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1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.49

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
 +
NADPH
 +
H+

Synonyms

6-phosphoglucose dehydrogenase, beta-D-glucose-6-phosphate; NADP oxidoreductase, beta-D-glucose-6-phosphate;NADP oxido-reductase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, P2-G6PDH, PF14_0511, PfGluPho, plastidial glucose 6-phosphate dehydrogenase, VEG11, Vegetative protein 11, Zwf, zwf-1, Zwf-2, Zwf1p, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

IC50 Value

IC50 Value on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.173
(1H-indol-1-yl)(furan-2-yl)methanone
Rattus norvegicus
pH 8, 25°C
0.0039
(1H-indol-1-yl)(tiyophen-2-yl)methanone
Rattus norvegicus
pH 8, 25°C
0.00018
(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
Saccharomyces cerevisiae
-
-
0.00025
(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
Saccharomyces cerevisiae
-
-
0.00024
(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
Saccharomyces cerevisiae
-
-
0.00023
(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
Saccharomyces cerevisiae
-
-
1.5
1-(2-nitro-1-(thiophen-2-yl)ethyl)-1H-indole
Rattus norvegicus
pH 8, 25°C
0.000015
16-bromoepiandrosterone
Trypanosoma cruzi
wild type enzyme, at pH 7.5 and 25°C
0.0018
2-[(E)-(4-nitrocyclohexa-2,4-dien-1-yl)(2-phenylhydrazinylidene)methyl]benzene-1,4-diol
Plasmodium falciparum
-
pH 7.5, temperature not specified in the publication
0.0039
4-fluoro-N-(4-hydroxynaphthalen-1-yl)benzenesulfonamide
Plasmodium falciparum
-
pH 7.5, temperature not specified in the publication
0.00097
4-methyl-3-(propan-2-yloxy)-6H-benzo[c]chromen-6-one
Plasmodium falciparum
-
pH 7.5, temperature not specified in the publication
0.000216
5alpha-androstan-16-alpha-bromo-3beta-ol-17-one
Trypanosoma cruzi
-
pH 7.6, temperature not specified in the publication
0.025
5alpha-Androstan-3beta-ol-17-one
Trypanosoma cruzi
-
pH 7.6, temperature not specified in the publication
0.000086
5alpha-androsten-16-alpha-bromo-3beta-ol-17-one
Trypanosoma cruzi
-
pH 7.6, temperature not specified in the publication
0.0187
ammonia
Oncorhynchus mykiss
-
inhibition in vitro and in vivo at sublethal concentration of 0.0022-0.0055 mM, IC50: 0.0187 mM
1007
amoxicillin
Alburnus tarichi
-
25°C, pH 8.5
0.0299
brimonidine
Homo sapiens
pH and temperature not specified in the publication
1.97
Cd2+
Oncorhynchus mykiss
-
pH 6.0, 25°C
0.33
ceftriaxone
Gallus gallus
-
-
7.69
Ciprofloxacin
Alburnus tarichi
-
25°C, pH 8.5
1.19
Cu2+
Oncorhynchus mykiss
-
pH 6.0, 25°C
0.63
cypermethrin
Oncorhynchus mykiss
-
-
0.0056
dehydroandrosterone
Trypanosoma cruzi
-
pH 7.6, temperature not specified in the publication
12
deltamethrin
Oncorhynchus mykiss
-
-
0.000076
ellagic acid
Plasmodium falciparum
pH 7.5, 25°C
0.003
epiandrosterone
Trypanosoma cruzi
wild type enzyme, at pH 7.5 and 25°C
0.39
Fe2+
Oncorhynchus mykiss
-
pH 6.0, 25°C
0.346
Fe3+
Rattus norvegicus
pH 7.6, and temperature not specified in the publication
0.87
Hg2+
Oncorhynchus mykiss
-
pH 6.0, 25°C
0.001
KMnO4
Alburnus tarichi
-
25°C, pH 8.5
1.54
lidocaine
Gallus gallus
-
-
0.0012
meloksikam
Gallus gallus
-
-
0.57
metamizol
Gallus gallus
-
-
0.0034
N-(4-chlorobenzoyl)-indole
Rattus norvegicus
pH 8, 25°C
0.0053
N-(4-hydroxynaphthalen-1-yl)-2,5-dimethylbenzenesulfonamide
Plasmodium falciparum
-
pH 7.5, temperature not specified in the publication
0.087
N-benzoylindole
Rattus norvegicus
pH 8, 25°C
0.0015
N-ethyl-N'-[(3alpha)-17-oxoandrostan-3-yl]urea
Trypanosoma cruzi
wild type enzyme, at pH 7.5 and 25°
0.0022
N-[(3alpha)-17-oxoandrostan-3-yl]sulfuric diamide
Trypanosoma cruzi
wild type enzyme, at pH 7.5 and 25°
1.15
nidazole
Alburnus tarichi
-
25°C, pH 8.5
0.78
Pb2+
Oncorhynchus mykiss
-
pH 6.0, 25°C
28.17
prilocaine
Gallus gallus
-
-
1.02
propoxur
Oncorhynchus mykiss
-
-
0.075
sulfanilacetamide
Alburnus tarichi
-
25°C, pH 8.5
0.119
sulfanilamide
Alburnus tarichi
-
25°C, pH 8.5
0.0000036
Tl+
Homo sapiens
-
201Tl solution, pH 8.5, 25°C
0.0238
Urea
Oncorhynchus mykiss
-
inhibition in vitro and in vivo at sublethal concentration of 0.02-0.05 mM, IC50: 0.0238 mM
1.18
Vancomycin
Alburnus tarichi
-
25°C, pH 8.5
2.16
Zn2+
Oncorhynchus mykiss
-
pH 6.0, 25°C