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1.1.1.37: malate dehydrogenase

This is an abbreviated version!
For detailed information about malate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.37

Reaction

(S)-malate
+
NAD+
=
oxaloacetate
 +
NADH
 +
H+

Synonyms

(R)-2-hydroxyacid dehydrogenase, (S)-malate dehydrogenase, A8B73_11505, CaMDH, cMDH, cMDH -S, cMDH-L, cyMDH, cyMDH1, cyMDH2, cyMDH3, cytMDH, cytMDH1, cytosolic malate dehydrogenase, cytosolic malate dehydrogenase 1, cytosolic MDH, cytosolic NAD-dependent malate dehydrogenase, flo16, floury endosperm16, halophilic malate dehydrogenase, HmMalDH, L-malate dehydrogenase, L-malate dehydrogenases, L-malate-NAD oxidoreductase, L-malate-NAD-oxidoreductase, L-malate: NAD oxidoreductase, L-malate: NAD+ oxidoreductase, L-malate:NAD oxidoreductase, L-malate:NAD-oxidoreductase, L-MDH, LDH-like malate dehydrogenase, ldh0076, LEUM_0076, m-MDH, malate (NAD) dehydrogenase, malate dehydrogenase, malate dehydrogenase (NAD), malate dehydrogenase 1, malate dehydrogenase 2, malate: NAD oxidoreductase, MalDH, malic acid dehydrogenase, malic dehydrogenase, mbNAD-MDH, MDH, MDH A, MDH B1, MDH B2, Mdh1, MDH2, Mdh2a, Mdh2b, Mdh3, mitochondrial malate dehydrogenase, mitochondrial MDH, mMDH, mNAD-MDH, More, NAD+ malate dehydrogenase, NAD+-dependent malate dehydrogenase, NAD+-dependent MDH, NAD+-MDH enzymes, NAD-dependent cytosolic malate dehydrogenase, NAD-dependent malate dehydrogenase, NAD-dependent MalDH, NAD-dependent malic dehydrogenase, NAD-dependent MDH, NAD-L-malate dehydrogenase, NAD-linked malate dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, NAD-MDH, NAD-specific malate dehydrogenase, NADP+-dependent malate dehydrogenase, Pcal_1699, pdNAD-MDH, peroxisomal malate dehydrogenase, peroxisomal NAD+-malate dehydrogenase 1, peroxisomal NAD+-malate dehydrogenase 2, plastid-localized NAD-dependent MDH, plastidial NAD+-dependent malate dehydrogenase, plastidial NAD-dependent malate dehydrogenase, plastidial NAD-dependent malate dehydrogenase 1, plNAD-MDH, PMDH, PMDH1, PMDH2, regulatory subunit of nucleic acid-conducting channel, s-MDH, SrMalDH, TaMDH, VEG69, Vegetative protein 69, YlMdh2p, [LDH-like] MDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.37 malate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.37 - malate dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-3-(4-((3R,5R,7R)-adamantan-1-yl)phenoxy)-N-(5-(piperidine-1-carbonyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl) acrylamide
-
(NH4)2SO4
reduction of oxaloacetate to malate and oxidation of malate to oxaloacetate
(S)-malate
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
-
i.e. differentiation-inducing factor DIF-1, a morphogen secreted from Dictyostelium discoideum, inhibits proliferation of several cancer cells via suppression of the Wnt/beta -catenin signaling pathway, specifically to mMDH and inhibits its activity, no binding of cytosolic MDH, overview
11-chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
65.3% inhibition at 0.010 mM
2',3'-Cyclic AMP
-
-
2,3-dimethoxy-6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carbonitrile
-
89.2% inhibition at 0.010 mM
2,3-dimethoxy-9-(trifluoromethyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
97.7% inhibition at 0.010 mM
2,4-dichlorophenoxybutyric acid
-
-
2-Hydroxy-5-nitrobenzyl bromide
-
-
2-methoxy-1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
-
i.e. differentiation-inducing factor 2-MIDIF-1, a morphogen secreted from Dictyostelium discoideum, inhibits proliferation of several cancer cells via suppression of the Wnt/beta -catenin signaling pathway, binds specifically to mMDH and inhibits its activity, no binding of cytosolic MDH, overview
2-oxoglutarate
2-Thenoyltrifluoroacetone
-
3-Aminopyridine adenine dinucleotide
-
-
3-methoxy-9-trifluormethyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
83.9% inhibition at 0.010 mM
3-methylpyridine adenine dinucleotide
-
-
3-pyridylacetonitrile adenine dinucleotide
-
-
3-pyridylcarbinol adenine dinucleotide
-
-
4-coumaric acid
-
13.4% inhibition at 0.1 mM
4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
87.6% inhibition at 0.010 mM
5-(3,4-dichlorobenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
5-(4-methylbenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
5-benzyl-9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
8.6% inhibition at 0.010 mM
5-benzyl-9-chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
5-benzyl-9-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
5-benzyl-9-methyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
5-benzyl-9-tert-butyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
5-benzyl-9-trifluoromethyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carbonitrile
-
91.3% inhibition at 0.010 mM
6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylic acid
-
98.7% inhibition at 0.010 mM
7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
78.7% inhibition at 0.010 mM
8,10-dichloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
28.7% inhibition at 0.010 mM
9-(methylsulfinyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
96.2% inhibition at 0.010 mM
9-(methylthio)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
76.6% inhibition at 0.010 mM
9-(trifluoromethyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
88.3% inhibition at 0.010 mM
9-bromo-12-(prop-2-en-1-yl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
74.1% inhibition at 0.010 mM
9-bromo-12-methyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
98.0% inhibition at 0.010 mM
9-bromo-2,3-dimethoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
56.3% inhibition at 0.010 mM
9-bromo-2-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
58.7% inhibition at 0.010 mM
9-bromo-3-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
15.0% inhibition at 0.010 mM
9-bromo-4-hydroxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
25.9% inhibition at 0.010 mM
9-bromo-4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
82.0% inhibition at 0.010 mM
9-bromo-5-(3,4-dichlorobenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
9-bromo-5-(4-methoxybenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
9-bromo-5-(4-methylbenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
9-bromo-5-methyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
81.9% inhibition at 0.010 mM
9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
74.5% inhibition at 0.010 mM
9-chloro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
73.4% inhibition at 0.010 mM
9-fluoro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
46.2% inhibition at 0.010 mM
9-methyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
87.8% inhibition at 0.010 mM
9-nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
54.2% inhibition at 0.010 mM
9-tert-butyl-5-(3,4-dichlorobenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
-
-
acetyl-CoA
adenosine 5'-diphosphoribose
-
-
alpha-ketoglutarate
arsenate
-
uncompetitive inhibition
aspartate
-
BaCl2
-
1 mM, 24.9% inhibition
butyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
-
CaCl2
-
1 mM, 29.1% inhibition
cAMP
-
competitive
citrate
Citric acid
-
-
CoA
Coccochloris peniocystis
-
-
CoCl2
-
1 mM, 39% inhibition
CuCl2
-
1 mM, 89.8% inhibition
D-fructose 1,6-diphosphate
-
heart s-MDH, inhibits the binding of NADH
Diamide
-
isoforms cy MDH1 and cyMDH2 are reversibly inactivated by diamide treatment. Both NADH and GSH separately or together prevented inactivation of cyMDH1 and cyMDH2 by diamide
Dicarbonate
diethyldicarbonate
-
-
EDTA
-
1 mM, 52.2% inhibition
ethyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
-
Fe3+
complete inhibition at 5 mM
ferulic acid
-
24.5% inhibition at 0.1 mM
gossypol
IC50: 0.0115 mM
guanidine hydrochloride
in the presence of 4 M guanidine hydrochloride enzyme structure is unfolded with complete loss of enzyme activity
hexyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
-
HgCl2
-
1 mM, complete inhibition
hydroxylamine
-
1 mM, 57.1% inhibition
Hydroxymalonate
iodoacetamide
-
-
iodoacetate
isocitrate
reduction of oxaloacetate to malate
L-malate
methyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
60.9% inhibition at 0.010 mM
MgCl2
-
1 mM,34.9% inhibition
MnCl2
-
1 mM, 28.6% inhibition
NADP+
-
product inhibition; product inhibition, 26% inhibition at 10 mM
NEM
-
1 mM, complete inhibition
NiCl2
-
1 mM, 36.8% inhibition
octyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
-
oxalic acid
-
inhibits L-malate oxidation reaction
oxaloacetate
p-chloromercuribenzoate
-
-
p-chloromercuriphenylsulfonate
-
-
pentyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
-
Phenylmethanesulfonylfluoride
-
-
propyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate
-
-
pyridine adenine dinucleotide
-
-
Semicarbazide
-
1 mM, 61.3% inhibition
sodium dodecylsulfate
0.1%, 70% loss of activity, 1%, complete loss of activity
succinate
slight inhibition of reduction of oxaloacetate
sulfite
Urea
-
enzyme activity and electrophoretic pattern of MDH and lactate dehydrogenase, EC 1.1.1.27, compared in relation to heat and urea inactivation, LDH is more sensitive than MDH, overview
ZnCl2
-
1 mM, 72.6% inhibition
additional information
-