1.1.1.31: 3-hydroxyisobutyrate dehydrogenase
This is an abbreviated version!
For detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.
Reaction
Synonyms
3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3-hydroxyisobutyric acid dehydrogenase, 3HIBDH-IV, 3HIBDHI, At4g20930, AtHDH1, beta-hydroxyisobutyrate dehydrogenase, HDH1, HIBADH, HIBDH
ECTree
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Inhibitors
Inhibitors on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase
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(R)-3-hydroxy-2-methylpropanoate
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competitive inhibitor of the S-isomer
ZnCl2
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0.2 mM, 60% inhibition; inhibits approximately 60% of 3-HIBADH activity at 0.2 mM but shows no effect at 0.005 mM
additional information
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is not inhibited by 1-propanol, lactate potassium, malate potassium, malonate potassium, acetaldehyde, ethanol, and glycerin
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competitive inhibition in the presence of NADH when NAD+ is varied, noncompetitive inhibition with NADH when (S)-3-hydroxyisobutyrate is varied