1.1.1.B18: L-1-amino-2-propanol dehydrogenase
This is an abbreviated version!
For detailed information about L-1-amino-2-propanol dehydrogenase, go to the full flat file.
Reaction
Synonyms
AADH, amino alcohol dehydrogenase, L-1-amino-2-propanol dehydrogenase, NADP+-dependent aminoalcohol dehydrogenase
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.B18 - L-1-amino-2-propanol dehydrogenase
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REACTION DIAGRAM
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
-
-
-
r
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
-
conversion with with more than 99% enantiomeric excess, 78% yield and a productivity of 3.9 mmol(S)-phenylepinephrine/l h in 12 h at 30°C and pH 7
-
?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
-
i.e. D-pseudoephedrine
-
?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
diastereoselective reduction
i.e. d-psi-pseudoephedrine, molar reaction yields of 89.1% and more than 99% enantiomeric and diastereomeric excess
-
?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
-
conversion with with more than 99% enantiomeric excess, 78% yield and a productivity of 3.9 mmol(S)-phenylepinephrine/l h in 12 h at 30°C and pH 7
-
?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
-
i.e. D-pseudoephedrine
-
?
(2S)-2-(methylamino)-1-phenylpropan-1-one + NADPH + H+
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + NADP+
-
-
-
r
? + NADP+
95% of the activity with L-1-amino-2-propanol
-
-
?
DL-1-amino-2-butanol + NADPH + H+
? + NADP+
95% of the activity with L-1-amino-2-propanol
-
-
?
? + NADP+
50% of the activity with L-1-amino-2-propanol
-
-
?
DL-2-aminocyclohexanol + NADPH + H+
? + NADP+
50% of the activity with L-1-amino-2-propanol
-
-
?
? + NADP+
best substrate
-
-
?
L-1-amino-2-propanol + NADPH + H+
? + NADP+
best substrate
-
-
?
?
-
no substrate: D-1-amino-2-propanol, 2-aminoethanol, 2-bromoethanol, 2-buten-1-ol, 2-propen-1-ol, 2-phenylethanol, 3-phenyl-1-propanol, 2,5-hexanediol, trimethyleneglycol, 1-nonanol, 1-decanol, 1-dodecanol, 2-butanol, 1,3-butanediol and 1,4-butanediol
-
-
?
additional information
?
-
-
no substrate: D-1-amino-2-propanol, 2-aminoethanol, 2-bromoethanol, 2-buten-1-ol, 2-propen-1-ol, 2-phenylethanol, 3-phenyl-1-propanol, 2,5-hexanediol, trimethyleneglycol, 1-nonanol, 1-decanol, 1-dodecanol, 2-butanol, 1,3-butanediol and 1,4-butanediol
-
-
?
additional information
?
-
no substrate: D-1-amino-2-propanol, 2-aminoethanol, 2-bromoethanol, 2-buten-1-ol, 2-propen-1-ol, 2-phenylethanol, 3-phenyl-1-propanol, 2,5-hexanediol, trimethyleneglycol, 1-nonanol, 1-decanol, 1-dodecanol, 2-butanol, 1,3-butanediol and 1,4-butanediol
-
-
?
additional information
?
-
-
no substrate: D-1-amino-2-propanol, 2-aminoethanol, 2-bromoethanol, 2-buten-1-ol, 2-propen-1-ol, 2-phenylethanol, 3-phenyl-1-propanol, 2,5-hexanediol, trimethyleneglycol, 1-nonanol, 1-decanol, 1-dodecanol, 2-butanol, 1,3-butanediol and 1,4-butanediol
-
-
?