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1.1.1.8: glycerol-3-phosphate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.8

Reaction

sn-glycerol 3-phosphate
+
acceptor
=
glycerone phosphate
+
reduced acceptor

Synonyms

(NAD+)-dependent G3pdh, (NAD+)-dependent glycerol-3-phosphate dehydrogenase, 100383152, alpha glycerophosphate dehydrogenase, alpha-glycerol phosphate dehydrogenase (NAD), alpha-glycerophosphate dehydrogenase (NAD), Cagpd1, Cagpd1p, Cagpd2, Cagpd2p, cG3PDH, CgGPD, cGPdH, cytoplasmic NAD-dependent glycerol-3-phosphate dehydrogenase, cytosolic GPDH, dehydrogenase, glycerol phosphate, DhGPD1, G-3-P dehydrogenase, G3P dehydrogenase, G3PD, G3PD1, G3PD2, G3PD3, G3PDH, GDM, GDP2, GLPD, GLY1, glycerol 1-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase 1, glycerol phosphate dehydrogenase (NAD), glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerophosphate dehydrogenase (NAD), GPD, GPD1, Gpd1p, gpd2p, GPDH, GPDH-1, GPDH-2, GPDH1, GPDH2, GPDH3, GPDH4, GPDH5, GPDH: NAD+ 2 oxidoreductase, GPDH: NAD+ 2 oxidorreductase, GPDHc1, GRMZM2G090747_T01, GRMZM2G155348_T01, GRMZM2G173195_T01, GRMZM6G161711_T01, hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol 3-phosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, mGPDH, NAD+-dependent G3P dehydrogenase, NAD+-dependent glycerol 3-phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-GPDH, NAD-alpha-glycerophosphate dehydrogenase, NAD-dependent cG3PDH, NAD-dependent glycerol phosphate dehydrogenase, NAD-dependent glycerol-3-phosphate dehydrogenase, NAD-L-glycerol-3-phosphate dehydrogenase, NAD-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, NADP+-dependent glycerol 3-phosphate dehydrogenase, SFD1, SFD1/GLY1, ZEAMMB73_Zm00001d010670, ZEAMMB73_Zm00001d041962, ZEAMMB73_Zm00001d042152, ZmGPDH1, ZmGPDH3, ZmGPDH4, ZmGPDH5

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)

Source Tissue

Source Tissue on EC 1.1.1.8 - glycerol-3-phosphate dehydrogenase (NAD+)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
very low expression level
Manually annotated by BRENDA team
-
mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A
Manually annotated by BRENDA team
-
mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A
Manually annotated by BRENDA team
high expression level
Manually annotated by BRENDA team
-
adipofibroblast, embryonic cell culture, up to 10fold increase of activity in presence of chicken serum, further increase in presence of embryonic chicken serum
Manually annotated by BRENDA team
-
in adult worms on tegument urface, and in metacercaria on tegument and tegumentary cells
Manually annotated by BRENDA team
very low expression level
Manually annotated by BRENDA team
-
mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A
Manually annotated by BRENDA team
and cerebellum, similar expression pattern that is at a low level at birth and increasing with aging to the highest level at postnatal day 8 in longissinus dorsi muscle and postnatal day 14 in cerebrum. Weaning decreases the expression level of the GPD1 gene
Manually annotated by BRENDA team
-
mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A
Manually annotated by BRENDA team
-
mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A
Manually annotated by BRENDA team
high level of transcripts accumulation in roots and early stage developing seeds
Manually annotated by BRENDA team
-
in the absence of Gpd2, hyperactivation and acrosome reaction are significantly altered, and a few changes in protein tyrosine phosphorylation are also observed during capacitation. GPD2 activity is required for generation of reactive oxygen species in mouse spermatozoa during capacitation, failing which, capacitation is impaired
Manually annotated by BRENDA team
additional information