1.1.1.387: L-serine 3-dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about L-serine 3-dehydrogenase (NAD+), go to the full flat file.
Reaction
Synonyms
L-SerDH, L-serine 3-dehydrogenase, L-serine dehydrogenase, NAD+-dependent L-serine dehydrogenase, PA0743
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.387 - L-serine 3-dehydrogenase (NAD+)
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REACTION DIAGRAM
2-aminomalonate semialdehyde
2-aminoacetaldehyde + CO2
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spontaneous
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-
?
D-serine + NAD+
2-aminoacetaldehyde + CO2 + NADH + H+
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overall reaction, 5% of the relative activity observed with L-serine
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-
?
L-serine + NAD(P)+
2-aminomalonate semialdehyde + NAD(P)H + H+
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-
-
-
?
L-serine + NAD+
2-aminoacetaldehyde + CO2 + NADH + H+
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overall reaction, NAD+ is the preferred cofactor
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-
?
L-serine + NADP+
2-aminoacetaldehyde + CO2 + NADPH + H+
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overall reaction, low activity with NADP+
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-
?
additional information
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modeling of the D-serine and 3-hydroxypropionate molecules into the enzyme's active site. No steric hindrance is observed between D-serine and the side chains of the active site residues. D-serine is placed at the position through interactions similar to the L-serine binding model. The C3 hydrogen of D-serine is located at the same position as that of L-serine. This may explain the high reactivity toward D-serine exhibited by Pyrobaculum calidifontis L-SerDH
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?
the enzyme might be involved in serine/threonine degradation. Since growth experiments with various nitrogen and carbon sources (including L-serine) reveal no difference between the Pseudomonas aeruginosa wild-type and PA0743 deletion strains, it is suggested hat this organism might contain other (complementing) serine dehydrogenases
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?
L-serine + NAD+
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the enzyme might be involved in serine/methylserine degradation. Since growth experiments with various nitrogen and carbon sources (including L-serine) reveal no difference between the Pseudomonas aeruginosa wild-type and PA0743 deletion strains, it is suggested hat this organism might contain other (complementing) serine dehydrogenases
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?