1.1.1.42: isocitrate dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.42
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1.1.1.42
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glioma
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glioblastoma
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astrocytomas
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dehydrogenases
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malate
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leukemia
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myeloid
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glucose-6-phosphate
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resect
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oncometabolite
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oligodendrogliomas
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d-2-hydroxyglutarate
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anaplastic
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malic
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idh1-mutant
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tricarboxylic
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hypermethylation
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multiforme
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high-grade
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progression-free
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temozolomide
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2-oxoglutarate
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radiotherapy
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codeletion
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neomorphic
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alpha-ketoglutarate
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6-phosphogluconate
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nadph-generating
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cholangiocarcinomas
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o6-methylguanine-dna
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gliomagenesis
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aconitase
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oligodendroglial
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lgg
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chondrosarcoma
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lower-grade
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oligoastrocytomas
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medicine
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nadp-malic
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supratentorial
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biotechnology
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nadph-producing
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analysis
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diagnostics
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nadp-me
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radiomics
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pilocytic
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karnofsky
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proneural
- 1.1.1.42
- glioma
- glioblastoma
- astrocytomas
- dehydrogenases
- malate
- leukemia
- myeloid
- glucose-6-phosphate
-
resect
-
oncometabolite
- oligodendrogliomas
- d-2-hydroxyglutarate
-
anaplastic
-
malic
-
idh1-mutant
-
tricarboxylic
-
hypermethylation
- multiforme
-
high-grade
-
progression-free
- temozolomide
- 2-oxoglutarate
-
radiotherapy
-
codeletion
-
neomorphic
- alpha-ketoglutarate
- 6-phosphogluconate
-
nadph-generating
- cholangiocarcinomas
-
o6-methylguanine-dna
-
gliomagenesis
- aconitase
-
oligodendroglial
- lgg
- chondrosarcoma
-
lower-grade
- oligoastrocytomas
- medicine
-
nadp-malic
-
supratentorial
- biotechnology
-
nadph-producing
- analysis
- diagnostics
- nadp-me
-
radiomics
-
pilocytic
-
karnofsky
-
proneural
Reaction
Synonyms
AbIDH1, AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, HICDH, ICD, ICD1, ICD2, icdA, ICDH, ICDH-1, IDH, IDH-90, IDH-I, IDH-IIa, IDH-IIb, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+ dependent isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent ICDH, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific IDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, NADPH-IDH, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148, YlIDP
ECTree
1.1.1.42 isocitrate dehydrogenase (NADP+)Advanced search results
results (
results (KM Value
KM Value on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.04
2-oxoglutarate
wild type enzyme, in Bis-Tris buffer, at pH 6.2 and 37°C
0.12
2-oxoglutarate
wild type enzyme, in Bis-Tris buffer, at pH 6.5 and 37°C
0.14
2-oxoglutarate
wild type enzyme, in Bis-Tris buffer, at pH 6.8 and 37°C
0.246
2-oxoglutarate
wild type enzyme, in Tris buffer, at pH 7.5 and 37°C
0.26
2-oxoglutarate
wild type enzyme, in Bis-Tris buffer, at pH 7.0 and 37°C
0.28
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 7.2 and 37°C
0.46
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 7.5 and 37°C
0.6
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 6.2 and 37°C
0.65
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 6.8 and 37°C
0.71
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 7.0 and 37°C
0.87
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 7.8 and 37°C
1
2-oxoglutarate
wild type enzyme, in potassium phosphate buffer, at pH 6.5 and 37°C
1.5
2-oxoglutarate
mutant enzyme R132H, in potassium phosphate buffer, at pH 7.5 and 37°C
0.01
DL-isocitrate
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isoform ICD-1, presence of Mg2+, pH 7.5, 25°C
0.011
DL-isocitrate
Q8X277
mutant R291S/K343D/Y344I/V350A/Y390P, pH 8.0, 30°C
0.02
DL-isocitrate
-
isoform ICD-2, presence of Mg2+, pH 7.5, 25°C
0.021
DL-isocitrate
pH and temperature not specified in the publication
0.022
DL-isocitrate
-
isoform ICD-1, presence of Zn2+, pH 7.5, 25°C
0.054
DL-isocitrate
pH and temperature not specified in the publication
0.0062
isocitrate
-
recombinant wild-type IDH1, pH not specified in the publication, temperature not specified in the publication
0.027
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 6.2 and 37°C
0.034
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 6.5 and 37°C
0.04
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 6.8 and 37°C
0.042
isocitrate
wild type enzyme, in Bis-Tris buffer, at pH 6.2 and 37°C
0.048
isocitrate
wild type enzyme, in Bis-Tris buffer, at pH 6.5 and 37°C
0.05
isocitrate
pH 7.5, temperature not specified in the publication, recombinant His-tagged enzyme
0.05
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 7.0 and 37°C
0.0505
isocitrate
in the presence of Mn2+, pH and temperature not specified in the publication
0.0505
isocitrate
pH 8.0, 25°C, in presence of Mn2+, wild-type enzyme
0.06
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 7.2 and 37°C
0.061
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 7.5 and 37°C
0.0654
isocitrate
in the presence of Mg2+, pH and temperature not specified in the publication
0.0654
isocitrate
pH 8.0, 25°C, in presence of Mg2+, wild-type enzyme
0.066
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 7.8 and 37°C
0.067
isocitrate
wild type enzyme, in potassium phosphate buffer, at pH 8.0 and 37°C
0.075
isocitrate
wild type enzyme, in Bis-Tris buffer, at pH 7.0 and 37°C
0.1043
isocitrate
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S22A
0.1169
isocitrate
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S22H
0.1414
isocitrate
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S22E
0.15
isocitrate
mutant enzyme K217M, in potassium phosphate buffer, at pH 7.5 and 37°C
0.2447
isocitrate
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S113T
0.25
isocitrate
mutant enzyme K217Q, in potassium phosphate buffer, at pH 7.5 and 37°C
0.3276
isocitrate
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S113A
0.3686
isocitrate
-
recombinant mutant R132C IDH1, pH not specified in the publication, temperature not specified in the publication
0.4341
isocitrate
-
recombinant mutant R132S IDH1, pH not specified in the publication, temperature not specified in the publication
0.5824
isocitrate
-
recombinant mutant R132H IDH1, pH not specified in the publication, temperature not specified in the publication
1.9
isocitrate
mutant enzyme D273L, in potassium phosphate buffer, at pH 7.5 and 37°C
2.525
isocitrate
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S113G
12
isocitrate
mutant enzyme D273S, in potassium phosphate buffer, at pH 7.5 and 37°C
19
isocitrate
mutant enzyme D273N, in potassium phosphate buffer, at pH 7.5 and 37°C
0.13
NAD+
pH 8.0, 25°C, recombinant mutant D253A/S257K/K260Q/R314D/H315I/T327A
2.62
NAD+
mutant enzyme H590L/R601D, in the presence of Mn2+, at pH 8.2 and 45°C
3.474
NAD+
mutant enzyme H590L/R601D/R650S, in the presence of Mn2+, at pH 8.2 and 45°C
3.58
NAD+
pH 8.0, 25°C, recombinant wild-type enzyme
8.49
NAD+
in 20 mM Tris-HCl (pH 8.0), at 25°C, in the presence of 2 mM Mn2+
18.6
NAD+
in 20 mM Tris-HCl (pH 8.0), at 25°C, in the presence of 2 mM Mg2+
0.00242
NADP+
in 20 mM Tris-HCl (pH 8.0), at 25°C, in the presence of 2 mM Mg2+
0.00278
NADP+
in 20 mM Tris-HCl (pH 8.0), at 25°C, in the presence of 2 mM Mn2+
0.0068
NADP+
-
recombinant mutant R132C IDH1, pH not specified in the publication, temperature not specified in the publication
0.0073
NADP+
-
recombinant wild-type IDH1, pH not specified in the publication, temperature not specified in the publication
0.0122
NADP+
-
recombinant mutant R132H IDH1, pH not specified in the publication, temperature not specified in the publication
0.0144
NADP+
-
recombinant mutant R132S IDH1, pH not specified in the publication, temperature not specified in the publication
0.015
NADP+
pH 7.5, temperature not specified in the publication, recombinant His-tagged enzyme
0.0168
NADP+
wild type enzyme, in the presence of Mn2+, at pH 8.2 and 45°C
0.0181
NADP+
in the presence of Mg2+, pH and temperature not specified in the publication
0.0181
NADP+
pH 8.0, 25°C, in presence of Mg2+, wild-type enzyme
0.01945
NADP+
pH 8.0, 25°C, recombinant wild-type enzyme
0.0223
NADP+
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S22H
0.0261
NADP+
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S22A
0.0289
NADP+
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S22E
0.045
NADP+
pH and temperature not specified in the publication
0.0466
NADP+
in the presence of Mn2+, pH and temperature not specified in the publication
0.0466
NADP+
pH 8.0, 25°C, in presence of Mn2+, wild-type enzyme
0.0552
NADP+
pH 8.0, 70°C, Km-value for NAD+ is about 140fold higher than the KM-value for NADP+
0.056
NADP+
pH and temperature not specified in the publication
0.0879
NADP+
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S113T
0.1221
NADP+
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S113A
0.324
NADP+
pH 8.0, 25°C, recombinant mutant D253A/S257K/K260Q/R314D/H315I/T327A
0.4868
NADP+
mutant enzyme H590L/R601D, in the presence of Mn2+, at pH 8.2 and 45°C
0.8546
NADP+
pH 8.0, 25°C, in presence of Mg2+, mutant enzyme S113G
10.457
NADP+
mutant enzyme H590L/R601D/R650S, in the presence of Mn2+, at pH 8.2 and 45°C
0.0025
NADPH
Km less than 0.0025 mM or equal, mutant enzyme R100Q, at pH 7.5 and 21°C
0.005
NADPH
Km less than 0.005 mM or equal, mutant enzyme R132H, at pH 7.5 and 21°C
0.01
NADPH
Km less than 0.01 mM or equal, wild type enzyme, at pH 7.5 and 37°C
0.025
NADPH
Km less than 0.025 mM or equal, mutant enzyme R132C, at pH 7.5 and 21°C
0.025
NADPH
Km less than 0.025 mM or equal, mutant enzyme R132G, at pH 7.5 and 21°C
0.025
NADPH
Km less than 0.025 mM or equal, mutant enzyme R132H, at pH 7.5 and 37°C
0.025
NADPH
Km less than 0.025 mM, mutant enzyme R132G, at pH 7.5 and 37°C
additional information
additional information
kinetic analysis
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additional information
additional information
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kinetics of isozymes IDP1 and IDP2
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additional information
additional information
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measurement methods, the maltose binding fusion protein of the recombinant enzymes alters the kinetic parameters, overview
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additional information
additional information
kinetics analysis, overview
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additional information
additional information
Km-values of wild-type and chimeric enzymes
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additional information
additional information
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Km-values of wild-type and chimeric enzymes
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additional information
additional information
Km-values of wild-type and chimeric enzymes
-
additional information
additional information
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Km-values of wild-type and chimeric enzymes
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additional information
additional information
steady-state kinetics, kinetic mechanism of ICDH-1, overview
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additional information
additional information
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steady-state kinetics, kinetic mechanism of ICDH-1, overview
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additional information
additional information
stopped-flow kinetics and steady-state kientics
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