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1.1.1.B38: hydroxymethylglutaryl-CoA reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.1.1.B38

Reaction

mevalonate
+
CoA
+ 2 NAD(P)+ =
3-hydroxy-3-methylglutaryl-CoA
+ 2 NAD(P)H + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl coenzyme A reductase, AF1736, class II HMG-CoA reductase, HGMR, HMG-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B38 hydroxymethylglutaryl-CoA reductase [NAD(P)H]

KCat KM Value

KCat KM Value on EC 1.1.1.B38 - hydroxymethylglutaryl-CoA reductase [NAD(P)H]

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5
NAD+
pH 10.0, 50°C
0.86 - 2
NADH
0.25
NADP+
pH 7.0, 50°C
1 - 240
NADPH