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1.1.1.305: UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)

This is an abbreviated version!
For detailed information about UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating), go to the full flat file.

Reaction

UDP-alpha-D-glucuronate
+
NAD+
=
UDP-beta-L-threo-pentapyranos-4-ulose
+
CO2
+
NADH
+
H+

Synonyms

ArnA, ArnA dehydrogenase, ArnADH, RsU4kpxs, UDP-alpha-D-xylose synthase, UDP-GlcUA dehydrogenase, UGA decarboxylase, UXS

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.305 UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)

Engineering

Engineering on EC 1.1.1.305 - UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E434Q
mutant is inactive, suggesting that chemical rather than steric properties of this residue are crucial in the decarboxylation reaction
R610M
activity is 800fold lower than wild-type activity
R619E
no activity
R619Y
no activity
S433A
activity is 30fold lower than wild-type activity
S433T
no activity