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1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about D-2-hydroxyacid dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.345

Reaction

an (R)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
+
NADH
+
H+

Synonyms

D-2-HADH, D-2-hydroxyacid dehydrogenase, D-2-hydroxyisocaproate dehydrogenase, D-HicDH, D-isomer specific 2-hydroxyacid dehydrogenase, D-isomer specific NAD+-dependent 2-hydroxyacid dehydrogenase, D-isomer-specific 2-hydroxyacid dehydrogenase, D-lactate dehydrogenase, D-lactate:NAD+ oxidoreductase, D-malate dehydrogenases, D-mandelate dehydrogenase, D-ManDH1, D-ManDH2, D-MDH, D2-HDH, HdhD, Ldb1010, ldh1837, LEUM_1837, ManDH2, NAD-dependent D-2-hydroxyacid dehydrogenase, PanE, R-HicDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.345 - D-2-hydroxyacid dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-2-hydroxy-4-methylpentanoate + NAD+
4-methyl-2-oxopentanoate + NADH + H+
show the reaction diagram
-
i.e. (R)-2-hydroxyisocaproate
i.e. 2-oxoisocaproate
-
r
(R)-2-hydroxycarboxylate + NAD+
a 2-oxocarboxylate + NADH + H+
show the reaction diagram
(R)-mandelate + NAD+
phenylglyoxylate + NADH + H+
show the reaction diagram
2-formylbutanethioate + NADH + H+
?
show the reaction diagram
2-hydroxyhexanoate + NAD+
2-oxohexanoate + NADH + H+
show the reaction diagram
-
-
-
-
r
2-hydroxyoctanoate + NAD+
2-oxooctanoate + NADH + H+
show the reaction diagram
-
-
-
-
r
2-hydroxypentanoate + NAD+
2-oxopentanoate + NADH + H+
show the reaction diagram
-
-
-
-
r
2-oxo-3-phenylpropanoate + NADH + H+
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
2-oxobutanoate + NADH + H+
2-hydroxybutanoate + NAD+
show the reaction diagram
2-oxobutyrate + NADH + H+
2-hydroxybutyrate + NAD+
show the reaction diagram
2-oxobutyrate + NADH + H+
?
show the reaction diagram
2-oxobutyrate + NADH + H+
? + NAD+
show the reaction diagram
2-oxobutyrate + NADH + H+
D-2-hydroxybutyrate + NAD+
show the reaction diagram
2-oxocaproate + NADH + H+
?
show the reaction diagram
2-oxocaproate + NADH + H+
? + NAD+
show the reaction diagram
2-oxocarboxylate + NADH + H+
(R)-2-hydroxycarboxylate + NAD+
show the reaction diagram
2-oxohexanoate + NADH + H+
2-hydroxyhexanoate + NAD+
show the reaction diagram
2-oxoisocaproate + NADH + H+
?
show the reaction diagram
2-oxoisocaproate + NADH + H+
? + NAD+
show the reaction diagram
2-oxoisocaproate + NADH + H+
L-2-hydroxyisocaproate + NAD+
show the reaction diagram
2-oxoisovalerate + NADH + H+
?
show the reaction diagram
2-oxoisovalerate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-oxomethylthiobutyrate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-oxomethylvalerate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
2-oxooctanoate + NADH + H+
2-hydroxyoctanoate + NAD+
show the reaction diagram
-
-
-
-
r
2-oxopentanoate + NADH + H+
2-hydroxypentanoate + NAD+
show the reaction diagram
2-oxovalerate + NADH + H+
?
show the reaction diagram
-
-
-
-
?
2-oxovalerate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
3-(4-hydroxyphenyl)-2-oxopropanoate + NADH + H+
2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD+
show the reaction diagram
-
-
-
-
?
3-hydroxypyruvate + NADH + H+
?
show the reaction diagram
-
-
-
-
?
3-methyl-2-oxobutanoate + NADH + H+
2-hydroxy-3-methylbutanoate + NAD+
show the reaction diagram
3-methyl-2-oxobutanoate + NADH + H+
3-methyl-2-hydroxybutanoate + NAD+
show the reaction diagram
3-methyl-2-oxopentanoate + NADH + H+
2-hydroxy-3-methylpentanoate + NAD+
show the reaction diagram
4-methyl-2-oxopentanoate + NADH + H+
(R)-2-hydroxy-4-methylpentanoate + NAD+
show the reaction diagram
4-methyl-2-oxopentanoate + NADH + H+
4-methyl-2-hydroxypentanoate + NAD+
show the reaction diagram
-
highest Vmax/Km value of all substrates tested
-
-
?
benzoylformate + NADH + H+
?
show the reaction diagram
benzoylformate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
D-2-hydroxybutyrate + NAD+
2-oxobutyrate + NADH + H+
show the reaction diagram
D-lactate + NAD+
pyruvate + NADH + H+
show the reaction diagram
-
-
-
-
r
D-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
D-mandelate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
DL-2-hydroxyisocaproate + NADH + H+
? + NAD+
show the reaction diagram
-
-
-
-
r
L-2-hydroxycaproate + NAD+
2-oxocaproate + NADH + H+
show the reaction diagram
-
-
-
-
r
oxaloacetate + NADH + H+
D-malate + NAD+
show the reaction diagram
phenylglyoxylate + NADH + H+
hydroxy(phenyl)acetic acid + NAD+
show the reaction diagram
phenylpyruvate + NADH + H+
?
show the reaction diagram
-
-
-
-
?
phenylpyruvate + NADH + H+
? + NAD+
show the reaction diagram
phenylpyruvate + NADH + H+
phenyl-D-lactate + NAD+
show the reaction diagram
phenylpyruvate + NADH + H+
phenyllactate + NAD+
show the reaction diagram
pyruvate + NADH + H+
D-lactate + NAD+
show the reaction diagram
pyruvate + NADH + H+
lactate + NAD+
show the reaction diagram
additional information
?
-