1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.1.1.363
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1.1.1.363
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citrate
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mesenteroides
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leuconostoc
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clarias
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batrachus
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4-hydroxy-2-nonenal
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freshwater
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multicatalytic
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catfish
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hne
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hne-treated
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lipogenic
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8-anilino-1-naphthalenesulfonic
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actinomycin
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pentose
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disease-related
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teleost
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synthesis
- 1.1.1.363
- citrate
- mesenteroides
-
leuconostoc
-
clarias
- batrachus
- 4-hydroxy-2-nonenal
-
freshwater
-
multicatalytic
- catfish
- hne
-
hne-treated
-
lipogenic
-
8-anilino-1-naphthalenesulfonic
- actinomycin
- pentose
-
disease-related
-
teleost
- synthesis
Reaction
Synonyms
G6-PDH, G6PD, G6PDH, G6PDH-1, Glc6PD, Glu-6-PDH, glucose 6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, NADP+- and NAD+-dependent G6PDH, PputG6PDH-1, zwf-1
ECTree
1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]Advanced search results
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results (KM Value
KM Value on EC 1.1.1.363 - glucose-6-phosphate dehydrogenase [NAD(P)+]
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.007
D-glucose 6-phosphate
-
pH 7.8, 25°C, cosubstrate: thionicotinamide-NAD+
0.009
D-glucose 6-phosphate
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pH 7.8, 25°C, cosubstrate: thionicotinamide-NADP+
0.063
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y415F
0.069
D-glucose 6-phosphate
25°C, pH 7.6, cosubstrate: NAD+, wild-type enzyme
0.0692
D-glucose 6-phosphate
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wild type enzyme, with NAD+ as cosubstrate, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.074
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y415F
0.075
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14S
0.075
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47A
0.078
D-glucose 6-phosphate
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25°C, pH 7.8, NAD+-dependent reaction
0.0891
D-glucose 6-phosphate
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mutant enzyme R46Q, with NAD+ as cosubstrate, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.09
D-glucose 6-phosphate
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25°C, pH 7.8, NADP+-dependent reaction
0.096
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47A
0.097
D-glucose 6-phosphate
25°C, pH 7.6, cosubstrate: NAD+, mutant enzyme K21R
0.114
D-glucose 6-phosphate
25°C, pH 7.6, cosubstrate: NADP+, wild-type enzyme
0.114
D-glucose 6-phosphate
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wild type enzyme, with NADP+ as cosubstrate, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.117
D-glucose 6-phosphate
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25°C, pH 7.6, cosubstrate: NADP+, mutant enzyme D177N
0.118
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14S
0.13
D-glucose 6-phosphate
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20°C, NADP+-linked reaction, pH not specified in the publication
0.132
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme R46E
0.135
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme D374Q
0.145
D-glucose 6-phosphate
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30°C, NADP+-linked reaction, pH not specified in the publication
0.165
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Y179F
0.169
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme T14A
0.175
D-glucose 6-phosphate
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mutant enzyme R46A, with NAD+ as cosubstrate, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.181
D-glucose 6-phosphate
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free enzyme, with NADP+ as cosubstrate, at pH 7.5 and 37°C
0.193
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme D374Q
0.228
D-glucose 6-phosphate
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tetraethyl orthosilicate-gel-immobilized enzyme, with NADP+ as cosubstrate, at pH 7.5 and 37°C
0.233
D-glucose 6-phosphate
-
25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme Q47E
0.239
D-glucose 6-phosphate
25°C, pH 7.6, cosubstrate: NADP+, mutant enzyme K21R
0.239
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Q47E
0.29
D-glucose 6-phosphate
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25°C, pH 7.6, cosubstrate: NAD+, mutant enzyme D177N
0.334
D-glucose 6-phosphate
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mutant enzyme R46Q, with NADP+ as cosubstrate, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.378
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme T14A
0.441
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme Y179F
0.467
D-glucose 6-phosphate
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mutant enzyme R46A, with NADP+ as cosubstrate, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.675
D-glucose 6-phosphate
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20°C, NAD+-linked reaction, pH not specified in the publication
0.8
D-glucose 6-phosphate
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25°C, pH 7.6, cosubstrate: NAD+, mutant enzyme H240N
0.825
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149G
0.946
D-glucose 6-phosphate
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with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.946
D-glucose 6-phosphate
pH 8.0, 30°C, recombinant enzyme, with NADP+
1.04
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme R46E
1.08
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149V
1.137
D-glucose 6-phosphate
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with NAD+ as cosubstrate, at pH 8.0 and 30°C
1.137
D-glucose 6-phosphate
pH 8.0, 30°C, recombinant enzyme, with NAD+
1.28
D-glucose 6-phosphate
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25°C, pH 7.6, cosubstrate: NADP+, mutant enzyme H240N
1.3
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343R
1.73
D-glucose 6-phosphate
-
25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme P149V
2.5
D-glucose 6-phosphate
25°C, pH 7.6, cosubstrate: NAD+, mutant enzyme K21Q
2.6
D-glucose 6-phosphate
-
25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme P149G
3.08
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343R
3.7
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182R
4.3
D-glucose 6-phosphate
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30°C, NAD+-linked reaction, pH not specified in the publication
6.07
D-glucose 6-phosphate
25°C, pH 7.6, cosubstrate: NADP+, mutant enzyme K21Q
6.8
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K182Q
13.1
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182Q
13.6
D-glucose 6-phosphate
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25°C, pH 7.6, cosubstrate: NAD+, mutant enzyme H1787N
16.1
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K182R
25.3
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NAD+, mutant enzyme K343Q
42.9
D-glucose 6-phosphate
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25°C, pH 7.6, cosubstrate: NADP+, mutant enzyme H1787N
106
D-glucose 6-phosphate
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25°C, pH 7.8, cosubstrate: NADP+, mutant enzyme K343Q
0.233
NAD+
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mutant enzyme R46Q, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.00799
NADP+
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wild type enzyme, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.854
NADP+
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mutant enzyme R46Q, in 33 mM Tris-HCl, pH 7.6, at 25°C
5.57
NADP+
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mutant enzyme R46A, in 33 mM Tris-HCl, pH 7.6, at 25°C
0.011
thionicotinamide-NAD+
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25°C, pH 7.2, cosubstrate: D-glucose 6-phosphate
additional information
additional information
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the Km-value of NAD+ is insensitive to ionic strength over the range tested but that the Km for glucose 6-phosphate is affected. This effect is greatest at pH 9.0
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additional information
additional information
kinetics and modelling, detailed overview
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