1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.64
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1.1.1.64
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androgen
-
testis
-
17beta-hsd3
-
androstenedione
-
testicular
-
leydig
-
hsd17b3
-
steroidogenic
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puberty
-
5alpha-reductase
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pseudohermaphroditism
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genitalia
-
dehydrogenase-3
-
estrone
-
p450scc
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medicine
-
drug development
-
diagnostics
- 1.1.1.64
- androgen
- testis
- 17beta-hsd3
- androstenedione
- testicular
- leydig
- hsd17b3
-
steroidogenic
-
puberty
-
5alpha-reductase
- pseudohermaphroditism
-
genitalia
-
dehydrogenase-3
- estrone
- p450scc
- medicine
- drug development
- diagnostics
Reaction
Synonyms
17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-HSD5, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, HSD17B3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase
ECTree
1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2,3,4-tetrahydro-1-naphthol + NADP+
1,2,3,4-tetrahydro-1-naphthone + NADPH
-
isoenzymes 1 and 2
-
r
1-acenaphthenol + NADP+
1-acenaphthenone + NADPH
-
isoenzymes 1 and 2
-
r
19-nortestosterone + NADP+
19-norandrostenedione + NADPH
-
93% activity compared to testosterone oxidation
-
r
5alpha-androstane-17beta-ol-3-one + NADP+
5alpha-androstane-3,17-dione + NADPH
-
30% activity compared to testosterone oxidation
-
r
5alpha-dihydrotestosterone + NADP+
5alpha-17-oxo-dihydrotestosterone + NADPH
-
isoenzymes 1 and 2
-
r
5beta-androstane-17beta-ol + NADP+
5alpha-androstane-17-one + NADPH
-
117% activity compared to testosterone oxidation
-
r
5beta-androstane-17beta-ol-3-one + NADP+
5beta-androstane-3,17-dione + NADPH
-
330% activity compared to testosterone oxidation
-
r
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-3alpha-ol-17-one + NADPH + H+
5beta-androstane-3beta,17beta-diol + NADP+
5alpha-androstane-3beta-ol-17-one + NADPH
-
-
-
-
r
benzene dihydrodiol + NADP+
o-benzoquinone + NADPH
-
isoenzymes 1 and 2
-
r
cyclohex-2-en-1-ol + NADP+
cyclohex-2-en-1-one + NADPH
-
isoenzymes 1 and 2
-
r
dehydroepiandrosterone + NADPH
androst-5-ene-3beta,17beta-diol + NADP+
-
-
-
r
pyridine-4-aldehyde + NADPH
pyridine-4-alcohol + NADP+
-
isoenzymes 1 and 2
-
r
additional information
?
-
-
human 17beta-hydroxysteroid dehydrogenases are multifunctional enzymes, isozyme 17beta-HSD4 also performs beta-oxidation of branched fatty acids, like pristanic acid, and in bile acid synthesis, e.g. of di- and trihydroxycholestanoic acids, overview
-
-
?
5alpha-androstane-3alpha,17beta-diol + NADP+
5alpha-androstane-3alpha-ol-17-one + NADPH
-
93% activity compared to testosterone oxidation
-
r
5alpha-androstane-3alpha,17beta-diol + NADP+
5alpha-androstane-3alpha-ol-17-one + NADPH
-
63% activity compared to testosterone oxidation
-
r
5alpha-androstane-3beta,17beta-diol + NADP+
5alpha-androstane-3beta-ol-17-one + NADPH
-
25% activity compared to testosterone oxidation
-
r
5alpha-androstane-3beta,17beta-diol + NADP+
5alpha-androstane-3beta-ol-17-one + NADPH
-
134% activity compared to testosterone oxidation
-
r
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-3alpha-ol-17-one + NADPH + H+
-
1180% activity compared to testosterone oxidation
-
r
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-3alpha-ol-17-one + NADPH + H+
-
-
-
r
5beta-dihydrotestosterone + NADP+
5beta-17-oxo-dihydrotestosterone + NADPH
-
-
-
-
?
5beta-dihydrotestosterone + NADP+
5beta-17-oxo-dihydrotestosterone + NADPH
-
isoenzymes 1 and 2
-
r
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
-
the enzyme plays a central role in the development of the male phenotype. Mutations that inactivate the enzyme give rise to a rare form of male pseudohermaphroditism, referred to as 17beta-HSD-3 deficiency
-
-
?
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
-
convertion of the weak androgen androstendione into the potent androgen testosterone
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-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
the equilibrium state is 92% testosterone to 8% androstenedione
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
the enzyme is involved in biosynthesis of testosterone
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
i.e. 4-androsten-17-ol-3-one
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?
androstenedione + NADPH + H+
testosterone + NADP+
the two reactions 11beta-HSD1-dehydrogenase, EC 1.1.1.146, and 17beta-HSD3, EC 1.1.1.64, which utilize NADPH are competing for NADPH from the same cofactor pool. 11beta-HSD1-dehydrogenase serves as a NADPH-regenerating system that is tightly coupled in regulating 17beta-HSD3 reaction synthesizing testosterone. A cycle can exist whereby the NADPH produced by 11beta-HSD1 dehydrogenase can drive the reductase activity of 17beta-HSD3 and the NADP+ produced by 17beta-HSD3 and other enzymes involved in testosterone biosynthesis can drive the dehydrogenase activity of 11beta-HSD1
i.e. 4-androsten-17beta-ol-3-one
-
?
testosterone + NAD+
androst-4-ene-3,17-dione + NADH + H+
-
NADP+ is preferred
-
r
testosterone + NAD+
androstenedione + NADH
-
NAD+ shows ess than 10% of the activity with NADP+
-
-
ir
testosterone + NAD+
androstenedione + NADH
-
NAD+ shows 20% of the activity with NADP+
-
-
ir
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
17beta-hydroxysteroid dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
17beta-hydroxysteroid dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred
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r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
rate of oxidation is less than 30% of those for reduction
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
?
