1.1.1.87: homoisocitrate dehydrogenase

This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.87

1.1.1.87

alpha-aminoadipate

3-isopropylmalate

homocitrate

homoaconitase

beta-decarboxylating

alpha-ketoadipate

medicine

synthesis

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

Synonyms

(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.87 homoisocitrate dehydrogenase

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Results	in table
2	Activating Compound
335	AA Sequence
5	Application
2	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
8	General Information
2	General Stability
3	IC50 Value
32	Inhibitors
40	kcat/KM [mM/s]
15	Ki Value [mM]
93	KM Value [mM]
30	Metals/Ions
8	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
58	Organism
9	Pathway
14	PDB ID
17	pH Optimum
6	pH Range
1	pH Stability
23	Protein Variants
11	Purification (Commentary)
3	Reaction
4	Reaction Type
30	Reference
9	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
93	Substrates and Products (Substrate)
10	Subunits
41	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
2	Temperature Stability [°C]
63	Turnover Number [1/s]

Purification

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Purification on EC 1.1.1.87 - homoisocitrate dehydrogenase

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3 entries

Ni-NTA His-Bind column chromatography

Thermococcus kodakarensis

760522

partial

Saccharomyces cerevisiae

644541, 644543

recombinant enzyme from Escherichia coli by anion exchange chromatography and gel filtration

Saccharomyces cerevisiae

667934

recombinant enzyme from Escherichia coli strain OM17 by anion exchange and hydrophobic interaction chromatography, followed by another step of anion exchange chromatography

Deinococcus radiodurans

660918

recombinant His-tagged enzyme from Escherichia coli strain TOP 10F by nickel affinity chromatography'

Candida albicans

722303

recombinant His-tagged wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by nickel affinity chrmatography

Saccharomyces cerevisiae

P40495

739958

recombinnat His-tagged enzyme from Escherichia coli by metal affinity chromatography

Pyrococcus horikoshii

A4CYJ9

660907