1.1.1.53: 3alpha(or 20beta)-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 3alpha(or 20beta)-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

Synonyms

(R)-20-hydroxysteroid dehydrogenase, 20-hydroxysteroid dehydrogenase, 20beta-HSD, 20beta-HSD type 2, 20beta-HSDH, 20beta-hydroxysteroid dehydrogenase, 20beta-hydroxysteroid dehydrogenase type 2, 20HSD, 3-alpha hydroxysteroid dehydrogenase type 3, 3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, carbonyl reductase-like 20beta-HSD, carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase, carbonyl reductase/20beta-hydroxysteroid dehydrogenase A, carbonyl reductase/20beta-hydroxysteroid dehydrogenase B, cortisone reductase, CR/20beta-HSD, CR/20beta-HSD A, CR/20beta-HSD B, dehydrogenase, 20beta-hydroxy steroid, delta4-3-ketosteroid hydrogenase, desE, NADH-20beta-hydroxysteroid dehydrogenase, retinol dehydrogenase 2, RoDH2, SDR12C55

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase

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Results	in table
8	Activating Compound
965	AA Sequence
1	CAS Registry Number
11	Cloned(Commentary)
34	Cofactor
5	Crystallization (Commentary)
119	Disease/ Diagnostics
2	Expression
4	General Information
4	General Stability
30	Inhibitors
4	kcat/KM [mM/s]
57	KM Value [mM]
9	Localization
8	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
48	Organism
2	Pathway
23	PDB ID
13	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
12	Protein Variants
12	Purification (Commentary)
7	Reaction
3	Reaction Type
48	Reference
2	Renatured (Commentary)
87	Source Tissue
22	Specific Activity [micromol/min/mg]
2	Storage Stability
129	Substrates and Products (Substrate)
9	Subunits
40	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 1.1.1.53 - 3alpha(or 20beta)-hydroxysteroid dehydrogenase

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10

Mycobacterium tuberculosis

P9WGT1

oxidation of androsterone shows a dual pH-optimum, one at pH 6.0-6.5 and the other at pH 10, mutant enzyme I6T/V47M/T69K/E142A

657157

5

Sus scrofa

-

reduction of 5alpha-androstan-17beta-ol-3-one with beta-NADPH

287097

5.1

Streptomyces exfoliatus

-

reduction of oxo-steroids

287091

5.5

Sus scrofa

-

reduction of oxosteroid

287084

5.8

Streptomyces exfoliatus

-

reduction of progesterone in aqueous solution

287083

6

Mycobacterium tuberculosis

P9WGT1

progesterone + NADH, mutant enzyme I6T/V47M/T69K

657157

6 - 6.5

Mycobacterium tuberculosis

P9WGT1

oxidation of androsterone shows a dual pH-optimum, one at pH 6.0-6.5 and the other at pH 10, mutant enzyme I6T/V47M/T69K/E142A

657157

6.4

Streptomyces exfoliatus

-

reduction of progesterone in reversed micelles

287083

6.5

Mycobacterium tuberculosis

P9WGT1

progesterone + NADH, mutant enzyme I6T/V47M/T69K/E142A

657157

7 - 7.5

Agathobaculum desmolans

-

reductive direction

763346

7.5

Streptomyces exfoliatus

-

-

287099

8.5 - 9.25

Agathobaculum desmolans

-

oxidative direction

763346

9.2

Streptomyces exfoliatus

-

oxidation of hydroxysteroid

287089