1.1.1.337: L-2-hydroxycarboxylate dehydrogenase (NAD+)

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For detailed information about L-2-hydroxycarboxylate dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

(R)-sulfolactate dehydrogenase, ComC, L-2-hydroxyacid dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), L-2-hydroxyisocaproate dehydrogenase, L-HicDH, L-hydroxyisocaproate dehydrogenase, L-sulfolactate dehydrogenase, MDH I, MJ1425, sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)

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Results	in table
36	AA Sequence
1	Application
4	Cloned(Commentary)
10	Cofactor
2	Crystallization (Commentary)
9	General Information
8	Inhibitors
91	kcat/KM [mM/s]
68	KM Value [mM]
2	Metals/Ions
5	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
6	Pathway
4	pH Optimum
2	pH Stability
1	pI Value
18	Protein Variants
3	Purification (Commentary)
1	Reaction
16	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
61	Substrates and Products (Substrate)
3	Subunits
27	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
91	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.1.1.337 - L-2-hydroxycarboxylate dehydrogenase (NAD+)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

in complex with NADH, to 2.5 A resolution. The asymmetric unit contains a tetramer of tight dimers. Structure does not contain a cofactor-binding domain with Rossmann-fold topology. The NADH is bound in an extended conformation in each active site, in a manner that explains the pro-S specificity. Cofactor binding involves residues belonging to both subunits within the tight dimers. The results indicate the existence of a substrate discrimination mechanism, which involves electrostatic interactions

Methanocaldococcus jannaschii

Q58820

719359

recombinant enzyme is crystallized with ammonium sulfate as precipitant in the presence of NAD+. The crystals belong to the trigonal space group P3(2)21, with a = 135.9 A and c = 205.9 A, and diffract X-rays to 2.2 A resolution

Weissella confusa

P14295

728117