1.1.1.399: 2-oxoglutarate reductase
This is an abbreviated version!
For detailed information about 2-oxoglutarate reductase, go to the full flat file.
Reaction
Synonyms
alpha-ketoglutarate reductase, alphaKG reductase, OGR, serA
ECTree
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Systematic Name
Systematic Name on EC 1.1.1.399 - 2-oxoglutarate reductase
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(R)-2-hydroxyglutarate,NAD+ 2-oxidireductase
The enzyme catalyses a reversible reaction. The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate [1,2]. The SerA enzyme from the bacterium Escherichia coli can also accept (S)-2-hydroxyglutarate with a much higher Km, and also catalyses the activity of EC 1.1.1.95, phosphoglycerate dehydrogenase [3].