1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)
This is an abbreviated version!
For detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.
Word Map on EC 1.1.1.38
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1.1.1.38
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glucose-6-phosphate
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lipogenic
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phosphoenolpyruvate
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lipogenesis
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isocitrate
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adipose
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citrate
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thyroid
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acetyl-coa
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carboxykinase
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co2
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6-phosphogluconate
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cholesterol
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triglyceride
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succinate
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nadp+
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1.1.1.40
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triiodothyronine
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l-malate
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tricarboxylic
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nadp+-dependent
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6-phosphate
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pentose
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nadp-malic
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nadp-me
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atp-citrate
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triacylglycerols
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pigeon
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fumarate
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oleaginous
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nadp-linked
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anaplerotic
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mesophyll
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refeeding
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pepck
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phosphoglucomutase
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refeed
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oxalacetate
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alpha-glycerophosphate
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dikinase
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nadph-generating
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ascaris
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panicum
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nadp-isocitrate
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crassulacean
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circinelloides
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hydrogenosomal
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5'-deiodinase
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mortierella
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alpina
- 1.1.1.38
- glucose-6-phosphate
-
lipogenic
- phosphoenolpyruvate
-
lipogenesis
- isocitrate
- adipose
- citrate
- thyroid
- acetyl-coa
-
carboxykinase
- co2
- 6-phosphogluconate
- cholesterol
- triglyceride
- succinate
- nadp+
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1.1.1.40
- triiodothyronine
- l-malate
-
tricarboxylic
-
nadp+-dependent
- 6-phosphate
- pentose
-
nadp-malic
- nadp-me
-
atp-citrate
- triacylglycerols
-
pigeon
- fumarate
-
oleaginous
-
nadp-linked
-
anaplerotic
- mesophyll
-
refeeding
- pepck
- phosphoglucomutase
-
refeed
- oxalacetate
- alpha-glycerophosphate
- dikinase
-
nadph-generating
- ascaris
- panicum
-
nadp-isocitrate
-
crassulacean
- circinelloides
- hydrogenosomal
- 5'-deiodinase
-
mortierella
- alpina
Reaction
Synonyms
m-NAD(P)-ME, maeA, malic enzyme, malic enzyme 2, ME2, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, NADH-dependent malic enzyme, pyruvic-malic carboxylase
ECTree
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)Advanced search results
results (
results (Inhibitors
Inhibitors on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1-(5-O-phosphono-beta-D-ribofuranosyl)-4-[2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole
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2-methylbutanoate
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5.22 mM, competitive inhibitor, 60% inhibition at pH 7.5, 54% inhibition at pH 7.0
2-methylpentanoate
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5.22 mM, competitive inhibitor, 45% inhibition at pH 7.5, 40% inhibition at pH 7.0
4,4'-dithiodipyridine
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sulfhydryl reagent, rapid and complete loss of activity, presence of Mg2+ or Mn2+ enhances inactivation rate
4-(2-aminophenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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4-(2-fluorophenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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4-(2-hydroxyethyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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4-(2-methylphenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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4-(4-fluorophenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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4-(4-methoxyphenyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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4-(naphthalen-1-yl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazole
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diethyldicarbonate
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80% inactivation after treatment with 5 mM diethyldicarbonate for 25 min, biphasic inactivation, 40-50% inactivation in first phase, 1-2 histidine residues are acylated by diethyldicarbonate, 250 mM malate provides complete protection, 50% protection with 50 mM MgSO4, 55% enzyme activity is restored with 0.5 M hydroxylamine
N-acetyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazol-4-amine
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N-benzoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-1,2,3-triazol-4-amine
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tiglic acid
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5.22 mM, competitive inhibitor, 58% inhibition at pH 7.5, 52% inhibition at pH 7.0
5,5'-dithiobis(2-nitrobenzoic acid)
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sulfhydryl reagent, rapid and complete loss of activity, presence of Mg2+ or Mn2+ enhances inactivation rate
5,5'-dithiobis(2-nitrobenzoic acid)
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inhibition of decarboxylation activity
acetyl-CoA
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0.005 mM, 18% inhibition, 0.01 mM, 42% inhibition, 0.1 mM, 68% inhibition
ADP
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57% inhibition, 2 mM ADP, 0.01 mM CoA, 1 mM malate, 2 mM NAD+, 4 mM Mn2+
ADP
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26% inhibition,2 mM ADP, 0.005 mM CoA, 5 mM malate, 2 mM NAD+, 4 mM Mn2+
AMP
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50% inhibition, 2 mM AMP, 0.01 mM CoA, 1 mM malate, 2 mM NAD+, 4 mM Mn2+
AMP
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39% inhibition, 2 mM AMP, 0.005 mM CoA, 5 mM malate, 2 mM NAD+, 4 mM Mn2+
ATP
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72% inhibition, 2 mM ATP, 0.01 mM CoA, 1 mM malate, 2 mM NAD+, 4 mM Mn2+
ATP
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more effective in the presence of Mn2+ than in the presence of Mg2+, 50% inhibition with 1.6 mM Mn2+ and 3.9 mM in the presence of Mg2+ respectively
CoA
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50% inhibition with 0.75 mM CoA in the presence of Mg2+ and 3.4 mM in the presence of Mn2+
CoA
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in the absence of L-aspartate 50% inhibition with 0.22 mM CoA, in the presence of 2 mM L-aspartate 50% inhibition with 1.1 mM
N-ethylmaleimide
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sulfhydryl reagent, rapid and complete loss of activity, presence of Mg2+ or Mn2+ enhances inactivation rate
N-ethylmaleimide
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L-malate and tartronate strongly protect the enzyme in the presence of MnCl2 and NAD+, 80% inhibition of decarboxylation activity, 10fold increase in reduction activity
additional information
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in vivo inhibition of the enzyme by oxidation, activity in leaves held under continuous light is reduced by 20-40%
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additional information
synthesis and inhibitor potencies of triazole moiety-containing nucleotide analogues, overview. The synthesis involves two key steps, the lipase-mediated selective deacylation of 1-azido-2,3,5-tri-O-acetyl-beta-D-ribofuranoside and the Huisgen 1,3-dipolar cycloaddition between terminal alkynes and the 1-azido ribofuranoside derivative
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additional information
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synthesis and inhibitor potencies of triazole moiety-containing nucleotide analogues, overview. The synthesis involves two key steps, the lipase-mediated selective deacylation of 1-azido-2,3,5-tri-O-acetyl-beta-D-ribofuranoside and the Huisgen 1,3-dipolar cycloaddition between terminal alkynes and the 1-azido ribofuranoside derivative
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additional information
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water stress reduces the enzyme activity in vivo
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