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1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.49

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, beta-D-glucose-6-phosphate; NADP oxidoreductase, beta-D-glucose-6-phosphate;NADP oxido-reductase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, P2-G6PDH, PF14_0511, PfGluPho, plastidial glucose 6-phosphate dehydrogenase, VEG11, Vegetative protein 11, Zwf, zwf-1, Zwf-2, Zwf1p, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Expression

Expression on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme activity decreases in the presence of 80 mM NaCl on day 2
-
enzyme expression is slightly induced by D-glucose
-
gene expressions is significantly repressed in the presence of nontoxic (0.87 and 3 ppm) and toxic iron concentrations (30 and 300 ppm)
high glucose level inhibits G6PD expression
immediately following application of hypoosmotic stress, the activity of the enzyme in leaves decreases compared to plants grown in soil. After 3 days, a defense response appears in the form of substantially (7.4fold) increased specific activities in hypoosmotically stressed leaves
-
no significant upregulation of expression in presence of artemisinin, chloroquine or methylene blue
plants exposed to salt stress for three days exhibit significantly (3.5fold) increased specific activity in leaves compared to non-stressed controls grown in soil
-
TAp73 protein stimulates the expression of glucose-6-phophate dehydrogenase. Enzyme expression is elevated in various tumors, correlating with the upregulation of TAp73
the AMPK signaling pathway as well as the inhibitory p38 MAPK pathway are cooperating to inhibit G6PD expression. Arachidonic acid activates AMP-activated protein kinase in primary rat hepatocytes, and this effect is p38 MAPK-dependent. Activation of AMP-activated protein kinase mimics the inhibition by arachidonic acid of the insulin-mediated induction of G6PD. Overexpression of dominant-negative AMP-activated protein kinase abolishes the effect of arachidonic acid on G6PD expression
-
when highland barley is exposed to UV-B radiation, the enzyme activity decreases
-