1.1.1.39: malate dehydrogenase (decarboxylating)

This is an abbreviated version!
For detailed information about malate dehydrogenase (decarboxylating), go to the full flat file.

Reaction

Synonyms

AT2g13560, At4g00570, AZC3656 protein, cytosolic malic enzyme, decarboxylating NAD-malic enzyme, dehydrogenase, malate, diphosphate nucleotide dependent malic enzyme, DMA, DME, m-NAD-ME, malic enzyme, malic enzyme 2, malic enzyme-NAD, ME, ME-NAD, ME1, ME2, mitochondrial malic enzyme, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD+-dependent malic enzyme, mitochondrial NAD-malic enzyme, mNAD-ME1, mNAD-ME2, NAD(P)+-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent malate dehydrogenase (decarboxylating), NAD-dependent malic enzyme, NAD-dependent malic enzyme 1, NAD-dependent malic enzyme 2, NAD-malate dehydrogenase, NAD-malic enzyme, NAD-ME, NAD-ME1, NAD-ME2, NAD-MEH, NAD-preferring malic enzyme, NAD-preferring ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.39 malate dehydrogenase (decarboxylating)

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Results	in table
49	Activating Compound
209	AA Sequence
3	Application
1	CAS Registry Number
16	Cloned(Commentary)
134	Cofactor
3	Crystallization (Commentary)
102	Disease/ Diagnostics
10	Expression
35	General Information
2	General Stability
78	Inhibitors
10	kcat/KM [mM/s]
21	Ki Value [mM]
116	KM Value [mM]
49	Localization
71	Metals/Ions
41	Molecular Weight [Da]
67	Natural Substrates/ Products (Substrates)
104	Organism
1	Oxidation Stability
6	Pathway
26	PDB ID
51	pH Optimum
7	pH Range
2	pH Stability
1	pI Value
28	Protein Variants
24	Purification (Commentary)
13	Reaction
4	Reaction Type
97	Reference
67	Source Tissue
28	Specific Activity [micromol/min/mg]
4	Storage Stability
148	Substrates and Products (Substrate)
23	Subunits
124	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
15	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

enzyme in binary complex with NAD+, by hanging drop vapour diffusion method, from solution containing 5 mM NAD+, 10 mM tartronate, and 20 mM MgSO4, for cryoprotection soaking overnight in 100 mM Tris-HCl, pH 7.5, with 25% PEG w/v 15 mM NAD+, 10 mM 2-mercaptoethanol, and glycerol up to a final concentration of 20% v/v, X-ray diffraction structure determination and analysis at 2.3 A resolution, structure modeling

Ascaris suum

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654651

quarternary complex of purified enzyme with NADH, tartronate, and Mg2+, hanging drop vapour diffusion method, from 100 mM Tris-SO4, pH 7.3, 100 mM sodium acetate, 15% PEG 4000, 5 mM NADH, 10 mM tartronate, 20 mM MgSO4, 10 mM 2-mercaptoethanol, and 0.02% sodium azide, for cryoprotection the crystals are soaked in 25% PEG 4000, 15 mM NAD+, 10 mM 2-mercaptoethanol, and 100 mM Tris-SO4, pH 7.5, for 2 h, then 24 h in the crystallization buffer plus 20% EG v/v, X-ray diffraction structure determination and analysis at 2.0 A resolution, structure modeling

Ascaris suum

-

656163

enzyme complexed with the natural substrate malate or pyruvate, NAD+ or NADH, Mn2+, and the allosteric activator fumarate, X-ray diffraction structure determination and analysis at 2.1 A resolution, structure modeling

Homo sapiens

-

657362