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1.1.1.75: (R)-aminopropanol dehydrogenase

This is an abbreviated version!
For detailed information about (R)-aminopropanol dehydrogenase, go to the full flat file.

Reaction

(R)-1-aminopropan-2-ol
+
NAD+
=
aminoacetone
+
NADH
+
H+

Synonyms

1-aminopropan-2-ol-dehydrogenase, 1-aminopropan-2-ol-NAD+ dehydrogenase, AADH, DL-1-aminopropan-2-ol: NAD+ dehydrogenase, L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase, L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase, L-1-amino-2-propanol dehydrogenase, L-aminopropanol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.75 (R)-aminopropanol dehydrogenase

Cloned

Cloned on EC 1.1.1.75 - (R)-aminopropanol dehydrogenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene aadh, DNA and amino acid sequence determination and analysis, expression in Escherichia coli JM109 leading to a 10.4fold increase in specific activity as to catalysis of the reduction of (S)-1-phenyl-2-methylaminopropan-1-one, as compared with that of Rhodococcus erythropolis strain MAK154 induced by 1-amino-2-propanol. Coexpression of aadh with glucose dehydrogenase gene gdh as cofactor regeneration enzyme, and installation of a system for sufficient production of d-psi-pseudoephedrine from racemic (S)-1-phenyl-2-methylaminopropan-1-one