1.1.1.399: 2-oxoglutarate reductase

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For detailed information about 2-oxoglutarate reductase, go to the full flat file.

Reaction

Synonyms

alpha-ketoglutarate reductase, alphaKG reductase, OGR, serA

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.399 2-oxoglutarate reductase

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Results	in table
1	Activating Compound
13199	AA Sequence
1	Cloned(Commentary)
2	Cofactor
1	IC50 Value
6	Inhibitors
1	kcat/KM [mM/s]
3	Ki Value [mM]
7	KM Value [mM]
3	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
18	Organism
2	Pathway
38	PDB ID
3	Purification (Commentary)
1	Reaction
18	Reference
2	Specific Activity [micromol/min/mg]
2	Storage Stability
41	Substrates and Products (Substrate)
4	Subunits
20	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 1.1.1.399 - 2-oxoglutarate reductase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0 - 40

Escherichia coli

-

the enzyme remains stable after 3 min incubation between 0 and 40°C, while 3 min at 45, 50 and 60°C leads to about 40, 70, and 100% loss of activity

287546

45 - 60

Fusobacterium nucleatum

-

the enzyme is stable at 45°C for 10 min, 70% of its activity is lost at 50°C, 5% of the original activity is retained at 55°C, while incubation at 60°C abolishes all activity

738269