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1.1.1.40: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

This is an abbreviated version!
For detailed information about malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+), go to the full flat file.

Word Map on EC 1.1.1.40

Reaction

(S)-malate
+
NADP+
=
pyruvate
+
CO2
+
NADPH
+
H+

Synonyms

ADP-malic enzyme2, c-NADP-ME, C4 NADP-malic enzyme, C4 photosynthetic NADP-malic enzyme, C4-NADP-malic enzyme, C4-NADP-ME, ChlME1, ChlME2, cNAD-ME, cytoNADPME, cytosolic malic enzyme, cytosolic NADP+-dependent isoform, cytosolic NADP+-dependent malic enzyme, L-malate: NADP oxidoreductase (decarboxylating), L-malate: NADP oxidoreductase [OAA decarboxylating], L-malate: NADP oxidoreductase [oxaloacetate decarboxylating], L-malate:NADP oxidoreductase, L-malate:NADP oxidoreductase (oxaloacetate decarboxylating), m-NAD(P)-ME, m-NADP-ME, MaeB, MaeB1, MalA, malate dehydrogenase (decarboxylating, NADP), malate dehydrogenase (NADP, decarboxylating), malE1, malic enzyme, malic enzyme 1, malic enzyme 2, malic enzyme 3, malic enzyme-NADP, ME, ME-61, ME-70, ME-NADP, ME1, ME2, ME3, mitochondrial malic enzyme, mitochondrial NADP malic enzyme, mNAD-ME, NAD(P)+-malic enzyme, NADP dependent malic enzyme, NADP malic enzyme, NADP(+)-dependent mitochondrial malic enzyme 2, NADP(H)-dependent malic enzyme, NADP+ dependent malic enzyme, NADP+-dependent decarboxylating malate dehydrogenase, NADP+-dependent malic enzyme, NADP+-dependent malic enzyme 3, NADP+-dependent ME, NADP+-ME, NADP-dependent malate dehydrogenase, NADP-dependent malic enzyme, NADP-dependent malic enzyme 1, NADP-dependent ME, NADP-linked decarboxylating malic enzyme, NADP-malate dehydrogenase, NADP-malate enzyme, NADP-malic enzyme, NADP-malic enzyme 1, NADP-malic enzyme 2, NADP-MDH, NADP-ME, NADP-ME1, NADP-ME2, NADP-ME3, NADP-ME4, NADP-specific malate dehydrogenase, NADP-specific malic enzyme, NADP-specific ME, NADPH-dependent malic enzyme, NADPH-dependent malic enzyme 1, NADPH-dependent ME1, nicotinamide adenine dinucleotide phosphate-dependent malic enzyme, nicotinamide adenine dinucleotide phosphate-malic enzyme, nonC4-NADP-ME, pNAD-ME, pyruvic-malic carboxylase, RHA1_RS44255, TME

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

Expression

Expression on EC 1.1.1.40 - malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
25% diminished cytosolic enzyme activity is found in Arabidopsis thaliana seedlings exposed to short-term low temperature (4°C for 48 h)
-
abscisic acid and PEG reduce enzyme expression, under cold condition the enzyme expression is sligtly reduced
aluminium treatment (0.03 mM AlCl3) induces higher enzyme activities and isoform ME1 expression levels in cultivar Jiyu 70 than in Jiyu 62 within 24 h
-
ammonium tartrate as nitrogen source induces isozyme D
cytosolic enzyme specific activity, amount of protein and transcription of mRNA in tobacco leaves of drought stressed plants are decreased after 11 days of stress
-
darkness does not affect enzyme expression in leves, no effect by salicylic acid or by salt stress
enzyme activity increases 1.5fold during fruit ripening
-
enzyme expression is induced by alkaline, UV and abscisic acid treatments
-
enzyme isoform NADP-ME1 expression is increased in imbibed aged as compared with non-aged seeds
-
enzyme transcription in sweet sorghum is enhanced by salt stress (50-200 mM NaCl)
-
immediately following application of hypoosmotic stress, the activity of the enzyme in leaves decreases compared to plants grown in soil. After 3 days, a defense response appears in the form of substantially (2.8fold) increased specific activities in hypoosmotically stressed leaves
-
inoculation of arbuscular mycorrhizal fungi in continuous cropping substrates increases the root and NADP-malic enzyme activity of tomato seedlings
-
isoform ME2 expression increases as tumor progression and invasion capabilities of cells are increased
-
isoform NADP-ME1 transcript and protein are almost undetectable during normal vegetative growth, but gradually increase and reach levels higher than those of the other isoforms in the latest stages of seed development (reaching a value 136fold higher at 18 days after pollination). The treatment with 0.01 mM abscisic acid, 100 mM NaCl and 225 mM mannitol specifically induces the accumulation of isoform NADP-ME1 in seedlings and roots
-
mitochondrial enzyme specific activity, amount of protein and transcription of mRNA in tobacco leaves of drought stressed plants are 3.9fold increased after 11 days of stress
-
NaCl salt stress upregulates the transcripts of putative plastidic isozymes PtNADP-ME4 and PtNADP-ME5 significantly. Expression of PtNADP-ME2 and PtNADP-ME3 increases during the course of leaf wounding, PtNADP-ME3 transcript levels peak at 6 h under NaCl and mannitol stresses. Expression of PtNADP-ME1 gene is induced slightly by mannitol and PEG osmotic stresses, but not by salt stress
-
p53 represses the expression of malic enzyme 1 and malic enzyme 2
-
plants exposed to salt stress for three days exhibit significantly (2fold) increased specific activity in leaves compared to non-stressed controls grown in soil
-
significant decrease of PtNADP-ME2 and PtNADP-ME3 in mRNA levels, but only a slight change in other PtNADP-ME genes, during the dark
-
supplementation by cell permeable exogenous dimethylmalate (DMM) in A-549 cells mimics the ME2 knockdown phenotype
-
the enzyme activity is induced under light
-
the enzyme's protein level is strongly upregulated (more than 2fold) under low glucose conditions
-
there is an increase in enzyme activity in fruit exposed to 20% (v/v) CO2
-
total enzyme activity increases by 1.8fold during cultivation under nitrogen-limiting conditions
-
total enzyme activity increases by 2.6fold during cultivation under nitrogen-limiting conditions
transverse aortic constriction induces elevated enzyme content in hearts. Enzyme expression is increased in hypertrophied rats heart
-