1.1.1.62: 17beta-estradiol 17-dehydrogenase
This is an abbreviated version!
For detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.62
-
1.1.1.62
-
progesterone
-
estrone
-
androgen
-
testosterone
-
17beta-hsds
-
ovarian
-
aromatase
-
steroidogenic
-
endometrium
-
androstenedione
-
aldo-keto
-
steroidogenesis
-
progestin
-
granulosa
-
luteal
-
akr1c2
-
alpha-hsd
-
sulfatase
-
medicine
-
alpha-dihydroprogesterone
-
corpora
-
pregnenolone
-
d-bifunctional
-
endometriotic
-
hsd17b3
-
3beta-hydroxysteroid
-
luteolysis
-
cyp19a1
-
alpha-hydroxyprogesterone
-
vlcfas
-
cochliobolus
-
17-ketosteroids
-
hsd3b2
-
3alpha-hydroxysteroid
-
sult1e1
-
5alpha-reductase
-
srd5a1
-
5alpha-dihydrotestosterone
-
lunatus
-
3betahsd
-
p450arom
-
alpha-diol
-
17-keto
-
c19-steroids
-
diagnostics
-
drug development
- 1.1.1.62
- progesterone
- estrone
- androgen
- testosterone
- 17beta-hsds
- ovarian
- aromatase
-
steroidogenic
- endometrium
- androstenedione
-
aldo-keto
-
steroidogenesis
- progestin
-
granulosa
- luteal
- akr1c2
-
alpha-hsd
-
sulfatase
- medicine
-
alpha-dihydroprogesterone
-
corpora
- pregnenolone
-
d-bifunctional
-
endometriotic
- hsd17b3
-
3beta-hydroxysteroid
-
luteolysis
- cyp19a1
-
alpha-hydroxyprogesterone
-
vlcfas
- cochliobolus
-
17-ketosteroids
- hsd3b2
-
3alpha-hydroxysteroid
- sult1e1
-
5alpha-reductase
- srd5a1
- 5alpha-dihydrotestosterone
- lunatus
- 3betahsd
- p450arom
-
alpha-diol
-
17-keto
-
c19-steroids
- diagnostics
- drug development
Reaction
Synonyms
(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-hsd 14, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD10, 17beta-HSD12, 17beta-HSD14, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 1, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 10, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 14, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase type IV, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, 7beta-HSD7, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, aldo-keto reductase 1B15, C6Y55_RS00895, C6Y55_RS01070, C6Y55_RS01190, C6Y55_RS15130, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, HSD17B7, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, NlHsd17b12, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, reductive 17beta-hydroxysteroid dehydrogenase type 7, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase
ECTree
1.1.1.62 17beta-estradiol 17-dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-dimethyl-6-dehydroestrone + NADH
1,2-dimethyl-6-dehydroestradiol + NAD+
-
-
-
-
?
1,4-diacetoxy-1,3,5(10)-estratrien-17-one + NADH
17beta-hydroxy-1,4-diacetoxy-1,3,5(10)-estratriene + NAD+
-
-
-
-
?
1,4-dihydroxy-1,3,5(10)-estratrien-17-one + NADH
1,4,17-trihydroxy-1,3,5(10)-estratrien + NAD+
-
-
-
-
?
11-ketoequilenin acetate + NADH
17beta-hydroxy-11-ketoequilenin acetate + NAD+
-
-
-
-
?
17beta-hydroxyestra-4-en-3-one + NADP+
estra-4-en-3,17-dione + NADPH + H+
-
-
-
-
r
18-nor-D-homoestrone 3-methyl ether + NADH
18-nor-D-homoestradiol 3-methyl ether + NAD+
-
-
-
-
?
19-nortestosterone + NAD+
4-estren-3,17-dione + NADH
-
2% of the activity with estradiol-17beta
-
-
?
2,4-dinitroestrone 3-oxyacetic acid ether + NADH
2,4-dinitroestradiol 3-oxyacetic acid ether + NAD+
-
-
-
-
?
2,5(10)-estradiene-1,4,17-trione + NADH
17beta-hydroxy-2,5(10)-estradiene-1,4-dione + NAD+
-
-
-
-
?
2-nitroestrone 3-oxyacetic acid ester + NADH + H+
2-nitroestradiol-17beta-3-oxyacetic acid ester + NAD+
-
-
-
-
?
3-hydroxy-2,5(10)-estradiene-1,4,17-trione + NADH
3,17beta-dihydroxy-2,5(10)-estradiene-1,4-dione + NAD+
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one + NADPH
3beta,17beta-dihydroxyandrost-5-ene + NADP+
-
i.e. dehydroepiandrosterone
-
-
?
4-aminoestrone 3,4-diacetate + NADH
4-aminoestradiol 3,4-diacetate + NAD+
-
-
-
-
?
4-estrene-3,17-dione + NADH + H+
4-estrene-17beta-ol-3-one + NAD+
-
-
-
r
4-estrene-3,17-dione + NADPH
4-estrene-17beta-ol-3-one + NADP+
-
-
-
-
r
4-estrene-3,17-dione + NADPH + H+
4-estrene-17beta-ol-3-one + NADP+
-
-
-
r
4-methyl-1,3,5(10)-estratriene-1,17beta-diol + NAD+
1-hydroxy-4-methyl-1,3,5(10)-estratriene-17-one + NADH
-
-
-
-
?
4-oestrene-17beta-ol-3-one + NADP+
4-oestrene-3,17-dione + NADPH + H+
-
-
-
?
5,7,9-estratrien-3beta-ol-17-one + NADH
5,7,9-estratriene-3beta,17beta-diol + NAD+
-
-
-
-
?
5,7,9-estratriene-3beta,17beta-diol + NAD+
5,7,9-estratriene-3beta-ol-17-one + NADH
-
-
-
-
?
5-androstene-3beta,17beta-diol + NAD+
5-androstene-3-beta-ol-17-one + NADH
-
5.9% of the activity with estradiol
-
-
?
5-androstene-3beta-ol-17-one + NADPH
5-androstene-3beta,17beta-diol + NADP+
-
-
-
?
5alpha-androstane-3,17-dione + NADH + H+
5alpha-androstane-17beta-ol-3-one + NAD+
-
-
-
r
5alpha-dihydrotestosterone + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
3.2% of the activity with estradiol
-
-
?
5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3,17-dione + NADP+
-
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3,17-dione + NADP+
-
-
-
?
5alpha-dihydrotestosterone + NADPH + H+
? + NADP+
kinetics demonstrates positive cooperativity
-
-
?
5beta-pregnan-20alpha-ol-3-one + NADPH
5beta-pregnane-3,20-dione + NADP+
-
-
-
?
6-dehydroestrone 3-benzoate + NADH
6-dehydro-17beta-estradiol 3-benzoate + NAD+
-
-
-
-
?
6alpha,7alpha-dihydroxyestrone + NADH
6alpha,7alpha-dihydroxyestradiol + NAD+
-
-
-
-
?
androst-4-ene-3,17-dione + NADPH
androst-4-ene-17beta-ol-3-one + NADP+
-
-
-
-
?
androstendiol + NAD(P)+
dehydroepiandrosterone + NAD(P)H + H+
-
-
-
?
androsterone + NAD(P)H
5alpha-androstane-3alpha,17beta-diol + NAD(P)+ + H+
-
-
-
?
androsterone + NADH + H+
5alpha-androstane-3alpha,17beta-diol + NAD+
-
-
-
?
dehydroepiandrosterone + NAD(P)H
5-androstene-3beta,17beta-diol + NAD(P)+
-
-
-
?
dehydroepiandrosterone + NAD(P)H
androst-5-ene-3beta,17beta-diol + NAD(P)+
-
-
-
?
dehydroepiandrosterone + NAD(P)H + H+
androstendiol + NAD(P)+
-
-
-
?
dehydroepiandrosterone + NADPH + H+
5-androstene-3beta,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NADPH + H+
androstenediol + NADP+
-
-
-
?
dihydrotestosterone + NAD(P)H + H+
androstane-3beta,17beta-diol + NAD(P)+
-
-
-
-
?
DL-6-methoxy-3-deoxy-equilenin + NADH + H+
17beta-hydroxy-DL-6-methoxy-3-deoxyequilenin + NAD+
-
-
-
-
?
epitestosterone + NADP+
4-androsten-3,17-dione + NADPH + H+
-
poor substrate
-
-
?
estradiol + NADP+
estrone + NADPH
-
the equilibrium state is 92% estradiol to 8% estrone
-
-
?
estradiol-17alpha + NADP+
estrone + NADPH
-
at about 3% of the activity with estradiol-17beta
-
-
?
estrogenic estrone + NAD(P)H + H+
17beta-estradiol + NAD(P)+
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases
-
-
?
estrone 3-oxyacetic acid ether + NADH
17beta-estradiol 3-O-oxyacetic acid ether + NAD+
-
-
-
-
?
testosterone + NAD(P)+
4-androstene-3,17-dione + NAD(P)H
-
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
-
-
?
17beta-estradiol + NAD+
estrone + NADH + H+
-
high efficiency, over 98% of 17beta-estradiol was oxidized into estrone in 5 min
-
-
?
17beta-estradiol + NAD+
estrone + NADH + H+
ANI02794.1
transformation efficiency of 17beta-estradiol into estrone is over 96.6% in five minutes
-
-
?
17beta-estradiol + NAD+
estrone + NADH + H+
-
high efficiency, over 98% of 17beta-estradiol was oxidized into estrone in 5 min
-
-
?
17beta-estradiol + NAD+
estrone + NADH + H+
ANI02794.1
transformation efficiency of 17beta-estradiol into estrone is over 96.6% in five minutes
-
-
?
20alpha-hydroxy-4-pregnen-3-one + NADP+
4-pregnen-3,20-dione + NADPH
-
low activity
-
-
?
3-O-methyl-17beta-estradiol + NAD+
3-O-methylestrone + NADH
-
85% of the activity with estradiol-17beta
-
-
?
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
17beta-HSD3 and 5, formation of active androgens in testis and prostate
-
-
?
5alpha-androstane-3alpha,17beta-diol + NAD+
androsterone + NADH + H+
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + NAD+
androsterone + NADH + H+
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
-
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
50% of the activity with estradiol-17beta
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
the enzyme show positive cooperativity
-
-
?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H
-
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
-
-
?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H + H+
-
17beta-HSD4 is involved in etsrogen inactivation and may protect against an excessive accumulation of E2 in human ovarian epithelial cells
-
-
?
estradiol-17beta + NAD+
estrone + NADH
-
-
-
-
?
estradiol-17beta + NAD+
estrone + NADH
-
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone
-
-
?
estradiol-17beta + NAD+
estrone + NADH
-
reversible at neutral pH, reduction of estrone at 5% of the activity of reduction of estradiol-17beta
-
-
r
estradiol-17beta + NAD+
estrone + NADH
-
reduction of estrone is 400fold slower than oxidation of 17beta-estradiol
-
-
r
estradiol-17beta + NAD+
estrone + NADH + H+
-
vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Vitamin K2 decreases the estradiol-17beta/estrone ratio in cells by 25%
-
-
?
estradiol-17beta + NAD+
estrone + NADH + H+
-
enzyme catalyzes the reduction of estrone to estradiol, the rate is 2.3% of the activity with estradiol
-
-
?
estradiol-17beta + NAD+
estrone + NADH + H+
-
activity with NAD+ is barely detectable
-
-
?
estradiol-17beta + NAD+
estrone + NADH + H+
-
activity with NAD+ is 2.2-3.8fold lower than with NADP+, depending on sample
-
-
?
estradiol-17beta + NADP+
estrone + NADPH
-
rate of oxidation of estradiol-17beta at the optimum, pH 9.9, is three to four times faster than that of the reverse reaction at pH 7.4
-
-
r
estradiol-17beta + NADP+
estrone + NADPH
-
maximal activity with NADP+ is approximately 1/3 of that with NAD+
-
-
r
estradiol-17beta + NADP+
estrone + NADPH
-
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity
-
-
?
estradiol-17beta + NADP+
estrone + NADPH
-
reverse reaction catalyzed by different isoforms of the enzyme
-
-
?
estradiol-17beta + NADP+
estrone + NADPH
-
reversible at neutral pH, reduction of estrone at 5% of the activity of reduction of estradiol-17beta
-
-
r
estradiol-17beta + NADP+
estrone + NADPH
-
activity with NADP+ is only 30% of the activity with NAD+
-
-
r
estrone + NAD(P)H
estradiol + NAD(P)+
-
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
-
-
?
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
-
final step in the synthesis of active estrogens
-
-
r
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
the enzyme produces active estradiol for cell proliferation
-
-
?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
-
17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours
-
-
?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
-
the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions
-
-
r
estrone + NAD(P)H + H+
estradiol + NAD(P)+
type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause
-
-
?
estrone + NAD(P)H + H+
estradiol-17beta + NAD(P)+
-
type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol
-
-
?
estrone + NADH
estradiol-17beta + NAD+
key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues
-
-
?
estrone + NADH
estradiol-17beta + NAD+
-
exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol
-
-
?
estrone + NADH
estradiol-17beta + NAD+
-
17beta-estradiol is a potent stimulator of certain endocrine-dependent forms of breast cancer. The enzyme catalyzes the last step in the biosynthesis of 17beta-estradiol from the less potent estrogen, estrone
-
-
?
estrone + NADH
estradiol-17beta + NAD+
-
type 1 enzyme, catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues
-
?
estrone + NADH
estradiol-17beta + NAD+
-
the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer
-
-
?
estrone + NADH
estradiol-17beta + NAD+
-
trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme
-
-
?
estrone + NADH
estradiol-17beta + NAD+
-
reversible at neutral pH, reduction of estrone at 5% of the activity of reduction of estradiol-17beta
-
-
r
estrone + NADH
estradiol-17beta + NAD+
-
reduction of estrone is 400fold slower than oxidation of 17beta-estradiol
-
-
r
estrone + NADH
estradiol-17beta + NAD+
-
progesterone treatment of ovariectomized gilts stimulates oxidative activity in uterus, anterior pituitary, skeletal muscle and kidney, constitutive levels of activity in adrenals, lung and liver
-
-
?
estrone + NADPH
17beta-estradiol + NADP+
-
convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol
-
-
?
estrone + NADPH
17beta-estradiol + NADP+
-
the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites
-
-
r
estrone + NADPH
17beta-estradiol + NADP+
-
substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14
-
-
r
estrone + NADPH
17beta-estradiol + NADP+
-
type 8 17beta-HSD can downregulate 17beta-estradiol levels in a large variety of tissues
-
-
?
estrone + NADPH
17beta-estradiol + NADP+
-
type 8 17beta-HSD is substrate-specific
-
-
?
estrone + NADPH + H+
17beta-estradiol + NAD(P)+
steroid hormone pathway
-
-
?
estrone + NADPH + H+
17beta-estradiol + NADP+
most active enzyme in regards to 17beta-estradiol production
-
-
?
estrone + NADPH + H+
17beta-estradiol + NADP+
the enzyme show positive cooperativity
-
-
?
estrone + NADPH + H+
estradiol + NADP+
kinetics demonstrates positive cooperativity
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
final step in the synthesis of active estrogens, important in the maintenance of pregnancy
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
final step in the synthesis of active estrogens, important in the maintenance of pregnancy
-
-
r
estrone + NADPH + H+
estradiol-17beta + NADP+
reductive activity is 1.5-3fold higher than oxidative activity
-
-
r
estrone + NADPH + H+
estradiol-17beta + NADP+
-
rate of oxidation of estradiol-17beta at the optimum, pH 9.9, is three to four times faster than that of the reverse reaction at pH 7.4
-
-
r
estrone + NADPH + H+
estradiol-17beta + NADP+
-
-
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
17beta-HSD1, final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
reverse reaction catalyzed by different isoforms of the enzyme
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in synthesis of estradiol
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
reversible at neutral pH, reduction of estrone at 5% of the activity of oxidation of estradiol-17beta
-
-
r
estrone + NADPH + H+
estradiol-17beta + NADP+
-
related to nuclear maturation in oocytes
-
-
?
testosterone + NAD+
4-androstene-3,17-dione + NADH + H+
-
2.4% of the activity with estradiol
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
poor substrate
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
-
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
-
androstenedione
r
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
75% of the activity with estradiol-17beta
-
r
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
activity is 22fold lower than with estradiol-17beta
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
lower activity than with estradiol 17beta
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
activity is 2.3-2.8fold lower than with estradiol-17beta, depending on sample
-
-
?
additional information
?
-
-
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 enzyme is a membrane bound isoform reactive with both estradiol and testosterone
-
-
?
additional information
?
-
-
the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis
-
-
?
additional information
?
-
-
17beta-HSD isozymes differ in their expression pattern, nucleotide cofactor preferences, steroid substrate specificity, and subcellular localization, detailed overview, substrate are androgens, estrogens, cholesterol, progestins, and eicosanoids, isozyme 17beta-HSD3 also shows 3beta-hydroxysteroid dehydrogenase, EC 1.1.1.51, isozyme 17beta-HSD8 also shows, to a lessser extent, NAD+-dependent testosterone oxidation to androstenedione, EC 1.1.1.63
-
-
?
additional information
?
-
-
human 17beta-hydroxysteroid dehydrogenases are multifunctional enzymes, isozyme 17beta-HSD4 also performs beta-oxidation of branched fatty acids, like pristanic acid, and in bile acid synthesis, e.g. of di- and trihydroxycholestanoic acids, overview
-
-
?
additional information
?
-
-
expression is stimulated 2fold by dexamethasone but is completly downregulated by phorbol ester
-
-
?
