!
For detailed information about succinate semialdehyde reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.B47

Reaction

4-hydroxybutanoate
+
NADP+
=
succinate semialdehyde
+
NADPH
+
H+

Synonyms

At3g25530, AtGLYR1, Msed_1424, SSA, succinate semialdehyde reductase, succinic semialdehyde reductase, succinic semialdehyde reductase (NADPH)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B47 succinate semialdehyde reductase (NADPH)

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.B47 - succinate semialdehyde reductase (NADPH)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
succinate semialdehyde + NADPH + H+
4-hydroxybutanoate + NADP+
show the reaction diagram
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
show the reaction diagram
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additional information
?
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the recombinant AtGLYR1 prefers NADPH over NADH and converts glyoxylate to glycolate, the enzyme has negligible hydroxypyruvate-dependent activity. Isozyme AtGLYR1 also converts succinic semialdehyde to gamma-hydroxybutyrate, albeit with much lower catalytic efficiency than for glyoxylate
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