1.1.1.365: D-galacturonate reductase

This is an abbreviated version!
For detailed information about D-galacturonate reductase, go to the full flat file.

Reaction

Synonyms

AKR2, AnGaaA, AnGar1, Cd-GAR, D-galacturonate reductase, D-galacturonic acid reductase, D-galacturonic acid reductases, FaGalUR, gaaA, GalA reductase, galacturonate reductase, GalUR, gar1, GAR2, NADPH-dependent D-galacturonate reductase, PcGOR

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.365 D-galacturonate reductase

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Results	in table
2	Activating Compound
38	AA Sequence
3	Application
18	Cloned(Commentary)
29	Cofactor
4	Expression
21	General Information
7	Inhibitors
7	kcat/KM [mM/s]
18	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
77	Organism
10	Pathway
6	pH Optimum
1	pH Range
15	Protein Variants
3	Purification (Commentary)
1	Reaction
32	Reference
19	Source Tissue
8	Specific Activity [micromol/min/mg]
69	Substrates and Products (Substrate)
12	Subunits
67	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
11	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.1.1.365 - D-galacturonate reductase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

C-4 epimer galacturonate

Penicillium camemberti

-

displays marked substrate inhibition

761270

-

glucuronate

Penicillium camemberti

-

weak substrate inhibition

761270

L-gulonate

Penicillium camemberti

-

competitive inhibitor, Ki in the low mM range

761270

L-gulono-1,4-lactone

Penicillium camemberti

-

competitive inhibitor, Ki in the low mM range

761270

N-ethylmaleimide

Euglena gracilis

-

84% residual activity at 1 mM

724580

NADP+

Aspergillus niger

A2R7U3, A8DRH9

mutant enzyme R267L shows a considerable sensitivity at the lower (0.16 mM) but not at the higher (0.8 mM) NADH concentration

763698

additional information

Penicillium camemberti

-

substrate inhibition by aldonic acids. The products L-galactonate and L-galactono-1,4-lactone are observed to mitigate substrate inhibition by galacturonate, with the lactone having a greater effect than the acid

761270

-