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1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.337

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
+
NADH
+
H+

Synonyms

(R)-sulfolactate dehydrogenase, ComC, L-2-hydroxyacid dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), L-2-hydroxyisocaproate dehydrogenase, L-HicDH, L-hydroxyisocaproate dehydrogenase, L-sulfolactate dehydrogenase, MDH I, MJ1425, sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)

Turnover Number

Turnover Number on EC 1.1.1.337 - L-2-hydroxycarboxylate dehydrogenase (NAD+)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.63 - 360000
2-oxocaproate
2 - 13000
2-oxoisocaproate
1.7 - 520000
4-methyl-2-oxopentanoate
0.07 - 52
oxo-tert-leucine
0.1 - 18000
phenylglyoxylate
8 - 89000
phenylpyruvate
0.004 - 340
pyruvate
62.8
sulfopyruvate
pH 6.5, 37°C