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1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)

This is an abbreviated version!
For detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.

Word Map on EC 1.1.1.B4

Reaction

(R)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

(R)-1-phenylethanolsynthase, (R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, RPES, SADH, SDR, secondary alcohol dehydrogenase, short chain dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B4 (R)-specific secondary alcohol dehydrogenase (NADH)

Reference

Reference on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pennacchio, A.; Pucci, B.; Secundo, F.; La Cara, F.; Rossi, M.; Raia, C.A.
Purification and characterization of a novel recombinant highly enantioselective short-chain NAD(H)-dependent alcohol dehydrogenase from Thermus thermophilus
Appl. Environ. Microbiol.
74
3949-3958
2008
Thermus thermophilus
Manually annotated by BRENDA team
Isobe, K.; Wakao, N.
Thermostable NAD+-dependent (R)-specific secondary alcohol dehydrogenase from cholesterol-utilizing Burkholderia sp. AIU 652
J. Biosci. Bioeng.
96
387-393
2003
Burkholderia sp., Burkholderia sp. AIU 652
Manually annotated by BRENDA team
Bradshaw, C.W.; Fu, H.; Shen, G.-J.; Wong, C.-H
A Pseudomonas sp. alcohol dehydrogenase with broad substrate specificity and unusual stereospecificity for organic synthesis
J. Org. Chem.
57
1526-1532
1992
Pseudomonas sp., Pseudomonas sp. PED
-
Manually annotated by BRENDA team
Nie, Y.; Xu, Y.; Yang, M.; Mu, X.Q.
A novel NADH-dependent carbonyl reductase with unusual stereoselectivity for (R)-specific reduction from an (S)-1-phenyl-1,2-ethanediol-producing micro-organism: purification and characterization
Lett. Appl. Microbiol.
44
555-562
2007
Candida parapsilosis
Manually annotated by BRENDA team
Pal, S.; Park, D.H.; Plapp, B.V.
Activity of yeast alcohol dehydrogenases on benzyl alcohols and benzaldehydes: characterization of ADH1 from Saccharomyces carlsbergensis and transition state analysis
Chem. Biol. Interact.
178
16-23
2009
Saccharomyces cerevisiae, Saccharomyces pastorianus, Saccharomyces pastorianus Y379-50
Manually annotated by BRENDA team
Pennacchio, A.; Esposito, L.; Zagari, A.; Rossi, M.; Raia, C.A.
Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase
Extremophiles
13
751-761
2009
Saccharolobus solfataricus
Manually annotated by BRENDA team
Machielsen, R.; Looger, L.; Raedts, J.; Dijkhuizen, S.; Hummel, W.; Henneman, H.; Daussmann, T.; van der Oost, J.
Cofactor engineering of Lactobacillus brevis alcohol dehydrogenase by computational design
Eng. Life Sci.
9
38-44
2009
Levilactobacillus brevis
-
Manually annotated by BRENDA team
Zhou, S.; Zhang, S.C.; Lai, D.Y.; Zhang, S.L.; Chen, Z.M.
Biocatalytic characterization of a short-chain alcohol dehydrogenase with broad substrate specificity from thermophilic Carboxydothermus hydrogenoformans
Biotechnol. Lett.
35
359-365
2013
Carboxydothermus hydrogenoformans (Q3ACV3), Carboxydothermus hydrogenoformans DSM 6008 (Q3ACV3)
Manually annotated by BRENDA team
Protsko, C.; Vieille, C.; Laivenieks, M.; Prasad, L.; Sanders, D.A.; Delbaere, L.T.
Crystallization and preliminary X-ray diffraction analysis of the Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase I86A mutant
Acta Crystallogr. Sect. F
66
831-833
2010
Thermoanaerobacter ethanolicus (P77990), Thermoanaerobacter ethanolicus
Manually annotated by BRENDA team
Li, Y.; Xu, J.; Xu, Y.
Deracemization of aryl secondary alcohols via enantioselective oxidation and stereoselective reduction with tandem whole-cell biocatalysts
J. Mol. Catal. B
64
48-52
2010
Microbacterium oxydans, Microbacterium oxydans ECU2010
-
Manually annotated by BRENDA team
Aggarwal, N.; Mandal, P.K.; Gautham, N.; Chadha, A.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of carbonyl reductase from Candida parapsilosis ATCC 7330
Acta Crystallogr. Sect. F
69
313-315
2013
Candida parapsilosis (M4VRJ6), Candida parapsilosis ATCC 7330 (M4VRJ6)
Manually annotated by BRENDA team
Wang, N.Q.; Sun, J.; Huang, J.; Wang, P.
Cloning, expression, and directed evolution of carbonyl reductase from Leifsonia xyli HS0904 with enhanced catalytic efficiency
Appl. Microbiol. Biotechnol.
98
8591-8601
2014
Leifsonia xyli (T2FLN4), Leifsonia xyli HS0904 (T2FLN4)
Manually annotated by BRENDA team
Chen, R.; Liu, X.; Wang, J.; Lin, J.; Wei, D.
Cloning, expression, and characterization of an anti-Prelog stereospecific carbonyl reductase from Gluconobacter oxydans DSM2343
Enzyme Microb. Technol.
70
18-27
2015
Gluconobacter oxydans, Gluconobacter oxydans DSM 2343
Manually annotated by BRENDA team
Nealon, C.M.; Welsh, T.P.; Kim, C.S.; Phillips, R.S.
I86A/C295A mutant secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus has broadened substrate specificity for aryl ketones
Arch. Biochem. Biophys.
606
151-156
2016
Thermoanaerobacter ethanolicus
Manually annotated by BRENDA team
Peng, Y.; Zhang, Y.
Continuous preparation of (R)-phenyl-ethanediol by catalysis of nanoparticles immobilized bi-enzyme coupling system
Chin. J. Proc. Engin.
16
286-291
2016
Morganella morganii, Morganella morganii CMCC(B)49208
-
Manually annotated by BRENDA team
He, S.; Wang, Z.; Zou, Y.; Chen, S.; Xu, X.
Purification and characterization of a novel carbonyl reductase involved in oxidoreduction of aromatic beta-amino ketones/alcohols
Process Biochem.
49
1107-1112
2014
Kocuria rhizophila
-
Manually annotated by BRENDA team
Zhou, Y.; Peng, Q.; Zhang, L.; Cheng, S.; Zeng, L.; Dong, F.; Yang, Z.
Characterization of enzymes specifically producing chiral flavor compounds (R)- and (S)-1-phenylethanol from tea (Camellia sinensis) flowers
Food Chem.
280
27-33
2019
Camellia sinensis (A0A494WKI6)
Manually annotated by BRENDA team