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1.1.1.62: 17beta-estradiol 17-dehydrogenase

This is an abbreviated version!
For detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.62

Reaction

17beta-estradiol
+
NAD(P)+
=
estrone
 +
NAD(P)H
 +
H+

Synonyms

(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-hsd 14, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD10, 17beta-HSD12, 17beta-HSD14, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 1, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 10, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 14, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase type IV, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, 7beta-HSD7, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, aldo-keto reductase 1B15, C6Y55_RS00895, C6Y55_RS01070, C6Y55_RS01190, C6Y55_RS15130, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, HSD17B7, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, NlHsd17b12, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, reductive 17beta-hydroxysteroid dehydrogenase type 7, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.62 17beta-estradiol 17-dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0012
(13alpha)-3-hydroxyestra-1(10),2,4-trien-17-one
Homo sapiens
pH and temperature not specified in the publication
0.000049
(13S,17R)-3-hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
Homo sapiens
-
-
0.000019
(13S,17R)-3-hydroxy-4',13-dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
Homo sapiens
-
-
0.000016
(13S,17R)-3-hydroxy-5',13-dimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
Homo sapiens
-
-
0.000028
(13S,17R)-3-hydroxy-5',5',13-trimethyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
Homo sapiens
-
-
0.000107
(13S,17R)-5'-cyclopropyl-3-hydroxy-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
Homo sapiens
-
-
0.00002
(13S,17S)-3-hydroxy-13-methyl-4',5',6,7,8,9,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-6'(3'H)-one
Homo sapiens
-
-
0.000042
(13S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-7'H-spiro[cyclopenta[a]phenanthrene-17,2'-oxepan]-7'-one
Homo sapiens
-
-
0.000101
(16alpha)-2-chloro-16-fluoro-3-hydroxyestra-1(10),2,4-trien-17-one
Homo sapiens
-
0.00032
(16beta)-16-(ethoxymethyl)-3-hydroxyestra-1(10),2,4-trien-17-one
Homo sapiens
-
0.000035
(16beta)-2-chloro-16-fluoro-3-hydroxyestra-1(10),2,4-trien-17-one
Homo sapiens
-
0.01
(16beta)-3-hydroxy-16-methyl-17-oxoestra-1(10),2,4-triene-16-carbonitrile
Homo sapiens
-
0.00011
(16Z)-3-hydroxy-16-(hydroxymethylidene)estra-1(10),2,4-trien-17-one
Homo sapiens
-
0.00051
(17beta)-3,17-dihydroxy-N-(pyridin-3-ylmethyl)estra-1(10),2,4-triene-16-carboxamide
Homo sapiens
-
0.000087
(2R,4aS,4bR,10bS,12aS)-9-chloro-2-fluoro-8-hydroxy-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.000126
(2S,4aS,4bR,10bS,12aS)-9-chloro-2-fluoro-8-hydroxy-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.00203
(3alpha,7alpha,17beta)-17-ethynyl-7-methylestr-5(10)-ene-3,17-diol
Homo sapiens
-
0.00483
(3beta,7alpha,17beta)-17-ethynyl-7-methylestr-5(10)-ene-3,17-diol
Homo sapiens
-
0.00041 - 0.0006
(4aR,6aS,7S)-7-[heptyl(methyl)amino]-1,4a,6a-trimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
0.00096
(4aR,6aS,7S)-7-[heptyl(methyl)amino]-4a,6a-dimethylhexadecahydro-2H-indeno[5,4-f]quinolin-2-one
Homo sapiens
pH and temperature not specified in the publication
0.000015
(4aS,4bR,10bS,12aS)-8-hydroxy-12a-methyl-9-(2-phenylethyl)-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.000024
(4aS,4bR,10bS,12aS)-8-hydroxy-12a-methyl-9-prop-2-en-1-yl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.000052
(4aS,4bR,10bS,12aS)-8-hydroxy-9-iodo-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.000085
(4aS,4bR,10bS,12aS)-8-hydroxy-9-methoxy-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.000052
(4aS,4bR,10bS,12aS)-9-bromo-8-hydroxy-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.000077
(4aS,4bR,10bS,12aS)-9-chloro-8-hydroxy-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydrochrysen-1(2H)-one
Homo sapiens
-
0.00001
(4R,5R)-4-(2-fluorophenyl)-5-[hydroxy(5-phenylthiophen-2-yl)methyl]-1-methylpyrrolidin-2-one
Homo sapiens
pH 7.4, 37°C
0.00005
(4R,5R)-5-[hydroxy[5-(pyridin-3-yl)thiophen-2-yl]methyl]-1-methyl-4-phenylpyrrolidin-2-one
Homo sapiens
pH 7.4, 37°C
0.00042
(4S,5S)-5-[biphenyl-3-yl(hydroxy)methyl]-4-(2-fluorophenyl)-1-methylpyrrolidin-2-one
Homo sapiens
pH 7.4, 37°C
0.00102
(4S,5S)-5-[biphenyl-4-yl(hydroxy)methyl]-4-(2-fluorophenyl)-1-methylpyrrolidin-2-one
Homo sapiens
pH 7.4, 37°C
0.00005
(4S,5S)-5-[hydroxy[5-(pyridin-3-yl)thiophen-2-yl]methyl]-1-methyl-4-phenylpyrrolidin-2-one
Homo sapiens
pH 7.4, 37°C
0.000044
(6-hydroxy-1,3-benzothiazol-2-yl)(3-hydroxyphenyl)methanone
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0003
(6aS)-2-hydroxy-6a-methyl-N-(2-pyridin-3-ylethyl)-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazole-9-carboxamide
Homo sapiens
0.01 mM, 99% inhibition, IC50: 0.0003 mM
0.00088
(6aS)-2-hydroxy-6a-methyl-N-(pyridin-2-ylmethyl)-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazole-9-carboxamide
Homo sapiens
0.01 mM, 93% inhibition, IC50: 0.00088 mM
0.00078
(6aS)-2-hydroxy-6a-methyl-N-(pyridin-3-ylmethyl)-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazole-9-carboxamide
Homo sapiens
0.01 mM, 92% inhibition, IC50: 0.00078 mM
0.0023
(6aS)-2-hydroxy-6a-methyl-N-[(1-methyl-1H-pyrrol-2-yl)methyl]-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazole-9-carboxamide
Homo sapiens
0.01 mM, 90% inhibition, IC50: 0.0023 mM
0.0007
(6aS)-3-ethyl-2-hydroxy-6a-methyl-N-(2-pyridin-3-ylethyl)-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazole-9-carboxamide
Homo sapiens
-
0.00053
(6aS)-8-(2-methoxyethyl)-6a-methyl-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazol-2-ol
Homo sapiens
-
0.00095
(6aS)-9-(hydroxymethyl)-6a-methyl-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazol-2-ol
Homo sapiens
-
0.000066
(6aS,6bS,11aS)-2-hydroxy-6a-methyl-4b,5,6,6a,6b,9,10,11,11a,12,12a,12b,13,14-tetradecahydro-8H-naphtho[2',1':4,5]indeno[1,2-b]oxepin-8-one
Homo sapiens
-
-
0.0019
(6Z,17E)-3-hydroxyestra-1(10),2,4-triene-6,17-dione dioxime
Homo sapiens
-
0.00144
(7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-4-en-3-one
Homo sapiens
-
0.0041
1'(2')H-estra-1,3,5(10)-trieno[17,16-c]pyrazol-3-ol
Homo sapiens
-
IC50: 0.0041 mM
0.000173
1,1':4',1''-terphenyl-3,3''-diol
Homo sapiens
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA
0.0054
1-(3'-ethyl-4'-hydroxy-biphenyl-4-yl)-ethanone
Homo sapiens
-
0.0099
1-(3-ethyl-4'-hydroxy-biphenyl-4-yl)-ethanone
Homo sapiens
-
0.0037
1-(4'-hydroxy-2'-methyl-biphenyl-4-yl)-ethanone
Homo sapiens
-
0.0037
1-(4'-hydroxy-2'_methyl-biphenyl-4-yl)-ethanone
Homo sapiens
-
0.0037
1-(4'-hydroxy-biphenyl-4-yl)-ethanone
Homo sapiens
-
0.0048
1-(6-hydroxy-9H-fluoren-2-yl)-ethanone
Homo sapiens
-
0.00004
1-bromo-6-(3-hydroxyphenyl)-2-naphthol
Homo sapiens
in 20 mM KH2PO4, pH 7.4, at 25°C
0.00014
10-((13S,16S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)-decanoic acid 5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
Homo sapiens
-
IC50: 140 nM
0.01
16-cyano-17-oxoestra-1(10),2,4-trien-3-yl sulfamate
Homo sapiens
-
0.0021
16-cyano-2-methoxy-17-oxoestra-1(10),2,4-trien-3-yl sulfamate
Homo sapiens
-
0.00046
16alpha-bromopropyl-estradiol
Homo sapiens
-
IC50: 0.00046 mM, reduction of estrone, the inhibitor is totally inactive against type 2 17beta-HSD and type type 1 17beta-HSD
0.00029
16beta-m-pyridylmethylamidomethyl-2-methoxyoestrone
Homo sapiens
-
IC50: 0.00029 mM
0.00291 - 0.00424
17beta-[(N-decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
-
0.00578 - 0.00601
17beta-[(N-heptyl)methylamino]-4-aza-5alpha-androstan-3-one
-
0.00041 - 0.00119
17beta-[(N-heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one
-
0.0007 - 0.00332
17beta-[(N-nonyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one
-
0.0338
2',4',4-trihydroxy-4'-chalcone
Homo sapiens
-
IC50: 0.0338 mM
0.0346
2',4'-dihydroxy-chalcone
Homo sapiens
-
IC50: 0.0346 mM
0.0103 - 0.042
2,2',4,4'-tetrahydroxybenzophenone
0.0043
2,2'-diimino-7,7'-dimethyl-5,5'-bis(1-methylethyl)-2H,2'H-8,8'-binaphtho[1,8-bc]furan-3,3',4,4'-tetrol
Homo sapiens
-
0.023
2-(2-bromo-4,6-dimethylphenoxy)-N'-[(E)-(2,4-dihydroxyphenyl)methylidene]acetohydrazide
Homo sapiens
pH 7.4, 37°C
0.00014
2-chloro-3-hydroxyestra-1(10),2,4-trien-17-one
Homo sapiens
-
0.0000222
2-chloro-4-[5-(2,6-difluoro-3-hydroxybenzoyl)thiophen-2-yl]phenyl sulfamate
Homo sapiens
whole cell assay, pH not specified in the publication, temperature not specified in the publication
0.0051
2-ethyl-17-oxo-16-[2-oxo-2-[(pyridin-3-ylmethyl)amino]ethyl]estra-1(10),2,4-trien-3-yl sulfamate
Homo sapiens
-
0.0024
2-methoxyoestrone
Homo sapiens
-
IC50: 0.0024 mM
0.0064
2-methylcinnamic acid
Homo sapiens
-
IC50: 0.0064 mM
0.00000362 - 0.000165
2-[2-ethyl-3-hydroxy-17-oxoestra-1(10),2,4-trien-16-yl]-N-(pyridin-2-ylmethyl)acetamide
0.000027
2-[2-ethyl-3-hydroxy-17-oxoestra-1(10),2,4-trien-16-yl]-N-(pyridin-3-ylmethyl)acetamide
Homo sapiens
-
0.000037
2-[3-hydroxy-17-oxoestra-1(10),2,4-trien-16-yl]-N-(pyridin-3-ylmethyl)acetamide
Homo sapiens
-
0.0047
2-[5-(3-ethyl-4-hydroxyphenyl)-1-oxo-indan-2-yl]-N-pyridin-3-ylmethyl-acetamide
Homo sapiens
-
0.0006
3',4',5,7-tetrahydroxy-flavone
Homo sapiens
-
IC50: 0.0006 mM
0.0052
3',4',7-trihydroxy-isoflavone
Homo sapiens
-
IC50: 0.0052 mM
0.00137 - 0.00194
3'-(1-benzothien-2-yl)biphenyl-3-ol
0.00056 - 0.00237
3'-(5-chloro-2-thienyl)biphenyl-3-ol
0.000934 - 0.004299
3'-hydroxy-N-(3-hydroxybenzyl)-N-methyl-[1,10-biphenyl]-4-sulfonamide
0.00064
3'-hydroxy-N-(3-hydroxybenzyl)-N-methylbiphenyl-3-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000594
3'-hydroxy-N-(3-hydroxybenzyl)-N-methylbiphenyl-4-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00054
3'-hydroxy-N-(3-hydroxyphenyl)-N-methyl-[1,10-biphenyl]-3-sulfonamide
Homo sapiens
pH 7.4, 37°C
0.001179 - 0.002031
3'-hydroxy-N-(3-hydroxyphenyl)-N-methyl-[1,10-biphenyl]-4-sulfonamide
0.000061
3'-hydroxy-N-(3-hydroxyphenyl)-N-methylbiphenyl-4-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000494
3'-methoxy-N-(3-methoxybenzyl)-N-methylbiphenyl-4-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00052
3'-methoxy-N-(3-methoxyphenyl)-N-methylbiphenyl-3-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000517
3'-methoxy-N-(3-methoxyphenyl)-N-methylbiphenyl-4-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0022
3,3',4,4'-tetrahydroxy-7,7'-dimethyl-5,5'-bis(1-methylethyl)-2H,2'H-8,8'-binaphtho[1,8-bc]furan-2,2'-dione
Homo sapiens
-
0.041
3,3'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol
Homo sapiens
-
37°C, pH not specified in the publication
0.017
3,3'-(1H-1,2,3-triazole-1,4-diyl)diphenol
0.000101
3,3'-pyridine-2,5-diyldiphenol
Homo sapiens
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA
0.049
3,4,5-trimethoxycinnamic acid
Homo sapiens
-
IC50: 0.049 mM
0.001 - 0.005
3,5,7,4'-tetrahydroxyflavone
Curvularia lunata
-
IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione
15
3,5,7-trihydroxy-4'-methoxy-flavone
Homo sapiens
-
IC50: 15 mM
0.001
3,7-dihydroxyflavone
Curvularia lunata
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one
0.000044
3-(3,17beta-dihydroxy-estra-1,3,5(10)-trien-16beta-ylmethyl)-benzamide
Homo sapiens
-
0.000171
3-(3-hydroxy-17-oxo-estra-1,3,5(10)-trien-16beta-ylmethyl)-benzamide
Homo sapiens
-
0.000042
3-([(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]methyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000083
3-([(16beta,17beta)-3-(2-bromoethyl)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000005
3-benzyl-2-(2-bromo-3,4,5-trimethoxyphenyl)-8-hydroxy[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Homo sapiens
87% inhibition at 100 nM, 95% inhibition at 0.001 mM. IC50: 5 nM
0.000005
3-benzyl-8-hydroxy-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
0.006 - 0.072
3-benzylidene camphor
0.00046
3-bromo-5-phenylsalicylic acid
Homo sapiens
-
pH not specified in the publication, 25°C
0.0063
3-bromo-N-(3-hydroxy-4-methylphenyl)benzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.1
3-cyclohexylpropanoic acid
Homo sapiens
-
weak inhibition, IC50: 0.1 mM, above
0.00095
3-hydroxy-1,3,5(10)-triene-[17,16-c]-(5'-hydroxymethyl)-pyrazole
Homo sapiens
-
0.01 mM: 94% inhibition, IC50: 0.00095 mM
0.00185
3-hydroxy-1,3,5(10)-triene-[17,16-c]-[5'-(carboxylic acid ethyl ester)]-pyrazole
Homo sapiens
-
0.01 mM: 94% inhibition, IC50: 0.00185 mM
0.00007
3-hydroxy-13alpha-D-secooxime
Homo sapiens
pH and temperature not specified in the publication
0.00094
3-hydroxy-17-oxoestra-1(10),2,4-triene-16-carboxylic acid
Homo sapiens
-
0.000168
3-hydroxy-17-oxoestra-1(10),2,4-triene-2-carbonitrile
Homo sapiens
-
0.00053
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methoxyethyl)-pyrazole
Homo sapiens
-
0.01 mM: 95% inhibition, IC50: 0.00053 mM
0.00092
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methyl acetate)-pyrazole
Homo sapiens
-
0.01 mM: 95% inhibition, IC50: 0.00092 mM
0.00275
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methyl)-pyrazole
Homo sapiens
-
0.01 mM: 94% inhibition, IC50: 0.00275 mM
0.00073
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-propionitrile)-pyrazole
Homo sapiens
-
0.01 mM: 95% inhibition, IC50: 0.00073 mM
0.0023
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(1'-methylpyrrol-2''-ylmethyl)carbamoyl]-pyrazole
Homo sapiens
-
0.01 mM: 89% inhibition, IC50: 0.0023 mM
0.00088
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-2''-ylmethyl)carbamoyl]-pyrazole
Homo sapiens
-
0.01 mM: 93% inhibition, IC50: 0.00088 mM
0.0003
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-3''-ylethyl)carbamoyl]-pyrazole
Homo sapiens
-
0.01 mM: 99% inhibition, IC50: 0.0003 mM
0.00078
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-3''-ylmethyl)carbamoyl]-pyrazole
Homo sapiens
-
0.01 mM: 92% inhibition, IC50: 0.00078 mM
0.000159
3-hydroxy-N-(3'-hydroxy-[1,1'-biphenyl]-3-yl)-N-methylbenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.000511
3-hydroxy-N-(3'-hydroxy-[1,1'-biphenyl]-4-yl)-N-methylbenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.000243
3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0011
3-hydroxyestra-1(10),2,4-triene-16,17-dione 16-oxime
Homo sapiens
-
0.0019
3-hydroxyestra-1,3,5(10),7-tetraen-17-one
Homo sapiens
-
IC50: 0.0019 mM, oxidation of estradiol
0.001 - 0.005
3-hydroxyflavone
0.043
3-trifluoromethylcinnamic acid
Homo sapiens
-
IC50: 0.043 mM
0.00073
3-[(6aS)-2-hydroxy-6a-methyl-4b,6,6a,10,10a,10b,11,12-octahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazol-8(5H)-yl]propanenitrile
Homo sapiens
-
0.00132 - 0.00812
3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-phenol
0.00084 - 40.88
3-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]phenol
0.00047 - 0.00238
3-[2-(5-chloro-2-thienyl)pyridin-4-yl]phenol
0.00047
3-[2-(5-chlorothiophen-2-yl)pyridin-4-yl]phenol
Homo sapiens
pH 7.4, 37°C
0.021
3-[3-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-5-yl]phenol
Homo sapiens
-
37°C, pH not specified in the publication
0.00027 - 0.00161
3-[3-(4-hydroxyphenyl)isoxazol-5-yl]-phenol
0.00025 - 0.00185
3-[4-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol
0.00084 - 0.00728
3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]-phenol
0.00084 - 46.94
3-[4-(4-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]phenol
0.000077
3-[4-(4-hydroxyphenyl)thiophen-2-yl]phenol
Homo sapiens
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA
0.00085 - 0.00364
3-[4-(5-chloro-2-thienyl)pyridin-2-yl]phenol
0.00031 - 0.0175
3-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-phenol
0.02
3-[5-(4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazol-3-yl]phenol
Homo sapiens
-
37°C, pH not specified in the publication
0.044
3-[5-(4-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazol-3-yl]phenol
Homo sapiens
-
37°C, pH not specified in the publication
0.000069
3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol
Homo sapiens
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA
0.000151
3-[5-(4-hydroxyphenyl)thiophen-3-yl]phenol
Homo sapiens
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA
0.00139 - 0.00711
3-[6-(5-chloro-2-thienyl)pyridin-2-yl]phenol
0.0031
3alpha-hydroxy-3beta-([4-[(2-methoxy-4-methylphenyl)methyl]piperazin-1-yl]methyl)-androstan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.00042
3alpha-hydroxy-3beta-([4-[(3-methoxy-4-methylphenyl)methyl]piperazin-1-yl]methyl)-androstan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.0026
3alpha-hydroxy-3beta-([4-[(3-methoxyphenyl)methyl]piperazin-1-yl]methyl)-androstan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.00097
3alpha-hydroxy-3beta-([4-[(quinolin-3-yl)methyl]piperazin-1-yl]methyl)-androstan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.00014
3alpha-hydroxy-3beta-[(4-[[3-methoxy-4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl)methyl]-androstan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.00126
3beta-[(4-[[3-methoxy-4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl)methyl]-17alpha-pregn-20-yne-3alpha,17-diol
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
-
0.00095
3beta-[(4-[[3-methoxy-4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl)methyl]-androstane-3alpha,17alpha-diol
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.00205
3beta-[[4-(3,5-dimethylbenzoyl)piperazin-1-yl]methyl]-3alpha-hydroxyandrostan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.0023
3beta-[[4-(3-acetylbenzoyl)piperazin-1-yl]methyl]-3alpha-hydroxyandrostan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.0026
3beta-[[4-([1,1'-biphenyl]-4-carbonyl)piperazin-1-yl]methyl]-3alpha-hydroxyandrostan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.0003
4',5,7-trihydroxy-flavone
Homo sapiens
-
IC50: 0.0003 mM
0.001
4',5,7-trihydroxy-isoflavone
Homo sapiens
-
IC50: 0.001 mM
0.01
4',7-dihydroxy-isoflavone
Homo sapiens
-
IC50: 0.01 mM
0.00102 - 0.01
4'-(5-chloro-2-thienyl)biphenyl-3-ol
0.00069 - 0.00297
4'-(6-methoxypyridin-3-yl)biphenyl-3-ol
0.00048 - 0.000482
4'-hydroxy-N-(3-hydroxybenzyl)-N-methylbiphenyl-3-carboxamide
0.0012
4'-methoxy-N-(3-methoxyphenyl)-N-methylbiphenyl-3-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0018
4-(3'-ethyl-4'-hydroxy-biphenyl)-2,2-dimethyl-4-oxo-N-pyridin-3-ylmethyl-butyramide
Homo sapiens
-
0.0037
4-(3'-ethyl-4'-hydroxy-biphenyl)-4-oxo-N-pyridin-3-ylmethyl-butyramide
Homo sapiens
-
0.0018
4-(3-ethyl-4-hydroxy-biphenyl)-2,2-dimethyl-4-oxo-N-pyridin-3-ylmethyl-butyramide
Homo sapiens
-
0.0017
4-(4-[[3alpha-hydroxy-17-oxoandrostan-3beta-yl]methyl]piperazine-1-carbonyl)benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.001
4-chloro-N-(3-hydroxyphenyl)-2,5-dimethylbenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.000023
4-fluoro-3-hydroxy-N-(3'-hydroxybiphenyl-3-yl)-N-methylbenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.016
4-hydroxychalcone
Homo sapiens
-
IC50: 0.016 mM
0.0059 - 0.07
4-methylbenzylidene camphor
0.000046
4-[5-(3-hydroxyphenyl)thiophen-2-yl]-2-methylphenol
Homo sapiens
-
at 37°C in phosphate buffer (50 mM) with 20% (v/v) glycerol and 1 mM EDTA
0.0014
4-[[3alpha-hydroxy-17-oxoandrostan-3beta-yl]methyl]-N-[[3-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamide
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.00014
5'-O-(10-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha-yl]-decanoyl)adenosine
Homo sapiens
-
IC50: 140 nM
0.00031
5'-O-(11-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha-yl]-undecanoyl) adenosine
Homo sapiens
-
IC50: 310 nM
0.00009
5'-O-(11-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha/beta-yl]-undecanoyl)adenosine
Homo sapiens
-
IC50: 90 nM
0.00012
5'-O-(11-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'beta-yl]-undecanoyl)adenosine
Homo sapiens
-
IC50: 120 nM
0.001
5'-O-(12-[3',17'beta-(dihydroxy)-1',3',5'(10')-estratrien-16'alpha-yl]-dodecanoyl)adenosine
Homo sapiens
-
IC50: 1000 nM
0.0069
5'-O-(6-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha/beta-yl]-hexanoyl)adenosine
Homo sapiens
-
IC50: 6900 nM
0.00043
5'-O-(7-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha-yl]-heptanoyl)adenosine
Homo sapiens
-
IC50: 430 nM
0.000093
5'-O-(8-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha-yl]-octanoyl)adenosine
Homo sapiens
-
IC50: 93 nM
0.000052
5'-O-(9-[3',17'beta-dihydroxy-1',3',5'(10')-estratrien-16'alpha-yl]-nonanoyl)adenosine
Homo sapiens
-
IC50: 52 nM
0.000052
5'-O-[9-[(16b,17b)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]nonanoyl]adenosine
Homo sapiens
-
0.001
5,7-dihydroxyflavone
Curvularia lunata
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one
0.000061
5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000062
5-(2-fluoro-3-methoxyphenyl)-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000062
5-(2-fluoro-3-methoxyphenyl)-N-methyl-N-(3-methylphenyl)thiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00041
5-(2-hydroxyphenyl)-N-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00049
5-(2-methoxyphenyl)-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.002
5-(3-ethyl-4-hydroxyphenyl)-indan-1-one
Homo sapiens
-
0.0029
5-(3-fluoro-4-hydroxyphenyl)-indan-1-one
Homo sapiens
-
0.00033
5-(3-fluorophenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00017
5-(3-fluorophenyl)-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00051
5-(4-cyanophenyl)-N-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0017
5-(4-hydroxyphenyl)-indan-1-one
Homo sapiens
-
0.001
5-hydroxyflavone
Curvularia lunata
-
IC50 below 0.001 mM, oxidation of 17beta-hydroxyestra-4-en-3-one
0.001 - 0.005
5-methoxyflavone
Curvularia lunata
-
IC50 between 0.001 and 0.005 mM, reduction of estra-4-en-3,17-dione
0.0083
6-(3-ethyl-4-methoxyphenyl)-3,4-dihydro-2H-naphthalen-1-one
Homo sapiens
-
0.00002
6-(3-hydroxyphenyl)-1-phenyl-2-naphthol
Homo sapiens
in 20 mM KH2PO4, pH 7.4, at 25°C
0.000116
6-(3-hydroxyphenyl)-2-naphthol
Homo sapiens
in 20 mM KH2PO4, pH 7.4, at 25°C
0.0156
6-(4-hydroxy-phenyl)-3,4-dihydro-2H-naphthalen-1-one
Homo sapiens
-
0.000302
6-(4-hydroxyphenyl)naphthalen-1-ol
Homo sapiens
pH 7.4, 37°C
0.028
7-hydroxy-flavanone
Homo sapiens
-
IC50: 0.028 mM
0.0009
7-hydroxy-flavone
Homo sapiens
-
IC50: 0.0009 mM
0.000093
8-((13S,16S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)-octanoic acid 5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
Homo sapiens
-
IC50: 93 nM
0.000052
9-((13S,16S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-16-yl)-nonanoic acid 5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester
Homo sapiens
-
IC50: 52 nM
0.05
Cinnamic acid
Homo sapiens
-
IC50: 0.050 mM
0.0002 - 0.005
coumestrol
0.0017
equilin
Homo sapiens
-
IC50: 0.0017 mM
0.00009 - 0.00081
estrone
0.00185
ethyl [(6aS)-2-hydroxy-6a-methyl-4b,5,6,6a,8,10,10a,10b,11,12-decahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazol-9-yl]acetate
Homo sapiens
-
0.000072
methyl (13S,17R)-3-hydroxy-13-methyl-6'-oxo-3',4',5',6,6',7,8,9,11,12,13,14,15,16-tetradecahydrospiro[cyclopenta[a]phenanthrene-17,2'-pyran]-5'-carboxylate
Homo sapiens
-
-
0.00092
methyl [(6aS)-2-hydroxy-6a-methyl-4b,6,6a,10,10a,10b,11,12-octahydronaphtho[2',1':4,5]indeno[1,2-c]pyrazol-8(5H)-yl]acetate
Homo sapiens
-
0.0011
N,4'-dimethyl-N-(3-methylphenyl)biphenyl-4-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000068
N,5-bis(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0011
N-(2,1,3-benzothiadiazol-4-yl)-2-[(4-hydroxypyrimidin-2-yl)sulfanyl]acetamide
Homo sapiens
pH 7.4, 37°C
0.24 - 0.52
N-(2-hydroxyphenyl)-2-methyl-4-(trifluoromethyl)benzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.003 - 0.01
N-(3-chloro-4-hydroxyphenyl)-4-fluorobenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.0071
N-(3-hydroxy-4-methylphenyl)-3-(trifluoromethyl)benzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.00039
N-(3-hydroxybenzyl)-5-(3-hydroxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00033
N-(3-hydroxybenzyl)-5-(4-hydroxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000161
N-(3-hydroxybenzyl)-5-(4-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.00016 - 0.000164
N-(3-hydroxybenzyl)-N-methyl-5-(3-methylphenyl)thiophene-2-carboxamide
0.0033
N-(3-hydroxyphenyl)-2,4,5-trimethylbenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.0069
N-(3-hydroxyphenyl)-4-methoxy-2,5-dimethylbenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.015
N-(3-hydroxyphenyl)-4-methoxy-2-methyl-5,6,7,8-tetrahydronaphthalene-1-sulfonamide
Homo sapiens
pH 7.4, 37°C
0.0049
N-(3-hydroxyphenyl)benzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.00037
N-(3-methoxybenzyl)-5-(3-methoxyphenyl)-N-methylthiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.000058
N-(3-methoxyphenyl)-N-methyl-5-(3-methylphenyl)thiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0096
N-(4-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-4-methoxybenzenesulfonamide
Homo sapiens
pH 7.4, 37°C
0.0008
N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]oxy]-N-methylhexanamide
Homo sapiens
-
73% inhibition at 0.001 mM, IC50: 0.0008 mM, reduction of estrone with NADH as cofactor
0.00016
N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]sulfanyl]-N-methylhexanamide
0.00291 - 0.00396
N-decyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00112 - 0.00578
N-decyl-N-[(4aR,6aS,7S)-4a,6a-dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.0016
N-ethyl-4-[[3alpha-hydroxy-17-oxoandrostan-3beta-yl]methyl]-N-methylpiperazine-1-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.000052
N-methyl-N,5-bis(3-methylphenyl)thiophene-2-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0007 - 0.00332
N-nonyl-N-[(4aR,6aS,7S)-1,4a,6a-trimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinolin-7-yl]formamide
0.00107
N-[4-(dimethylsulfamoyl)phenyl]-4-[[3alpha-hydroxy-17-oxoandrostan-3beta-yl]methyl]piperazine-1-carbothioamide
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
0.000027
STX1040
Homo sapiens
-
0.00285
[[4-(4-benzoylbenzoyl)piperazin-1-yl]methyl]-3alpha-hydroxyandrostan-17-one
Homo sapiens
-
pH and temperature not specified in the publication, transformation of E2 to E1 by HEK-293[17beta-HSD10] cells
additional information
(2,4-dihydroxyphenyl)-phenylmethanone