1.1.1.51: 3(or 17)beta-hydroxysteroid dehydrogenase
This is an abbreviated version!
For detailed information about 3(or 17)beta-hydroxysteroid dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.51
-
1.1.1.51
-
testosterone
-
androgen
-
steroidogenic
-
progesterone
-
estradiol
-
adrenal
-
steroidogenesis
-
androstenedione
-
estrone
-
testicular
-
aromatase
-
testis
-
ovarian
-
leydig
-
17beta-hsds
-
dehydroepiandrosterone
-
pregnenolone
-
gonad
-
lh
-
granulosa
-
gonadotropin
-
alpha-reductase
-
dihydrotestosterone
-
cyp11a1
-
alpha-hydroxylase
-
acth
-
p450scc
-
dheas
-
luteal
-
progestin
-
sulfatase
-
pseudohermaphroditism
-
trilostane
-
hsd3b1
-
genitalia
-
p450arom
-
alpha-dihydrotestosterone
-
beta-diol
-
hirsutism
-
alpha-hydroxysteroid
-
17-hydroxyprogesterone
-
lhcgr
-
alpha-hydroxyprogesterone
-
virilization
-
17-ketosteroids
-
synthesis
-
drug development
-
hcg-stimulated
-
pubarche
-
srd5a2
-
diagnostics
-
17-hydroxylase
-
medicine
-
environmental protection
-
adrenarche
- 1.1.1.51
- testosterone
- androgen
-
steroidogenic
- progesterone
- estradiol
- adrenal
-
steroidogenesis
- androstenedione
- estrone
- testicular
- aromatase
- testis
- ovarian
- leydig
- 17beta-hsds
- dehydroepiandrosterone
- pregnenolone
- gonad
- lh
-
granulosa
- gonadotropin
-
alpha-reductase
- dihydrotestosterone
- cyp11a1
-
alpha-hydroxylase
- acth
- p450scc
- dheas
- luteal
- progestin
-
sulfatase
- pseudohermaphroditism
- trilostane
- hsd3b1
- genitalia
- p450arom
-
alpha-dihydrotestosterone
-
beta-diol
- hirsutism
-
alpha-hydroxysteroid
- 17-hydroxyprogesterone
-
lhcgr
-
alpha-hydroxyprogesterone
-
virilization
-
17-ketosteroids
- synthesis
- drug development
-
hcg-stimulated
-
pubarche
- srd5a2
- diagnostics
-
17-hydroxylase
- medicine
- environmental protection
-
adrenarche
Reaction
Synonyms
17 beta-HSD3, 17 beta-hydroxysteroid dehydrogenase, 17-beta-HSD, 17-ketoreductase, 17beta-HSD, 17beta-HSD (type 1), 17beta-HSD (type 3), 17beta-HSD type 2, 17beta-HSD type 3, 17beta-HSD type II, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD2, 17beta-HSD3, 17beta-HSD5, 17beta-HSD7_2, 17beta-HSOR, 17beta-hydroxy steroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenases, 17beta-hydroxysteroid dehydrogenases type 2, 17beta-hydroxysteroid oxidoreductase, 17beta-hydroxysteroid: NADP 17-oxidoreductase, 17betaHSD2, 3 beta-hydroxysteroid dehydrogenase, 3,17beta-HSD, 3,17beta-hydroxysteroid dehydrogenase, 3-beta HSD, 3beta,17beta-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD (type 1), 3beta-HSD type-I, 3beta-HSD type-II, 3beta-HSD/isomerase, 3beta-hydroxy steroid dehydrogenase, 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxystroid oxidoreductase, 3beta/17beta-HSD, 3beta/17beta-hydroxysteroid dehydrogenase, 3beta17betaHSDH, 3betaHSD, AKR1C3, AKR1C35, aldo keto reductase 1C3, beta-hydroxy steroid dehydrogenase, betahsd, dehydrogenase, 17beta-hydroxy steroid, dehydrogenase, 3beta-hydroxy steroid, dehydrogenase, beta-hydroxy steroid, DELTA5-3beta-HSD, DELTA5-3beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD, HSD17B1, HSD17B3, LOC101842245, More, pQ3 beta HSD, RDH11, Rdh11/12-like 1, Rdh11/12-like 2, Rdh11/12-like 3, retinol dehydrogenases 11-like, steroid 17beta-reductase, type 17beta-HSD, type 2 17beta-HSD, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17-beta-hydroxysteroid dehydrogenase
ECTree
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.1.51 - 3(or 17)beta-hydroxysteroid dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-1,2,3,4-tetrahydro-1-naphthol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
i.e. R-tetralol
-
-
?
(S)-1,2,3,4-tetrahydro-1-naphthol + NAD+
3,4-dihydronaphthalen-1(2H)-one + NADH + H+
i.e. S-tetralol
-
-
?
(S)-1,2,3,4-tetrahydro-1-naphthol + NADP+
3,4-dihydronaphthalen-1(2H)-one + NADPH + H+
i.e. S-tetralol
-
-
?
(S)-1-indanol + NAD+
2,3-dihydro-1H-inden-1-one + NADH + H+
-
-
-
?
1-acenaphthenol + NAD+
acenaphthylen-1(2H)-one + NADH + H+
-
-
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
17-oxo steroids + NADPH
?
-
maintenance of balance between oxidized and reduced steroids in blood
-
-
?
17alpha-hydroxypregnenolone + NAD(P)+
17alpha-hydroxy-pregn-5-en-3,20-dione + NAD(P)H + H+
-
-
-
-
?
17alpha-hydroxypregnenolone + NAD(P)H + H+
17alpha-hydroxyprogesterone + NAD(P)+
-
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NAD(P)H + H+
testosterone + NAD(P)+
-
-
-
?
2-cyclohexen-1-ol + NAD+
2-cyclohexen-1-one + NADH + H+
-
-
-
?
20alpha-dihydroprogesterone + NAD+
4-pregnen-3alpha,20beta-diol + NADH
-
-
-
-
r
20alpha-dihydroprogesterone + NADP+
4-pregnen-3alpha,20beta-diol + NADPH
-
-
-
-
r
3beta-hydroxy-5alpha-androstan-17-one + NADP+
5alpha-androstane-3,17-dione + NADPH
-
-
-
?
4-androsten-17beta-ol-3-one + NAD(P)+
4-androstene-3,17-dione + NAD(P)H + H+
17keto function is reduced. NADP+ is 3-5times less effective than NAD+
-
-
?
4-estrene-17beta-ol-3-one + NADP+
4-estrene-3,17-dione + NADPH
-
-
-
-
r
5-androsten-3beta-ol-17-one + NAD(P)+
5-androstene-3,17-dione + NAD(P)H + H+
NADP+ is 3-5times less effective than NAD+
-
-
?
5-androstenedione + NADPH
5alpha-dihydrotestosterone + NADP+
-
isozyme 17beta-HSD3
-
-
r
5-pregnen-3beta-ol-20-one + NAD(P)+
5-pregnene-3,20-dione + NAD(P)H + H+
NADP+ is 3-5times less effective than NAD+
-
-
?
5alpha-androst-16-en-3-one + NADH
3beta-hydroxy-5alpha-androst-16-ene + NAD+
-
-
-
?
5alpha-androstan-3alpha-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
-
-
?
5alpha-androstan-3beta-ol-17-one + NAD+
5alpha-androstan-3,17-dione + NADH + H+
-
-
-
?
5alpha-androstane-3beta,17beta-diol + NADP+
3beta-hydroxy-5alpha-androstan-17-one + NADPH
-
-
-
?
5alpha-dihydrotestosterone + NAD(P)H
5alpha-androstane-3beta,17beta-diol + NADP+
-
-
-
?
5alpha-pregnan-3alpha-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH + H+
-
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD(P)+
5alpha-pregnan-3,20-dione + NAD(P)H + H+
NADP+ and NADPH are 3-5times less effective than NAD+ and NADH
-
-
r
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH + H+
-
-
-
?
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnane-3,20-dione + NADH + H+
-
-
-
r
5alpha-pregnane-3,20-dione + NADH + H+
5alpha-pregnan-3beta-ol-20-one + NAD+
-
-
-
r
5beta-androstan-17beta-ol-3-one + NAD+
5beta-androstan-3,17-dione + NADH + H+
-
-
-
?
5beta-androstan-3alpha-ol-17-one + NAD+
5beta-androstan-3,17-dione + NADH + H+
-
-
-
?
5beta-pregnan-20alpha-ol-3-one + NAD+
5beta-pregnan-3,20-dione + NADH + H+
-
-
-
?
5beta-pregnan-3,20-dione + NAD(P)H + H+
3beta-hydroxy-5beta-pregnan-20-one + NAD(P)+
NADP+ is 3-5times less effective than NAD+
-
-
?
5beta-pregnan-3,20-dione + NADH
3beta-hydroxy-5beta-pregnan-20-one + NAD+
-
-
-
?
5beta-pregnan-3beta,21-diol-20-one + NADH + H+
? + NAD+
-
-
-
?
5beta-pregnan-3beta-ol-20-one + NAD(P)+
5-pregnan-3,20-dione + NAD(P)H + H+
NADP+ and NADPH are 3-5times less effective than NAD+ and NADH
-
-
r
5beta-pregnan-3beta-ol-20-one + NAD+
5beta-pregnan-3,20-dione + NADH + H+
-
-
-
?
androstenediol + NAD(P)H + H+
testosterone + NAD(P)+
-
reaction catalysed by 3beta-HSD (type 1)
-
-
?
androstenedione + NAD(P)H + H+
testosterone + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
-
?
androsterone + NADPH + H+
androstane-3beta,17beta-diol + NADP+
-
reduction at C17
-
-
?
beta-ionol + NAD+
(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one + NADH + H+
-
-
-
?
dehydroepiandrosterone + NAD(P)H + H+
androstenediol + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
-
?
dehydroepiandrosterone + NADPH + H+
androst-5-ene-3beta,17beta-diol + NADP+
-
-
-
-
?
dihydrotestosterone + NADPH + H+
5alpha-androstane-3beta,17beta-diol + NADP+
-
androsterone inactivation
-
-
?
epiandrosterone + NADPH
5-androstane-3beta,17beta-diol + NADP+
-
reduction at C17
-
-
?
epiandrosterone + NADPH
androstane-3beta,17beta-diol + NADP+
reduction at C17
-
-
?
estrogenic estrone + NAD(P)H + H+
17beta-estradiol + NAD(P)+
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases
-
-
?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
-
reaction catalysed by 17beta-HSD (type 1 and 3)
-
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
i.e. 11beta-hydroxy-androstenedione, reduction at C17
i.e. 11beta-testosterone
-
?
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH
11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+
-
i.e. 11beta-hydroxy-androstenedione, reduction at C17
i.e. 11beta-testosterone
-
?
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+
?
-
-
-
-
?
3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one + NAD(P)+
?
-
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
isozymes 17beta-HSD3 and 17beta-HSD5
-
-
r
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
selective reduction at C17
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
-
-
-
r
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
-
-
?
5beta-pregnan-3,20-dione + NADPH + H+
5beta-pregnane-3beta-ol-20-one + NADP+
-
-
-
?
5beta-pregnan-3,20-dione + NADPH + H+
5beta-pregnane-3beta-ol-20-one + NADP+
-
-
-
-
?
androst-4-ene-3,17-dione + NADPH + H+
testosterone + NADP+
-
-
-
?
androst-4-ene-3,17-dione + NADPH + H+
testosterone + NADP+
-
-
-
?
androst-5-ene-3,11,17-trione + NADPH
17beta-hydroxyandrost-5-ene-3,11-dione + NADP+
i.e. 11-keto-androstenedione, reduction at C17
i.e. 11-keto-testosterone
-
?
androst-5-ene-3,11,17-trione + NADPH
17beta-hydroxyandrost-5-ene-3,11-dione + NADP+
-
i.e. 11-ketoandrostenedione, reduction at C17
i.e. 11-keto-testosterone
-
?
androst-5-ene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH
-
-
-
r
androst-5-ene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH
-
-
-
r
androst-5-ene-3beta,17beta-diol + NADP+
dehydroepiandrosterone + NADPH
-
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
the equilibrium state is 2% testosterone to 95% androstenedione
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview
-
-
r
androstenedione + NADPH + H+
testosterone + NADP+
-
isozymes 17beta-HSD1 and 17beta-HSD8
-
-
r
androsterone + NADPH + H+
5alpha-androstane-3alpha,17beta-diol + NADP+
-
-
-
?
androsterone + NADPH + H+
5alpha-androstane-3alpha,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NAD(P)+
androst-5-en-3,17-dione + NAD(P)H + H+
-
-
-
-
?
dehydroepiandrosterone + NAD(P)+
androst-5-en-3,17-dione + NAD(P)H + H+
-
-
-
-
?
dehydroepiandrosterone + NAD(P)+
androst-5-en-3,17-dione + NAD(P)H + H+
-
-
-
-
?
dehydroepiandrosterone + NAD+
4-androstene-3,17-dione + NADH + H+
-
-
-
-
?
dehydroepiandrosterone + NAD+
4-androstene-3,17-dione + NADH + H+
-
-
-
-
?
dehydroepiandrosterone + NADPH + H+
5-androstene-3beta,17beta-diol + NADP+
-
reduction at C17
-
-
?
dehydroepiandrosterone + NADPH + H+
5-androstene-3beta,17beta-diol + NADP+
reduction at C17
-
-
?
dehydroepiandrosterone + NADPH + H+
5-androstene-3beta,17beta-diol + NADP+
-
reduction at C17
-
-
?
estradiol + NADP+
estrone + NADPH
-
the equilibrium state is 3% estradiol and 97% estrone
-
-
r
pregnenolone + NAD(P)+
progesterone + NAD(P)H + H+
-
-
-
?
pregnenolone + NAD+
progesterone + NADH + H+
-
the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NAD(P)+
androst-4-en-3,17-dione + NAD(P)H + H+
-
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
?
additional information
?
-
the wild-type strain ATCC 119960 degrades steroids, such as testosterone, estradiol, or cholesterol, differences in the enzyme mutant strains, overview
-
-
?
additional information
?
-
the wild-type strain ATCC 119960 degrades steroids, such as testosterone, estradiol, or cholesterol, differences in the enzyme mutant strains, overview
-
-
?
additional information
?
-
no activity with androstanedione and androsterone
-
-
?
additional information
?
-
-
no activity with androstanedione and androsterone
-
-
?
additional information
?
-
-
activity of the enzyme is associated with the mechanism of prostatic regulation by androgens after castration, which is important in prostate cancer
-
-
?
additional information
?
-
-
the enzyme is an important therapeutic target for androgen-sensitive diseases, overview
-
-
?
additional information
?
-
-
the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis
-
-
?
additional information
?
-
-
the isozyme might play an imporant role in modulation of active hormone levels in estrogen-sensitive cells or tissues
-
-
?
additional information
?
-
-
isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities
-
-
?
additional information
?
-
AKR1C3 physically interacts with the androgen receptor
-
-
?
additional information
?
-
-
AKR1C3 physically interacts with the androgen receptor
-
-
?
additional information
?
-
the enzyme AKR1C35 efficiently oxidizes various 3beta- and 17beta-hydroxysteroids, including biologically active 3beta-hydroxy-5alpha/beta-dihydro-C19/C21-steroids, dehydroepiandrosterone, and 17beta-estradiol, substrate specificity, detailed overview. Val54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS). No activity with 5beta-pregnan-3alpha-ol-20-one, 3alpha-hydroxyprogesterone, 5beta-androstan-3alpha-ol-17-one, 20alpha-hydroxyprogesterone, and 5alpha-pregnan-20alpha-ol-3-one
-
-
?
additional information
?
-
-
the enzyme AKR1C35 efficiently oxidizes various 3beta- and 17beta-hydroxysteroids, including biologically active 3beta-hydroxy-5alpha/beta-dihydro-C19/C21-steroids, dehydroepiandrosterone, and 17beta-estradiol, substrate specificity, detailed overview. Val54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS). No activity with 5beta-pregnan-3alpha-ol-20-one, 3alpha-hydroxyprogesterone, 5beta-androstan-3alpha-ol-17-one, 20alpha-hydroxyprogesterone, and 5alpha-pregnan-20alpha-ol-3-one
-
-
?
additional information
?
-
-
the enzyme plays a role in gonadal steroidogenesis
-
-
?
